| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lifeng Yang, Xiangmei Zhou, Jianmin Yang, Xiaomin Yin, Lifang Han, Deming Zha. Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro. Journal of neuroimmunology. vol 199. issue 1-2. 2008-10-14. PMID:18547651. |
the synthetic peptide consisting of amino acid residues 106-126 of the human prion protein prp106-126 has been demonstrated to generate fibrils, which damage neurons either directly by interacting with components of the cell surface to trigger cell apoptosis signaling or indirectly by activating microglia to produce inflammatory mediators. |
2008-10-14 |
2023-08-12 |
human |
| Lifeng Yang, Xiangmei Zhou, Jianmin Yang, Xiaomin Yin, Lifang Han, Deming Zha. Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro. Journal of neuroimmunology. vol 199. issue 1-2. 2008-10-14. PMID:18547651. |
inhibitory activity of aspirin on neurotoxicity of prp106-126 associated with microglia activation was determined using an apoptosis detection kit. |
2008-10-14 |
2023-08-12 |
human |
| David M Thomas, Dina M Francescutti-Verbeem, Donald M Kuh. Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18410508. |
furthermore, it appears that striatal-resident microglia respond to meth with an activation cascade and then return to a surveying state without undergoing apoptosis or migration. |
2008-09-16 |
2023-08-12 |
mouse |
| Shirley Wakselman, Catherine Béchade, Anne Roumier, Delphine Bernard, Antoine Triller, Alain Bessi. Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 32. 2008-09-09. PMID:18685038. |
in several brain regions, microglia actively promote neuronal apoptosis during development. |
2008-09-09 |
2023-08-12 |
mouse |
| G Jean Harry, Christian Lefebvre d'Hellencourt, Christopher A McPherson, Jason A Funk, Mineyoshi Aoyama, Robert N Win. Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. Journal of neurochemistry. vol 106. issue 1. 2008-08-19. PMID:18373618. |
), neuronal apoptosis [terminal deoxynucleotidyl transferase-mediated dutp-biotin in situ end labeling, active caspase 3 (ac3)] was accompanied by amoeboid microglia and elevated tnfalpha mrna levels. |
2008-08-19 |
2023-08-12 |
mouse |
| A R Alvaro, J Martins, A C Costa, E Fernandes, F Carvalho, A F Ambrósio, C Cavada. Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience. vol 152. issue 1. 2008-08-05. PMID:18249070. |
mdma induced necrosis [mtt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and propidium iodide assays] and apoptosis (immunoreactivity of cleaved caspase-3) in mixed cultures of retinal neural cells (neurons, macroglia and microglia), in a concentration-dependent manner. |
2008-08-05 |
2023-08-12 |
rat |
| Hui Qin Xing, Kazuyasu Mori, Chie Sugimoto, Fumiko Ono, Kimiko Izumo, Ryuji Kuboda, Shuji Izum. Impaired astrocytes and diffuse activation of microglia in the cerebral cortex in simian immunodeficiency virus-infected Macaques without simian immunodeficiency virus encephalitis. Journal of neuropathology and experimental neurology. vol 67. issue 6. 2008-07-15. PMID:18520778. |
to elucidate the pathogenesis of cortical degeneration, we examined the frontal cortex of siv-infected macaques and found apoptosis and decreased expression of the excitatory amino acid transporter 2 in astrocytes and diffuse activation of microglia in association with limited neuronal damage. |
2008-07-15 |
2023-08-12 |
monkey |
| Gefei Wang, Juan Zhang, Weizhong Li, Gang Xin, Yun Su, Yuanli Gao, Heng Zhang, Guimei Lin, Xiaoyang Jiao, Kangsheng L. Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cellular & molecular immunology. vol 5. issue 2. 2008-06-12. PMID:18445341. |
apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human h1n1 and avian h5n1 influenza viruses. |
2008-06-12 |
2023-08-12 |
mouse |
| Gefei Wang, Juan Zhang, Weizhong Li, Gang Xin, Yun Su, Yuanli Gao, Heng Zhang, Guimei Lin, Xiaoyang Jiao, Kangsheng L. Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cellular & molecular immunology. vol 5. issue 2. 2008-06-12. PMID:18445341. |
this study is the first demonstration that both human h1n1 and avian h5n1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis, cytopathy, and proinflammatory cytokine production in them in vitro. |
2008-06-12 |
2023-08-12 |
mouse |
| P S Chen, C-C Wang, C D Bortner, G-S Peng, X Wu, H Pang, R-B Lu, P-W Gean, D-M Chuang, J-S Hon. Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience. vol 149. issue 1. 2008-02-14. PMID:17850978. |
we found that vpa induced apoptosis of microglia cells in a time- and concentration-dependent manner. |
2008-02-14 |
2023-08-12 |
Not clear |
| P S Chen, C-C Wang, C D Bortner, G-S Peng, X Wu, H Pang, R-B Lu, P-W Gean, D-M Chuang, J-S Hon. Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience. vol 149. issue 1. 2008-02-14. PMID:17850978. |
the apoptosis of microglia was accompanied by the disruption of mitochondrial membrane potential and the enhancement of acetylation levels of the histone h3 protein. |
2008-02-14 |
2023-08-12 |
Not clear |
| Rosa M Solano, Maria J Casarejos, Jamie Menéndez-Cuervo, Jose A Rodriguez-Navarro, Justo García de Yébenes, Maria A Men. Glial dysfunction in parkin null mice: effects of aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 3. 2008-02-08. PMID:18199761. |
pk-ko-gcm was a less powerful suppressor of apoptosis and microglia in neuronal cultures. |
2008-02-08 |
2023-08-12 |
mouse |
| J J Neher, G C Brow. Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system. Biochemical Society transactions. vol 35. issue Pt 5. 2008-02-05. PMID:17956303. |
lta-activated microglia kill co-cultured neurons apparently via nitric oxide, superoxide and peroxynitrite, which may induce apoptosis of neurons that are then phagocytosed by microglia. |
2008-02-05 |
2023-08-12 |
Not clear |
| Megan E Knoch, Karen A Hartnett, Hirokazu Hara, Karl Kandler, Elias Aizenma. Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge. Glia. vol 56. issue 1. 2008-01-16. PMID:17955552. |
we report here that reactive species released from activated microglia induce the liberation of zn(2+) from intracellular stores in cultured cortical neurons, with a subsequent enhancement in neuronal voltage-gated k(+) currents, two events that have been intimately linked to apoptosis. |
2008-01-16 |
2023-08-12 |
Not clear |
| Malabendu Jana, Arundhati Jana, Utpal Pal, Kalipada Paha. A simplified method for isolating highly purified neurons, oligodendrocytes, astrocytes, and microglia from the same human fetal brain tissue. Neurochemical research. vol 32. issue 12. 2008-01-02. PMID:17447141. |
elucidation of the underlying pathogenic mechanisms leading to apoptosis of neurons and oligodendrocytes and activation of microglia and astrocytes in different neurodegenerative and neuroinflammatory disorders remains a challenge in neuroscience. |
2008-01-02 |
2023-08-12 |
human |
| M S Petrik, J M B Wilson, S C Grant, S J Blackband, R C Tabata, X Shan, C Krieger, C A Sha. Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits. Neuromolecular medicine. vol 9. issue 3. 2007-12-27. PMID:17914180. |
increased apoptosis, gfap positive astrocytes, and/or activated microglia were observed in all those cns regions that showed volume loss except for the hippocampus. |
2007-12-27 |
2023-08-12 |
mouse |
| Seija Lehnardt, Julia Wennekamp, Dorette Freyer, Christian Liedtke, Christina Krueger, Robert Nitsch, Ingo Bechmann, Joerg R Weber, Philipp Hennek. TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 9. 2007-12-06. PMID:17947688. |
tlr2 and caspase-8 are essential for group b streptococcus-induced apoptosis in microglia. |
2007-12-06 |
2023-08-12 |
Not clear |
| Seija Lehnardt, Julia Wennekamp, Dorette Freyer, Christian Liedtke, Christina Krueger, Robert Nitsch, Ingo Bechmann, Joerg R Weber, Philipp Hennek. TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 9. 2007-12-06. PMID:17947688. |
we report in this study that gbs not only activates microglia, but also induces apoptosis in these cells via tlr2 and the tlr-adaptor molecule myd88. |
2007-12-06 |
2023-08-12 |
Not clear |
| Shinrye Lee, Jayoung Lee, Sangseop Kim, Jae-Yong Park, Won-Ha Lee, Kiyoshi Mori, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Su. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 5. 2007-11-20. PMID:17709539. |
a dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. |
2007-11-20 |
2023-08-12 |
Not clear |
| Shinrye Lee, Jayoung Lee, Sangseop Kim, Jae-Yong Park, Won-Ha Lee, Kiyoshi Mori, Sang-Hyun Kim, In Kyeom Kim, Kyoungho Su. A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 5. 2007-11-20. PMID:17709539. |
activated microglia are thought to undergo apoptosis as a self-regulatory mechanism. |
2007-11-20 |
2023-08-12 |
Not clear |