| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina Svoboda, Hubert H Kerschbau. L-Glutamine-induced apoptosis in microglia is mediated by mitochondrial dysfunction. The European journal of neuroscience. vol 30. issue 2. 2010-01-08. PMID:19614980. |
l-glutamine-induced apoptosis in microglia is mediated by mitochondrial dysfunction. |
2010-01-08 |
2023-08-12 |
Not clear |
| So-Young Hwang, Byong-Chul Yoo, Jae-won Jung, Eok-Soo Oh, Ji-Sun Hwang, Jin-A Shin, Song-Yi Kim, Seok-Ho Cha, Inn-Oc Ha. Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B. Biochimica et biophysica acta. vol 1793. issue 11. 2009-12-23. PMID:19748528. |
induction of glioma apoptosis by microglia-secreted molecules: the role of nitric oxide and cathepsin b. microglia contributes significantly to brain tumor mass, particularly in astrocytic gliomas. |
2009-12-23 |
2023-08-12 |
rat |
| So-Young Hwang, Byong-Chul Yoo, Jae-won Jung, Eok-Soo Oh, Ji-Sun Hwang, Jin-A Shin, Song-Yi Kim, Seok-Ho Cha, Inn-Oc Ha. Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B. Biochimica et biophysica acta. vol 1793. issue 11. 2009-12-23. PMID:19748528. |
however, since unstimulated resting microglia produces low or very limited level of no, mcm may contain other critical molecule(s) that induce glioma apoptosis. |
2009-12-23 |
2023-08-12 |
rat |
| Staci D Bilbo, Jaclyn M Schwar. Early-life programming of later-life brain and behavior: a critical role for the immune system. Frontiers in behavioral neuroscience. vol 3. 2009-12-16. PMID:19738918. |
microglia and astrocytes, the primary immunocompetent cells of the cns, are involved in every major aspect of brain development and function, including synaptogenesis, apoptosis, and angiogenesis. |
2009-12-16 |
2023-08-12 |
human |
| Claudie Hooper, Victoria A H Fry, Ioanna G Sevastou, Jennifer M Pococ. Scavenger receptor control of chromogranin A-induced microglial stress and neurotoxic cascades. FEBS letters. vol 583. issue 21. 2009-12-03. PMID:19800883. |
here we show that cga-dependent inducible nitric oxide synthase (inos) expression and stress responses in microglia involved signalling via scavenger receptors (sr), since sr class-a (sr-a) ligands blocked inos expression, mitochondrial depolarisation, apoptosis and glutamate release. |
2009-12-03 |
2023-08-12 |
Not clear |
| Lisa C Hutton, Mahila Abbass, Hayley Dickinson, Zoe Ireland, David W Walke. Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Developmental neuroscience. vol 31. issue 5. 2009-11-04. PMID:19684403. |
at 24 h of age, birth asphyxia had increased markers of cns inflammation (microglia, macrophage infiltration) and apoptosis (activated caspase-3, fractin) in cortical gray matter, which were reduced to control levels by prior maternal melatonin treatment. |
2009-11-04 |
2023-08-12 |
mouse |
| Yoko S Kaneko, Akira Nakashima, Keiji Mori, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ot. Lipopolysaccharide extends the lifespan of mouse primary-cultured microglia. Brain research. vol 1279. 2009-09-30. PMID:19442652. |
these data show that the optimal dose of lps suppresses the induction of both apoptosis and autophagy in primary-cultured microglia, allowing the cells to stay alive for more than 1 month. |
2009-09-30 |
2023-08-12 |
mouse |
| Jordi Calderó, Núria Brunet, Dolors Ciutat, Marta Hereu, Josep E Esquerd. Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death. Journal of neuroscience research. vol 87. issue 11. 2009-09-21. PMID:19382239. |
we found that: 1) macrophages/microglial cells were present in the spinal cord at early developmental stages (e3) and that they were recruited after normal and induced mn apoptosis; 2) although many microglial cells were seen phagocytosing apoptotic bodies, a proportion of dying cells were devoid of engulfing microglia; 3) axotomy of mature mns was accompanied by microglial activation in the absence of mn death; 4) excitotoxic (necrotic) mn death provoked a rapid and massive microglial recruitment with phagocytic activity; 5) lipopolysaccharide-induced microglial activation in vivo resulted in the death of immature, but not mature, microglia; and 6) overactivation of microglia modulated the survival of mature mns, either by killing them or by enhancing their vulnerability to die in response to a mild injury. |
2009-09-21 |
2023-08-12 |
chicken |
| Jordi Calderó, Núria Brunet, Dolors Ciutat, Marta Hereu, Josep E Esquerd. Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death. Journal of neuroscience research. vol 87. issue 11. 2009-09-21. PMID:19382239. |
taken together, these observations indicate that normal microglia do not play an active role in triggering apoptosis of developing mns. |
2009-09-21 |
2023-08-12 |
chicken |
| Tae Y Yune, Jee Y Lee, Chun M Cui, Ho C Kim, Tae H O. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. Journal of neurochemistry. vol 110. issue 4. 2009-09-21. PMID:19519665. |
microglia are activated after injury and produce a variety of proinflammatory factors such as tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, and reactive oxygen species leading to apoptosis of neurons and oligodendrocytes. |
2009-09-21 |
2023-08-12 |
rat |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
therefore, this study was aimed to investigate the temporal expression of dpysl2 and spna2 genes in normal and stroke rat brain and to characterize stroke brains for cell areas, apoptosis, and microglia cells. |
2009-09-02 |
2023-08-12 |
rat |
| Fransisca Indraswari, Peter T H Wong, Elgin Yap, Y K Ng, S Thameem Dhee. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochemistry international. vol 55. issue 4. 2009-09-02. PMID:19524114. |
characterization of stroke brain for apoptosis and microglia cells showed apoptotic cells and activated microglia, mainly in the infarct core of ipsilateral cortex and striatum of stroke brain. |
2009-09-02 |
2023-08-12 |
rat |
| Shunsuke Matsuda, Masahiro Umeda, Hiroyuki Kato, Tsutomu Arak. Glial damage after transient focal cerebral ischemia in rats. Journal of molecular neuroscience : MN. vol 38. issue 2. 2009-08-31. PMID:19051061. |
furthermore, our results show that most microglia and astrocytes in the ipsilateral striatum after focal cerebral ischemia may not die by apoptosis. |
2009-08-31 |
2023-08-12 |
rat |
| Jianjun Zhai, Anna-Lena Ström, Renee Kilty, Priya Venkatakrishnan, James White, William V Everson, Eric J Smart, Haining Zh. Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord. The FEBS journal. vol 276. issue 12. 2009-07-17. PMID:19438725. |
other protein changes were correlated with alterations in: microglia activation and inflammation; astrocyte and oligodendrocyte function; cell signaling; cellular stress response and apoptosis; and neuronal ion channels and neurotransmitter receptor functions. |
2009-07-17 |
2023-08-12 |
mouse |
| Pär Thored, Ursula Heldmann, Walace Gomes-Leal, Ramiro Gisler, Vladimer Darsalia, Jalal Taneera, Jens M Nygren, Sten-Eirik W Jacobsen, Christine T Ekdahl, Zaal Kokaia, Olle Lindval. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia. vol 57. issue 8. 2009-07-09. PMID:19053043. |
at 16 weeks, 5% of microglia but no other cells in svz expressed the igf-1 protein, which mitigates apoptosis and promotes proliferation and differentiation of nscs. |
2009-07-09 |
2023-08-12 |
rat |
| Sandra Black, Fuqiang Gao, Juan Bilba. Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment. Stroke. vol 40. issue 3 Suppl. 2009-03-26. PMID:19064767. |
activated microglia, oligodendroglial apoptosis, clasmatodendritic astrocytosis, and upregulated hypoxia-markers are seen on immunohistochemistry. |
2009-03-26 |
2023-08-12 |
Not clear |
| Katharina Stoecker, Karin Weigelt, Stefanie Ebert, Marcus Karlstetter, Yana Walczak, Thomas Langman. Induction of STAP-1 promotes neurotoxic activation of microglia. Biochemical and biophysical research communications. vol 379. issue 1. 2009-02-06. PMID:19100238. |
taken together, our study implicates a previously unknown role of stap-1 in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration. |
2009-02-06 |
2023-08-12 |
mouse |
| Juan Li, Biyun Shao, Liang Zhu, Yongyao Cui, Changzhi Dong, Jean-Marc Miezan Ezoulin, Xiaoling Gao, Qiushi Ren, Françoise Heymans, Hongzhuan Che. PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. Cellular and molecular neurobiology. vol 28. issue 1. 2009-01-28. PMID:17712622. |
platelet-activating factor (paf), mainly released from activated microglia and acts as a high potent inflammatory mediator and a neurotoxin, is indicated to be a principle initiator of neuroinflammation, neuronal dysfunction, and apoptosis related to had. |
2009-01-28 |
2023-08-12 |
mouse |
| Martin B Wax, Gülgün Tezel, Junjie Yang, Guanghua Peng, Rajkumar V Patil, Neeraj Agarwal, Rebecca M Sappington, David J Calkin. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 46. 2009-01-26. PMID:19005073. |
in vitro studies found that t-cells activated by hsp immunization induced rgc apoptosis via the release of the inflammatory cytokine fasl, whereas hsp immunization induced activation of microglia cells and upregulation of the fasl receptor in rgcs. |
2009-01-26 |
2023-08-12 |
human |
| Stefanie Ebert, Tobias Schoeberl, Yana Walczak, Katharina Stoecker, Thomas Stempfl, Christoph Moehle, Bernhard H F Weber, Thomas Langman. Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype. Journal of leukocyte biology. vol 84. issue 3. 2008-10-28. PMID:18550791. |
furthermore, conditioned media from cspg-ds-treated microglia did not diminish the viability or cause apoptosis of cultured photoreceptor cells and partially rescued these cells from ifn-gamma-induced apoptosis. |
2008-10-28 |
2023-08-12 |
Not clear |