| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neelima Gupta, Shweta Jadhav, Kai-Leng Tan, Genevieve Saw, Karthik Babu Mallilankaraman, S Thameem Dhee. miR-142-3p Regulates BDNF Expression in Activated Rodent Microglia Through Its Target CAMK2A. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32508597. |
in this study, we performed a microrna (mirna) microarray in activated primary microglia derived from rat pup's brain and identified differentially expressed mirnas targeting key genes involved in cell survival, apoptosis, and inflammatory responses. |
2020-09-28 |
2023-08-13 |
rat |
| Ryuji Owada, Saaya Awata, Kazutomo Suzue, Hiroyasu Kanetaka, Yohei Kakuta, Kazuhiro Nakamur. Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells. Heliyon. vol 6. issue 9. 2020-09-28. PMID:32954034. |
in addition, an expanded polyq-containing protein in microglia also leads to apoptosis of neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Edith Arnold, Stéphanie Thébault, Rodrigo M Aroña, Gonzalo Martínez de la Escalera, Carmen Clap. Prolactin mitigates deficiencies of retinal function associated with aging. Neurobiology of aging. vol 85. 2020-09-11. PMID:31698287. |
lack of prl signaling in aged mice, but not in adult mice, correlated with photosensitive retinal dysfunction, increased photoreceptor apoptosis, differential expression of proapoptotic mediators, and microglia activation. |
2020-09-11 |
2023-08-13 |
mouse |
| Chayanut Kaewmool, Prachya Kongtawelert, Thanyaluck Phitak, Peraphan Pothacharoen, Sasimol Udomru. Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis. Journal of neuroimmunology. vol 341. 2020-09-03. PMID:32007785. |
protocatechuic acid inhibits inflammatory responses in lps-activated bv2 microglia via regulating sirt1/nf-κb pathway contributed to the suppression of microglial activation-induced pc12 cell apoptosis. |
2020-09-03 |
2023-08-13 |
Not clear |
| Chayanut Kaewmool, Prachya Kongtawelert, Thanyaluck Phitak, Peraphan Pothacharoen, Sasimol Udomru. Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis. Journal of neuroimmunology. vol 341. 2020-09-03. PMID:32007785. |
we found that pa inhibited the release of inflammatory mediators in lps-activated bv2 microglia via the sirt1/nf-κb pathway and thereby attenuated microglial activation-induced pc12 cell apoptosis. |
2020-09-03 |
2023-08-13 |
Not clear |
| Irune Diaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodríguez-Iglesias, Mar Márquez-Ropero, Sol Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, Carlos Matute, Irantzu Bernales, Angela Schulz, Lilla Otrokocsi, Beata Sperlagh, Kaisa E Happonen, Greg Lemke, Mirjana Maletic-Savatic, Jorge Valero, Amanda Sierr. Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31896673. |
during adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. |
2020-08-19 |
2023-08-13 |
mouse |
| Shiming Ju, Chen Xu, Gan Wang, Lin Zhan. VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30958378. |
moreover, in a tbi model in rats, vegf-c administration induced m2 polarization of microglia cells, significantly improved motor deficits after experimental tbi, and significantly improved neurological function following tbi, likely through a reduction in cell apoptosis. |
2020-08-17 |
2023-08-13 |
rat |
| Jia-Qi Liu, Shi-Feng Chu, Xin Zhou, Da-Yong Zhang, Nai-Hong Che. Role of chemokines in Parkinson's disease. Brain research bulletin. vol 152. 2020-08-14. PMID:31136787. |
they might be involved in the pathogenesis of pd by inducing neuronal apoptosis and microglia activation. |
2020-08-14 |
2023-08-13 |
Not clear |
| Cheng-Fang Hsieh, Ching-Kuan Liu, Ching-Tien Lee, Liang-En Yu, Jiz-Yuh Wan. Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation. Scientific reports. vol 9. issue 1. 2020-08-04. PMID:30696869. |
in contrast, the hg-to-ng shift trapped microglia in a state of metabolic stress, which led to apoptosis and autophagy, as evidenced by decreased bcl-2 and increased cleaved caspase-3, tunel staining, and lc3b-ii expression. |
2020-08-04 |
2023-08-13 |
Not clear |
| Waka Ushioda, Osamu Kotani, Kengo Kawachi, Naoko Iwata-Yoshikawa, Tadaki Suzuki, Hideki Hasegawa, Hiroyuki Shimizu, Kimimasa Takahashi, Noriyo Nagat. Neuropathology in Neonatal Mice After Experimental Coxsackievirus B2 Infection Using a Prototype Strain, Ohio-1. Journal of neuropathology and experimental neurology. vol 79. issue 2. 2020-07-27. PMID:31845989. |
histopathology showed that virus replication triggered activation of microglia and astrocytes, and induced apoptosis in the cortex, with severe necrosis and lateral ventricular dilation. |
2020-07-27 |
2023-08-13 |
mouse |
| Waka Ushioda, Osamu Kotani, Kengo Kawachi, Naoko Iwata-Yoshikawa, Tadaki Suzuki, Hideki Hasegawa, Hiroyuki Shimizu, Kimimasa Takahashi, Noriyo Nagat. Neuropathology in Neonatal Mice After Experimental Coxsackievirus B2 Infection Using a Prototype Strain, Ohio-1. Journal of neuropathology and experimental neurology. vol 79. issue 2. 2020-07-27. PMID:31845989. |
however, apoptosis and neuroinflammation from activated microglia and astrocytes differed in thalamic and cortical areas. |
2020-07-27 |
2023-08-13 |
mouse |
| Titikorn Chunchai, Puntarik Keawtep, Apiwan Arinno, Napatsorn Saiyasit, Dillon Prus, Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats. Aging. vol 11. issue 11. 2020-07-13. PMID:31160542. |
all treatments equally ameliorated cognitive decline by improving gut dysbiosis, alleviating bbb dysfunction, decreasing hippocampal ros production, decreasing hippocampal apoptosis, and reducing microglia and astrocyte activity. |
2020-07-13 |
2023-08-13 |
rat |
| Miwako Yamamiya, Shogo Tanabe, Rieko Muramats. Microglia promote the proliferation of neural precursor cells by secreting osteopontin. Biochemical and biophysical research communications. vol 513. issue 4. 2020-07-10. PMID:31003770. |
it has been reported that microglia regulate the number of npc by phagocytosis, inducing apoptosis, and promoting proliferation. |
2020-07-10 |
2023-08-13 |
Not clear |
| De-Qi Jiang, Yan-Jiao Ma, Yong Wang, Hai-Xiao Lu, Shu-Hui Mao, Shi-Hua Zha. Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 5. 2020-07-01. PMID:31004314. |
the cytotoxicity of lipopolysaccharide-induced microglia activation led to the accumulation of intracellular reactive oxygen species, increased cell apoptosis rate, reduced number of dacs, concomitant to cell cycle arrest at g |
2020-07-01 |
2023-08-13 |
Not clear |
| Sarah R Anderson, Jacqueline M Roberts, Jianmin Zhang, Michael R Steele, Cesar O Romero, Alejandra Bosco, Monica L Vette. Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia. Cell reports. vol 27. issue 7. 2020-07-01. PMID:31091440. |
developmental apoptosis promotes a disease-related gene signature and independence from csf1r signaling in retinal microglia. |
2020-07-01 |
2023-08-13 |
Not clear |
| Zhen-Tao Mo, Yu-Ling Liao, Jie Zheng, Wen-Na L. Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway. Life sciences. vol 255. 2020-06-29. PMID:32470450. |
at 24 h after reoxygenation, the protein expression of il-1 β, il-6, tnf-α in the supernatant of microglia was measured using elisa assay; neuronal apoptosis was assessed by tunel staining; and cell viability was detected using ckk-8 assay; the expression of ire1α, xbp1u, xbp1s, and cleaved caspase-3 in neurons was examined by western blotting and qrt-pcr; the expression of p-ire1α in neurons was detected by western blotting. |
2020-06-29 |
2023-08-13 |
Not clear |
| Zhen-Tao Mo, Yu-Ling Liao, Jie Zheng, Wen-Na L. Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway. Life sciences. vol 255. 2020-06-29. PMID:32470450. |
we found that ogd/r induced the expression of il-1 β, il-6, tnf-α in the supernatant of microglia; ogd/r and these proinflammatory cytokines promoted the mrna as well as protein expression of xbp1u, xbp1s and cleaved caspase-3, increased the ratio of p-ire1α/ire1α, as well as apoptosis, and decreased cell viability in primary cortical neurons, while ica reversed the levels of the above factors. |
2020-06-29 |
2023-08-13 |
Not clear |
| Chong Han, Xiangping Xia, Song Jiao, Gang Li, Qishan Ran, Shengtao Ya. Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1β release. Biochemical and biophysical research communications. vol 516. issue 4. 2020-06-08. PMID:31301768. |
tripartite motif containing protein 37 involves in thrombin stimulated bv-2 microglial cell apoptosis and interleukin 1β release. |
2020-06-08 |
2023-08-13 |
mouse |
| Chong Han, Xiangping Xia, Song Jiao, Gang Li, Qishan Ran, Shengtao Ya. Tripartite motif containing protein 37 involves in thrombin stimulated BV-2 microglial cell apoptosis and interleukin 1β release. Biochemical and biophysical research communications. vol 516. issue 4. 2020-06-08. PMID:31301768. |
in summary, trim37 involved in apoptosis and il-1β release in bv-2 microglia by regulating pparγ ubiquitination. |
2020-06-08 |
2023-08-13 |
mouse |
| Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Hamed Jafarpour, Zatollah Asem. Aquaporin 4: A key player in Parkinson's disease. Journal of cellular physiology. vol 234. issue 12. 2020-06-05. PMID:31127615. |
given that a sequence of cellular and molecular mechanisms, including oxidative stresses, apoptosis, inflammatory pathways, microglia, astrocyte activation, and aquaporin 4 (aqp4) are associated with initiation and the progression of pd. |
2020-06-05 |
2023-08-13 |
Not clear |