| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zhu, Honghua Zheng, Xinli Shao, Wei Wang, Qing Yao, Zhengli L. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20438614. |
we use electrophysiological techniques, elisa, western-blot, rt-pcr assay and tunel method to explore whether over-produced tumor necrosis factor alpha (tnfalpha) released from activated microglia results in neuronal injuries, and further causes apoptosis through increasing excitotoxicity of hippocampal neurons. |
2010-08-23 |
2023-08-12 |
rat |
| Wei Zhu, Honghua Zheng, Xinli Shao, Wei Wang, Qing Yao, Zhengli L. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20438614. |
these studies suggest that tnfalpha derived from ka activated microglia increases excitotoxicity of hippocampal neurons, and might induce neuronal apoptosis in vitro and in vivo. |
2010-08-23 |
2023-08-12 |
rat |
| Yuan-Jin Guo, Lei Zhao, Xiao-Feng Li, Yuan-Wu Mei, Shu-Ling Zhang, Jun-Yan Tao, Yu Zhou, Ji-Hua Don. Effect of Corilagin on anti-inflammation in HSV-1 encephalitis and HSV-1 infected microglias. European journal of pharmacology. vol 635. issue 1-3. 2010-08-17. PMID:20338162. |
furthermore, corilagin induced apoptosis of hsv-stimulated microglia through all the 3 known apoptotic pathways. |
2010-08-17 |
2023-08-12 |
mouse |
| Nou-Ying Tang, Chung-Hsiang Liu, Shan-Yu Su, Ya-Min Jan, Ching-Tou Hsieh, Chin-Yi Cheng, Woei-Cherng Shyu, Ching-Liang Hsie. Uncaria rhynchophylla (miq) Jack plays a role in neuronal protection in kainic acid-treated rats. The American journal of Chinese medicine. vol 38. issue 2. 2010-07-29. PMID:20387223. |
this study demonstrates that ur can reduce microglia activation, nnos, inos and apoptosis, suggesting that ur plays a neuro-protective role against neuronal damage in ka-treated rats. |
2010-07-29 |
2023-08-12 |
mouse |
| David R Wallac. HIV neurotoxicity: potential therapeutic interventions. Journal of biomedicine & biotechnology. vol 2006. issue 3. 2010-06-10. PMID:17047310. |
the glutamatergic system, nitric oxide, calcium, oxidative stress, apoptosis, and microglia have all been implicated in the pathogenesis of hiv-related neuronal degeneration. |
2010-06-10 |
2023-08-12 |
human |
| Roberta Bianchi, Ileana Giambanco, Rosario Donat. S100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alpha. Neurobiology of aging. vol 31. issue 4. 2010-06-08. PMID:18599158. |
whereas at relatively low concentrations s100b exerts trophic effects on neurons and astrocytes, at relatively high concentrations the protein causes neuronal apoptosis and activates astrocytes and microglia, thus potentially representing an endogenous factor implicated in neuroinflammation. |
2010-06-08 |
2023-08-12 |
Not clear |
| Clara García Samartino, M Victoria Delpino, Clara Pott Godoy, María Silvia Di Genaro, Karina A Pasquevich, Astrid Zwerdling, Paula Barrionuevo, Patricia Mathieu, Juliana Cassataro, Fernando Pitossi, Guillermo H Giambartolome. Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis. The American journal of pathology. vol 176. issue 3. 2010-06-07. PMID:20093491. |
b. abortus infection induced astrocyte, but not microglia, apoptosis. |
2010-06-07 |
2023-08-12 |
mouse |
| Shing Hwa Liu, Cheng Ning Yang, Hung Chuan Pan, Yen Jen Sung, Ko Kaung Liao, Wen Bao Chen, Wen Zheng Lin, Meei Ling She. IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cellular and molecular life sciences : CMLS. vol 67. issue 9. 2010-05-10. PMID:20221786. |
we observed that il-13, but not il-4 or il-10, significantly enhanced endoplasmic reticulum (er) stress induction, apoptosis and death in microglia activated by lipopolysaccharide (lps). |
2010-05-10 |
2023-08-12 |
Not clear |
| Shing Hwa Liu, Cheng Ning Yang, Hung Chuan Pan, Yen Jen Sung, Ko Kaung Liao, Wen Bao Chen, Wen Zheng Lin, Meei Ling She. IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cellular and molecular life sciences : CMLS. vol 67. issue 9. 2010-05-10. PMID:20221786. |
both ho-1 inhibitor and ppar-gamma antagonist augmented, but calpain inhibitor and ppar-gamma agonists reversed, apoptosis induction in activated microglia. |
2010-05-10 |
2023-08-12 |
Not clear |
| Tereance A Myers, Deepak Kaushal, Mario T Philip. Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS pathogens. vol 5. issue 11. 2010-03-01. PMID:19911057. |
microglia are mediators of borrelia burgdorferi-induced apoptosis in sh-sy5y neuronal cells. |
2010-03-01 |
2023-08-12 |
Not clear |
| Tereance A Myers, Deepak Kaushal, Mario T Philip. Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS pathogens. vol 5. issue 11. 2010-03-01. PMID:19911057. |
in experiments where b. burgdorferi was co-cultured in vitro with primary microglia, we observed robust expression and release of il-6 and il-8, ccl2 (mcp-1), ccl3 (mip-1alpha), ccl4 (mip-1beta) and ccl5 (rantes), but we detected no induction of microglial apoptosis. |
2010-03-01 |
2023-08-12 |
Not clear |
| Tereance A Myers, Deepak Kaushal, Mario T Philip. Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS pathogens. vol 5. issue 11. 2010-03-01. PMID:19911057. |
when sy cells were co-cultured with microglia and b. burgdorferi, significant neuronal apoptosis consistently occurred. |
2010-03-01 |
2023-08-12 |
Not clear |
| Tereance A Myers, Deepak Kaushal, Mario T Philip. Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS pathogens. vol 5. issue 11. 2010-03-01. PMID:19911057. |
significant transcript alterations in essential p53 pathway genes also occurred in sy cells cultured in the presence of microglia and b. burgdorferi, which indicated a shift from cell survival to preparation for apoptosis when compared to sy cells cultured in the presence of b. burgdorferi alone. |
2010-03-01 |
2023-08-12 |
Not clear |
| Jean-Pierre Louboutin, Beverly A S Reyes, Lokesh Agrawal, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19913017. |
sv(gp120), a recombinant sv40-derived gene transfer vector was inoculated into the rat cp, leading to chronic expression of gp120, ongoing apoptosis in microglia and neurons, and oxidative stress. |
2010-02-16 |
2023-08-12 |
rat |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
microglial activation can lead to microglial apoptosis, which may serve to remove highly reactive and possibly neurotoxic microglia. |
2010-02-05 |
2023-08-12 |
Not clear |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
the p53 transcription inhibitor, pifithrin-alpha, (10 microm) significantly reduced the expression of p53 in microglia and significantly modulated the levels of microglial apoptosis induced by activation. |
2010-02-05 |
2023-08-12 |
Not clear |
| Christopher M Davenport, Ioanna G Sevastou, Claudie Hooper, Jennifer M Pococ. Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides. Journal of neurochemistry. vol 112. issue 2. 2010-02-05. PMID:19895660. |
inhibiting p53 mediated microglial apoptosis prevented microglial neurotoxicity suggesting targeting of p53-mediated pathways in microglia may have therapeutic benefit in alzheimer's disease. |
2010-02-05 |
2023-08-12 |
Not clear |
| Robert N Wine, Christopher A McPherson, G Jean Harr. IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526277. |
an acute systemic injection of trimethyltin (tmt; 2 mg/kg, ip) to mice induces apoptosis of dentate granule neurons within 24 h and a differential response of microglia with ramified microglia present in the ca-1 region. |
2010-01-25 |
2023-08-12 |
mouse |
| Birgit Nimmervoll, Nina Svoboda, Beata Sacha, Hubert H Kerschbau. Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia. Brain research bulletin. vol 80. issue 6. 2010-01-20. PMID:19682559. |
sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia. |
2010-01-20 |
2023-08-12 |
Not clear |
| Birgit Nimmervoll, Nina Svoboda, Beata Sacha, Hubert H Kerschbau. Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia. Brain research bulletin. vol 80. issue 6. 2010-01-20. PMID:19682559. |
thus, according to the nuclear structure as well as to changes in the plasma membrane, chronic elevation of cgmp induces apoptosis in microglia. |
2010-01-20 |
2023-08-12 |
Not clear |