| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Schampel, Oleg Volovitch, Tobias Koeniger, Claus-Jürgen Scholz, Stefanie Jörg, Ralf A Linker, Erhard Wischmeyer, Marie Wunsch, Johannes W Hell, Süleyman Ergün, Stefanie Kuerte. Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 16. 2018-05-17. PMID:28381594. |
surprisingly, we observed calcium channel-independent effects on microglia, resulting in apoptosis. |
2018-05-17 |
2023-08-13 |
mouse |
| Yuanyuan Ma, Jixian Wang, Yongting Wang, Guo-Yuan Yan. The biphasic function of microglia in ischemic stroke. Progress in neurobiology. vol 157. 2018-05-14. PMID:26851161. |
however, increasing evidence show that microglia activation is critical for attenuating neuronal apoptosis, enhancing neurogenesis, and promoting functional recovery after cerebral ischemia. |
2018-05-14 |
2023-08-13 |
Not clear |
| Rachelle Balez, Nicole Steiner, Martin Engel, Sonia Sanz Muñoz, Jeremy Stephen Lum, Yizhen Wu, Dadong Wang, Pascal Vallotton, Perminder Sachdev, Michael O'Connor, Kuldip Sidhu, Gerald Münch, Lezanne Oo. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease. Scientific reports. vol 6. 2018-05-14. PMID:27514990. |
the ipsc-derived ad neurons demonstrated a hyper-excitable calcium signalling phenotype, elevated levels of nitrite, increased cytotoxicity and apoptosis, reduced neurite length and increased susceptibility to inflammatory stress challenge from activated murine microglia, in comparison to control neurons. |
2018-05-14 |
2023-08-13 |
human |
| Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Matheus Grunevald, Letícia F Pettenuzzo, Giselli Scaini, Emilio L Streck, Carlos A Netto, Angela T S Wys. Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats. Molecular neurobiology. vol 54. issue 6. 2018-05-10. PMID:27324900. |
bdnf and ptrkb immunocontents and ngf levels were decreased, while tnf-α and il-6 levels, iba-1 and caspase 3 cleaved immunocontents (microglia marker and active apoptosis marker, respectively) were increased. |
2018-05-10 |
2023-08-13 |
rat |
| David T White, Sumitra Sengupta, Meera T Saxena, Qingguo Xu, Justin Hanes, Ding Ding, Hongkai Ji, Jeff S Mum. Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 18. 2018-04-23. PMID:28416692. |
to investigate possible roles innate immune cells play during retinal cell regeneration, we used intravital microscopy to visualize neutrophil, macrophage, and retinal microglia responses to induced rod photoreceptor apoptosis. |
2018-04-23 |
2023-08-13 |
zebrafish |
| G Tong, A Krauss, J Mochner, S Wollersheim, P Soltani, F Berger, K R L Schmit. Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway. Neuroscience. vol 358. 2018-04-23. PMID:28687308. |
moreover, attenuation of the inflammatory response resulted in decreased apoptosis in a direct co-culture of microglia and neurons. |
2018-04-23 |
2023-08-13 |
Not clear |
| Xinchun Ye, Lu Yu, Dandan Zuo, Liang Zhang, Jie Zu, Jinxia Hu, Jiao Tang, Lei Bao, Chengcheng Cui, Ruixue Zhang, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Zunsheng Zhang, Qihua Xiao, Yonghai Liu, Jie Xiang, Xueling Zhang, Guiyun Cu. Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway. Neuroscience letters. vol 654. 2018-04-17. PMID:28642149. |
to investigate the role of activated mglur5 against oxygen-glucose deprivation (ogd)/reoxygenation (r)-mediated cytotoxicity, the cell viability, apoptosis, the release of inflammatory cytokines and accumulation of reactive oxygen species (ros) were evaluated in bv2 cells (microglia cell line) with or without ogd/r exposure. |
2018-04-17 |
2023-08-13 |
Not clear |
| ChaoYi Feng, Xin Wang, TianJin Liu, Meng Zhang, GeZhi Xu, YingQin N. Expression of CCL2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis. Molecular vision. vol 23. 2018-04-13. PMID:29142497. |
expression of ccl2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis. |
2018-04-13 |
2023-08-13 |
Not clear |
| ChaoYi Feng, Xin Wang, TianJin Liu, Meng Zhang, GeZhi Xu, YingQin N. Expression of CCL2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis. Molecular vision. vol 23. 2018-04-13. PMID:29142497. |
to explore the effect of the ccl2 and ccr2 system on the activation and migration of microglia and monocytes in light-induced photoreceptor apoptosis. |
2018-04-13 |
2023-08-13 |
Not clear |
| Yunhong Li, Rui Zhang, Xiaolin Hou, Yumei Zhang, Feijia Ding, Fan Li, Yao Yao, Yin Wan. Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586011. |
microglia activation triggers oligodendrocyte precursor cells apoptosis via hsp60. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yunhong Li, Rui Zhang, Xiaolin Hou, Yumei Zhang, Feijia Ding, Fan Li, Yao Yao, Yin Wan. Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586011. |
hsp60 was demonstrated to be released extracellularly by lps‑activated microglia and to bind to opcs, triggering opc apoptosis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yunhong Li, Rui Zhang, Xiaolin Hou, Yumei Zhang, Feijia Ding, Fan Li, Yao Yao, Yin Wan. Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586011. |
these results suggest that hsp60 released by microglia may mediate opc apoptosis through binding to tlr4 on the surface of opcs and subsequently activating the tlr4‑nfκb signaling pathway. |
2018-03-26 |
2023-08-13 |
Not clear |
| Xiao He, Dayu Sun, Siyu Chen, Haiwei X. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404878. |
t0 markedly delayed apoptosis of the photoreceptors, partially through suppressing the activation of microglia and the gliosis of müller cells, and decreased the expression levels of il-6, inos, cox-2 and eng in rd1 mice; as a result, the visual function of t0-treated rd1 mice measured with electroretinograms (erg) was preserved for a longer time than that of vehicle-treated rd1 mice. |
2018-03-05 |
2023-08-13 |
mouse |
| Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeri. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. European journal of cell biology. vol 96. issue 3. 2018-03-02. PMID:28336086. |
we confirm these results by demonstrating that glp-1 and gip also inhibit apoptosis of primary murine microglia, and upregulate expression of bdnf by primary murine microglia. |
2018-03-02 |
2023-08-13 |
human |
| Pallavi Shrivastava, Miguel A Cabrera, Lucy G Chastain, Nadka I Boyadjieva, Shaima Jabbar, Tina Franklin, Dipak K Sarka. Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol. Journal of neuroinflammation. vol 14. issue 1. 2018-03-02. PMID:28407740. |
we investigated the role of mu-opioid receptors (mor) and delta-opioid receptors (dor) on microglia in the regulation of apoptosis in proopiomelanocortin (pomc) neurons induced by neonatal ethanol in the hypothalamus. |
2018-03-02 |
2023-08-13 |
Not clear |
| Chunxia Xiao, Pandi He, Jingjing Han, Miaoling Tang, Zhen Wang, Yashi Mi, Xuebo Li. 1,3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF-κB signaling pathways mediated by reactive oxygen species. Toxicology letters. vol 284. 2018-02-21. PMID:29248572. |
1,3-dichloro-2-propanol evokes inflammation and apoptosis in bv-2 microglia via mapks and nf-κb signaling pathways mediated by reactive oxygen species. |
2018-02-21 |
2023-08-13 |
Not clear |
| Vera Chesnokova, Robert N Pechnick, Kolja Wawrowsk. Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:26802985. |
activated microglia reduce neurogenesis by suppressing neuronal stem cell proliferation, increasing apoptosis of neuronal progenitor cells, and decreasing survival of newly developing neurons and their integration into existing neuronal circuits. |
2018-01-17 |
2023-08-13 |
human |
| Xiao-Mei Wu, Yong Liu, Zhong-Ming Qian, Qian-Qian Luo, Ya K. CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway. Molecular neurobiology. vol 53. issue 6. 2018-01-15. PMID:26189830. |
we investigated the effects of cx3cl1, cx3cr1 shrna, and p38mapk inhibitor on the apoptosis, proliferation, and myelin proteolipid protein (plp) expression in oligodendrocytes in co-cultures with bv2 microglia under ischemia. |
2018-01-15 |
2023-08-13 |
Not clear |
| Nan Yan, Yan Liu, Shengnan Liu, Siqi Cao, Fei Wang, Zhengdong Wang, Shuhua X. Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26253724. |
fluoride-induced neuron apoptosis and expressions of inflammatory factors by activating microglia in rat brain. |
2018-01-08 |
2023-08-13 |
rat |
| Nan Yan, Yan Liu, Shengnan Liu, Siqi Cao, Fei Wang, Zhengdong Wang, Shuhua X. Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26253724. |
after 10 weeks, rats were sacrificed under anesthesia then apoptosis in neuron and inflammatory factors secreted by microglia were determined. |
2018-01-08 |
2023-08-13 |
rat |