| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lihong Zhan, Grietje Krabbe, Fei Du, Ian Jones, Meredith C Reichert, Maria Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian West, Li Ga. Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain. PLoS biology. vol 17. issue 2. 2019-11-25. PMID:30735499. |
temporal transcriptome profiling at different repopulation stages revealed that adult newborn microglia gradually regain steady-state maturity from an immature state that is reminiscent of the neonatal stage and follow a series of maturation programs, including nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) activation, interferon immune activation, and apoptosis. |
2019-11-25 |
2023-08-13 |
mouse |
| Kurt A. Jellinger, Christine Stadelman. Problems of cell death in neurodegeneration and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 3. issue 1. 2019-11-20. PMID:12214070. |
apoptosis mainly involves reactive microglia and oligodendroglia, the latter occasionally involved by deposits of insoluble fibrillary proteins, while alternative mechanisms of neuronal death may occur. |
2019-11-20 |
2023-08-12 |
human |
| Clive Bate, Mario Salmona, Alun William. Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285798. |
in primary cortical neurons apoptosis (caspase-3) in response to amyloid-beta1-42 or sprp106 was measured, and in co-cultures the effects of the ginkgolides on the killing of amyloid-beta1-42 or sprp106 damaged neurons by microglia was tested. |
2019-11-20 |
2023-08-12 |
Not clear |
| Hung-Lin Chen, Fang Liao, Teng-Nan Lin, Fu-Tong Li. Galectins and neuroinflammation. Advances in neurobiology. vol 9. 2019-11-20. PMID:25151395. |
galectin-3 promotes microglial cell proliferation and attenuates ischemic damage and neuronal apoptosis after cerebral ischemia. |
2019-11-20 |
2023-08-13 |
Not clear |
| Leonardo Iaccarino, Luca Presotto, Valentino Bettinardi, Luigi Gianolli, Ignazio Roiter, Sabina Capellari, Piero Parchi, Pietro Cortelli, Daniela Peran. An in vivo Annals of clinical and translational neurology. vol 5. issue 1. 2019-11-20. PMID:29376088. |
an in vivo postmortem studies reported significant microglia activation in association with neuronal apoptosis in fatal familial insomnia (ffi), indicating a specific glial response, but negative evidence also exists. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ninh B Doan, Ha S Nguyen, Hisham S Alhajala, Basem Jaber, Mona M Al-Gizawiy, Eun-Young Erin Ahn, Wade M Mueller, Christopher R Chitambar, Shama P Mirza, Kathleen M Schmaind. Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model. Oncotarget. vol 9. issue 34. 2019-11-20. PMID:29805753. |
these genes were enriched in various biological processes such as inflammatory response, cell migration, positive regulation of epithelial to mesenchymal transition, angiogenesis, apoptosis, positive regulation of t-cell migration, positive regulation of macrophage chemotaxis, t-cell antigen processing and presentation, and microglial cell activation involved in immune response genes. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mike Yoshio Hamasaki, Marcel Cerqueira César Machado, Fabiano Pinheiro da Silv. Animal models of neuroinflammation secondary to acute insults originated outside the brain. Journal of neuroscience research. vol 96. issue 3. 2019-11-18. PMID:29044654. |
animal models that promote alterations in blood-brain barrier permeability-the activation of microglia or astrocytes, modifications in neuropeptide expression, oxidative stress, increased apoptosis, release of inflammatory mediators, leukocyte infiltration, and brain edema-are likely to involve neuroinflammation and therefore can serve as useful models for human inflammatory cns injury. |
2019-11-18 |
2023-08-13 |
human |
| Mario G Oyola, Elizabeth A Shupe, Anthony R Soltis, Gauthaman Sukumar, Marcelo Paez-Pereda, Darwin O Larco, Matthew D Wilkerson, Stephen Rothwell, Clifton L Dalgard, T John W. Sleep Deprivation Alters the Pituitary Stress Transcriptome in Male and Female Mice. Frontiers in endocrinology. vol 10. 2019-11-01. PMID:31649619. |
the pituitary transcriptome of restraint+psd animals was enriched for microglia and macrophage proliferation, cellular response to corticosteroids, and apoptosis, among others. |
2019-11-01 |
2023-08-13 |
mouse |
| Kamaldeep S Dhami, Matthew A Churchward, Glen B Baker, Kathryn G Tod. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30613984. |
interestingly, we found that fluoxetine-treated microglial cultures contained fewer numbers of cells compared to other groups and hypothesized that fluoxetine and citalopram attenuated the release of glutamate and d-serine by promoting the apoptosis of microglia. |
2019-10-28 |
2023-08-13 |
Not clear |
| Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 14. issue 1. 2019-10-18. PMID:30645642. |
lrrk2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. |
2019-10-18 |
2023-08-13 |
human |
| Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 14. issue 1. 2019-10-18. PMID:30645642. |
lrrk2 deletion and its pharmacological inhibition attenuated mn-induced apoptosis in macrophages and microglia, along with concomitant decreases in the pro-apoptotic bcl-2-associated x (bax) protein. |
2019-10-18 |
2023-08-13 |
human |
| M J Ruggiero, K E Boschen, T L Roth, A Y Klintsov. Sex Differences in Early Postnatal Microglial Colonization of the Developing Rat Hippocampus Following a Single-Day Alcohol Exposure. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29274031. |
microglia are involved in various homeostatic processes in the brain, including phagocytosis, apoptosis, and synaptic pruning. |
2019-10-02 |
2023-08-13 |
rat |
| Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahaja. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29644532. |
methamphetamine induces apoptosis of microglia via the intrinsic mitochondrial-dependent pathway. |
2019-10-02 |
2023-08-13 |
human |
| Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahaja. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29644532. |
our goals were to understand the impact of meth on microglial mitochondrial respiration and to determine whether meth induces the activation of the mitochondrial-dependent intrinsic apoptosis pathway in microglia. |
2019-10-02 |
2023-08-13 |
human |
| Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahaja. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29644532. |
we assessed the expression of pro- apoptosis genes using qpcr of rna extracted from a human microglial cell line (hthu). |
2019-10-02 |
2023-08-13 |
human |
| Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahaja. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29644532. |
several events, such as oxidative stress, neuro-inflammatory responses, and mitochondrial dysfunction, may converge to mediate meth-induced apoptosis of microglia that may contribute to neurotoxicity of the cns. |
2019-10-02 |
2023-08-13 |
human |
| Clarissa von Haefen, Marco Sifringer, Stefanie Endesfelder, Alexander Kalb, Adrián González-López, Annalena Tegethoff, Nadine Paeschke, Claudia D Spie. Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29790105. |
furthermore, physostigmine reduced activated microglia and apoptosis relevant proteins and elevated the increased expression of tgf-beta1 and mfg-e8 after surgery stress. |
2019-10-02 |
2023-08-13 |
rat |
| Oanh Le, Lina Palacio, Gilbert Bernier, Ines Batinic-Haberle, Gilles Hickson, Christian Beauséjou. INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. Stem cell reports. vol 10. issue 6. 2019-09-30. PMID:29706499. |
increased neurogenesis in the absence of ink4a/arf expression was independent of apoptosis and activation of the microglia. |
2019-09-30 |
2023-08-13 |
mouse |
| Asiyeh Golabchi, Bingchen Wu, Xia Li, Diane L Carlisle, Takashi D Y Kozai, Robert M Friedlander, Xinyan Tracy Cu. Melatonin improves quality and longevity of chronic neural recording. Biomaterials. vol 180. 2019-09-30. PMID:30053658. |
histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around the implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. |
2019-09-30 |
2023-08-13 |
mouse |
| Meili Wu, Lu Xu, Yu Wang, Ning Zhou, Fei Zhen, Ying Zhang, Xuebin Qu, Hongbin Fan, Sihan Liu, Yan Chen, Ruiqin Ya. S100A8/A9 induces microglia activation and promotes the apoptosis of oligodendrocyte precursor cells by activating the NF-κB signaling pathway. Brain research bulletin. vol 143. 2019-09-30. PMID:30266587. |
s100a8/a9 induces microglia activation and promotes the apoptosis of oligodendrocyte precursor cells by activating the nf-κb signaling pathway. |
2019-09-30 |
2023-08-13 |
Not clear |