| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Wang, Shixin Zhao, Junwei Pan, Zhen Wang, Yu Li, Xiaoxiao Xu, Jiahao Yang, Xi Zhang, Yisheng Wang, Ming Li. Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis. Journal of cellular physiology. vol 236. issue 3. 2021-09-14. PMID:32761843. |
the results showed that grb1 alleviated sci through inhibiting neuronal apoptosis and proinflammatory factor expression via increasing mir-130b-5p.grb1 weakened the damage of activated microglia to neurons through upregulating mir-130b-5p. |
2021-09-14 |
2023-08-13 |
rat |
| Line S Reinert, Ahmad S Rashidi, Diana N Tran, Georgios Katzilieris-Petras, Astrid K Hvidt, Mette Gohr, Stefanie Fruhwürth, Chiranjeevi Bodda, Martin K Thomsen, Mikkel H Vendelbo, Ahmad R Khan, Brian Hansen, Petra Bergström, Lotta Agholme, Trine H Mogensen, Maria H Christensen, Jens R Nyengaard, Ganes C Sen, Henrik Zetterberg, Georges Mgm Verjans, Søren R Paluda. Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:32990676. |
based on data from mouse models, human hse cases, and primary cell culture systems, we showed that microglia and other immune cells undergo apoptosis in the hsv-1-infected brain through a mechanism dependent on the cyclic gmp-amp synthase/stimulator of interferon genes (cgas/sting) pathway, but independent of ifn-i. |
2021-09-07 |
2023-08-13 |
mouse |
| Line S Reinert, Ahmad S Rashidi, Diana N Tran, Georgios Katzilieris-Petras, Astrid K Hvidt, Mette Gohr, Stefanie Fruhwürth, Chiranjeevi Bodda, Martin K Thomsen, Mikkel H Vendelbo, Ahmad R Khan, Brian Hansen, Petra Bergström, Lotta Agholme, Trine H Mogensen, Maria H Christensen, Jens R Nyengaard, Ganes C Sen, Henrik Zetterberg, Georges Mgm Verjans, Søren R Paluda. Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:32990676. |
hsv-1 infection of microglia induced cgas-dependent apoptosis at high viral doses, whereas lower viral doses led to ifn-i responses. |
2021-09-07 |
2023-08-13 |
mouse |
| Diego Delgado, Ane Miren Bilbao, Maider Beitia, Ane Garate, Pello Sánchez, Imanol González-Burguera, Amaia Isasti, Maider López De Jesús, Jone Zuazo-Ibarra, Alejandro Montilla, María Domercq, Estibaliz Capetillo-Zarate, Gontzal García Del Caño, Joan Sallés, Carlos Matute, Mikel Sánche. Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33572157. |
although both prps had effects in terms of reducing neural progenitor cell apoptosis, stabilizing neuronal synapses, and decreasing inflammation in the microglia, the effect of the young prp was more pronounced. |
2021-09-06 |
2023-08-13 |
Not clear |
| Hui Pei, Qian Peng, Shewei Guo, Yulei Gu, Tongwen Sun, Dong Xu, Yumin Jiang, Jiafeng Xie, Luanluan Zhang, Zhiqiang Zh. MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA. In vitro cellular & developmental biology. Animal. vol 56. issue 10. 2021-08-27. PMID:33150481. |
flow cytometry was performed to determine the level of apoptosis in the cells transfected with mir-367 and cebpa in erythrocyte lysate-treated microglia. |
2021-08-27 |
2023-08-13 |
Not clear |
| Hui Pei, Qian Peng, Shewei Guo, Yulei Gu, Tongwen Sun, Dong Xu, Yumin Jiang, Jiafeng Xie, Luanluan Zhang, Zhiqiang Zh. MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA. In vitro cellular & developmental biology. Animal. vol 56. issue 10. 2021-08-27. PMID:33150481. |
overexpression of mir-367 could significantly decrease the expressions of mhc-ІІ, il-1β, and bax, reduced apoptosis rate, and increased the expressions of cd206, bal-2, and arg-1 in erythrocyte lysate-treated microglia. |
2021-08-27 |
2023-08-13 |
Not clear |
| Hui Pei, Qian Peng, Shewei Guo, Yulei Gu, Tongwen Sun, Dong Xu, Yumin Jiang, Jiafeng Xie, Luanluan Zhang, Zhiqiang Zh. MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA. In vitro cellular & developmental biology. Animal. vol 56. issue 10. 2021-08-27. PMID:33150481. |
cebpa was proved to be a direct target for mir-367, which could inhibit microglia m2 polarization and increase apoptosis rate. |
2021-08-27 |
2023-08-13 |
Not clear |
| Hui Pei, Qian Peng, Shewei Guo, Yulei Gu, Tongwen Sun, Dong Xu, Yumin Jiang, Jiafeng Xie, Luanluan Zhang, Zhiqiang Zh. MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA. In vitro cellular & developmental biology. Animal. vol 56. issue 10. 2021-08-27. PMID:33150481. |
however, in the presence of both cebpa and mir-367 mimic, the protein and mrna expressions of cebpa were decreased, leading to promoted microglia m2 polarization and a decreased apoptosis rate. |
2021-08-27 |
2023-08-13 |
Not clear |
| Ying-Ying Fang, Jing-Hui Zhan. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. The International journal of neuroscience. vol 131. issue 1. 2021-08-26. PMID:32098538. |
mfg-e8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by stat3 regulating the selective polarization of microglia. |
2021-08-26 |
2023-08-13 |
Not clear |
| Bram Van den Broek, Isabel Pintelon, Ibrahim Hamad, Sofie Kessels, Mansour Haidar, Niels Hellings, Jerome J A Hendriks, Markus Kleinewietfeld, Bert Brône, Vincent Timmerman, Jean-Pierre Timmermans, Veerle Somers, Luc Michiels, Joy Irob. Microglial derived extracellular vesicles activate autophagy and mediate multi-target signaling to maintain cellular homeostasis. Journal of extracellular vesicles. vol 10. issue 1. 2021-08-25. PMID:33708355. |
inflammation and immunity transcriptome gene panel sequencing of both activated and normal microglia stimulated with m-evs showed involvement of several canonical pathways and reduced expression of key genes involved in neuroinflammation, inflammasome and apoptosis signalling pathways compared to control cells. |
2021-08-25 |
2023-08-13 |
mouse |
| Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang, Wen Huan. MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-08-25. PMID:34215174. |
mscs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal mir-26a-5p mediated suppression of cdk6. |
2021-08-25 |
2023-08-13 |
Not clear |
| Laura Fernandez Garcia-Agudo, Agnes A Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jähne, Umer Javed Butt, Katharina Grewe, Martin S Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreic. Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell reports. vol 36. issue 8. 2021-08-25. PMID:34433021. |
surprisingly, epo affects microglia in phases, initially by inducing apoptosis, later by reducing proliferation, and overall dampens microglia activity and metabolism, as verified by selective genetic targeting of either the microglial or pyramidal neuronal epo receptor. |
2021-08-25 |
2023-08-13 |
mouse |
| Yuki Tatara, Ryo Shimada, Kazuhiko Kibayash. Effects of Preexisting Diabetes Mellitus on the Severity of Traumatic Brain Injury. Journal of neurotrauma. vol 38. issue 7. 2021-08-24. PMID:32998635. |
immunohistochemical examinations of brain sections were performed to assess the infiltration of neutrophils, astrocytes, microglia, and macrophages, and to detect apoptosis. |
2021-08-24 |
2023-08-13 |
mouse |
| Xueren Zhong, Yongzheng Bao, Qiang Wu, Xinhua Xi, Wengang Zhu, Sanmei Chen, Junjian Lia. Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p. Open medicine (Warsaw, Poland). vol 16. issue 1. 2021-08-21. PMID:34414282. |
in conclusion, xist silencing promoted microglial cell viability and repressed apoptosis and inflammation by sponging mir-219-5p, thus promoting the recovery of sci. |
2021-08-21 |
2023-08-13 |
mouse |
| Dianquan Zhang, Guoliang Cai, Kai Liu, Zhe Zhuang, Kunping Jia, Siying Pei, Xiuzhen Wang, Hong Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Wenli Song, Guofeng Ca. Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1. Aging. vol 13. issue 3. 2021-08-16. PMID:33461167. |
the results demonstrated that exosomes derived from microglia in m2 phenotype (bv2-exo) were internalized by neurons and attenuated neuronal apoptosis in response to ischemic injury |
2021-08-16 |
2023-08-13 |
mouse |
| Jian Tan, Shuang-Xi Chen, Qing-Yun Lei, Shan-Qing Yi, Na Wu, Yi-Lin Wang, Zi-Jian Xiao, Heng W. Mitochonic acid 5 regulates mitofusin 2 to protect microglia. Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510088. |
microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis. |
2021-08-10 |
2023-08-13 |
mouse |
| Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia T. The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia. Analytical cellular pathology (Amsterdam). vol 2021. 2021-08-03. PMID:34336554. |
the synergistic effect of trpv1 on oxidative stress-induced autophagy and apoptosis in microglia. |
2021-08-03 |
2023-08-13 |
Not clear |
| Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia T. The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia. Analytical cellular pathology (Amsterdam). vol 2021. 2021-08-03. PMID:34336554. |
transient receptor potential vanilloid 1 (trpv1) has been shown to regulate oxidative stress and apoptosis in microglia; however, the detailed mechanisms remain unclear. |
2021-08-03 |
2023-08-13 |
Not clear |
| Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia T. The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia. Analytical cellular pathology (Amsterdam). vol 2021. 2021-08-03. PMID:34336554. |
the results indicated that oxidative stress-induced injury and apoptosis may be impeded by the increasing autophagy, and trpv1 inhibition could suppress the ogd/r-induced autophagy of microglia. |
2021-08-03 |
2023-08-13 |
Not clear |
| Min Cheng, Yue Geng, Yeting Chen, Yongjie Zhang, Runjie Guo, Hong Xu, Jianfeng Liang, Jiajun Xie, Zean Zhang, Xuesong Tia. δ-Opioid receptor activation ameliorates lipopolysaccharide-induced inflammation and apoptosis by inhibiting the MAPK/caspase-3 pathway in BV2 microglial cells. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33206235. |
dor activation by the specific agonist tan-67 significantly enhanced bv2 microglial cell viability and reduced apoptosis, as evidenced by decreased cleaved caspase-3 levels and tdt-mediated autp-x nick end labelling (tunel) staining after lps stimulation. |
2021-07-28 |
2023-08-13 |
mouse |