| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas H Hunt, Jacob Golenser, Tailoi Chan-Ling, Sapan Parekh, Caroline Rae, Sarah Potter, Isabelle M Medana, Jenny Miu, Helen J Bal. Immunopathogenesis of cerebral malaria. International journal for parasitology. vol 36. issue 5. 2007-01-18. PMID:16678181. |
we suggest that this, in turn, leads to the activation of microglia and the activation and apoptosis of astrocytes. |
2007-01-18 |
2023-08-12 |
human |
| Andrew Chan, Vera Hummel, Franz X Weilbach, Bernd C Kieseier, Ralf Gol. Phagocytosis of apoptotic inflammatory cells downregulates microglial chemoattractive function and migration of encephalitogenic T cells. Journal of neuroscience research. vol 84. issue 6. 2007-01-04. PMID:16941488. |
apoptosis of autoaggressive t cells in the central nervous system (cns) and subsequent phagocytosis by microglia is probably crucial in the rapid resolution of the inflammatory infiltrate in t cell mediated neuroinflammatory diseases. |
2007-01-04 |
2023-08-12 |
rat |
| Holger M Reichardt, Ralf Gold, Fred Lühde. Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis. Expert review of neurotherapeutics. vol 6. issue 11. 2006-12-28. PMID:17144780. |
experimental autoimmune encephalomyelitis has been instrumental for many years in studying multiple sclerosis, revealing the blood-brain barrier, the microglia and t-cell apoptosis as major targets of glucocorticoids in this disease. |
2006-12-28 |
2023-08-12 |
Not clear |
| M Dragunow, J M Greenwood, R E Cameron, P J Narayan, S J O'Carroll, A G Pearson, H M Gibbon. Valproic acid induces caspase 3-mediated apoptosis in microglial cells. Neuroscience. vol 140. issue 4. 2006-10-26. PMID:16600518. |
we report that valproic acid induces apoptosis in the mouse microglial cell line, bv-2, at concentrations within the therapeutic range. |
2006-10-26 |
2023-08-12 |
mouse |
| He Li, Zhou Gang, He Yuling, Xie Luokun, Xiong Jie, Lei Hao, Wei Li, Hu Chunsong, Liu Junyan, Jiang Mingshen, Jin Youxin, Gong Feili, Jin Boquan, Tan Jinqua. Different neurotropic pathogens elicit neurotoxic CCR9- or neurosupportive CXCR3-expressing microglia. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 6. 2006-10-24. PMID:16951324. |
we report here that intracranial priming and rechallenging with toxoplasma gondii in mice elicit neurotoxic ccr9+ irg1+ (immunoresponsive gene 1) microglia, which render resistance to apoptosis and produce a high level of tnf-alpha; priming and rechallenging with lymphocytic choriomeningitis virus elicit neurosupportive cxcr3+ irg1- microglia, which are sensitive to apoptosis and produce a high level of il-10 and tgf-beta. |
2006-10-24 |
2023-08-12 |
mouse |
| A Gehrig, A Janssen, F Horling, C Grimm, B H F Webe. The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse. Cytogenetic and genome research. vol 115. issue 1. 2006-10-20. PMID:16974082. |
no direct influence of the casp1 genotype on apoptosis could be identified although striking differences in the overall number of resident microglia were observed independent of the rs1h genotype. |
2006-10-20 |
2023-08-12 |
mouse |
| Jiyeon Ock, Heasuk Lee, Sangseop Kim, Won-Ha Lee, Dong-Kug Choi, Eun Jung Park, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Su. Induction of microglial apoptosis by corticotropin-releasing hormone. Journal of neurochemistry. vol 98. issue 3. 2006-09-08. PMID:16893426. |
vasoactive intestinal peptide, substance p, cholecystokinin and neuropeptide y did not affect microglial cell viability, whereas corticotropin-releasing hormone (crh) induced a classical apoptosis of mouse microglia in culture as shown by nuclear condensation and fragmentation, terminal deoxynucleotidyl transferase dutp nick-end labeling, and cleavage of caspase 3 and poly(adp-ribose) polymerase protein. |
2006-09-08 |
2023-08-12 |
mouse |
| Jiyeon Ock, Heasuk Lee, Sangseop Kim, Won-Ha Lee, Dong-Kug Choi, Eun Jung Park, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Su. Induction of microglial apoptosis by corticotropin-releasing hormone. Journal of neurochemistry. vol 98. issue 3. 2006-09-08. PMID:16893426. |
taken together, our results indicate that the stress neuropeptide crh may regulate neuroinflammation by inducing the apoptosis of microglia, the major cellular source of inflammatory mediators in the cns. |
2006-09-08 |
2023-08-12 |
mouse |
| Seija Lehnardt, Philipp Henneke, Egil Lien, Dennis L Kasper, Joseph J Volpe, Ingo Bechmann, Robert Nitsch, Joerg R Weber, Douglas T Golenbock, Timothy Vartania. A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 1. 2006-08-09. PMID:16785556. |
we show that both heat-inactivated whole gbs and a secreted proteinaceous factor from gbs (gbs-f) induce neuronal apoptosis via the activation of murine microglia through a tlr2-dependent and myd88-dependent pathway in vitro. |
2006-08-09 |
2023-08-12 |
mouse |
| Qing Huang, Li-Jun Wu, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Elevated levels of DNA repair enzymes and antioxidative enzymes by (+)-catechin in murine microglia cells after oxidative stress. Journal of Asian natural products research. vol 8. issue 1-2. 2006-07-28. PMID:16753784. |
in this study, tunel assay and dna electrophorysis indicated that (+)-catechin markedly blocked dna fragmentation and apoptosis of microglia cells by tbhp exposure. |
2006-07-28 |
2023-08-12 |
cat |
| Barry W Festoff, Syed Ameenuddin, Paul M Arnold, Andrea Wong, Karen S Santacruz, Bruce A Citro. Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638021. |
these results support reports that modulating apoptosis, caspases, and microglia provide promising therapeutic targets for prevention and/or limiting the degree of functional loss after cns trauma. |
2006-07-21 |
2023-08-12 |
mouse |
| M J Casarejos, J Menéndez, R M Solano, J A Rodríguez-Navarro, J García de Yébenes, M A Men. Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline. Journal of neurochemistry. vol 97. issue 4. 2006-06-22. PMID:16573651. |
minocycline, an inhibitor of microglia, prevented the dropout of tyrosine hydroxylase and apoptosis by rot; the addition of microglia from pk-ko to wt neuronal cultures increased the sensitivity of dopaminergic neurons to rot. |
2006-06-22 |
2023-08-12 |
mouse |
| Ibolja Cernak, Bogdan Stoica, Kimberly R Byrnes, Simone Di Giovanni, Alan I Fade. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell cycle (Georgetown, Tex.). vol 4. issue 9. 2006-06-12. PMID:16082214. |
in mitotic cells, such as astroglia and microglia, they induce proliferation, whereas in post-mitotic cells such as neurons they initiate caspase-related apoptosis. |
2006-06-12 |
2023-08-12 |
rat |
| Małgorzata Krzyzowska, Joanna Cymerys, Anna Winnicka, Marek Niemiałtowsk. Involvement of Fas and FasL in Ectromelia virus-induced apoptosis in mouse brain. Virus research. vol 115. issue 2. 2006-05-16. PMID:16169110. |
infected cells consisted of microglia and monocytes, astrocytes and oligodendrocytes and these type of cells underwent apoptosis within 5-15 days post infection (d.p.i.). |
2006-05-16 |
2023-08-12 |
mouse |
| Małgorzata Krzyzowska, Joanna Cymerys, Anna Winnicka, Marek Niemiałtowsk. Involvement of Fas and FasL in Ectromelia virus-induced apoptosis in mouse brain. Virus research. vol 115. issue 2. 2006-05-16. PMID:16169110. |
taking together we may conclude that ectv-mos infection of microglia and astrocytes leads to local inflammation resulting in fas/fasl up-regulation and apoptosis, which limits mouse central nervous system infection with ectv-mos. |
2006-05-16 |
2023-08-12 |
mouse |
| Elisabetta Polazzi, Antonio Contestabil. Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium. Journal of neuroimmunology. vol 172. issue 1-2. 2006-05-09. PMID:16376436. |
prolonged exposure (72 h) to neuron-conditioned media in the presence of lps induced microglial apoptosis, thus suggesting that neuronal overactivation of stimulated microglia favors their subsequent apoptotic elimination as part of a safety mechanism. |
2006-05-09 |
2023-08-12 |
Not clear |
| Henry H Majed, Siddharthan Chandran, Simone P Niclou, Richard S Nicholas, Alastair Wilkins, Mark G Wing, Kate E Rhodes, Maria Grazia Spillantini, Alastair Compsto. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 6. 2006-04-26. PMID:16467521. |
furthermore, recombinant sema3a induced apoptosis of microglia when added to the in vitro culture, and a similar result was obtained on activated microglia when sema3a was produced by stressed neurons. |
2006-04-26 |
2023-08-12 |
rat |
| Dong-ge Liu, Shu-rong He, Wei Zhang, Di Cui, Yuekui Li, W Sue T Griffi. [Relationship between apoptosis of neurons and microglia activation in Alzheimer's disease]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 33. issue 5. 2006-03-17. PMID:15498206. |
[relationship between apoptosis of neurons and microglia activation in alzheimer's disease]. |
2006-03-17 |
2023-08-12 |
Not clear |
| Dong-ge Liu, Shu-rong He, Wei Zhang, Di Cui, Yuekui Li, W Sue T Griffi. [Relationship between apoptosis of neurons and microglia activation in Alzheimer's disease]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 33. issue 5. 2006-03-17. PMID:15498206. |
to assess the relationship between microglia activation and apoptosis of neurons, and the significance of activated microglias in the formation and progression of senile plaques in alzheimer's disease. |
2006-03-17 |
2023-08-12 |
Not clear |
| Gareth Jones, Christopher Powe. Regulation of neural cell survival by HIV-1 infection. Neurobiology of disease. vol 21. issue 1. 2006-03-09. PMID:16298136. |
alternatively, neuronal apoptosis may result indirectly from the secretion of neurotoxic host molecules by resident brain macrophages or microglia in response to hiv-1 infection, stimulation by viral proteins or immune activation. |
2006-03-09 |
2023-08-12 |
human |