| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Licheng Yan, Jinghua Yang, Miao Yu, Yanxin Lu, Liling Huang, Jing Wang, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Ca. Lanthanum chloride induces neuron damage by activating the nuclear factor-kappa B signaling pathway in activated microglia. Metallomics : integrated biometal science. vol 11. issue 7. 2020-05-28. PMID:31187842. |
in a neuron-microglia co-culture system, bv2 microglia treated with lacl3 resulted in a significant increase of the rates of neuron apoptosis. |
2020-05-28 |
2023-08-13 |
Not clear |
| Mengmeng Li, Dongmei Zhang, Xin Ge, Xiangyang Zhu, Yong Zhou, Yi Zhang, Xiao Peng, Aiguo She. TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation. Experimental cell research. vol 376. issue 2. 2020-05-26. PMID:30763583. |
inhibiting atf2 significantly decreased the expression of pro-inflammatory factors in lps-treated microglia, and alleviated neuronal apoptosis induced by the conditioned medium of activated microglia. |
2020-05-26 |
2023-08-13 |
mouse |
| Alexey M Petrov, Natalia Mast, Yong Li, Irina A Pikulev. The key genes, phosphoproteins, processes, and pathways affected by efavirenz-activated CYP46A1 in the amyloid-decreasing paradigm of efavirenz treatment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 8. 2020-05-21. PMID:31063705. |
the data obtained pointed to efv effects at the synaptic level, plasmin-depended amyloid clearance, inflammation and microglia phenotype, oxidative stress and cellular hypoxia, autophagy and ubiquitin-proteasome systems as well as apoptosis. |
2020-05-21 |
2023-08-13 |
mouse |
| Longping Yao, Zhiyuan Zhu, Jiayu Wu, Yizhou Zhang, Hongbo Zhang, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhang, Guohui L. MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 7. 2020-05-20. PMID:30995872. |
in the microglial culture supernatant transfer model, the knockdown of p62 in bv2 cells prevented apoptosis and death of human neuroblastoma cell lines sh-sy5y (sh-sy5y) cells following microglia activation. |
2020-05-20 |
2023-08-13 |
mouse |
| Yuluo Rong, Wei Liu, Jiaxing Wang, Jin Fan, Yongjun Luo, Linwei Li, Fanqi Kong, Jian Chen, Pengyu Tang, Weihua Ca. Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. Cell death & disease. vol 10. issue 5. 2020-05-19. PMID:31000697. |
we demonstrate that nsc-sevs can significantly reduce the extent of sci, improve functional recovery, and reduce neuronal apoptosis, microglia activation, and neuroinflammation in rats. |
2020-05-19 |
2023-08-13 |
rat |
| Wenxin Ma, Sean M Silverman, Lian Zhao, Rafael Villasmil, Maria M Campos, Juan Amaral, Wai T Won. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. eLife. vol 8. 2020-04-20. PMID:30666961. |
tgfbr2-deficient retinal microglia induced secondary gliotic changes in müller cells, neuronal apoptosis, and decreased light-evoked retinal function reflecting abnormal synaptic transmission. |
2020-04-20 |
2023-08-13 |
mouse |
| Wei Liu, Yongxiang Wang, Fangyi Gong, Yuluo Rong, Yongjun Luo, Pengyu Tang, Zheng Zhou, Zhimin Zhou, Tao Xu, Tao Jiang, Siting Yang, Guoyong Yin, Jian Chen, Jin Fan, Weihua Ca. Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes. Journal of neurotrauma. vol 36. issue 3. 2020-04-10. PMID:29848167. |
using a series of in vitro functional assays, we also confirmed that treatment with bsmcs-exos significantly enhanced human umbilical vein endothelial cell proliferation, migration, and angiogenic tubule formation, attenuated neuronal cells apoptosis, and suppressed nitric oxide release in microglia. |
2020-04-10 |
2023-08-13 |
human |
| Jing Meng, Dong-Ming Wang, Li-Ling Lu. CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-07. PMID:31629950. |
importantly, the in vitro experiments demonstrated that ctrp3 knockdown-exacerbated apoptosis and inflammatory responsewere remarkably abrogated by the blockage of p38 and jnk signaling pathways in microglia stimulated by lps. |
2020-04-07 |
2023-08-13 |
mouse |
| Maryam Kamarehei, Sussan Kabudanian Ardestani, Masoumeh Firouzi, Hamid Zahednasab, Hossein Keyvani, Mohammad Hossein Harirchia. Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice. Brain research bulletin. vol 147. 2020-04-06. PMID:30738137. |
higher levels of caspase-12/chop in hippocampal oligodendrocytes as compared with microglia and astrocytes denote that oligodendrocytes are particularly sensitive to er-mediated apoptosis. |
2020-04-06 |
2023-08-13 |
mouse |
| Congde Chen, Suichun Wu, Zipu Hong, Xiaoming Chen, Xiaoou Shan, Shane Fischbach, Xiangwei Xia. Chronic hyperglycemia regulates microglia polarization through ERK5. Aging. vol 11. issue 2. 2020-04-03. PMID:30684443. |
conditioned media from the m2a-polarized microglia reduced neuronal cell apoptosis in hypoxic condition, while media from m2b-like or m1-like microglia enhanced apoptosis. |
2020-04-03 |
2023-08-13 |
Not clear |
| James F Striebel, Brent Race, Katie Williams, James A Carroll, Mikael Klingeborn, Bruce Chesebr. Microglia are not required for prion-induced retinal photoreceptor degeneration. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30909963. |
the onset of apoptosis and degeneration of pr neurons correlates with invasion of the pr cellular areas by microglia or monocytes, suggesting a causal role for these cells in pathogenesis of pr degenerative disease. |
2020-03-30 |
2023-08-13 |
mouse |
| Xin Zhou, Jiajun Chen, Hongjun Zhang, Xiao Chen, Gaohai Sha. MicroRNA-23b attenuates the H International journal of clinical and experimental pathology. vol 11. issue 12. 2020-03-25. PMID:31949662. |
microrna-23b attenuates the h apoptosis of microglia is one of the most important pathophysiologic changes after spinal cord injury (sci). |
2020-03-25 |
2023-08-13 |
rat |
| Anitha Krishnan, Andrew J Kocab, David N Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksande. A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma. Journal of neuroinflammation. vol 16. issue 1. 2020-03-23. PMID:31570110. |
glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (rgcs) and axon degeneration. |
2020-03-23 |
2023-08-13 |
mouse |
| Saori Nonaka, Hiroshi Nakanish. Microglial clearance of focal apoptotic synapses. Neuroscience letters. vol 707. 2020-03-11. PMID:31175934. |
this phenomenon is referred to as synaptic apoptosis or synaptosis, which triggers a rapid clearance of localized synaptic compartments by microglia. |
2020-03-11 |
2023-08-13 |
Not clear |
| Juan Yang, Haining Li, Zhao Wang, Liming Yu, Qiang Liu, Xiaoyan Niu, Ting Xu, Zhenhai Wan. Dihydroartemisinin inhibits multiplication of Brucella suis vaccine strain 2 in murine microglia BV2 cells via stimulation of caspase‑dependent apoptosis. Molecular medicine reports. vol 20. issue 5. 2020-03-03. PMID:31545433. |
dihydroartemisinin inhibits multiplication of brucella suis vaccine strain 2 in murine microglia bv2 cells via stimulation of caspase‑dependent apoptosis. |
2020-03-03 |
2023-08-13 |
human |
| Lixing Xu, Jing Su, Liting Guo, Siqi Wang, Xueyang Deng, Shiping M. Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression. Neuropharmacology. vol 155. 2020-02-28. PMID:31145906. |
additionally, ssd significantly decreased the expression of lpa1 and the degree of neuronal apoptosis in sh-sy5y cells which were co-cultured with lps-stimulated bv2 microglia. |
2020-02-28 |
2023-08-13 |
mouse |
| Zhigang Jiao, Wenlong Zhang, Chaojun Chen, Xiaoqin Zhu, Xiang Chen, Miaomiao Zhou, Guoyou Peng, Hanqun Liu, Jiewen Qiu, Yuwan Lin, Shuxuan Huang, Mingshu Mo, Xinling Yang, Shaogang Qu, Pingyi X. Gene Dysfunction Mediates Immune Response to Dopaminergic Degeneration in Parkinson's Disease. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30289236. |
this immune disorder results in subsequent inflammatory reaction, which stimulates microglia or other immune cells to secrete cytokines and chemokines and disturbs the proportion of peripheral blood lymphocyte subsets contributing to dopaminergic (da) neuron apoptosis. |
2020-02-26 |
2023-08-13 |
Not clear |
| Morgan L Sherer, Pragyan Khanal, Gwen Talham, Erin M Brannick, Mark S Parcells, Jaclyn M Schwar. Zika virus infection of pregnant rats and associated neurological consequences in the offspring. PloS one. vol 14. issue 6. 2020-02-12. PMID:31220154. |
we examined the febrile response and sickness behavior in the dams, in addition to neonatal mortality, microglia morphology, cortical organization, apoptosis, and brain region-specific volumes in the offspring. |
2020-02-12 |
2023-08-13 |
rat |
| Stefano Calovi, Paula Mut-Arbona, Beáta Sperlág. Microglia and the Purinergic Signaling System. Neuroscience. vol 405. 2020-01-30. PMID:30582977. |
microglia are activated during diverse conditions, such as apoptosis, trauma, inflammation, and infection. |
2020-01-30 |
2023-08-13 |
Not clear |
| Lotte G van den Heuij, Mhoyra Fraser, Suzanne L Miller, Graham Jenkin, Euan M Wallace, Joanne O Davidson, Christopher A Lear, Rebecca Lim, Guido Wassink, Alistair J Gunn, Laura Benne. Delayed intranasal infusion of human amnion epithelial cells improves white matter maturation after asphyxia in preterm fetal sheep. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 2. 2019-12-23. PMID:28895475. |
neuronal survival in deep grey matter nuclei was improved, with reduced microglia, astrogliosis and cleaved-caspase-3-positive apoptosis. |
2019-12-23 |
2023-08-13 |
human |