| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoon Seong Kim, Sung Soo Kim, Jeong Je Cho, Dong Hee Choi, Onyou Hwang, Dong Hoon Shin, Hong Sung Chun, M Flint Beal, Tong H Jo. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814801. |
these results strongly suggest that the distinctive signal of neuronal apoptosis is the release of active form of mmp-3 that activates microglia and subsequently exacerbates neuronal degeneration. |
2006-03-01 |
2023-08-12 |
mouse |
| Takayuki Nagano, Shinya H Kimura, Eri Takai, Toshio Matsuda, Motohiko Takemur. Lipopolysaccharide sensitizes microglia toward Ca(2+)-induced cell death: mode of cell death shifts from apoptosis to necrosis. Glia. vol 53. issue 1. 2006-02-24. PMID:16158419. |
lipopolysaccharide sensitizes microglia toward ca(2+)-induced cell death: mode of cell death shifts from apoptosis to necrosis. |
2006-02-24 |
2023-08-12 |
rat |
| Takayuki Nagano, Shinya H Kimura, Eri Takai, Toshio Matsuda, Motohiko Takemur. Lipopolysaccharide sensitizes microglia toward Ca(2+)-induced cell death: mode of cell death shifts from apoptosis to necrosis. Glia. vol 53. issue 1. 2006-02-24. PMID:16158419. |
thapsigargin or ionomycin induced apoptosis in lps-untreated microglia, while they induced necrosis in lps-treated microglia, which were partially reversed by o,o'-bis(2-aminophenyl)ethyleneglycol-n,n,n',n'-tetraacetic acid tetraacetoxymethyl ester (bapta-am, an intracellular ca2+ chelator). |
2006-02-24 |
2023-08-12 |
rat |
| Antonietta Bernardo, Luisa Minghett. PPAR-gamma agonists as regulators of microglial activation and brain inflammation. Current pharmaceutical design. vol 12. issue 1. 2006-02-22. PMID:16454728. |
moreover, one of the major natural ppar-gamma agonist, 15d-prostaglandin j(2) may contribute to the safe elimination of activated microglia by inducing apoptosis. |
2006-02-22 |
2023-08-12 |
human |
| Xijin Wang, Shengdi Chen, Guozhao Ma, Min Ye, Guoqiang L. Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. Mechanisms of ageing and development. vol 126. issue 12. 2006-01-26. PMID:16112714. |
involvement of proinflammatory factors, apoptosis, caspase-3 activation and ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. |
2006-01-26 |
2023-08-12 |
rat |
| Xijin Wang, Shengdi Chen, Guozhao Ma, Min Ye, Guoqiang L. Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. Mechanisms of ageing and development. vol 126. issue 12. 2006-01-26. PMID:16112714. |
apoptosis assay on pc12 cells and primary dopaminergic neurons showed that apoptosis was a mechanism for both microglia activation-mediated dopaminergic cell death. |
2006-01-26 |
2023-08-12 |
rat |
| Xijin Wang, Shengdi Chen, Guozhao Ma, Min Ye, Guoqiang L. Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. Mechanisms of ageing and development. vol 126. issue 12. 2006-01-26. PMID:16112714. |
using primary vm cultures and pc12 cells, our study shows the roles of proinflammatory factors, apoptosis, caspase-3 activation and ca(2+) disturbance in microglia activation-mediated dopaminergic cell degeneration. |
2006-01-26 |
2023-08-12 |
rat |
| Isamu Mori, Fumi Goshima, Terukazu Mizuno, Yoshinori Imai, Shinichi Kohsaka, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyam. Axonal injury in experimental herpes simplex encephalitis. Brain research. vol 1057. issue 1-2. 2006-01-04. PMID:16122712. |
they appeared where infected neurons were undergoing apoptosis and iba1-immunopositive microglia transformed themselves into macrophages. |
2006-01-04 |
2023-08-12 |
mouse |
| Chih-Jui Lao, Jaung-Geng Lin, Jon-Son Kuo, Pei-dawn Lee Chao, Chin-Yi Cheng, Nou-Ying Tang, Ching-Liang Hsie. Microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats. The American journal of Chinese medicine. vol 33. issue 3. 2005-12-21. PMID:16047560. |
microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats. |
2005-12-21 |
2023-08-12 |
rat |
| Chih-Jui Lao, Jaung-Geng Lin, Jon-Son Kuo, Pei-dawn Lee Chao, Chin-Yi Cheng, Nou-Ying Tang, Ching-Liang Hsie. Microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats. The American journal of Chinese medicine. vol 33. issue 3. 2005-12-21. PMID:16047560. |
this effect of sj involves its suppressive action of microglia, interleukin-1beta and apoptosis. |
2005-12-21 |
2023-08-12 |
rat |
| Ching-Liang Hsieh, Chi-Long Chen, Nou-Ying Tang, Chin-Min Chuang, Ching-Tou Hsieh, Su-Yin Chiang, Jaung-Geng Lin, Sheng-Feng Hs. Gastrodia elata BL mediates the suppression of nNOS and microglia activation to protect against neuronal damage in kainic acid-treated rats. The American journal of Chinese medicine. vol 33. issue 4. 2005-11-07. PMID:16173534. |
this study demonstrated that ge was able to reduce nnos, microglia activation and apoptosis, suggesting that ge has a protective effect against neuronal damage in ka-treated rats. |
2005-11-07 |
2023-08-12 |
rat |
| Bettina Gerstner, Alexander Gratopp, Monika Marcinkowski, Marco Sifringer, Michael Obladen, Christoph Bühre. Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency. Pediatric research. vol 57. issue 6. 2005-09-23. PMID:15774829. |
apoptosis but not necrosis was detected at various stages (early: annexin-v; effector: caspase-3) after 24-48 h of incubation with ga, gc, or 3-oh-ga in oln-93 but not in neuroblastoma or microglia cells. |
2005-09-23 |
2023-08-12 |
rat |
| Takayuki Nagano, Masakazu Osakada, Yukio Ago, Yutaka Koyama, Akemichi Baba, Sadaaki Maeda, Motohiko Takemura, Toshio Matsud. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678087. |
sea0400, a specific inhibitor of the na+-ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. |
2005-09-22 |
2023-08-12 |
rat |
| Takayuki Nagano, Masakazu Osakada, Yukio Ago, Yutaka Koyama, Akemichi Baba, Sadaaki Maeda, Motohiko Takemura, Toshio Matsud. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678087. |
using sea0400, a potent and selective inhibitor of the na+-ca2+ exchanger (ncx), we examined whether ncx is involved in nitric oxide (no)-induced disturbance of endoplasmic reticulum (er) ca2+ homeostasis followed by apoptosis in cultured rat microglia. |
2005-09-22 |
2023-08-12 |
rat |
| Takayuki Nagano, Masakazu Osakada, Yukio Ago, Yutaka Koyama, Akemichi Baba, Sadaaki Maeda, Motohiko Takemura, Toshio Matsud. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678087. |
sea0400 at 0.3-1.0 microm protected microglia against snp-induced apoptosis. |
2005-09-22 |
2023-08-12 |
rat |
| Takayuki Nagano, Masakazu Osakada, Yukio Ago, Yutaka Koyama, Akemichi Baba, Sadaaki Maeda, Motohiko Takemura, Toshio Matsud. SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678087. |
these results suggest that snp induces apoptosis via the er stress pathway and sea0400 attenuates snp-induced apoptosis via suppression of the er stress in cultured microglia. |
2005-09-22 |
2023-08-12 |
rat |
| E P K Mensah-Brown, A Shahin, L J Garey, M L Luki. Neuroglial response after induction of experimental allergic encephalomyelitis in susceptible and resistant rat strains. Cellular immunology. vol 233. issue 2. 2005-09-20. PMID:15963481. |
our findings are compatible with the notion that microglia terminate effector t cells by apoptosis and that lack of this mechanism as evidenced by the lack of cd11b/c expression, support t cell survival and clinical expression of disease. |
2005-09-20 |
2023-08-12 |
rat |
| Hui-Yang Zeng, Xiu-An Zhu, Cheng Zhang, Li-Ping Yang, Le-Meng Wu, Mark O M Ts. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Investigative ophthalmology & visual science. vol 46. issue 8. 2005-09-15. PMID:16043876. |
to elucidate the role of activated microglia in the photoreceptor apoptosis of rd mice by identifying sequential events and factors associated with microglial activation, migration, and cytotoxicity during retinal degeneration. |
2005-09-15 |
2023-08-12 |
mouse |
| Ravi Shankar Akundi, Eduardo Candelario-Jalil, Sandra Hess, Michael Hüll, Klaus Lieb, Peter J Gebicke-Haerter, Bernd L Fiebic. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia. vol 51. issue 3. 2005-09-08. PMID:15800925. |
this potential nature of ceramides in activating microglia suggests that endogenously produced ceramides during neuronal apoptosis in ischemia or neurodegenerative diseases could also contribute to the amplification of neuroinflammatory events. |
2005-09-08 |
2023-08-12 |
rat |
| Dae Young Jung, Heasuk Lee, Kyoungho Su. Pro-apoptotic activity of N-myc in activation-induced cell death of microglia. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953367. |
tetracycline-based conditional expression of n-myc sensitized microglia to nitric oxide (no)-induced apoptosis. |
2005-08-08 |
2023-08-12 |
Not clear |