| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
taken together, these findings suggest that upregulated production of ros plays a vital role in pfos-mediated apoptosis in hapi microglia via the modulation of p53 signaling. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jiawei Wang, Shida Chen, Xiulan Zhang, Wenbin Huang, Jost B Jona. Intravitreal triamcinolone acetonide, retinal microglia and retinal ganglion cell apoptosis in the optic nerve crush model. Acta ophthalmologica. vol 94. issue 5. 2017-01-11. PMID:25708663. |
intravitreal triamcinolone acetonide, retinal microglia and retinal ganglion cell apoptosis in the optic nerve crush model. |
2017-01-11 |
2023-08-13 |
Not clear |
| Eun-Young Lee, Jeong-Ah Yoo, So-Mang Lim, Kyung-Hyun Ch. Anti-Aging and Tissue Regeneration Ability of Policosanol Along with Lipid-Lowering Effect in Hyperlipidemic Zebrafish via Enhancement of High-Density Lipoprotein Functionality. Rejuvenation research. vol 19. issue 2. 2017-01-02. PMID:26413884. |
a reconstituted high-density lipoprotein containing policosanol (pco-rhdl) facilitated greater cell growth and replication with less apoptosis and reactive oxygen species (ros) production in bv-2 microglial cell lines. |
2017-01-02 |
2023-08-13 |
zebrafish |
| Pei-Cai Fu, Rong-Hua Tang, Yue Wan, Min-Jie Xie, Wei Wang, Xiang Luo, Zhi-Yuan Y. ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838736. |
in this study, western blotting was conducted to detect rock2 expression after the sci; the rock activity assay kit was used for assay of rock pathway activity; microglia morphology was examined using the cd11b antibody; electron microscopy was used to detect microglia phagocytosis; tunel was used to detect tissue cell apoptosis; myelin staining was performed using an antibody against myelin basic protein (mbp); behavioral outcomes were evaluated according to the methods of basso, beattie, and bresnahan (bbb). |
2016-12-30 |
2023-08-13 |
rat |
| Da-ming Sui, Qun Xie, Wen-jing Yi, Sahil Gupta, Xi-ya Yu, Jin-bao Li, Jun Wang, Jia-feng Wang, Xiao-ming Den. Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia. Mediators of inflammation. vol 2016. 2016-12-19. PMID:26924896. |
the tunel assay demonstrated significantly attenuated rates of apoptosis, in resveratrol treated mice, while decreasing the number of iba-1 positive microglia in the hippocampus region. |
2016-12-19 |
2023-08-13 |
mouse |
| Yang Liu, Yue Wan, Yongkang Fang, Ensheng Yao, Shabei Xu, Qin Ning, Guibing Zhang, Wei Wang, Xiaojiang Huang, Minjie Xi. Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia. Journal of molecular neuroscience : MN. vol 58. issue 2. 2016-11-08. PMID:26545915. |
the results showed that exogenous administration of 14,15-eet or auda could suppress astrogliosis and glial scar formation, inhibit microglia activation and inflammatory response, promote angiogenesis, attenuate neuronal apoptosis and infarct volume, and further promote the behavioral function recovery after focal ischemia. |
2016-11-08 |
2023-08-13 |
rat |
| Mayumi Kamigaki, Izumi Hide, Yuhki Yanase, Hiroko Shiraki, Kana Harada, Yoshiki Tanaka, Takahiro Seki, Toshihiko Shirafuji, Shigeru Tanaka, Michihiro Hide, Norio Saka. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling. Neurochemistry international. vol 93. 2016-10-31. PMID:26802935. |
toll-like receptor (tlr) 4 mediates inflammation and is also known to trigger apoptosis in microglia. |
2016-10-31 |
2023-08-13 |
rat |
| Tamara C Hornik, Anna Vilalta, Guy C Brow. Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis. Journal of cell science. vol 129. issue 1. 2016-10-07. PMID:26567213. |
activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis. |
2016-10-07 |
2023-08-13 |
Not clear |
| Tamara C Hornik, Anna Vilalta, Guy C Brow. Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis. Journal of cell science. vol 129. issue 1. 2016-10-07. PMID:26567213. |
thus, activated microglia can induce reversible apoptosis of target cells, which is insufficient to cause apoptotic cell death, but sufficient to induce their phagocytosis and therefore cell death by phagoptosis. |
2016-10-07 |
2023-08-13 |
Not clear |
| Frances Zenón, Yisel Cantres-Rosario, Radhika Adiga, Mariangeline Gonzalez, Eillen Rodriguez-Franco, Dianne Langford, Loyda M Melende. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. Journal of neurovirology. vol 21. issue 5. 2016-08-24. PMID:26092112. |
human primary neurons were exposed to supernatants from hiv-infected and uninfected microglia in the presence of cathepsin b inhibitors and apoptosis was assessed by tunel. |
2016-08-24 |
2023-08-13 |
human |
| Frances Zenón, Yisel Cantres-Rosario, Radhika Adiga, Mariangeline Gonzalez, Eillen Rodriguez-Franco, Dianne Langford, Loyda M Melende. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. Journal of neurovirology. vol 21. issue 5. 2016-08-24. PMID:26092112. |
increased apoptosis was observed in neurons exposed to supernatants from hiv-1 infected microglia at day 12 post-infection. |
2016-08-24 |
2023-08-13 |
human |
| Frances Zenón, Yisel Cantres-Rosario, Radhika Adiga, Mariangeline Gonzalez, Eillen Rodriguez-Franco, Dianne Langford, Loyda M Melende. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. Journal of neurovirology. vol 21. issue 5. 2016-08-24. PMID:26092112. |
our results suggest that hiv-1-induced cathepsin b production in microglia contributes to neuronal apoptosis and may be an important factor in neuronal death associated with hive. |
2016-08-24 |
2023-08-13 |
human |
| Pengfei Xu, Yongteng Xu, Bin Hu, Jue Wang, Rui Pan, Madhuvika Murugan, Long-Jun Wu, Yamei Tan. Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor. Brain, behavior, and immunity. vol 50. 2016-08-15. PMID:26122280. |
in addition, atp administration activated microglia, induced the release of the inflammatory mediators such as cyclooxygenase-2, tumor necrosis factor α and interleukin 6, and promoted neuronal apoptosis. |
2016-08-15 |
2023-08-13 |
mouse |
| Qun Zhang, Lin Yuan, Qingrui Zhang, Yan Gao, Guangheng Liu, Meng Xiu, Xiang Wei, Zhen Wang, Dexiang Li. Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. International immunopharmacology. vol 28. issue 1. 2016-07-19. PMID:26225925. |
importantly, treating primary cortical neurons with conditioned medium (cm) from hypoxia-stimulated microglia induced neuronal apoptosis, which was reversed by cm co-treated with resveratrol. |
2016-07-19 |
2023-08-13 |
Not clear |
| Joseph Jebelli, Thomas Piers, Jennifer Pococ. Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester. Journal of visualized experiments : JoVE. issue 101. 2016-07-06. PMID:26275019. |
one such technique - described here - is the use of l-leucine methyl ester, a lysomotropic agent that is internalized by macrophages and microglia, wherein it causes lysosomal disruption and subsequent apoptosis(13,14). |
2016-07-06 |
2023-08-13 |
Not clear |
| Lihong Li, Qiang Sun, Yuqian Li, Yang Yang, Yanlong Yang, Tao Chang, Minghao Man, Longlong Zhen. Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia. Journal of molecular neuroscience : MN. vol 56. issue 4. 2016-06-27. PMID:25725784. |
mice microglia cell lines were transfected with mir-204 mimics and inhibitors or treated with resveratrol, and the effects on cell growth, proliferation, and apoptosis of cells were assessed. |
2016-06-27 |
2023-08-13 |
mouse |
| Lihong Li, Qiang Sun, Yuqian Li, Yang Yang, Yanlong Yang, Tao Chang, Minghao Man, Longlong Zhen. Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia. Journal of molecular neuroscience : MN. vol 56. issue 4. 2016-06-27. PMID:25725784. |
through overexpression of sirt1, resveratrol, and inhibitor of mir-204 inhibited inflammation process, proliferation of mice microglia cells and promoted its apoptosis. |
2016-06-27 |
2023-08-13 |
mouse |
| Alexandra C Adams, Michele Kyle, Carol M Beaman-Hall, Edward A Monaco, Matthew Cullen, Mary Lou Vallan. Microglia in Glia-Neuron Co-cultures Exhibit Robust Phagocytic Activity Without Concomitant Inflammation or Cytotoxicity. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25894384. |
a simple method to co-culture granule neurons and glia from a single brain region is described, and microglia activation profiles are assessed in response to naturally occurring neuronal apoptosis, excitotoxin-induced neuronal death, and lipopolysaccharide (lps) addition. |
2016-06-24 |
2023-08-13 |
rat |
| Alexandra C Adams, Michele Kyle, Carol M Beaman-Hall, Edward A Monaco, Matthew Cullen, Mary Lou Vallan. Microglia in Glia-Neuron Co-cultures Exhibit Robust Phagocytic Activity Without Concomitant Inflammation or Cytotoxicity. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25894384. |
after 7-8 days in vitro, microglia in arac(-) cultures are abundant and activated based on their amoeboid morphology, expressions of ed1 and iba1, and ability to phagocytose polystyrene beads and the majority of neurons undergoing spontaneous apoptosis. |
2016-06-24 |
2023-08-13 |
rat |
| Wan-Jie Chia, Francis Chee Kuan Tan, Wei-Yi Ong, Gavin S Daw. Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity. Neurochemistry international. vol 87. 2016-05-24. PMID:26004810. |
increased expression of the pro-apoptotic marker, bim, was found in both neurons and microglia after ka injection, but tunel staining indicating apoptosis was found primarily in bim-expressing neurons, but not microglia. |
2016-05-24 |
2023-08-13 |
rat |