| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisato Nako, Keiichiro Kataoka, Nobutaka Koibuchi, Yi-Fei Dong, Kensuke Toyama, Eiichiro Yamamoto, Osamu Yasuda, Hidenori Ichijo, Hisao Ogawa, Shokei Kim-Mitsuyam. Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF. Hypertension research : official journal of the Japanese Society of Hypertension. vol 35. issue 2. 2012-05-25. PMID:22089532. |
moreover, ds rats with significant cardiac hypertrophy and fibrosis displayed decreased myocardial vascular endothelial growth factor (vegf) expression and increased cardiac apoptosis signal-regulating kinase 1 (ask1) activation. |
2012-05-25 |
2023-08-12 |
mouse |
| Hong Wei, Djahida Bedja, Norimichi Koitabashi, Dongmei Xing, Jasper Chen, Karen Fox-Talbot, Rosanne Rouf, Shaoping Chen, Charles Steenbergen, John W Harmon, Harry C Dietz, Kathleen L Gabrielson, David A Kass, Gregg L Semenz. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 14. 2012-05-21. PMID:22403061. |
here we report that hif1a(f/f);tie2-cre conditional knockout mice, which lack hif-1α expression only in tie2(+) lineage cells, develop normally, but when subjected to pressure overload induced by transaortic constriction (tac), they manifest rapid cardiac decompensation, which is accompanied by excess cardiac fibrosis and myocardial hypertrophy, decreased myocardial capillary density, increased myocardial hypoxia and apoptosis, and increased tgf-β signaling through both canonical and noncanonical pathways that activate smad2/3 and erk1/2, respectively, within endothelial cells of cardiac blood vessels. |
2012-05-21 |
2023-08-12 |
mouse |
| Helen V Edwards, John D Scott, George S Bailli. PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochemical Society transactions. vol 40. issue 1. 2012-05-18. PMID:22260692. |
the small heat-shock protein hsp20 (heat-shock protein 20), also known as hspb6, has been shown to protect against a number of pathophysiological cardiac processes, including hypertrophy and apoptosis. |
2012-05-18 |
2023-08-12 |
mouse |
| You-fu Xie, Jun-cheng Zhang, Si-jun Liu, Li-bing Dai, Gao-wei D. [Effect of melatonin on proliferation and apoptosis of fibroblasts in human hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 27. issue 6. 2012-05-17. PMID:22340787. |
[effect of melatonin on proliferation and apoptosis of fibroblasts in human hypertrophic scar]. |
2012-05-17 |
2023-08-12 |
human |
| You-fu Xie, Jun-cheng Zhang, Si-jun Liu, Li-bing Dai, Gao-wei D. [Effect of melatonin on proliferation and apoptosis of fibroblasts in human hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 27. issue 6. 2012-05-17. PMID:22340787. |
to study the effect of melatonin on proliferation and apoptosis of fibroblasts in human hypertrophic scar and its mechanism. |
2012-05-17 |
2023-08-12 |
human |
| Dutmanee Seriwatanachai, Nateetip Krishnamra, Narattaphol Charoenphandh. Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22405773. |
a recent investigation in lactating rats has provided evidence that the lactogenic hormone prolactin (prl) increases endochondral bone growth and bone elongation, presumably by accelerating apoptosis of hypertrophic chondrocytes in the growth plate and/or subsequent chondrogenic matrix mineralization. |
2012-05-16 |
2023-08-12 |
mouse |
| Dutmanee Seriwatanachai, Nateetip Krishnamra, Narattaphol Charoenphandh. Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22405773. |
it could be concluded that chondrocytes directly but differentially responded to non-pregnant and pregnant/lactating levels of prl, thus suggesting the stimulatory effect of prl on chondrogenesis in young growing individuals, and supporting the hypothesis of hypertrophic chondrocyte apoptosis in the growth plate of lactating rats. |
2012-05-16 |
2023-08-12 |
mouse |
| S Van Linthout, F Spillmann, H-P Schultheiss, C Tschöp. Effects of mesenchymal stromal cells on diabetic cardiomyopathy. Current pharmaceutical design. vol 17. issue 30. 2012-05-14. PMID:21919875. |
hallmarks of diabetic cardiomyopathy are besides others, interstitial inflammation, cardiac oxidative stress, interstitial and perivascular fibrosis, cardiac apoptosis, intramyocardial microangiopathy, endothelial dysfunction, abnormal intracellular ca²⁺-handling, cardiomyocyte hypertrophy, and impaired cardiac stem cells. |
2012-05-14 |
2023-08-12 |
Not clear |
| Yongnan Fu, Han Xiao, Youyi Zhan. Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22201979. |
meanwhile, chronic catecholamine stimulation of adrenoceptors has been proved to be involved in the adverse myocardial remodeling, including cardiac hypertrophy, fibrosis, and apoptosis, which finally develop into heart failure. |
2012-05-14 |
2023-08-12 |
Not clear |
| Francisco J López-Hernández, Jose M López-Novo. Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects. Cell and tissue research. vol 347. issue 1. 2012-05-07. PMID:22105921. |
tgf-β induces (1) podocytopenia caused by podocyte apoptosis and detachment from the glomerular basement membrane; (2) mesangial expansion caused by mesangial cell hypertrophy, proliferation (and eventually apoptosis) and ecm synthesis; (3) endothelial to mesenchymal transition giving rise to glomerular myofibroblasts, a major source of ecm. |
2012-05-07 |
2023-08-12 |
Not clear |
| Yingmei Zhang, Ming Yuan, Katherine M Bradley, Feng Dong, Piero Anversa, Jun Re. Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension (Dallas, Tex. : 1979). vol 59. issue 3. 2012-04-17. PMID:22275536. |
intriguingly, igf-1 mitigated high-fat-diet feeding-induced alterations in reactive oxygen species, protein and mitochondrial damage, atp content, apoptosis, myocardial contraction, intracellular ca(2+) handling, and insulin signaling but not whole body glucose intolerance and cardiac hypertrophy. |
2012-04-17 |
2023-08-12 |
mouse |
| Carlos E de Andrea, Malgorzata I Wiweger, Judith V M G Bovée, Salvatore Romeo, Pancras C W Hogendoor. Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Archiv : an international journal of pathology. vol 460. issue 1. 2012-04-12. PMID:22116208. |
endochondral chondrocytes undergo sequences of cell division, matrix secretion, cell hypertrophy, apoptosis, and matrix calcification/mineralisation. |
2012-04-12 |
2023-08-12 |
Not clear |
| Jinfeng Xiao, Mark Moon, Ling Yan, Min Nian, Yan Zhang, Chen Liu, Jing Lu, Hongjing Guan, Manyin Chen, Dingsheng Jiang, Hong Jiang, Peter P Liu, Hongliang L. Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction. Basic research in cardiology. vol 107. issue 1. 2012-04-09. PMID:22202974. |
impaired lv function in the het mice was associated with increases in infarct size, hypertrophy, apoptosis, inflammation, and interstitial fibrosis, and reduced capillary density. |
2012-04-09 |
2023-08-12 |
mouse |
| Yewen Wu, Xing Yin, Cori Wijaya, Ming-He Huang, Bradley K McConnel. Acute myocardial infarction in rats. Journal of visualized experiments : JoVE. issue 48. 2012-04-02. PMID:21372786. |
myocyte apoptosis, necrosis and the resultant increased hemodynamic load activate multiple biochemical intracellular signaling that initiates lv dilatation, hypertrophy, ventricular shape distortion, and collagen scar formation. |
2012-04-02 |
2023-08-12 |
human |
| Hui Yang, Xiang-Jun Zeng, Hong-Xia Wang, Li-Ke Zhang, Xiao-Li Dong, Shubin Guo, Jie Du, Hui-Hua Li, Chao-Shu Tan. Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor. Peptides. vol 32. issue 10. 2012-03-29. PMID:21963909. |
moreover, ang iv inhibited ang ii-induced cardiac cell apoptosis, cardiomyocyte hypertrophy, and proliferation and collagen synthesis of cardiac fibroblasts; these effects were mediated through the at4 receptor as confirmed by sirna knockdown. |
2012-03-29 |
2023-08-12 |
rat |
| Shiao-Ying Chang, Yun-Wen Chen, Isabelle Chenier, Stella Le Minh Tran, Shao-Ling Zhan. Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type I diabetes via oxidative stress and ACE2. Experimental diabetes research. vol 2011. 2012-03-15. PMID:22110472. |
after 4 weeks of diabetes, compared to wt controls, at(2)rko mice clearly developed features of early diabetic nephropathy (dn), such as renal hypertrophy, tubular apoptosis, and progressive extracellular matrix (ecm) protein accumulation as well as increased gfr. |
2012-03-15 |
2023-08-12 |
mouse |
| M Zulf Mugha. Rickets. Current osteoporosis reports. vol 9. issue 4. 2012-03-08. PMID:21968816. |
rickets is disorder of a growing child arising from disorders that result in impaired apoptosis of hypertrophic cells and mineralization of the growth plate. |
2012-03-08 |
2023-08-12 |
Not clear |
| James N Tsoporis, Forough Mohammadzadeh, Thomas G Parke. S100B: a multifunctional role in cardiovascular pathophysiology. Amino acids. vol 41. issue 4. 2012-03-01. PMID:20204434. |
forced expression of s100b in neonatal rat myocyte cultures, and high level expression of s100b in transgenic mice hearts and aortic smooth muscle cells inhibit cardiac hypertrophy and the associated phenotype, arterial smooth muscle proliferation, respectively, but demonstrate increased apoptosis following α(1)-adrenergic stimulation or myocardial infarction. |
2012-03-01 |
2023-08-12 |
mouse |
| James N Tsoporis, Forough Mohammadzadeh, Thomas G Parke. S100B: a multifunctional role in cardiovascular pathophysiology. Amino acids. vol 41. issue 4. 2012-03-01. PMID:20204434. |
knocking out s100b, augmented hypertrophy, decreased apoptosis and preserved cardiac function following myocardial infarction. |
2012-03-01 |
2023-08-12 |
mouse |
| A Cataldi, S Zara, M Rapino, M Zingariello, V di Giacomo, A Antonucc. p53 and telomerase control rat myocardial tissue response to hypoxia and ageing. European journal of histochemistry : EJH. vol 53. issue 4. 2012-02-29. PMID:22073357. |
also hypoxia, producing reactive oxygen species (ros), can damage cellular components through the oxidation of dna, proteins and lipids, thus influencing the shortening of telomeres.since ribonucleoprotein telomerase (tert), catalyzing the replication of the ends of eukaryotic chromosomes, promotes cardiac muscle cell proliferation, hypertrophy and survival, here we investigated its role in the events regulating apoptosis occurrence and life span in hearts deriving from young and old rats exposed to hypoxia.tunel (terminal-deoxinucleotidyl -transferase- mediated dutp nick end-labeling) analysis reveals an increased apoptotic cell number in both samples after hypoxia exposure, mainly in the young with respect to the old. |
2012-02-29 |
2023-08-12 |
human |