| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Zheng, Ruyi He, Peng Wang, Yijie Shi, Liang Zhao, Jia Lian. Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization. Biomaterials science. vol 7. issue 5. 2019-09-09. PMID:30843911. |
after ischemic stroke, inflammation was significantly triggered and microglia were activated to phenotypes (m1) typically releasing pro-inflammatory mediators, thus inducing neuron apoptosis and exacerbating brain injury. |
2019-09-09 |
2023-08-13 |
rat |
| Matteo Dal Ben, Rosario Bongiovanni, Simone Tuniz, Emanuela Fioriti, Claudio Tiribelli, Rita Moretti, Silvia Gazzi. Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra. International journal of molecular sciences. vol 20. issue 9. 2019-08-20. PMID:31064126. |
significant microglia activation, apoptosis, a reduction in dopamine vesicle transporters, and the ubiquitination of misfolded protein clearance pathways were late (96 h, consequential) events. |
2019-08-20 |
2023-08-13 |
human |
| X J Zhang, M M Lv, X Q Zhu, L Y Tian, J J Li, Y P Shao, C J Gao, X D Su. Microglia M1/M2 polarization contributes to electromagnetic pulse-induced brain injury. Journal of biological regulators and homeostatic agents. vol 33. issue 4. 2019-08-15. PMID:31392878. |
in this study, we investigated the effect of emp on neuronal apoptosis and microglia polarization in vivo and in vitro, using an emp of 400 kv/m and 1 hertz for 200 pulses. |
2019-08-15 |
2023-08-13 |
Not clear |
| Xin Ge, Dong-Mei Zhang, Meng-Meng Li, Yi Zhang, Xiang-Yang Zhu, Yong Zhou, Xiao Peng, Ai-Guo She. Microglial LOX-1/MAPKs/NF-κB positive loop promotes the vicious cycle of neuroinflammation and neural injury. International immunopharmacology. vol 70. 2019-08-13. PMID:30807932. |
furthermore, utilizing the conditioned medium of activated microglia (mg-cm), we discovered microglial lox-1 aggravated the neuroinflammation-induced neuronal apoptosis. |
2019-08-13 |
2023-08-13 |
Not clear |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
dna binding protein hmgb1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with osa. |
2019-08-06 |
2023-08-13 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
we aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (hmgb1), after high glucose (hg) and intermittent hypoxia (ih) exposure. |
2019-08-06 |
2023-08-13 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
in vitro, a cellular co-culture experiment showed that hg combined with ih could activate bv2 microglia, leading to the release of neuroinflammatory factors (ros, tnf-α, il-1β) and mediating the apoptosis of ht22 cells via the pi3k/akt/gsk-3β signaling pathway. |
2019-08-06 |
2023-08-13 |
mouse |
| Hui-Xing Wei, Pei-Sen Yao, Ping-Ping Chen, Jian-Hua Guan, Jin-Hong Zhuang, Jia-Bin Zhu, Gang Wu, Jin-Shan Yan. Neuronal EphA4 Regulates OGD/R-Induced Apoptosis by Promoting Alternative Activation of Microglia. Inflammation. vol 42. issue 2. 2019-08-02. PMID:30361852. |
neuronal epha4 regulates ogd/r-induced apoptosis by promoting alternative activation of microglia. |
2019-08-02 |
2023-08-13 |
human |
| Hui-Xing Wei, Pei-Sen Yao, Ping-Ping Chen, Jian-Hua Guan, Jin-Hong Zhuang, Jia-Bin Zhu, Gang Wu, Jin-Shan Yan. Neuronal EphA4 Regulates OGD/R-Induced Apoptosis by Promoting Alternative Activation of Microglia. Inflammation. vol 42. issue 2. 2019-08-02. PMID:30361852. |
we found that epha4 shrna treatment attenuated ogd/r-induced apoptosis and microglia proliferation. |
2019-08-02 |
2023-08-13 |
human |
| Xiao-Hua Sun, Ming-Fen Song, Hai-Dong Song, Yu-Wen Wang, Ming-Jin Luo, Li-Ming Yi. miR‑155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia. Molecular medicine reports. vol 19. issue 4. 2019-08-01. PMID:30720115. |
mir‑155‑treated microglia increased the apoptosis of neuronal hippocampal cells by modulating the expression levels of apoptosis regulator bax, apoptosis regulator bcl‑2, pro‑caspase‑3 and cleaved‑caspase‑3. |
2019-08-01 |
2023-08-13 |
Not clear |
| Huilin Wang, Zheng Li, Jingyan Gao, Qingwu Lia. Circular RNA circPTK2 regulates oxygen-glucose deprivation-activated microglia-induced hippocampal neuronal apoptosis via miR-29b-SOCS-1-JAK2/STAT3-IL-1β signaling. International journal of biological macromolecules. vol 129. 2019-07-12. PMID:30742923. |
oxygen-glucose deprivation (ogd)-activated microglia contribute to neuronal apoptosis via releasing pro-inflammatory cytokines, and some mirnas have been reported to be involved in this process. |
2019-07-12 |
2023-08-13 |
Not clear |
| Yu Zhao, Jinquan Cai, Zichen Liu, Yansheng Li, Chunxiong Zheng, Yadan Zheng, Qun Chen, Hongyun Chen, Feihe Ma, Yingli An, Lehui Xiao, Chuanlu Jiang, Linqi Shi, Chunsheng Kang, Yang Li. Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer's Disease Mice. Nano letters. vol 19. issue 2. 2019-06-24. PMID:30444372. |
with the reduction of the pathological aβ oligomers, the nanocomposites attenuated the aβ-induced neuron damages, regained endocranial microglia's capability to phagocytose aβ, and eventually protected hippocampal neurons against apoptosis. |
2019-06-24 |
2023-08-13 |
mouse |
| Shu-Qi Yao, Wei Yi, Rong Liu, Neng-Gui X. [Development of research on mechanisms of electroacupuncture intervention underlying improvement of cerebral ischemia rats in recent five years]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 5. 2019-06-07. PMID:31155874. |
moreover, ea preconditioning also could suppress the expression of pro-apoptosis genes and proteins to relieve apoptosis, regulate activation of microglia, and down-regulate the expression of blood brain barrier integrity-related matrix metalloprotein 9. |
2019-06-07 |
2023-08-13 |
rat |
| I K Malashenkova, S A Krynskiy, D P Ogurtsov, M V Mamoshina, N V Zakharova, V L Ushakov, B M Velichkovsky, N A Didkovsk. [A role of the immune system in the pathogenesis of schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 12. 2019-05-30. PMID:30698566. |
neuroinflammation as a part of the pathophysiology of schizophrenia is characterized by the higher transcription of cns inflammatory mediators, excessive activation of microglia, inhibition of glutamatergic receptors that leads to the decrease in the number of cortical synapses and neuronal apoptosis. |
2019-05-30 |
2023-08-13 |
Not clear |
| Fan He, Nannan Zhang, Yan Lv, Wenhao Sun, Huisheng Che. Low‑dose lipopolysaccharide inhibits neuronal apoptosis induced by cerebral ischemia/reperfusion injury via the PI3K/Akt/FoxO1 signaling pathway in rats. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30628689. |
following the addition of pi3k signaling pathway inhibitor ly294002 to microglia, lps reduced the levels of activated akt, increased the downstream regulatory gene phosphorylation of foxo1 and reduced microglia apoptosis. |
2019-05-24 |
2023-08-13 |
rat |
| Salome Murinello, Yoshihiko Usui, Susumu Sakimoto, Maki Kitano, Edith Aguilar, H Maura Friedlander, Amelia Schricker, Carli Wittgrove, Yoshihiro Wakabayashi, Michael I Dorrell, Peter D Westenskow, Martin Friedlande. miR-30a-5p inhibition promotes interaction of Fas Glia. vol 67. issue 2. 2019-05-13. PMID:30484883. |
our data suggest that mir-30a-5p inhibition accelerates tissue repair by enhancing fasl-fas crosstalk between microglia and endothelial cells, to promote endothelial cell apoptosis and removal of dead endothelial cells. |
2019-05-13 |
2023-08-13 |
Not clear |
| Zhiguo Li, Xinwei Ha. Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway. Biological chemistry. vol 399. issue 11. 2019-05-08. PMID:30067508. |
the results showed that rsv significantly reduced microglia activation and the release of inflammatory cytokines, resulting in the alleviation of neurological behavior impairment, brain edema and neural apoptosis at 24 h post-sah. |
2019-05-08 |
2023-08-13 |
rat |
| Chunhua Liu, Renfu Wang, Yu Zhan. GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-05-06. PMID:30513217. |
to explore if gins2 is involved in alcohol-induced microglia apoptosis, we examined cell viability in gins2 knockdown cells by tunel staining and caspase activity assays. |
2019-05-06 |
2023-08-13 |
mouse |
| Chenggui Wang, Qingqing Wang, Yiting Lou, Jianxiang Xu, Zhenhua Feng, Yu Chen, Qian Tang, Gang Zheng, Zengjie Zhang, Yaosen Wu, Naifeng Tian, Yifei Zhou, Huazi Xu, Xiaolei Zhan. Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation. Journal of cellular and molecular medicine. vol 22. issue 2. 2019-04-26. PMID:29148269. |
the results showed that sal prevents apoptosis of pc12 cells in coculture with lps-induced m1 bv-2 microglia, also the inflammatory secretion phenotype of m1 bv-2 microglia was suppressed by sal, and further studies demonstrated that autophagic flux regulation through ampk/mtor pathway was involved in sal regulated microglia polarization after sci. |
2019-04-26 |
2023-08-13 |
rat |
| Meng Du, Zheng Sun, Yao Lu, Yu-Zhu Li, Hong-Rui Xu, Chang-Qian Zen. Osthole inhibits proliferation and induces apoptosis in BV-2 microglia cells in kainic acid-induced epilepsy via modulating PI3K/AKt/mTOR signalling way. Pharmaceutical biology. vol 57. issue 1. 2019-04-26. PMID:30922159. |
osthole inhibits proliferation and induces apoptosis in bv-2 microglia cells in kainic acid-induced epilepsy via modulating pi3k/akt/mtor signalling way. |
2019-04-26 |
2023-08-13 |
Not clear |