| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Yu, Jin Liu, Shu-Qin Li, Lei Peng, Richard D Y. Serum amyloid a differentially activates microglia and astrocytes via the PI3K pathway. Journal of Alzheimer's disease : JAD. vol 38. issue 1. 2014-06-17. PMID:23948927. |
interestingly, saa increased the viability of microglia by inhibiting their apoptosis and reduced the viability of astrocytes by inducing g1 cell cycle arresting. |
2014-06-17 |
2023-08-12 |
Not clear |
| M Kalm, K Roughton, K Blomgre. Lipopolysaccharide sensitized male and female juvenile brains to ionizing radiation. Cell death & disease. vol 4. 2014-06-12. PMID:24336082. |
caspase-3 activity, reflecting apoptosis and possibly microglia activation, was elevated 6 h after ir. |
2014-06-12 |
2023-08-12 |
mouse |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
further, we found that factors derived from activated microglia significantly decreased the level of deacetylation of p53 by reducing the expression of sirt1, an effect that increased the apoptosis of pc12 and reduced cell viability. |
2014-05-08 |
2023-08-12 |
Not clear |
| Jieming Ye, Zhenhua Liu, Jipeng Wei, Lingli Lu, Yanjun Huang, Lili Luo, Huifang Xi. Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway. Neuroscience letters. vol 553. 2014-05-08. PMID:23973301. |
together, these data suggests that: sirt1 inhibits lps-mediated proinflammatory cytokines release in microglia, and circumvents dopaminergic neurons injury induced by activated microglial-derived factors via p53-caspase-3-dependent mechanism of apoptosis. |
2014-05-08 |
2023-08-12 |
Not clear |
| Temugin Berta, Chul-Kyu Park, Zhen-Zhong Xu, Ruo-Gang Xie, Tong Liu, Ning Lü, Yen-Chin Liu, Ru-Rong J. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. The Journal of clinical investigation. vol 124. issue 3. 2014-05-06. PMID:24531553. |
the intracellular protease caspase-6 (casp6) is known to regulate neuronal apoptosis and axonal degeneration; however, the contribution of microglia and casp6 in modulating synaptic transmission and pain is unclear. |
2014-05-06 |
2023-08-12 |
mouse |
| Joana Vindeirinho, Gabriel N Costa, Mariana B Correia, Cláudia Cavadas, Paulo F Santo. Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840723. |
the early stages of diabetic retinopathy (dr) are characterized by alterations similar to neurodegenerative and inflammatory conditions such as increased neural apoptosis, microglial cell activation and amplified production of pro-inflammatory cytokines. |
2014-04-24 |
2023-08-12 |
rat |
| Nan-Kai Wang, Chi-Chun Lai, Chi-Hsiu Liu, Lung-Kun Yeh, Chai Lin Chou, Jian Kong, Takayuki Nagasaki, Stephen H Tsang, Chung-Liang Chie. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Disease models & mechanisms. vol 6. issue 5. 2014-04-22. PMID:23828046. |
by crossing rd7 mice (a model for hereditary retinal degeneration owing to nr2e3 mutation) with mice carrying the macrophage fas-induced apoptosis (mafia) transgene, we generated double-mutant mice and studied the role of the resident retinal microglia. |
2014-04-22 |
2023-08-12 |
mouse |
| Viktoria Gudi, Stefan Gingele, Thomas Skripuletz, Martin Stange. Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned. Frontiers in cellular neuroscience. vol 8. 2014-04-21. PMID:24659953. |
cuprizone induces apoptosis of mature oligodendrocytes that leads to a robust demyelination and profound activation of both astrocytes and microglia with regional heterogeneity between different white and gray matter regions. |
2014-04-21 |
2023-08-12 |
human |
| Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Don. Curcumin protects microglia and primary rat cortical neurons against HIV-1 gp120-mediated inflammation and apoptosis. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936448. |
curcumin protects microglia and primary rat cortical neurons against hiv-1 gp120-mediated inflammation and apoptosis. |
2014-04-01 |
2023-08-12 |
rat |
| Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Don. Curcumin protects microglia and primary rat cortical neurons against HIV-1 gp120-mediated inflammation and apoptosis. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936448. |
we conclude that hiv-1 gp120 increases ros, tnf-α and mcp-1 production in microglia, and induces cortical neuron apoptosis by affecting the delayed rectification and transient outward k(+) channel current. |
2014-04-01 |
2023-08-12 |
rat |
| Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Don. Curcumin protects microglia and primary rat cortical neurons against HIV-1 gp120-mediated inflammation and apoptosis. PloS one. vol 8. issue 8. 2014-04-01. PMID:23936448. |
curcumin reduces production of ros and inflammatory mediators in hiv-1-gp120-stimulated microglia, and protects cortical neurons against hiv-1-mediated apoptosis, most likely through inhibition of hiv-1 gp120-induced elevation of the delayed rectification and transient outward k(+) current. |
2014-04-01 |
2023-08-12 |
rat |
| Tianjian Ding, Xiangmei Zhou, Mohammed Kouadir, Fushan Shi, Yang Yang, Jin Liu, Min Wang, Xiaomin Yin, Lifeng Yang, Deming Zha. Cellular prion protein participates in the regulation of inflammatory response and apoptosis in BV2 microglia during infection with Mycobacterium bovis. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23345082. |
cellular prion protein participates in the regulation of inflammatory response and apoptosis in bv2 microglia during infection with mycobacterium bovis. |
2014-03-12 |
2023-08-12 |
Not clear |
| Tianjian Ding, Xiangmei Zhou, Mohammed Kouadir, Fushan Shi, Yang Yang, Jin Liu, Min Wang, Xiaomin Yin, Lifeng Yang, Deming Zha. Cellular prion protein participates in the regulation of inflammatory response and apoptosis in BV2 microglia during infection with Mycobacterium bovis. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23345082. |
for this purpose, we examined the mrna expression of prion protein gene (prnp) upon m. bovis infection and analyzed the effect of sirna-mediated disruption of prnp on different parameters of microglial activation and apoptosis in m. bovis-infected microglia. |
2014-03-12 |
2023-08-12 |
Not clear |
| Tianjian Ding, Xiangmei Zhou, Mohammed Kouadir, Fushan Shi, Yang Yang, Jin Liu, Min Wang, Xiaomin Yin, Lifeng Yang, Deming Zha. Cellular prion protein participates in the regulation of inflammatory response and apoptosis in BV2 microglia during infection with Mycobacterium bovis. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23345082. |
we found that m. bovis infection induced a gradual increase in prnp mrna level and that sirna-mediated silencing of prnp in m. bovis-infected microglia reduced m. bovis-induced upregulation of pro-inflammatory factors, increased the rate of apoptosis in infected microglia, promoted the intrinsic apoptotic pathway, and downregulated the extrinsic apoptotic pathway. |
2014-03-12 |
2023-08-12 |
Not clear |
| Tianjian Ding, Xiangmei Zhou, Mohammed Kouadir, Fushan Shi, Yang Yang, Jin Liu, Min Wang, Xiaomin Yin, Lifeng Yang, Deming Zha. Cellular prion protein participates in the regulation of inflammatory response and apoptosis in BV2 microglia during infection with Mycobacterium bovis. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23345082. |
we conclude that prp(c) participates in the regulation of the response of microglia to m. bovis infection through the upregulation of pro-inflammatory cytokines and the modulation of apoptosis by interference with the intrinsic apoptotic pathway. |
2014-03-12 |
2023-08-12 |
Not clear |
| Jiajia Chen, Zhiming Cui, Weidong Li, Aiguo Shen, Guanhua Xu, Guofeng Bao, Yuyu Sun, Lingling Wang, Jianbo Fan, Jinlong Zhang, Longfei Yang, Zhiming Cu. MCM7 expression is altered in rat after spinal cord injury. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23526403. |
our results suggest that mcm7 might be implicated in the apoptosis of neuron and proliferation of astrocytes and microglia after sci. |
2014-03-12 |
2023-08-12 |
rat |
| E P Azevedo, J H Ledo, G Barbosa, M Sobrinho, L Diniz, A C C Fonseca, F Gomes, L Romão, F R S Lima, F L Palhano, S T Ferreira, D Fogue. Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis. Cell death & disease. vol 4. 2014-03-12. PMID:24008733. |
while a25t fibrils were not directly toxic to neurons, the exposure of neuronal cultures to media conditioned by fibril-activated microglia caused synapse loss that culminated in extensive neuronal death via apoptosis. |
2014-03-12 |
2023-08-12 |
mouse |
| Ukpong B Eyo, Michael E Daile. Microglia: key elements in neural development, plasticity, and pathology. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 3. 2014-02-11. PMID:23354784. |
these data suggest that microglia play important developmental roles in synapse remodeling, developmental apoptosis, phagocytic clearance, and angiogenesis. |
2014-02-11 |
2023-08-12 |
zebrafish |
| Jie Zhang, Na Niu, Mingyu Wang, Michael A McNutt, Donghong Zhang, Baogang Zhang, Shijun Lu, Yuqing Liu, Zhihui Li. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcγR I and TLR4 pathways. The international journal of biochemistry & cell biology. vol 45. issue 8. 2014-02-11. PMID:23791745. |
with an in vitro parkinson's disease model, we found that neuron-derived igg can improve the survival and reduce apoptosis of dopaminergic neurons induced by 6-hydroxydopamine toxicity, and also depress the release of no from microglia triggered by 6-hydroxydopamine. |
2014-02-11 |
2023-08-12 |
human |
| Jingjing Guo, Jianing Wang, Zhe Zhang, Jun Yan, Mingming Chen, Tao Pang, Luyong Zhang, Hong Lia. proNGF inhibits neurogenesis and induces glial activation in adult mouse dentate gyrus. Neurochemical research. vol 38. issue 8. 2014-02-06. PMID:23709363. |
prongf infusion also induced prominent cell apoptosis and activated residential astrocyte and microglia, which might further impair the hippocampal neurogenesis. |
2014-02-06 |
2023-08-12 |
mouse |