| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zong-yong Zhang, Bao-liang Sun, Ming-feng Yang, Da-wei Li, Jie Fang, Shuai Zhan. Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model. Cellular and molecular neurobiology. vol 35. issue 2. 2015-11-17. PMID:25179154. |
furthermore, carnosine treatment attenuated sah-induced microglia activation and cortical neuron apoptosis. |
2015-11-17 |
2023-08-13 |
rat |
| Ming-Che Tsai, Ching-Ping Chang, Syue-Wei Peng, Kai-Sheng Jhuang, Yi-Hsien Fang, Mao-Tsun Lin, Thomas Chang-Yao Tsa. Therapeutic efficacy of Neuro AiD™ (MLC 601), a traditional Chinese medicine, in experimental traumatic brain injury. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 1. 2015-11-12. PMID:25331680. |
cerebral contusion caused by tbi was associated with neurological motor deficits, brain apoptosis, and activated microglia (e.g., microgliosis, amoeboid microglia, and microglial overexpression of tnf-α), which all were significantly attenuated by mlc 601 therapy. |
2015-11-12 |
2023-08-13 |
rat |
| Xiao-jing Dai, Na Li, Le Yu, Zi-yang Chen, Rong Hua, Xia Qin, Yong-Mei Zhan. Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell stress & chaperones. vol 20. issue 2. 2015-11-10. PMID:25387796. |
activation of bv2 microglia by lipopolysaccharide triggers an inflammatory reaction in pc12 cell apoptosis through a toll-like receptor 4-dependent pathway. |
2015-11-10 |
2023-08-13 |
Not clear |
| Xiao-jing Dai, Na Li, Le Yu, Zi-yang Chen, Rong Hua, Xia Qin, Yong-Mei Zhan. Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell stress & chaperones. vol 20. issue 2. 2015-11-10. PMID:25387796. |
we carried out a prospective study to detect that activation of bv2 microglia induced pc12 cell apoptosis in vitro through the tlr4/adapter protein myeloid differentiation factor 88 (myd88)/nuclear factor-κb (nf-κb) signaling pathway. |
2015-11-10 |
2023-08-13 |
Not clear |
| Yoko S Kaneko, Akira Ota, Akira Nakashima, Hiroshi Nagasaki, Yu Kodani, Keiji Mori, Toshiharu Nagats. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 2. 2015-09-25. PMID:24919883. |
in this study, we investigated the effects of lps pretreatment on uv light-induced apoptosis of cells from the microglial cell line bv-2. |
2015-09-25 |
2023-08-13 |
Not clear |
| Yoko S Kaneko, Akira Ota, Akira Nakashima, Hiroshi Nagasaki, Yu Kodani, Keiji Mori, Toshiharu Nagats. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G₁ phase and protects them from UV light-induced apoptosis. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 2. 2015-09-25. PMID:24919883. |
excessive activation of microglia may play a critical role in the exacerbation of neurodegeneration, therefore, normalizing the precise regulation of apoptosis may be a new strategy to prevent the deterioration caused by neurodegenerative disorders. |
2015-09-25 |
2023-08-13 |
Not clear |
| Sandra M Garraway, Sarah A Woller, J Russell Huie, John J Hartman, Michelle A Hook, Rajesh C Miranda, Yung-Jen Huang, Adam R Ferguson, James W Gra. Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis. Pain. vol 155. issue 11. 2015-09-25. PMID:25180012. |
in addition, immunohistochemical analysis revealed distinct morphological signs of apoptosis in neurons and microglia at 24h after stimulation. |
2015-09-25 |
2023-08-13 |
rat |
| Renato Socodato, Camila C Portugal, Ivan Domith, Nádia A Oliveira, Vivian S M Coreixas, Erick C Loiola, Tânia Martins, Ana Raquel Santiago, Roberto Paes-de-Carvalho, António F Ambrósio, João B Relva. c-Src function is necessary and sufficient for triggering microglial cell activation. Glia. vol 63. issue 3. 2015-09-21. PMID:25421817. |
c-src inhibition in retinal neuroinflammation experimental paradigms consisting of intravitreal injection of lps or ischemia-reperfusion injury significantly reduced microglia activation changing their morphology to a more resting phenotype and prevented neuronal apoptosis. |
2015-09-21 |
2023-08-13 |
Not clear |
| Lucia Račková, Volkan Ergin, Elif Burcu Bali, Marcela Kuniaková, Çimen Karas. Pomegranate Seed Oil Modulates Functions and Survival of BV-2 Microglial Cells in vitro. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. vol 84. issue 5-6. 2015-09-18. PMID:26255551. |
unlike quercetin and stobadine, only the pufa preparations effectively prevented apoptosis of microglia (as confirmed by the suppression of caspase 3 activation) exposed to the toxic concentration of lps. |
2015-09-18 |
2023-08-13 |
Not clear |
| E Kavanagh, J Rodhe, M A Burguillos, J L Venero, B Josep. Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. Cell death & disease. vol 5. 2015-09-11. PMID:25501826. |
an unexpected role of caspase-3, commonly known to have executioner role for apoptosis, was uncovered in the microglia activation process. |
2015-09-11 |
2023-08-13 |
Not clear |
| E Kavanagh, J Rodhe, M A Burguillos, J L Venero, B Josep. Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. Cell death & disease. vol 5. 2015-09-11. PMID:25501826. |
here, we show that the induction of cellular inhibitor of apoptosis protein 2 (ciap2) expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit and is responsible for restraining caspase-3 in terms of activity and subcellular localization. |
2015-09-11 |
2023-08-13 |
Not clear |
| Shun-Tai Yang, Jia-Wei Lin, Bi-Ying Chiu, Yao-Chin Hsu, Ching-Ping Chang, Cheng-Kuei Chan. Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation. The American journal of Chinese medicine. vol 42. issue 6. 2015-08-27. PMID:25384449. |
our results indicate that ast may protect against brain contusion and neuronal apoptosis after tbi by attenuating microglia activation in male rats. |
2015-08-27 |
2023-08-13 |
rat |
| Takayuki Nagano, Shinya H Kimura, Motohiko Takemur. Prostaglandin E2 induces apoptosis in cultured rat microglia. Brain research. vol 1568. 2015-08-21. PMID:24845544. |
prostaglandin e2 induces apoptosis in cultured rat microglia. |
2015-08-21 |
2023-08-13 |
rat |
| Takayuki Nagano, Shinya H Kimura, Motohiko Takemur. Prostaglandin E2 induces apoptosis in cultured rat microglia. Brain research. vol 1568. 2015-08-21. PMID:24845544. |
these results suggest that pge2 induces apoptosis in microglia independent of intracellular cyclic amp concentration, and there are different mechanisms between pge2-induced apoptosis and the modulation of microglial function. |
2015-08-21 |
2023-08-13 |
rat |
| Yujiao Fu, Myung-Soon Yang, Jianxiong Jiang, Thota Ganesh, Eunhye Joe, Raymond Dingledin. EP2 Receptor Signaling Regulates Microglia Death. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25715797. |
in the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. |
2015-08-11 |
2023-08-13 |
rat |
| Yujiao Fu, Myung-Soon Yang, Jianxiong Jiang, Thota Ganesh, Eunhye Joe, Raymond Dingledin. EP2 Receptor Signaling Regulates Microglia Death. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25715797. |
butaprost also caused the expression of activated caspase-3 in microglia, pointing to apoptosis. |
2015-08-11 |
2023-08-13 |
rat |
| Saurabh Kumar Jha, Niraj Kumar Jha, Rohan Kar, Rashmi K Ambasta, Pravir Kuma. p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's Disease. International journal of molecular and cellular medicine. vol 4. issue 2. 2015-08-11. PMID:26261796. |
out of the several factors contributing to pd prognosis, the role of p38 mapk (mitogen activated protein-kinase) and pi3k/akt signalling module in pd brains is crucial because the impaired balance between the pro- apoptotic and anti-apoptotic pathways trigger unwanted phenotypes such as microglia activation, neuroinflammation, oxidative stress and apoptosis. |
2015-08-11 |
2023-08-13 |
Not clear |
| Wei-Yi Ong, Tahira Farooqui, Hwee-Ling Koh, Akhlaq A Farooqui, Eng-Ang Lin. Protective effects of ginseng on neurological disorders. Frontiers in aging neuroscience. vol 7. 2015-08-03. PMID:26236231. |
this is followed by molecular mechanisms of effects of ginseng on the brain, including glutamatergic transmission, monoamine transmission, estrogen signaling, nitric oxide (no) production, the keap1/nrf2 adaptive cellular stress pathway, neuronal survival, apoptosis, neural stem cells and neuroregeneration, microglia, astrocytes, oligodendrocytes and cerebral microvessels. |
2015-08-03 |
2023-08-13 |
Not clear |
| Cui Wang, Nanchang Xie, Huiru Zhang, Yulin Li, Yunlong Wan. Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25173404. |
puerarin protects against β-amyloid-induced microglia apoptosis via a pi3k-dependent signaling pathway. |
2015-07-29 |
2023-08-13 |
Not clear |
| Ishani De, Maria Nikodemova, Megan D Steffen, Emily Sokn, Vilena I Maklakova, Jyoti J Watters, Lara S Collie. CSF1 overexpression has pleiotropic effects on microglia in vivo. Glia. vol 62. issue 12. 2015-06-19. PMID:25042473. |
furthermore, small molecule inhibition of csf1r has the potential to reverse csf1-driven microglial accumulation that is frequently observed in cns pathologies, but can also promote apoptosis of normal microglia. |
2015-06-19 |
2023-08-13 |
mouse |