| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timm Schlegelmilch, Katrin Henke, Francesca Per. Microglia in the developing brain: from immunity to behaviour. Current opinion in neurobiology. vol 21. issue 1. 2011-06-27. PMID:20817438. |
indeed, microglia implement key functions already during development, such as the clearance of the huge amount of neurons that are produced in large excess in the embryo and later die of apoptosis. |
2011-06-27 |
2023-08-12 |
Not clear |
| Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee, Oksun Bang, Seong-Gyu K. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Journal of biomedical science. vol 18. 2011-04-28. PMID:21299906. |
ros, neuroinflammation and apoptosis related molecules expression such as cox-2, inos, procaspase-3, cleaved caspase-3, 8 and 9, bcl-2 and bax protein and the products of inos and cox-2, no, pge2, were studied using lps-activated raw 264.7 cells and microglia bv2 cells. |
2011-04-28 |
2023-08-12 |
mouse |
| A Chocyk, D Dudys, A Przyborowska, I Majcher, M Maćkowiak, K Wędzon. Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neuroscience. vol 173. 2011-04-20. PMID:21108994. |
cleaved caspase-9 was present in microglia cells, which exhibited the morphological hallmarks of apoptosis, but not in neuronal, astrocytic or oligodendrocytic cells. |
2011-04-20 |
2023-08-12 |
rat |
| Judy Choi, Masataka Ifuku, Mami Noda, Tomás R Guilart. Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state. Glia. vol 59. issue 2. 2011-04-14. PMID:21125642. |
finally, ro-like ligands may be involved in the elimination of activated microglia via apoptosis. |
2011-04-14 |
2023-08-12 |
Not clear |
| Catherine Verney, Anne Monier, Catherine Fallet-Bianco, Pierre Gressen. Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants. Journal of anatomy. vol 217. issue 4. 2011-02-24. PMID:20557401. |
the spatiotemporal organization of microglia in the immature white and grey matter suggests that these cells may play active roles in developmental processes such as axonal guidance, synaptogenesis, and neurodevelopmental apoptosis as well as in injuries to the developing brain, in particular in the periventricular white-matter injury of preterm infants. |
2011-02-24 |
2023-08-12 |
human |
| Nanchang Xie, Hui Li, Dailin Wei, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth Ferslew, Lei He, Zhaofu Chi, Deling Yi. Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20600172. |
glycogen synthase kinase-3 and p38 mapk are required for opioid-induced microglia apoptosis. |
2011-01-20 |
2023-08-12 |
mouse |
| Nanchang Xie, Hui Li, Dailin Wei, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth Ferslew, Lei He, Zhaofu Chi, Deling Yi. Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20600172. |
however, the underlying mechanism by which microglia apoptosis in response to opioids is not yet known. |
2011-01-20 |
2023-08-12 |
mouse |
| Nanchang Xie, Hui Li, Dailin Wei, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth Ferslew, Lei He, Zhaofu Chi, Deling Yi. Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20600172. |
in this study, we show that morphine induces microglia apoptosis and caspase-3 activation in an opioid-receptor dependent manner. |
2011-01-20 |
2023-08-12 |
mouse |
| Nanchang Xie, Hui Li, Dailin Wei, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth Ferslew, Lei He, Zhaofu Chi, Deling Yi. Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20600172. |
more interestingly, gsk-3β inhibitor sb216763 significantly increases morphine-induced apoptosis in both bv-2 microglia and mouse primary microglial cells. |
2011-01-20 |
2023-08-12 |
mouse |
| Choong Hyun Lee, Seung Myung Moon, Ki-Yeon Yoo, Jung Hoon Choi, Ok Kyu Park, In Koo Hwang, Youdong Sohn, Joong Bum Moon, Jun Hwi Cho, Moo-Ho Wo. Long-term changes in neuronal degeneration and microglial activation in the hippocampal CA1 region after experimental transient cerebral ischemic damage. Brain research. vol 1342. 2011-01-18. PMID:20423705. |
delayed neuronal death following transient cerebral ischemia is mixed with apoptosis and necrosis, and the activation of microglia are activated after the ischemic insult. |
2011-01-18 |
2023-08-12 |
Not clear |
| Nanchang Xie, Cui Wang, Youting Lin, Hui Li, Lin Chen, Tongxia Zhang, Yong Sun, Yi Zhang, Deling Yin, Zhaofu Ch. The role of p38 MAPK in valproic acid induced microglia apoptosis. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20621161. |
the role of p38 mapk in valproic acid induced microglia apoptosis. |
2010-12-13 |
2023-08-12 |
mouse |
| Nanchang Xie, Cui Wang, Youting Lin, Hui Li, Lin Chen, Tongxia Zhang, Yong Sun, Yi Zhang, Deling Yin, Zhaofu Ch. The role of p38 MAPK in valproic acid induced microglia apoptosis. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20621161. |
valproic acid (vpa), a widely prescribed drug for seizures and bipolar disorder, induces apoptosis in microglia, but the underlying mechanism by which microglia apoptosis in response to vpa is not yet known. |
2010-12-13 |
2023-08-12 |
mouse |
| Nanchang Xie, Cui Wang, Youting Lin, Hui Li, Lin Chen, Tongxia Zhang, Yong Sun, Yi Zhang, Deling Yin, Zhaofu Ch. The role of p38 MAPK in valproic acid induced microglia apoptosis. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20621161. |
in this study, we found that the mitochondrial pathway played an important role in vpa-induced apoptosis in both bv-2 microglia and mouse primary microglial cells. |
2010-12-13 |
2023-08-12 |
mouse |
| Nanchang Xie, Cui Wang, Youting Lin, Hui Li, Lin Chen, Tongxia Zhang, Yong Sun, Yi Zhang, Deling Yin, Zhaofu Ch. The role of p38 MAPK in valproic acid induced microglia apoptosis. Neuroscience letters. vol 482. issue 1. 2010-12-13. PMID:20621161. |
taken together, our results clearly demonstrated that vpa could induce apoptosis of microglia via p38 mapk and mitochondrial apoptosis pathway. |
2010-12-13 |
2023-08-12 |
mouse |
| Antonio Wenceslao Danilo Gavilanes, Markus Gantert, Eveline Strackx, Luc J Zimmermann, Saskia Seeldrayers, Johan S H Vles, Boris W Krame. Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury. Frontiers in bioscience (Scholar edition). vol 2. 2010-09-30. PMID:20036959. |
a direct association was demonstrated between eeg delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and wm activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). |
2010-09-30 |
2023-08-12 |
Not clear |
| J M Dean, X Wang, A M Kaindl, P Gressens, B Fleiss, H Hagberg, C Mallar. Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro. Brain, behavior, and immunity. vol 24. issue 5. 2010-09-13. PMID:19903519. |
primary neuronal cultures were supplemented with the 14 or 24 h mcm, and the degree of neuronal apoptosis examined after exposure for 24 h. results showed a rapid and sustained elevation in multiple inflammatory mediators in the mcm of wt microglia exposed to lps, which was largely inhibited in myd88 ko microglia. |
2010-09-13 |
2023-08-12 |
mouse |
| Jenica L Harrison, Gabriela A Ferreira, Erinn S Raborn, Audrey D Lafrenaye, Francine Marciano-Cabral, Guy A Cabra. Acanthamoeba culbertsoni elicits soluble factors that exert anti-microglial cell activity. Infection and immunity. vol 78. issue 9. 2010-09-13. PMID:20605979. |
furthermore, soluble factors present in cocultures of a. culbertsoni and bv-2 cells, as well as in cocultures of a. culbertsoni and primary neonatal rat cerebral cortex microglia, induced apoptosis of these macrophage-like cells. |
2010-09-13 |
2023-08-12 |
mouse |
| Liu-fang He, Hui-Jin Chen, Long-hua Qian, Guan-yi Chen, Jeffrey S Buzb. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain research. vol 1339. 2010-09-02. PMID:20403340. |
in vitro, preols in coculture with microglia exhibited increased apoptosis after exposure to lps. |
2010-09-02 |
2023-08-12 |
rat |
| Liu-fang He, Hui-Jin Chen, Long-hua Qian, Guan-yi Chen, Jeffrey S Buzb. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain research. vol 1339. 2010-09-02. PMID:20403340. |
our results suggest that inos and nox contribute to the apoptosis of preols by activated microglia. |
2010-09-02 |
2023-08-12 |
rat |
| Liu-fang He, Hui-Jin Chen, Long-hua Qian, Guan-yi Chen, Jeffrey S Buzb. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain research. vol 1339. 2010-09-02. PMID:20403340. |
curcumin (10 microg/ml) was found to significantly inhibit the apoptosis of preol and expression of either inos or nox in the lps-activated microglia. |
2010-09-02 |
2023-08-12 |
rat |