| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ricardo J Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E Vatner, Stephen F Vatne. Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21148760. |
apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. |
2011-05-26 |
2023-08-12 |
rat |
| Ricardo J Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E Vatner, Stephen F Vatne. Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21148760. |
it is widely held that myocyte apoptosis in left ventricular hypertrophy (lvh) contributes to left ventricle (lv) dysfunction and heart failure. |
2011-05-26 |
2023-08-12 |
rat |
| Ricardo J Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E Vatner, Stephen F Vatne. Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21148760. |
the main goal of this investigation was to determine if there is a statistical relationship among lv hypertrophy, apoptosis and lv function, and importantly whether the apoptosis occurs in myocytes or nonmyocytes in the heart. |
2011-05-26 |
2023-08-12 |
rat |
| Ricardo J Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E Vatner, Stephen F Vatne. Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. American journal of physiology. Heart and circulatory physiology. vol 300. issue 3. 2011-05-26. PMID:21148760. |
the extent of apoptosis was linearly related to the amount of lv hypertrophy, but not to lv function. |
2011-05-26 |
2023-08-12 |
rat |
| Rhian M Touyz, Ana M Brione. Reactive oxygen species and vascular biology: implications in human hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. vol 34. issue 1. 2011-05-25. PMID:20981034. |
oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in hypertension. |
2011-05-25 |
2023-08-12 |
human |
| Daisuke Ikegami, Haruhiko Akiyama, Akira Suzuki, Takashi Nakamura, Toru Nakano, Hideki Yoshikawa, Noriyuki Tsumak. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development (Cambridge, England). vol 138. issue 8. 2011-05-23. PMID:21367821. |
sox9 inactivation in flat chondrocytes caused immediate terminal maturation without hypertrophy and with excessive apoptosis. |
2011-05-23 |
2023-08-12 |
mouse |
| Marvin A Konstam, Daniel G Kramer, Ayan R Patel, Martin S Maron, James E Udelso. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC. Cardiovascular imaging. vol 4. issue 1. 2011-05-02. PMID:21232712. |
the gross pathologic changes of increased lv volume and perturbation in the normal elliptical lv chamber configuration is driven, on a histologic level, by myocyte hypertrophy and apoptosis and by increased interstitial collagen. |
2011-05-02 |
2023-08-12 |
Not clear |
| Ruth Dooley, Brian J Harvey, Warren Thoma. The regulation of cell growth and survival by aldosterone. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196180. |
aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. |
2011-04-21 |
2023-08-12 |
Not clear |
| Mei Hua Gao, Tong Tang, Ngai Chin Lai, Atsushi Miyanohara, Tracy Guo, Rouying Tang, Amy L Firth, Jason X Yuan, H Kirk Hammon. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Molecular pharmacology. vol 79. issue 3. 2011-04-18. PMID:21127130. |
for example, both ac6 and ac6mut reduced phenylephrine-induced cardiac myocyte hypertrophy and apoptosis (p < 0.001), expression of cardiac ankyrin repeat protein (p < 0.01), and phospholamban (p < 0.05). |
2011-04-18 |
2023-08-12 |
rat |
| Kisho Ohtani, Stefanie Dimmele. Control of cardiovascular differentiation by microRNAs. Basic research in cardiology. vol 106. issue 1. 2011-04-18. PMID:21184089. |
in the cardiovascular system, mirs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. |
2011-04-18 |
2023-08-12 |
Not clear |
| Bingfang Zhang, Subat Turdi, Quan Li, Faye L Lopez, Anna R Eason, Piero Anversa, Jun Re. Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3beta, and PTEN. Free radical biology & medicine. vol 49. issue 7. 2011-04-11. PMID:20678571. |
chronic alcohol intake led to cardiac hypertrophy, interstitial fibrosis, reduced mitochondrial number, compromised cardiac contractile function and intracellular ca(2+) handling, decreased sod1 expression, elevated superoxide production, and overt apoptosis, all of which, with the exception of cardiac hypertrophy, were abrogated by the igf-1 transgene. |
2011-04-11 |
2023-08-12 |
mouse |
| G Alkistis Frentzou, Mary E W Collier, Anne-Marie L Seymour, Camille Ettelai. Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Molecular and cellular biochemistry. vol 345. issue 1-2. 2011-03-23. PMID:20730477. |
differential induction of cellular proliferation, hypertrophy and apoptosis in h9c2 cardiomyocytes by exogenous tissue factor. |
2011-03-23 |
2023-08-12 |
rat |
| J David Port, Carmen Sucharo. Role of microRNAs in cardiovascular disease: therapeutic challenges and potentials. Journal of cardiovascular pharmacology. vol 56. issue 5. 2011-03-21. PMID:20729754. |
additionally, cell-based and transgenic mouse studies have demonstrated that individual mirs can affect a number of aspects of cardiac biology including developmental processes, stem cell differentiation, progression of hypertrophy and failure, ion channel function, as well as angiogenesis, rates of apoptosis, and fibroblast proliferation. |
2011-03-21 |
2023-08-12 |
mouse |
| David Semple, Katie Smith, Sunil Bhandari, Anne-Marie L Seymou. Uremic cardiomyopathy and insulin resistance: a critical role for akt? Journal of the American Society of Nephrology : JASN. vol 22. issue 2. 2011-03-17. PMID:20634295. |
imbalance among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. |
2011-03-17 |
2023-08-12 |
Not clear |
| Man-Jiang Xie, Hui Chang, Yun-Ying Wang, Lin Zhang, Zhen Song, Wan-Gang Guo, Tao Wang, Hong-Lei Che, Zhi-Bin Y. Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. Clinical and experimental pharmacology & physiology. vol 37. issue 12. 2011-03-10. PMID:20880184. |
cardiomyocyte apoptosis plays an important role in the transition from cardiac hypertrophy to heart failure. |
2011-03-10 |
2023-08-12 |
rat |
| Man-Jiang Xie, Hui Chang, Yun-Ying Wang, Lin Zhang, Zhen Song, Wan-Gang Guo, Tao Wang, Hong-Lei Che, Zhi-Bin Y. Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. Clinical and experimental pharmacology & physiology. vol 37. issue 12. 2011-03-10. PMID:20880184. |
et-1 plus angii had a threefold and significant increase in apoptosis in the hypertrophic cultures compared with angii alone. |
2011-03-10 |
2023-08-12 |
rat |
| André S D Molgat, AnneMarie Gagnon, Alexander Sorisk. Macrophage-induced preadipocyte survival depends on signaling through Akt, ERK1/2, and reactive oxygen species. Experimental cell research. vol 317. issue 4. 2011-03-08. PMID:21056559. |
obesity is associated with adipose tissue remodeling, characterized by macrophage accumulation, adipocyte hypertrophy, and apoptosis. |
2011-03-08 |
2023-08-12 |
Not clear |
| Yamuna Devi Paila, Ekta Jindal, Shyamal K Goswami, Amitabha Chattopadhya. Cholesterol depletion enhances adrenergic signaling in cardiac myocytes. Biochimica et biophysica acta. vol 1808. issue 1. 2011-03-07. PMID:20851100. |
depending upon the dose of norepinephrine (agonist) exposure, hypertrophy and apoptosis are initiated by differential induction of two discrete constituents of the transcription factor ap-1, i.e., fosb and fra-1. |
2011-03-07 |
2023-08-12 |
Not clear |
| Yamuna Devi Paila, Ekta Jindal, Shyamal K Goswami, Amitabha Chattopadhya. Cholesterol depletion enhances adrenergic signaling in cardiac myocytes. Biochimica et biophysica acta. vol 1808. issue 1. 2011-03-07. PMID:20851100. |
we explored differential adrenergic signaling as a paradigm for understanding how cholesterol dictates cells to choose hypertrophy or apoptosis. |
2011-03-07 |
2023-08-12 |
Not clear |
| Atsushi Sugita, Shinji Kawai, Tetsuyuki Hayashibara, Atsuo Amano, Takashi Ooshima, Toshimi Michigami, Hideki Yoshikawa, Toshiyuki Yoned. Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis. The Journal of biological chemistry. vol 286. issue 4. 2011-03-04. PMID:21075853. |
hyp mice showed reduced apoptosis and mineralization in hypertrophic cartilage. |
2011-03-04 |
2023-08-12 |
mouse |