| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditya Sunkaria, Willayat Yousuf Wani, Deep Raj Sharma, Kiran Dip Gil. Dichlorvos exposure results in activation induced apoptotic cell death in primary rat microglia. Chemical research in toxicology. vol 25. issue 8. 2012-12-26. PMID:22817663. |
the dna fragmentation pattern of dichlorvos treated microglia along with increased expression of bax in mitochondria, cytochrome c release from mitochondria, and caspase-3 activation led us to assume that microglia were undergoing apoptosis. |
2012-12-26 |
2023-08-12 |
rat |
| Julie Bournival, Marilyn Plouffe, Justine Renaud, Cindy Provencher, Maria-Grazia Martinol. Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxidative medicine and cellular longevity. vol 2012. 2012-11-06. PMID:22919443. |
we then measured neuronal cell death and apoptosis after mpp(+) activation of microglia, in a microglial (n9)-neuronal (pc12) coculture system. |
2012-11-06 |
2023-08-12 |
Not clear |
| S Tanaka, H Kato, T Koik. Microglial Response Factor (MRF)-1: Constitutive Expression in Ramified Microglia and Upregulation upon Neuronal Death Induced by Ischemia or Glutamate Exposure. Zoological science. vol 17. issue 5. 2012-10-02. PMID:18517291. |
we have isolated a new microglial gene, mrf-1, which is upregulated on microglia in response to apoptosis of granule neurons in cerebellar cell cultures. |
2012-10-02 |
2023-08-12 |
rat |
| Ashley S Harms, Jae-Kyung Lee, Thi A Nguyen, Jianjun Chang, Kelly M Ruhn, Isaac Treviño, Malú G Tanse. Regulation of microglia effector functions by tumor necrosis factor signaling. Glia. vol 60. issue 2. 2012-08-24. PMID:21989628. |
although tnf-null microglia displayed an atypical morphology with cytoplasmic vacuoles in response to stimulation with lipopolysaccharide (lps), the phagocytic response of tnf-null microglia to escherichia coli particles in vitro was normal and there were no signs of enhanced caspase 3 activation or apoptosis. |
2012-08-24 |
2023-08-12 |
mouse |
| Yi-Fang Tu, Pei-Jung Lu, Chao-Ching Huang, Chien-Jung Ho, Ya-Ping Cho. Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. Stroke. vol 43. issue 2. 2012-08-15. PMID:22076005. |
neurovascular damage, including neuronal apoptosis and blood-brain barrier (bbb) damage, and microglia activation account for the hypoxic-ischemia (hi) susceptibility in neonatal brain. |
2012-08-15 |
2023-08-12 |
rat |
| Yi-Fang Tu, Pei-Jung Lu, Chao-Ching Huang, Chien-Jung Ho, Ya-Ping Cho. Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. Stroke. vol 43. issue 2. 2012-08-15. PMID:22076005. |
the p53 upregulation is involved in apoptosis, endothelial cell damage, and microglia activation. |
2012-08-15 |
2023-08-12 |
rat |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia. Current neurovascular research. vol 8. issue 4. 2012-05-15. PMID:22023617. |
downstream from these pathways, epo and wnt1 control "anti-apoptotic" pathways of microglia through the modulation of mitochondrial membrane permeability, the release of cytochrome c, and the expression of apoptotic protease activating factor-1 (apaf-1) and x-linked inhibitor of apoptosis protein (xiap). |
2012-05-15 |
2023-08-12 |
Not clear |
| Jun-Min Li, Yan Yang, Ping Zhu, Fang Zheng, Fei-Li Gong, Yuan-Wu Me. Mitoxantrone exerts both cytotoxic and immunoregulatory effects on activated microglial cells. Immunopharmacology and immunotoxicology. vol 34. issue 1. 2012-04-16. PMID:21517718. |
indeed, we have found that mx induced microglial cell death in a dose-dependent manner, and the cell death was mainly from late apoptosis and necrosis. |
2012-04-16 |
2023-08-12 |
Not clear |
| Takashi Yoshino, Hiroko Tabunoki, Shigeo Sugiyama, Keitaro Ishii, Seung U Kim, Jun-Ichi Sato. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cellular and molecular neurobiology. vol 31. issue 7. 2012-04-16. PMID:21519925. |
non-phosphorylated fty720 induces apoptosis of human microglia by activating srebp2. |
2012-04-16 |
2023-08-12 |
human |
| Takashi Yoshino, Hiroko Tabunoki, Shigeo Sugiyama, Keitaro Ishii, Seung U Kim, Jun-Ichi Sato. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cellular and molecular neurobiology. vol 31. issue 7. 2012-04-16. PMID:21519925. |
we studied fty720-mediated apoptosis of a human microglia cell line hmo6. |
2012-04-16 |
2023-08-12 |
human |
| Takashi Yoshino, Hiroko Tabunoki, Shigeo Sugiyama, Keitaro Ishii, Seung U Kim, Jun-Ichi Sato. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cellular and molecular neurobiology. vol 31. issue 7. 2012-04-16. PMID:21519925. |
these observations suggest that fty720-non-p-induced apoptosis of hmo6 human microglia is independent of s1p receptor binding, and positively regulated by the srebp2-dependent proapoptotic signaling pathway. |
2012-04-16 |
2023-08-12 |
human |
| Yingxin Ma, Jingwen Jiang, Lu Wang, Hui Nie, Weiliang Xia, Jianrong Liu, Weihai Yin. CD38 is a key enzyme for the survival of mouse microglial BV2 cells. Biochemical and biophysical research communications. vol 418. issue 4. 2012-04-16. PMID:22293203. |
collectively, our study has provided the first evidence suggesting that cd38 plays a critical role in the basal survival of microglia, and decreased cd38 can lead to caspase 3-dependent apoptosis of the cells. |
2012-04-16 |
2023-08-12 |
mouse |
| Jerome E Roger, Keerthi Ranganath, Lian Zhao, Radu I Cojocaru, Matthew Brooks, Norimoto Gotoh, Shobi Veleri, Avinash Hiriyanna, Rivka A Rachel, Maria Mercedes Campos, Robert N Fariss, Wai T Wong, Anand Swaroo. Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 2. 2012-03-06. PMID:22238088. |
here, we report that nrl(-/-) retina undergoes a rapid but transient period of degeneration in early adulthood, with cone apoptosis, retinal detachment, alterations in retinal vessel structure, and activation and translocation of retinal microglia. |
2012-03-06 |
2023-08-12 |
mouse |
| Yang-Jin Lee, Chang-Eun Park, Jong-Hyun Kim, Hae-Jin Sohn, Jinyoung Lee, Suk-Yul Jung, Ho-Joon Shi. Naegleria fowleri lysate induces strong cytopathic effects and pro-inflammatory cytokine release in rat microglial cells. The Korean journal of parasitology. vol 49. issue 3. 2012-02-22. PMID:22072830. |
in this study, we treated rat microglial cells with amebic lysate to probe contact-independent mechanisms for cytotoxicity, determining through a combination of light microscopy and scanning and transmission electron microscopy whether n. fowleri lysate could effect on both necrosis and apoptosis on microglia in a time- as well as dose-dependent fashion. |
2012-02-22 |
2023-08-12 |
rat |
| Xueping Zhou, Lili Wang, Mingyan Wang, Li Xu, Li Yu, Taihui Fang, Mianhua W. Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacology and immunotoxicology. vol 33. issue 4. 2012-02-21. PMID:21275776. |
in the present study, the mouse microglial cell line, bv-2, was selected to investigate the effects of emodin on microglial activation and apoptosis. |
2012-02-21 |
2023-08-12 |
mouse |
| Xueping Zhou, Lili Wang, Mingyan Wang, Li Xu, Li Yu, Taihui Fang, Mianhua W. Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacology and immunotoxicology. vol 33. issue 4. 2012-02-21. PMID:21275776. |
these results demonstrate that emodin induces bv-2 cell apoptosis through trb3 and consequently eliminates inflammatory microglia. |
2012-02-21 |
2023-08-12 |
mouse |
| Gurugirijha Rathnasamy, Eng-Ang Ling, Charanjit Kau. Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159112. |
this was reversed to control levels on treatment with conditioned medium from deferoxamine treated hypoxic microglia; also, there was reduction in apoptosis of oligodendrocytes. |
2012-02-02 |
2023-08-12 |
rat |
| J L Venero, M A Burguillos, P Brundin, B Josep. The executioners sing a new song: killer caspases activate microglia. Cell death and differentiation. vol 18. issue 11. 2012-02-01. PMID:21836616. |
we showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. |
2012-02-01 |
2023-08-12 |
human |
| Yuan-Jin Guo, Wei Li, Xiao-Feng Li, Lei Zhao, Shu-Ling Zhang, Yu Zhou, Ji-Hua Dong, Yuan-Wu Me. S-methylisothiourea induces apoptosis of herpes simplex virus-1-infected microglial cells. Inflammation. vol 34. issue 5. 2012-01-16. PMID:20809280. |
smt induction of apoptosis of hsv-stimulated microglia seemed to be through three pathways: the death receptor, mitochondrially gated, and endoplasmic reticulum. |
2012-01-16 |
2023-08-12 |
mouse |
| Yuan-Jin Guo, Wei Li, Xiao-Feng Li, Lei Zhao, Shu-Ling Zhang, Yu Zhou, Ji-Hua Dong, Yuan-Wu Me. S-methylisothiourea induces apoptosis of herpes simplex virus-1-infected microglial cells. Inflammation. vol 34. issue 5. 2012-01-16. PMID:20809280. |
its mechanism of action is most probably due to the induction of microglial cell apoptosis. |
2012-01-16 |
2023-08-12 |
mouse |