| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew D Kraft, Christopher A McPherson, G Jean Harr. Association Between Microglia, Inflammatory Factors, and Complement with Loss of Hippocampal Mossy Fiber Synapses Induced by Trimethyltin. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:26892644. |
neuronal apoptosis was accompanied by amoeboid microglia and elevations in tumor necrosis factor [tnfa], interleukin 1β [il1b], and il6 mrna and c1q protein. |
2017-06-26 |
2023-08-13 |
mouse |
| Sandra Kuehn, Jose Hurst, Adelina Jashari, Kathrin Ahrens, Teresa Tsai, Ilan M Wunderlich, H Burkhard Dick, Stephanie C Joachim, Sven Schnichel. The novel induction of retinal ganglion cell apoptosis in porcine organ culture by NMDA - an opportunity for the replacement of animals in experiments. Alternatives to laboratory animals : ATLA. vol 44. issue 6. 2017-06-26. PMID:28094536. |
nmda treatment induced apoptosis, oxidative stress and a slight microglia activation. |
2017-06-26 |
2023-08-13 |
Not clear |
| Li Su, Rongrong Zhang, Yuanyuan Chen, Zhenyu Zhu, Chao M. Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 3. 2017-06-26. PMID:28245468. |
raf kinase inhibitor protein attenuates ischemic-induced microglia cell apoptosis and activation through nf-κb pathway. |
2017-06-26 |
2023-08-13 |
Not clear |
| Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J P Deudero, Amy L Brewster, Anne E Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M Encinas, Amanda Sierr. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS biology. vol 14. issue 5. 2017-06-21. PMID:27228556. |
recent findings suggest that in the adult hippocampal neurogenic niche, where the excess of newborn cells undergo apoptosis in physiological conditions, phagocytosis is efficiently executed by surveillant, ramified microglia. |
2017-06-21 |
2023-08-13 |
mouse |
| Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J P Deudero, Amy L Brewster, Anne E Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M Encinas, Amanda Sierr. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS biology. vol 14. issue 5. 2017-06-21. PMID:27228556. |
when challenged with excitotoxicity in vitro (via the glutamate agonist nmda) or inflammation in vivo (via systemic administration of bacterial lipopolysaccharides or by omega 3 fatty acid deficient diets), microglia resorted to different strategies to boost their phagocytic efficiency and compensate for the increased number of apoptotic cells, thus maintaining phagocytosis and apoptosis tightly coupled. |
2017-06-21 |
2023-08-13 |
mouse |
| Kathrin Heiss, Luca Vanella, Paolo Murabito, Orazio Prezzavento, Agostino Marrazzo, Carlo Castruccio Castracani, Ignazio Barbagallo, Agata Zappalà, Emanuela Arena, Marinella Astuto, Antonino Giarratano, Giovanni Li Volt. (+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury. Neuroscience letters. vol 626. 2017-06-19. PMID:27208832. |
(+)-pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury. |
2017-06-19 |
2023-08-13 |
Not clear |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
ros/txnip pathway contributes to thrombin induced nlrp3 inflammasome activation and cell apoptosis in microglia. |
2017-06-13 |
2023-08-13 |
human |
| Aine Tonouchi, Jun Nagai, Kentaro Togashi, Yoshio Goshima, Toshio Ohshim. Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Journal of neurochemistry. vol 137. issue 5. 2017-06-05. PMID:26991935. |
several lines of evidence suggest that neurodegeneration in pd is accelerated by a vicious cycle in which apoptosis in dopaminergic neurons triggers the activation of microglia and harmful inflammatory processes that further amplify neuronal death. |
2017-06-05 |
2023-08-13 |
mouse |
| Jiamin Mao, Jianbing Yang, Yan Zhang, Ting Li, Cheng Wang, Lingfei Xu, Qiaoyun Hu, Xiaoke Wang, Shengyang Jiang, Xiaoke Nie, Gang Che. Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway. Toxicology and applied pharmacology. vol 303. 2017-05-23. PMID:27174766. |
arsenic trioxide mediates hapi microglia inflammatory response and subsequent neuron apoptosis through p38/jnk mapk/stat3 pathway. |
2017-05-23 |
2023-08-13 |
Not clear |
| Dagmar E Ehrnhoefer, Nicholas S Caron, Yu Deng, Xiaofan Qiu, Michelle Tsang, Michael R Hayde. Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27296315. |
our results demonstrate that laquinimod can directly downregulate neuronal apoptosis pathways relevant for axonal degeneration in addition to its known effects on astrocytes and microglia in the cns. |
2017-05-05 |
2023-08-13 |
mouse |
| Xiang-Sheng Zhang, Wei Li, Qi Wu, Ling-Yun Wu, Zhen-Nan Ye, Jing-Peng Liu, Zong Zhuang, Meng-Liang Zhou, Xin Zhang, Chun-Hua Han. Resveratrol Attenuates Acute Inflammatory Injury in Experimental Subarachnoid Hemorrhage in Rats via Inhibition of TLR4 Pathway. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27529233. |
meanwhile, rsv significantly reduced microglia activation, as well as inflammatory cytokines leading to the amelioration of neural apoptosis, brain edema, and neurological behavior impairment at 24 h after sah. |
2017-04-17 |
2023-08-13 |
rat |
| Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Ya-An Chang, Meei-Ling Sheu, Shing Hwa Li. Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells. Journal of agricultural and food chemistry. vol 64. issue 20. 2017-04-06. PMID:27144449. |
catechin significantly inhibited the hypoxia/reperfusion-induced decreased cell viability and increased reactive oxygen species (ros) and apoptosis in microglia. |
2017-04-06 |
2023-08-13 |
Not clear |
| Yi Feng, Huaqing Xue, Jie Zhu, Likun Yang, Feng Zhang, Rong Qian, Wei Lin, Yuhai Wan. ESE1 is Associated with Neuronal Apoptosis in Lipopolysaccharide Induced Neuroinflammation. Neurochemical research. vol 41. issue 10. 2017-04-04. PMID:27350582. |
neuronal apoptosis induced by the over-activation of microglia during neuroinflammation contributes to the pathology of central nervous system (cns) degenerative diseases. |
2017-04-04 |
2023-08-13 |
Not clear |
| Yi Feng, Huaqing Xue, Jie Zhu, Likun Yang, Feng Zhang, Rong Qian, Wei Lin, Yuhai Wan. ESE1 is Associated with Neuronal Apoptosis in Lipopolysaccharide Induced Neuroinflammation. Neurochemical research. vol 41. issue 10. 2017-04-04. PMID:27350582. |
in vitro, ese1 depletion in cortical primary neurons inhibited active caspase-3 and bax expression as well as lactate dehydrogenase (ldh) release with up-regulation of bcl-2, while ese1 overexpression can exert opposite effects, indicating that ese1 promoted neuronal apoptosis induced by lps or lps exposed microglia conditioned media (cm). |
2017-04-04 |
2023-08-13 |
Not clear |
| Xia Liu, Yuwei Huang, Yuanyuan Zhang, Xiaohong Li, Chun Liu, Shen Huang, Dezhi Xu, Yang Wu, Xiaojuan Li. T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation. Cellular and molecular neurobiology. vol 36. issue 6. 2017-03-22. PMID:27090258. |
in addition, co-localization of tcf4 with active caspase-3 or proliferating cell nuclear antigen was observed in neurons and microglia, respectively, suggesting that tcf4 might participate in neuronal apoptosis and microglial proliferation after tbi. |
2017-03-22 |
2023-08-13 |
rat |
| Rong-Xia Xie, Da-Wei Li, Xi-Chang Liu, Ming-Feng Yang, Jie Fang, Bao-Liang Sun, Zong-Yong Zhang, Xiao-Yi Yan. Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats. Neurochemical research. vol 42. issue 2. 2017-03-07. PMID:27868153. |
the results indicate that intraperitoneal administration of carnosine (1000 mg/kg) significantly attenuates brain edema, blood-brain barrier (bbb) disruption, oxidative stress, microglia activation and neuronal apoptosis of perihematoma at 72 h following ich in rats models, as convinced by preventing the disruption of tight junction protein zo-1, occludin and claudin-5, followed by the decrease of ros, mda, 3-nt, 8-ohdg level and the increase of gsh-px and sod activity, then followed by the decline of iba-1, ed-1, active caspase-3 and tunel positive cells and the decrease of il-1β, il-6, tnf-α, active caspase-3 and cytochrome c level. |
2017-03-07 |
2023-08-13 |
rat |
| Yanni Lv, Yisong Qian, Aijun Ou-Yang, Longsheng F. Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26754542. |
the microglia were activated prior to neuronal apoptosis, which were induced by increasing tlr4 expression in the activated microglia. |
2017-02-21 |
2023-08-13 |
Not clear |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
ros-mediated apoptosis of hapi microglia through p53 signaling following pfos exposure. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
the results showed that pfos could significantly reduce the cell viability and mediate cell apoptosis in hapi microglia, which was closely accompanied with ros production and p53 overexpression. |
2017-02-08 |
2023-08-13 |
Not clear |
| Jianbin Ge, Cheng Wang, Xiaoke Nie, Jianbin Yang, Hongjian Lu, Xinjian Song, Kai Su, Ting Li, Jingling Han, Yan Zhang, Jiamin Mao, Yiyang Gu, Jianya Zhao, Shengyang Jiang, Qiyun W. ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure. Environmental toxicology and pharmacology. vol 46. 2017-02-08. PMID:27414741. |
interestingly, nac, a ros inhibitor, inhibited p53 expression, and decreased the apoptosis of hapi microglia. |
2017-02-08 |
2023-08-13 |
Not clear |