| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Trevor L Cameron, Katrina M Bell, Liliana Tatarczuch, Eleanor J Mackie, M Helen Rajpar, Ben T McDermott, Raymond P Boot-Handford, John F Batema. Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy. PloS one. vol 6. issue 9. 2012-02-28. PMID:21935428. |
despite upregulation of the chop/cebpb pathway, apoptosis was not increased in mutant hypertrophic zones. |
2012-02-28 |
2023-08-12 |
Not clear |
| Makhosazane Zungu, Jonathan Schisler, Monte S Willi. All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-. Circulation journal : official journal of the Japanese Circulation Society. vol 75. issue 11. 2012-02-14. PMID:22001293. |
disruption of these protein quality control mechanisms has recently been identified in multiple cardiac diseases, including cardiac hypertrophy, heart failure, dilated cardiomyopathy, and ischemic heart disease, and is intimately tied to mitochondrial control of apoptosis. |
2012-02-14 |
2023-08-12 |
Not clear |
| Piet Finckenberg, Ove Eriksson, Marc Baumann, Saara Merasto, Maciej M Lalowski, Jouko Levijoki, Kristiina Haasio, Ville Kytö, Dominik N Muller, Friedrich C Luft, Matej Oresic, Eero Mervaal. Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 59. issue 1. 2012-02-07. PMID:22068868. |
cr ameliorated angiotensin ii-induced cardiomyocyte hypertrophy, vascular inflammation, cardiac damage and fibrosis, cardiomyocyte apoptosis, and cardiac atrial natriuretic peptide mrna overexpression. |
2012-02-07 |
2023-08-12 |
human |
| Bryan G Schwartz, Laurence A Levine, Gary Comstock, Vera J Stecher, Robert A Klone. Cardiac uses of phosphodiesterase-5 inhibitors. Journal of the American College of Cardiology. vol 59. issue 1. 2012-02-07. PMID:22192662. |
in animal models of acute myocardial infarction, pde5is consistently reduced infarct size indicating cardioprotection and pde5is also promote reverse remodeling and reduce myocardial apoptosis, fibrosis, and hypertrophy. |
2012-02-07 |
2023-08-12 |
Not clear |
| Fei Gao, Zhi-Qi Han, Xin Zhou, Rui Shi, Yan Dong, Tie-Min Jiang, Yu-Ming L. High salt intake accelerated cardiac remodeling in spontaneously hypertensive rats: time window of left ventricular functional transition and its relation to salt-loading doses. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 33. issue 7. 2012-01-26. PMID:21529316. |
lv invasive hemodynamics and morphologic staining [collagen deposition, cardiomyocte hypertrophy, dna damage (8-hydroxy-2-deoxyguanosine, 8-ohdg) and apoptosis] were performed at time of sacrifice. |
2012-01-26 |
2023-08-12 |
rat |
| Fei Gao, Zhi-Qi Han, Xin Zhou, Rui Shi, Yan Dong, Tie-Min Jiang, Yu-Ming L. High salt intake accelerated cardiac remodeling in spontaneously hypertensive rats: time window of left ventricular functional transition and its relation to salt-loading doses. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 33. issue 7. 2012-01-26. PMID:21529316. |
furthermore, when compared to 4% salt shr, lv functions were significantly compromised in 8% salt shr, accompanied by more prominent cardiomyoctye hypertrophy, oxidative stress (and related dna damage), and apoptosis. |
2012-01-26 |
2023-08-12 |
rat |
| Chris McDermott-Roe, Junmei Ye, Rizwan Ahmed, Xi-Ming Sun, Anna Serafín, James Ware, Leonardo Bottolo, Phil Muckett, Xavier Cañas, Jisheng Zhang, Glenn C Rowe, Rachel Buchan, Han Lu, Adam Braithwaite, Massimiliano Mancini, David Hauton, Ramon Martí, Elena García-Arumí, Norbert Hubner, Howard Jacob, Tadao Serikawa, Vaclav Zidek, Frantisek Papousek, Frantisek Kolar, Maria Cardona, Marisol Ruiz-Meana, David García-Dorado, Joan X Comella, Leanne E Felkin, Paul J R Barton, Zoltan Arany, Michal Pravenec, Enrico Petretto, Daniel Sanchis, Stuart A Coo. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature. vol 478. issue 7367. 2012-01-25. PMID:21979051. |
here we identified endonuclease g (endog), which previously was implicated in apoptosis but not hypertrophy, as the gene at the locus, and we found a loss-of-function mutation in endog that is associated with increased lvm and impaired cardiac function. |
2012-01-25 |
2023-08-12 |
mouse |
| Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushim. Oxidative stress and heart failure. American journal of physiology. Heart and circulatory physiology. vol 301. issue 6. 2012-01-23. PMID:21949114. |
moreover, ros activate a broad variety of hypertrophy signaling kinases and transcription factors and mediate apoptosis. |
2012-01-23 |
2023-08-12 |
Not clear |
| Ekta Jindal, Shyamal K Goswam. In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules. Free radical biology & medicine. vol 51. issue 8. 2012-01-12. PMID:21820506. |
depending on the dose, norepineprine (ne) can induce hypertrophy or apoptosis in cardiac myocytes. |
2012-01-12 |
2023-08-12 |
Not clear |
| Rajamma Mathe. Pulmonary hypertension: current therapy and future prospects. Cardiovascular & hematological agents in medicinal chemistry. vol 9. issue 3. 2012-01-03. PMID:21838666. |
the main effects are loss of vascular relaxation response, increased cell proliferation and impaired apoptosis, matrix deposition, obstruction in the small pulmonary arteries, right ventricular hypertrophy; and eventually leading to right heart failure and death. |
2012-01-03 |
2023-08-12 |
Not clear |
| Yunzeng Zou, Yanyan Liang, Hui Gong, Ning Zhou, Hong Ma, Aili Guan, Aijun Sun, Ping Wang, Yuhong Niu, Hong Jiang, Hiroyuki Takano, Haruhiro Toko, Atsushi Yao, Hiroshi Takeshima, Hiroshi Akazawa, Ichiro Shiojima, Yuqi Wang, Issei Komuro, Junbo G. Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 58. issue 6. 2012-01-03. PMID:21986507. |
during a 3-week period of pressure overload, which was induced by constriction of transverse aorta, isolated ryr-2(+/-) cardiomyocytes displayed more reduction of ca(2+) transient amplitude, rate of an increase in intracellular ca(2+) concentration during systole, and percentile of fractional shortening, and hearts of ryr-2(+/-) mice displayed less compensated hypertrophy, fibrosis, and contractility; more apoptosis with less autophagy of cardiomyocytes; and similar decrease of angiogenesis as compared with wild-type ones. |
2012-01-03 |
2023-08-12 |
mouse |
| Theodora Papamitsou, Dimitris Barlagiannis, Vasileios Papaliagkas, Eleni Kotanidou, Maria Dermentzopoulou-Theodorido. Testosterone-induced hypertrophy, fibrosis and apoptosis of cardiac cells--an ultrastructural and immunohistochemical study. Medical science monitor : international medical journal of experimental and clinical research. vol 17. issue 9. 2011-12-27. PMID:21873939. |
testosterone-induced hypertrophy, fibrosis and apoptosis of cardiac cells--an ultrastructural and immunohistochemical study. |
2011-12-27 |
2023-08-12 |
Not clear |
| Timoklia Orfanidou, Dimitrios Iliopoulos, Konstantinos N Malizos, Aspasia Tsezo. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196777. |
chondrocytes' hypertrophy includes metabolic changes, matrix remodelling, proliferation and apoptosis, characteristics associated with the progression of osteoarthritis. |
2011-12-23 |
2023-08-12 |
human |
| Dario Diviani, Kimberly L Dodge-Kafka, Jinliang Li, Michael S Kapilof. A-kinase anchoring proteins: scaffolding proteins in the heart. American journal of physiology. Heart and circulatory physiology. vol 301. issue 5. 2011-12-23. PMID:21856912. |
under conditions of prolonged catecholaminergic stimulation, camp also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. |
2011-12-23 |
2023-08-12 |
Not clear |
| Mohamed Ameen Ismahil, Tariq Hamid, Petra Haberzettl, Yan Gu, Bysani Chandrasekar, Sanjay Srivastava, Aruni Bhatnagar, Sumanth D Prabh. Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 301. issue 5. 2011-12-23. PMID:21908791. |
acrolein also induced myocyte hypertrophy (~2.2-fold increased myocyte area, p < 0.05), increased apoptosis (~7.5-fold), and disrupted endothelial nitric oxide synthase in the heart. |
2011-12-23 |
2023-08-12 |
mouse |
| Evgeny V Mymrikov, Alim S Seit-Nebi, Nikolai B Guse. Large potentials of small heat shock proteins. Physiological reviews. vol 91. issue 4. 2011-12-13. PMID:22013208. |
hspb8 also seems to be directly or indirectly involved in regulation of apoptosis and carcinogenesis, contributes to cardiac cell hypertrophy and survival and, when mutated, might be involved in development of neurodegenerative diseases. |
2011-12-13 |
2023-08-12 |
human |
| Chun-Hsien Chu, Jeng-Fan Lo, Wei-Syun Hu, Ru-Band Lu, Mu-Hsin Chang, Fuu-Jen Tsai, Chang-Hai Tsai, Yueh-Shan Weng, Bor-Show Tzang, Chih-Yang Huan. Histone acetylation is essential for ANG-II-induced IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart. Journal of cellular physiology. vol 227. issue 1. 2011-12-08. PMID:21412773. |
the igf-ii/mannose 6-phosphate receptor (igf-iir/man-6-p) up-regulation correlates with heart disease progression and its signaling cascades directly trigger pathological cardiac hypertrophy, fibrosis, and cardiomyocytes apoptosis. |
2011-12-08 |
2023-08-12 |
rat |
| O Lorenzo, B Picatoste, S Ares-Carrasco, E Ramírez, J Egido, J Tuñó. Potential role of nuclear factor κB in diabetic cardiomyopathy. Mediators of inflammation. vol 2011. 2011-12-06. PMID:21772665. |
in this paper, we review the nuclear factor-kappa b pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis. |
2011-12-06 |
2023-08-12 |
Not clear |
| Fay Lin Khong, Yuan Zhang, Amanda J Edgley, Weier Qi, Kim A Connelly, Owen L Woodman, Henry Krum, Darren J Kell. 3',4'-Dihydroxyflavonol antioxidant attenuates diastolic dysfunction and cardiac remodeling in streptozotocin-induced diabetic m(Ren2)27 rats. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829510. |
both increased reactive oxygen species (ros) generation and impaired ros scavenging have been implicated in the pathogenesis of hyperglycemia-induced left ventricular dysfunction, cardiac fibrosis, apoptosis and hypertrophy. |
2011-12-06 |
2023-08-12 |
rat |
| Thomais Markou, Eleftheria Barlaka, Monica Bartucci, Antigone Lazo. Signal transduction pathways through cytoprotective, apoptotic and hypertrophic stimuli: a comparative study in adult cardiac myocytes. Cell biochemistry and function. vol 29. issue 6. 2011-12-01. PMID:21751224. |
in response to pathophysiological stresses, cardiac myocytes undergo hypertrophic growth or apoptosis. |
2011-12-01 |
2023-08-12 |
rat |