| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianjun Zhong, Chongjie Cheng, Han Liu, Zhijian Huang, Yue Wu, Zhipeng Teng, Junchi He, Hongrong Zhang, Jinchuan Wu, Fang Cao, Li Jiang, Xiaochuan Su. Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E. Neuroscience. vol 343. 2017-11-17. PMID:27235741. |
the inflammatory cytokines, microglia amount, cell apoptosis rate, and protein of cleaved caspase-3 around the injury site were markedly upregulated after tbi in both c57bl/6 and apoe-ko mice, and all these upregulation were significantly mitigated by bexarotene treatment in c57bl/6 mice, but not in apoe-ko mice. |
2017-11-17 |
2023-08-13 |
mouse |
| Shiqi Cheng, WeiWei Gao, Xin Xu, Hengyi Fan, Yingang Wu, Fei Li, Jianning Zhang, Xingen Zhu, Yan Zhan. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain research bulletin. vol 127. 2017-11-13. PMID:27746369. |
neutrophils, microglia were measured by immunohistochemistry staining, neuronal apoptosis was measured by tunel and neun co-stained. |
2017-11-13 |
2023-08-13 |
mouse |
| Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui X. Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. PloS one. vol 12. issue 8. 2017-11-07. PMID:28832643. |
we showed that hiv-1 gp120 peptide (v3 loop, fragment 308-331) appeared to induce apoptosis of primary cultured microglia. |
2017-11-07 |
2023-08-13 |
human |
| Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui X. Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia. PloS one. vol 12. issue 8. 2017-11-07. PMID:28832643. |
however, there was a decrease of microglia apoptosis in gp120+naringin group compared with gp120 group. |
2017-11-07 |
2023-08-13 |
human |
| Daniele Lana, Ludovica Iovino, Daniele Nosi, Gary L Wenk, Maria Grazia Giovannin. The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats. Experimental gerontology. vol 83. 2017-10-16. PMID:27466072. |
inflammaging-induced modifications of astrocytes and microglia in ca3 of aged rats may help clearing neuronal debris derived from low-grade inflammation and apoptosis. |
2017-10-16 |
2023-08-13 |
rat |
| Xiang Zhang, Hongquan Dong, Nana Li, Susu Zhang, Jie Sun, Shu Zhang, Yanning Qia. Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis. Journal of neuroinflammation. vol 13. issue 1. 2017-10-10. PMID:27245661. |
activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis. |
2017-10-10 |
2023-08-13 |
Not clear |
| Seema Yousuf, Fahim Atif, Iqbal Sayeed, Jun Wang, Donald G Stei. Neuroprotection by progesterone after transient cerebral ischemia in stroke-prone spontaneously hypertensive rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27283379. |
to assess morphological protection we measured activation of microglia and astrocytes, oxidative stress, apoptosis, expression of vascular endothelial growth factor (vegf), an angiogenic marker, and il-1β, a marker of inflammation, on day 14 post-stroke. |
2017-10-03 |
2023-08-13 |
rat |
| Hai-Yan Xing, Bin Li, Dan Peng, Chun-Yan Wang, Guan-Ying Wang, Pan Li, Ying-Ying Le, Ji-Ming Wang, George Ye, Jian-Hong Che. A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer's disease. PloS one. vol 12. issue 6. 2017-10-03. PMID:28662102. |
in a mouse model of ad, administration with 3f5 for 3 months in 6 months-old mice demonstrated that the mab specifically bound with aβ1-42 to promote the depolymerization of aβ fibrils, facilitated endocytosis of aβ1-42 by microglia, and attenuated the death and apoptosis of neuronal cells, accompanied by neurite outgrowth. |
2017-10-03 |
2023-08-13 |
mouse |
| Yan Lu, Yuechao Gu, Xiaowei Ding, Jiaqiang Wang, Jiawei Chen, Changhong Mia. Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis. PloS one. vol 12. issue 5. 2017-09-18. PMID:28542400. |
intracellular ca2+ homeostasis and jak1/stat3 pathway are involved in the protective effect of propofol on bv2 microglia against hypoxia-induced inflammation and apoptosis. |
2017-09-18 |
2023-08-13 |
Not clear |
| Thomas Weber, Kazuhiko Namikawa, Barbara Winter, Karina Müller-Brown, Ralf Kühn, Wolfgang Wurst, Reinhard W Köste. Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons. Development (Cambridge, England). vol 143. issue 22. 2017-09-11. PMID:27729409. |
we observed synchronous cell death autonomous to the pc population and phagocytosing microglia in the cerebellum, reminiscent of developmental apoptosis in the forebrain. |
2017-09-11 |
2023-08-13 |
zebrafish |
| Tuan Leng Tay, Dominic Mai, Jana Dautzenberg, Francisco Fernández-Klett, Gen Lin, Sagar, Moumita Datta, Anne Drougard, Thomas Stempfl, Alberto Ardura-Fabregat, Ori Staszewski, Anca Margineanu, Anje Sporbert, Lars M Steinmetz, J Andrew Pospisilik, Steffen Jung, Josef Priller, Dominic Grün, Olaf Ronneberger, Marco Prin. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nature neuroscience. vol 20. issue 6. 2017-08-29. PMID:28414331. |
in the resolution phase, excess disease-associated microglia are removed by a dual mechanism of cell egress and apoptosis to re-establish the stable microglial network. |
2017-08-29 |
2023-08-13 |
Not clear |
| Qing-Peng Hu, Ding-An Ma. Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation. BMC neuroscience. vol 17. issue 1. 2017-08-21. PMID:27193049. |
seizure-induced tlr4/myd88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. |
2017-08-21 |
2023-08-13 |
rat |
| Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Ki. Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro. Nutrients. vol 9. issue 3. 2017-08-17. PMID:28264445. |
additionally, equol protects neurons from neuroinflammatory injury mediated by lps-activated microglia through downregulation of neuronal apoptosis, increased neurite outgrowth in n2a cell and neurotrophins like nerve growth factor (ngf) production through astrocytes further supporting its neuroprotective potential. |
2017-08-17 |
2023-08-13 |
Not clear |
| Danying Su, Yuefeng Cheng, Shi Li, Dawei Dai, Wei Zhang, Manhua L. Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion. Journal of neuroimmunology. vol 305. 2017-08-17. PMID:28284343. |
moreover, we also found that after suppression of traf2 or nf-κb by sirna in microglia, reductions in the downstream molecules nf-κb and il-17 and in neuronal apoptosis were observed in response to ogdr. |
2017-08-17 |
2023-08-13 |
Not clear |
| Xinyi Ding, Meng Zhang, Ruiping Gu, Gezhi Xu, Haixiang W. Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 255. issue 4. 2017-08-09. PMID:28074262. |
activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes. |
2017-08-09 |
2023-08-13 |
Not clear |
| Xinyi Ding, Meng Zhang, Ruiping Gu, Gezhi Xu, Haixiang W. Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 255. issue 4. 2017-08-09. PMID:28074262. |
we hypothesized that activated microglia may promote pericyte apoptosis by enhancing ros production. |
2017-08-09 |
2023-08-13 |
Not clear |
| Jong Kil Lee, Kai Wang, Min Hee Park, Namoh Kim, Ju Youn Lee, Hee Kyung Jin, In-San Kim, Byung-Heon Lee, Jae-Sung Ba. Probing amyloid beta-induced cell death using a fluorescence-peptide conjugate in Alzheimer's disease mouse model. Brain research. vol 1646. 2017-07-20. PMID:27369450. |
the fluorescein-labeled apopep-1 co-localized with brain cells such as neurons, astrocytes, and microglia, all of which undergo apoptosis in the app/ps1 mice brain. |
2017-07-20 |
2023-08-13 |
mouse |
| Dianelys Gonzalez-Pena, Scott E Nixon, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Za. Differential Transcriptome Networks between IDO1-Knockout and Wild-Type Mice in Brain Microglia and Macrophages. PloS one. vol 11. issue 6. 2017-07-12. PMID:27314674. |
enriched biological processes among the genes over- and under-expressed in microglia relative to macrophages included cell adhesion and apoptosis, respectively. |
2017-07-12 |
2023-08-13 |
mouse |
| Ke Pan, Xiaojun Li, Yan Chen, Dan Zhu, Yuping Li, Guocai Tao, Zhiyi Zu. Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus. Neuropharmacology. vol 111. 2017-07-11. PMID:27608977. |
furthermore, deferoxamine sharply reduced the hippocampal reactive oxygen species, malondialdehyde concentration and ox-42 that is a marker of microglia, which might reduce postoperative brain cell apoptosis. |
2017-07-11 |
2023-08-13 |
rat |
| Anja Pišlar, Biljana Božić, Nace Zidar, Janko Ko. Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation. Neuropharmacology. vol 114. 2017-07-11. PMID:27889490. |
inhibition of cathepsin x suppressed microglial activation through the reduced caspase-3 activity, together with diminished microglial cell death and apoptosis, and also through inhibition of the activity of the mitogen-activated protein kinases. |
2017-07-11 |
2023-08-13 |
Not clear |