| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jan-Philipp Bach, David Mengel, Tina Wahle, Andreas Kautz, Monika Balzer-Geldsetzer, Yousef Al-Abed, Richard Dodel, Michael Bache. The role of CNI-1493 in the function of primary microglia with respect to amyloid-β. Journal of Alzheimer's disease : JAD. vol 26. issue 1. 2012-01-10. PMID:21593565. |
western-blot/dot-blot techniques were used to show the interaction of cni-1493 with aβ-oligomers as well as to measure apoptosis in microglia cells. |
2012-01-10 |
2023-08-12 |
mouse |
| Jan-Philipp Bach, David Mengel, Tina Wahle, Andreas Kautz, Monika Balzer-Geldsetzer, Yousef Al-Abed, Richard Dodel, Michael Bache. The role of CNI-1493 in the function of primary microglia with respect to amyloid-β. Journal of Alzheimer's disease : JAD. vol 26. issue 1. 2012-01-10. PMID:21593565. |
cni-1493 is able to prevent oligomer formation as well as apoptosis in microglia. |
2012-01-10 |
2023-08-12 |
mouse |
| X-F Li, Y-J Guo, M-L Wang, D-M Zhang, Y-H Li, Y-F Wang, J-Y Tao, S-L Zhang, J-H Dong, Lv-Li Li, Lei Zha. Inducing-apoptotic activity of the ethanol extract of Duchesnea indica Focke on treatment of herpes simplex encephalitis. International journal of immunopathology and pharmacology. vol 24. issue 3. 2011-12-02. PMID:21978695. |
in conclusion, the ethanol extract of duchesnea indica can reduce hsv-induced inflammatory injury on neuron due to the induction of microglia apoptosis. |
2011-12-02 |
2023-08-12 |
Not clear |
| Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yi. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559519. |
toll-like receptor 9 is required for opioid-induced microglia apoptosis. |
2011-11-28 |
2023-08-12 |
Not clear |
| Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yi. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559519. |
interestingly, tlr9 deficiency significantly inhibited morphine-induced apoptosis in microglia. |
2011-11-28 |
2023-08-12 |
Not clear |
| Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yi. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559519. |
inhibition of p38 mapk by its specific inhibitor sb203580 attenuated morphine-induced microglia apoptosis in wild type microglia. |
2011-11-28 |
2023-08-12 |
Not clear |
| Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yi. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559519. |
moreover, morphine-induced tlr9 expression and microglia apoptosis appears to require μor. |
2011-11-28 |
2023-08-12 |
Not clear |
| Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yi. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559519. |
collectively, these results reveal that opioids prime microglia to undergo apoptosis through tlr9 and µor as well. |
2011-11-28 |
2023-08-12 |
Not clear |
| Misty L McDowell, Arabinda Das, Joshua A Smith, Abhay K Varma, Swapan K Ray, Naren L Bani. Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21672594. |
however, little is known about the neuroprotective effects of gen. we therefore tested whether gen would prevent apoptosis in cultured motoneurons following exposure to pro-inflammatory cytokines released from ifn-γ activated microglia. |
2011-11-22 |
2023-08-12 |
Not clear |
| Clara Quintas, Sónia Fraga, Jorge Gonçalves, Glória Queiro. P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation. Purinergic signalling. vol 7. issue 2. 2011-11-10. PMID:21559785. |
none of the uracil nucleotides tested had any effect in proliferation of highly enriched astroglial cultures, but uridine-5'-triphosphate (utp; 0.1-1 mm) inhibited proliferation up to 66% in co-cultures, an effect that was dependent on uridine-5'-diphosphate (udp) accumulation, coincident with a co-localization of p2y(6) receptors in microglia and due to cell apoptosis. |
2011-11-10 |
2023-08-12 |
Not clear |
| Hannah M Gibbons, Amy M Smith, H Heng Teoh, Peter M Bergin, Edward W Mee, Richard L M Faull, Mike Draguno. Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20816784. |
in this study, using microglia derived from adult human brains, we demonstrate that vpa does not induce microglial apoptosis as determined by the absence of caspase-3 cleavage. |
2011-09-27 |
2023-08-12 |
human |
| Caroline C Rodger. Dental X-ray exposure and Alzheimer's disease: a hypothetical etiological association. Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21458164. |
the hypothesis that alzheimer's is caused specifically by microglia telomere damage would explain the delay of one decade or longer between the presence of alzheimer's brain pathology and symptoms; telomere damage would not cause any change in microglial function, it would just reset the countdown clock so that senescence and apoptosis occurred earlier than they would have without the environmental insult. |
2011-09-26 |
2023-08-12 |
human |
| Cheng-Gang Zou, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xiu-Zhen Cao, Min Zhang, Ke-Qin Zhan. Homocysteine promotes proliferation and activation of microglia. Neurobiology of aging. vol 31. issue 12. 2011-08-29. PMID:19131143. |
although homocysteine-induced apoptosis in neurons has been extensively studied, little information is available regarding the effect of homocysteine on microglia. |
2011-08-29 |
2023-08-12 |
mouse |
| Ling Zhang, Yuan-yuan Li, Huai-cai Zeng, Miao Li, Yan-Jian Wan, Hermann J Schluesener, Zhi-yuan Zhang, Shun-qing X. Perfluorooctane sulfonate induces apoptosis in N9 microglial cell line. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21115943. |
perfluorooctane sulfonate induces apoptosis in n9 microglial cell line. |
2011-08-18 |
2023-08-12 |
human |
| Ling Zhang, Yuan-yuan Li, Huai-cai Zeng, Miao Li, Yan-Jian Wan, Hermann J Schluesener, Zhi-yuan Zhang, Shun-qing X. Perfluorooctane sulfonate induces apoptosis in N9 microglial cell line. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21115943. |
to study the apoptosis effects of pfos on microglia, murine n9 cell line was used as a model in current research. |
2011-08-18 |
2023-08-12 |
human |
| Hee Jae Yun, Je-Hyun Yoon, Jae Keun Lee, Kyung-Tae Noh, Kyoung-Wan Yoon, Sang Phil Oh, Hyun Jung Oh, Ji Soo Chae, Sang Gil Hwang, Eun Hee Kim, Gerd G Maul, Dae-Sik Lim, Eui-Ju Cho. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. The EMBO journal. vol 30. issue 12. 2011-08-09. PMID:21572393. |
although the persistent secretion of inflammatory mediators by the activated cells contributes to the pathogenesis of various neurological disorders, most activated microglia eventually undergo apoptosis through the process of activation-induced cell death (aicd). |
2011-08-09 |
2023-08-12 |
mouse |
| Hee Jae Yun, Je-Hyun Yoon, Jae Keun Lee, Kyung-Tae Noh, Kyoung-Wan Yoon, Sang Phil Oh, Hyun Jung Oh, Ji Soo Chae, Sang Gil Hwang, Eun Hee Kim, Gerd G Maul, Dae-Sik Lim, Eui-Ju Cho. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. The EMBO journal. vol 30. issue 12. 2011-08-09. PMID:21572393. |
here, we show that daxx and mammalian ste20-like kinase-1 (mst1) mediate apoptosis elicited by interferon-γ (ifn-γ) in microglia. |
2011-08-09 |
2023-08-12 |
mouse |
| Jean-Jacques Hoarau, Pascale Krejbich-Trotot, Marie-Christine Jaffar-Bandjee, Trina Das, Gerard-Vincent Thon-Hon, Shiril Kumar, Jim W Neal, Philippe Gasqu. Activation and control of CNS innate immune responses in health and diseases: a balancing act finely tuned by neuroimmune regulators (NIReg). CNS & neurological disorders drug targets. vol 10. issue 1. 2011-07-29. PMID:21143144. |
in the absence of these regulators, when neurons die by apoptosis, become infected or damaged, microglia and infiltrating immune cells are free to cause injury and an adverse inflammatory response in acute and chronic settings. |
2011-07-29 |
2023-08-12 |
Not clear |
| Viswanathan Sivakumar, Wallace S Foulds, Chi D Luu, Eng-Ang Ling, Charanjit Kau. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. The Journal of pathology. vol 224. issue 2. 2011-07-25. PMID:21404274. |
primary cultured retinal ganglion cells (rgcs) treated with conditioned medium derived from hypoxic microglia showed enhanced apoptosis, which was significantly reduced when the cells were treated with microglia conditioned medium neutralized with tnf-α/il-1β antibody. |
2011-07-25 |
2023-08-12 |
rat |
| Elona Rrapo, Yuyan Zhu, Jun Tian, Huayan Hou, Adam Smith, Francisco Fernandez, Jun Tan, Brian Giunt. Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. American journal of translational research. vol 1. issue 1. 2011-07-14. PMID:19966940. |
this was accompanied by a mild reduction in activated microglia by iba-1 staining and significant reduction in neuronal loss through apoptosis as demonstrated by map2 staining and western blot analysis respectively. |
2011-07-14 |
2023-08-12 |
mouse |