| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
both pre- and post-treatment with rhdgf ab significantly attenuated proliferation of microglia and astrocyte and inhibited apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |
| Xiaoru Chang, Jiangyan Li, Shuyan Niu, Yuying Xue, Meng Tan. Neurotoxicity of metal-containing nanoparticles and implications in glial cells. Journal of applied toxicology : JAT. vol 41. issue 1. 2021-07-05. PMID:32686875. |
the potential mechanisms are related to inflammation, oxidative stress, dna and/or mitochondrial damage and cell death, all of which are mediated by microglial cell activation, inflammatory factor release, generation of reactive oxygen species, apoptosis and/or autophagy in glial cells. |
2021-07-05 |
2023-08-13 |
Not clear |
| Mohammadmahdi Sabahi, Asef Joshaghanian, Mahsa Dolatshahi, Parnian Jabbari, Farzaneh Rahmani, Nima Rezae. Modification of Glial Cell Activation through Dendritic Cell Vaccination: Promises for Treatment of Neurodegenerative Diseases. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33713321. |
such protein aggregations trigger activation of immune mechanisms in neuronal and glial, mainly m1-type microglia cells, leading to release of pro-inflammatory mediators, and subsequent neuronal dysfunction and apoptosis. |
2021-06-28 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. |
2021-06-28 |
2023-08-13 |
Not clear |
| b' Eduard Parellada, Patricia Gass\\xc3\\xb. Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33958577.' |
this driving hypothesis has relevant therapeutic implications, including the importance of pharmacological interventions during the prodromal phase or the transition to psychosis, targeting apoptosis, microglia cells or the glutamate storm. |
2021-06-28 |
2023-08-13 |
Not clear |
| Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Son. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. Toxicology. vol 457. 2021-06-22. PMID:33961949. |
polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing dna damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia bv2 cells. |
2021-06-22 |
2023-08-13 |
Not clear |
| Xiuqing Zhang, Tiejun Liu, Shijun Xu, Peng Gao, Wei Dong, Weiran Liu, Ming Gao, Lihua Song, Lusha Cui, Xiaoliu Don. A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage. Molecular therapy. Methods & clinical development. vol 21. 2021-06-19. PMID:34141823. |
then, through loss- and gain-of-function assays, usp11 knockdown was revealed to alleviate ich-induced symptoms, corresponding to reduced modified neurological severity scores (mnss) value, brain water content, blood-brain barrier permeability, neuron apoptosis, microglial cell activation, neutrophil infiltration, and inflammatory factor secretion. |
2021-06-19 |
2023-08-13 |
rat |
| Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, Ya-Xin Zhu, Min-Qi Wang, Mei-Liang Guo, Xing-Jie Zan, Ai-Min W. Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury. Colloids and surfaces. B, Biointerfaces. vol 199. 2021-06-17. PMID:33385822. |
baricitinib can effectively inhibit the jak2/stat3 pathway of microglia in vitro; while in vivo experiments show that bari-p hydrogel treatment can inhibit the phosphorylation of jak2, stat3 and suppress the production of inflammatory cytokines, and reduces neuronal apoptosis. |
2021-06-17 |
2023-08-13 |
rat |
| Dae Ki Hong, Yoo Seok Park, Ji Sun Woo, Ju Hee Kim, Jin Ho Beom, Sung Phil Chung, Je Sung You, Sang Won Su. Transient Global Ischemia-Induced Brain Inflammatory Cascades Attenuated by Targeted Temperature Management. International journal of molecular sciences. vol 22. issue 10. 2021-06-10. PMID:34066051. |
we found that ttm at 36 °c and at 33 °c attenuated neuronal cell death and apoptosis, with significant improvements in behavioral function that lasted for up to 72 h. ttm at 33 °c and 36 °c suppressed the propagation of inflammation including the release of high mobility group box 1 from damaged cells, the activation and polarization of the microglia, and the excessive release of activated microglia-induced inflammatory cytokines. |
2021-06-10 |
2023-08-13 |
rat |
| Kenan Yıldızhan, Mustafa Nazıroğl. Glutathione Depletion and Parkinsonian Neurotoxin MPP Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32535761. |
environmental stressors such as oxidative stress (os), calcium ion influx, apoptosis, and inflammation mechanisms are linked to activated microglia in patients with pd. |
2021-06-07 |
2023-08-13 |
mouse |
| Kenan Yıldızhan, Mustafa Nazıroğl. Glutathione Depletion and Parkinsonian Neurotoxin MPP Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32535761. |
however, the cellular and molecular effects of gsh alteration on trpm2 activation, os, apoptosis, and inflammation in the microglia remain elusive. |
2021-06-07 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
we found that this aie-induced decline in hippocampal microglia was mediated by both microglial activation and apoptosis, as (i) 1 day of alcohol exposure induced a distinct activation of hippocampal microglia followed by their apoptosis, and (ii) blocking the initial activation of hippocampal microglia by pretreatment with minocycline suppressed the aie-induced apoptosis and loss of hippocampal microglia as well as the aie-induced depression-like symptoms. |
2021-06-03 |
2023-08-13 |
mouse |
| Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen, Ye Jia. Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury. Cell & bioscience. vol 11. issue 1. 2021-05-30. PMID:34039431. |
semaphorin3a increases m1-like microglia and retinal ganglion cell apoptosis after optic nerve injury. |
2021-05-30 |
2023-08-13 |
Not clear |
| Liu Yun-Jia, Chen Xi, Zhang Jie-Qiong, Zhu Jing-Yi, Lin Sen, Ye Jia. Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury. Cell & bioscience. vol 11. issue 1. 2021-05-30. PMID:34039431. |
in this study, we investigated the contribution of microglial-derived sema3a to progressive rgc apoptosis through regulating paradigm of m1- and m2-like microglia after onc. |
2021-05-30 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
by considering those relationships and microglia related nootrophic factors, such as the brain derived neurotrophic factor (bdnf) in cns, we attempted to assess the relationship between microglia dependent bdnf and its precursor with pain behavior through spinal cell apoptosis as well as the effect of noopept on this relationship. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
thermal hyperalgesia, paw edema, microglial activity, microglia dependent bdnf, pro-bdnf expression, and apoptosis were assessed in different experimental groups by confirmed behavioral and molecular methods on days 0, 7, and 21 of the study. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
our results also indicated that daily administration of noopept (during 21 days of the study) not only caused a significant decrease in hyperalgesia and microglia dependent bdnf expression but also changed the apoptosis process in relation to microglia activity alteration. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
it appears that the administration of noopept can decrease spinal cell apoptosis and hyperalgesia during cfa-induced inflammation due to its direct effects on microglial activity and microglia dependent bdnf and pro-bdnf expression. |
2021-05-27 |
2023-08-13 |
Not clear |
| Zhiqiang Yao, Ningning Liu, Xiaoshan Zhu, Ling Wang, Yali Zhao, Qinqin Liu, Chunfang Gao, Juntang L. Subanesthetic isoflurane abates ROS-activated MAPK/NF-κB signaling to repress ischemia-induced microglia inflammation and brain injury. Aging. vol 12. issue 24. 2021-05-26. PMID:33373319. |
we investigated whether sub-anesthetic (0.7%) iso post-conditioning attenuates the inflammation and apoptosis in oxygen-glucose deprivation (ogd)-insulted co-cultures (microglia and neurons) |
2021-05-26 |
2023-08-13 |
Not clear |
| Yutaka Nakagawa, Shizuo Yamad. A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications. European journal of pharmacology. vol 892. 2021-05-18. PMID:33220280. |
these events could prompt intracellular calcium dyshomeostasis, pathological tdp-43 formation, and reactive microglia with neuroinflammation, which in turn activate the apoptosis signaling pathways within the lmns and umns. |
2021-05-18 |
2023-08-13 |
Not clear |