| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael S Hester, Natalia Tulina, Amy Brown, Guillermo Barila, Michal A Elovit. Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells. Brain research. vol 1685. 2019-04-19. PMID:29448014. |
intrauterine inflammation had no effect on hippocampal astrocyte or microglia density or on apoptosis rate at the postnatal time points examined. |
2019-04-19 |
2023-08-13 |
mouse |
| Pan Jiang, Lei Chen, Jing Sun, Jingsong Li, Jian Xu, Wenyuan Liu, Feng Feng, Wei Q. Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway. Journal of pharmacological sciences. vol 139. issue 2. 2019-04-17. PMID:30642751. |
furthermore, chotosan could significantly reverse reactive oxygen species production, neuronal apoptosis and microglia over-activation in hippocampus. |
2019-04-17 |
2023-08-13 |
Not clear |
| You Lang Zhou, Luzhong Zhang, Zhou Zhou, Wei Liu, Yang Lu, Shumin He, Yajuan Cui, Yongwei Qin, Minhui Hu. Antibody Modified Nanoparticle-Mediated Delivery of miR-124 Regulates Apoptosis via Repression the Stat3 Signal in Mycobacterial-Infected Microglia. Journal of biomedical nanotechnology. vol 14. issue 12. 2019-04-16. PMID:30305225. |
antibody modified nanoparticle-mediated delivery of mir-124 regulates apoptosis via repression the stat3 signal in mycobacterial-infected microglia. |
2019-04-16 |
2023-08-13 |
Not clear |
| Tianyang Xi, Feng Jin, Ying Zhu, Jialu Wang, Ling Tang, Yanzhe Wang, David S Liebeskind, Fabien Scalzo, Zhiyi H. miR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11. The Journal of biological chemistry. vol 293. issue 52. 2019-04-08. PMID:30337368. |
of note, mir-27a-3p mimic treatment also inhibited neuronal apoptosis and microglia activation in the perihematomal zone. |
2019-04-08 |
2023-08-13 |
rat |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
we also showed that resveratrol treatment decreased il-1β, il-6, tnf-ɑ, pcna, bcl-2, and acetyl-p65 levels, but increased bax and caspase 3 levels in hippocampus, suggesting a suppressive effect of resveratrol on cellular neuroinflammation and proliferation while a promotive effect on apoptosis of microglia in hippocampus. |
2019-04-05 |
2023-08-13 |
mouse |
| Ting Wang, Xiahui Sun, Wen Qin, Xiaoli Zhang, Leilei Wu, Yan Li, Chunxue Zhou, Huaiyu Zhou, Shenyi He, Hua Con. From inflammatory reactions to neurotransmitter changes: Implications for understanding the neurobehavioral changes in mice chronically infected with Toxoplasma gondii. Behavioural brain research. vol 359. 2019-04-03. PMID:30253194. |
histopathology revealed the activation of astrocytes and microglia, apoptosis of neurons and decreases in synapses in the brain of infected mice. |
2019-04-03 |
2023-08-13 |
mouse |
| Yong-Fei Fan, Shao-Yu Guan, Li Luo, Yan-Jiao Li, Le Yang, Xuan-Xuan Zhou, Guo-Dong Guo, Ming-Gao Zhao, Qi Yang, Gang Li. Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex. Molecular pain. vol 14. 2019-04-01. PMID:30380983. |
tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and glun2b overexpression in anterior cingulate cortex. |
2019-04-01 |
2023-08-13 |
mouse |
| Reginald C Adiele, Chiedukam A Adiel. Metabolic defects in multiple sclerosis. Mitochondrion. vol 44. 2019-03-08. PMID:29246870. |
bioenergetics, oxygen and ion metabolism dominate the metabolic and biochemical pathways that maintain neuronal viability and impulse transmission which directly or indirectly point to mitochondrial integrity and adenosine triphosphate (atp) availability indicating the involvement of mitochondria in the pathogenesis of ms. loss of myelin proteins including myelin basic protein (mbp), proteolipid protein (plp), myelin associated glycoprotein (mag), myelin oligodendrocyte glycoproetin (mog), 2, 3,-cyclic nucleotide phosphodiestarase (cnpase); microglia and microphage activation, oligodendrocyte apoptosis as well as expression of inducible nitric oxide synthase (i-nos) and myeloperoxidase activities have been implicated in a subset of balo's type and relapsing remitting ms (rrms) lesions indicating the involvement of metabolic defects and oxidative stress in ms. |
2019-03-08 |
2023-08-13 |
Not clear |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
we found that this esi-induced loss of hippocampal microglia was mediated by both microglial activation and apoptosis. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
this was demonstrated by the following results: (i) 1 day of esi induced an obvious activation of hippocampal microglia followed by their apoptosis, and (ii) the blockade of the initial activation of hippocampal microglia by minocycline pretreatment suppressed the esi-induced apoptosis and loss as well as esi-induced depressive-like behavior. |
2019-02-04 |
2023-08-13 |
mouse |
| Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yua. Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221727. |
effect of chemokine cc ligand 2 (ccl2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis. |
2019-01-29 |
2023-08-13 |
Not clear |
| Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yua. Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221727. |
the present study aimed to investigate the effect of chemokine cc ligand 2 (ccl2) on α‑synuclein‑mediated microglia proliferation and neuronal apoptosis. |
2019-01-29 |
2023-08-13 |
Not clear |
| Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yua. Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221727. |
taken together, these results have demonstrated that ccl2 is able to promote α‑synuclein secretion and the apoptosis of neurons induced by α‑synuclein, thus inducing proliferation of the microglia and secretion of tnf‑α, il‑1β and no. |
2019-01-29 |
2023-08-13 |
Not clear |
| Runxiao Lv, Lili Du, Lixin Zhang, Zhiqiang Zhan. Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway. Life sciences. vol 217. 2019-01-11. PMID:30481506. |
polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via nrf2/ho-1 pathway. |
2019-01-11 |
2023-08-13 |
rat |
| Jie Wang, Yan-Ling Zhang, Nan Zhuan. [Salidroside inhibits inflammatory factor release in BV-2 cells through p38 and JNK pathways]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926065. |
these results suggest that salidroside inhibits pc12 cell apoptosis by decreasing inflammatory factor release as well as p38 and jnk activation in activated microglia. |
2019-01-04 |
2023-08-13 |
Not clear |
| Zhen-Song Jiang, Jian-Ru Zhan. LncRNA SNHG5 enhances astrocytes and microglia viability via upregulating KLF4 in spinal cord injury. International journal of biological macromolecules. vol 120. issue Pt A. 2019-01-02. PMID:30076931. |
the knockdown of klf4 effectively decreased astrocytes and microglia viability induced by shng5 overexpression and attenuated the pcdna-snhg5-mediated repression of the apoptosis. |
2019-01-02 |
2023-08-13 |
rat |
| Qasim Alhadidi, Zahoor A Sha. Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NF-κB and JAK-STAT Pathway. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28194647. |
in conclusion, we demonstrated that cofilin is involved in the cascade of microglial cell activation and further validates our previous study on cofilin's role in mediating neuronal apoptosis. |
2018-12-21 |
2023-08-13 |
Not clear |
| Yucong Peng, Pingyou He, Linfeng Fan, Hangzhe Xu, Jianru Li, Ting Chen, Wu Ruan, Zhangqi Dou, Gao Che. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats. The American journal of Chinese medicine. vol 46. issue 6. 2018-12-18. PMID:30149758. |
in addition, immunofluorescence staining demonstrated that mlb dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis. |
2018-12-18 |
2023-08-13 |
rat |
| Meng-Xian Pan, Jun-Chun Tang, Rui Liu, Yu-Gong Feng, Qi Wa. Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 21. issue 4. 2018-11-27. PMID:30017543. |
effects of estrogen receptor gpr30 agonist g1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats. |
2018-11-27 |
2023-08-13 |
rat |
| Di Li, Haibo Ni, Qin Rui, Rong Gao, Gang Che. Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury. Current neuropharmacology. vol 16. issue 9. 2018-11-26. PMID:29766810. |
this article reviews the role of mst1 in the signaling pathways which is related with the neuronal cell apoptosis or microglia activation following myocardial and brain injury. |
2018-11-26 |
2023-08-13 |
Not clear |