| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingmei Zhang, Linlin Li, Yinan Hua, Jennifer M Nunn, Feng Dong, Masashi Yanagisawa, Jun Re. Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. Journal of molecular cell biology. vol 4. issue 2. 2012-08-17. PMID:22442497. |
cold stress triggered cardiac hypertrophy, depressed myocardial contractile capacity, including fractional shortening, peak shortening, and maximal velocity of shortening/relengthening, reduced intracellular ca(2+) release, prolonged intracellular ca(2+) decay and relengthening duration, generation of ros and superoxide, as well as apoptosis, the effects of which were blunted by etako. |
2012-08-17 |
2023-08-12 |
mouse |
| Thor Ueland, Arne Yndestad, Christen P Dahl, Lars Gullestad, Pål Aukrus. TNF revisited: osteoprotegerin and TNF-related molecules in heart failure. Current heart failure reports. vol 9. issue 2. 2012-08-14. PMID:22453763. |
by activating the nuclear factor-κb (nf-κb) and death-related pathways, tnf ligands can induce a variety of effects within the myocardium, including apoptosis, hypertrophy, inflammation, and extracellular matrix remodeling. |
2012-08-14 |
2023-08-12 |
Not clear |
| Man-jiang Xie, Zhi-bin Y. [Independent or combined effects of endothelin-1 and prostaglandin F2alpha on cardiomyocytes]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 21. issue 2. 2012-08-09. PMID:21171338. |
to elucidate the independent or combined effects of endothelin-1 (et-1) and prostaglandin f2alpha (pgf2alpha) on cardiomyocytes and investigate the relationship between hypertrophy and apoptosis of cardiomyocytes. |
2012-08-09 |
2023-08-12 |
Not clear |
| Madhu V Singh, Paari D Swaminathan, Elizabeth D Luczak, W Kutschke, Robert M Weiss, Mark E Anderso. MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. Journal of molecular and cellular cardiology. vol 52. issue 5. 2012-08-07. PMID:22326848. |
post-mi cardiac hypertrophy, inflammation, apoptosis, ox-camkii expression and mortality were significantly reduced in myd88(-/-) compared to wt littermates. |
2012-08-07 |
2023-08-12 |
Not clear |
| Chan Chen, Chun Chen, Zhiyi Wang, Liangxing Wang, Lehe Yang, Minjiao Ding, Cheng Ding, Yu Sun, Quan Lin, Xiaoying Huang, Xiaohong Du, Xiaowei Zhao, Chuangyi Wan. Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. PloS one. vol 7. issue 3. 2012-08-03. PMID:22457823. |
pulmonary vascular medial hypertrophy in hypoxic pulmonary arterial hypertension (pah) is caused in part by decreased apoptosis in pulmonary artery smooth muscle cells (pasmcs). |
2012-08-03 |
2023-08-12 |
human |
| Jisun Kim, Wonbong Lim, Youngjong Ko, Hyukil Kwon, Sangwoo Kim, Oksu Kim, Gyeongju Park, Hongran Choi, Okjoon Ki. The effects of cadmium on VEGF-mediated angiogenesis in HUVECs. Journal of applied toxicology : JAT. vol 32. issue 5. 2012-07-23. PMID:21425301. |
the effects of cadmium are a multisystem phenomenon involving inflammation, hypertrophy, apoptosis, angiogenesis and important processes involved in vascular remodeling systems. |
2012-07-23 |
2023-08-12 |
Not clear |
| Augusto C Montezano, Rhian M Touy. Molecular mechanisms of hypertension--reactive oxygen species and antioxidants: a basic science update for the clinician. The Canadian journal of cardiology. vol 28. issue 3. 2012-07-20. PMID:22445098. |
in the cardiovascular system ros play a physiological role in controlling endothelial function, vascular tone, and cardiac function, and a pathophysiological role in inflammation, hypertrophy, proliferation, apoptosis, migration, fibrosis, angiogenesis, and rarefaction, all of which are important processes contributing to endothelial dysfunction and cardiovascular remodelling in hypertension. |
2012-07-20 |
2023-08-12 |
Not clear |
| E Mandache, M Penesc. Nanostructural features of diabetic podocytopathy. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 53. issue 1. 2012-07-16. PMID:22395495. |
thus, the diabetic podocytopathy includes cellular hypertrophy, foot process effacement, detachment from glomerular basement membrane (gbm), and apoptosis. |
2012-07-16 |
2023-08-12 |
Not clear |
| Hanna E Abbou. Mesangial cell biology. Experimental cell research. vol 318. issue 9. 2012-07-13. PMID:22414873. |
in response to metabolic, immunologic or hemodynamic injury, these cells undergo apoptosis or acquire an activated phenotype and undergo hypertrophy, proliferation with excessive production of matrix proteins, growth factors, chemokines and cytokines. |
2012-07-13 |
2023-08-12 |
Not clear |
| John M Canty, Gen Suzuk. Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. Journal of molecular and cellular cardiology. vol 52. issue 4. 2012-07-12. PMID:21889943. |
the resulting "hibernating myocardium" develops regional myocyte cellular hypertrophy as a compensatory response to ischemia-induced apoptosis along with a series of molecular adaptations that while regional, are similar to global changes found in advanced heart failure. |
2012-07-12 |
2023-08-12 |
Not clear |
| Takeshi Minashima, William Small, Stephen E Moss, Thorsten Kirsc. Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22399299. |
in addition, reduced mineralization was evident in the hypertrophic zone of anxa6-/- growth plate cartilage, although apoptosis was not altered compared with wild type growth plates. |
2012-07-02 |
2023-08-12 |
mouse |
| Stav Simsa-Maziel, Efrat Monsonego-Orna. Interleukin-1β promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21. Endocrinology. vol 153. issue 5. 2012-06-29. PMID:22492305. |
here we show that il-1β affects bone growth by directly disturbing the normal sequence of events in the growth plate, resulting in increased proliferation and widening of the proliferative zone, whereas the hypertrophic zone becomes disorganized, with impaired matrix structure and increased apoptosis and osteoclast activity. |
2012-06-29 |
2023-08-12 |
Not clear |
| M Jane Black, Andrew L Siebel, Oksan Gezmish, Karen M Moritz, Mary E Wlode. Normal lactational environment restores cardiomyocyte number after uteroplacental insufficiency: implications for the preterm neonate. American journal of physiology. Regulatory, integrative and comparative physiology. vol 302. issue 9. 2012-06-25. PMID:22403799. |
in male offspring, genes involved in cardiomyocyte differentiation, proliferation, hypertrophy and apoptosis were examined at gestational day 20 and postnatal days 1 and 7 to assess effects on cardiomyocyte growth. |
2012-06-25 |
2023-08-12 |
rat |
| Chunfa Huang, Leslie A Bruggeman, Lindsey M Hydo, R Tyler Mille. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. Experimental cell research. vol 318. issue 10. 2012-06-25. PMID:22472346. |
phosphatidic acid, produced by shear stress-induced pld activation, stimulated mtor signaling, and caused podocyte hypertrophy and apoptosis. |
2012-06-25 |
2023-08-12 |
Not clear |
| Karim C El Kasmi, Aimee L Anderson, Michael W Devereaux, Sophie A Fillon, J Kirk Harris, Mark A Lovell, Milton J Finegold, Ronald J Soko. Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury. Hepatology (Baltimore, Md.). vol 55. issue 5. 2012-06-19. PMID:22120983. |
markers of liver injury remained elevated in pn28d/dss mice associated with lobular inflammation, hepatocyte apoptosis, peliosis, and kc hypertrophy and hyperplasia. |
2012-06-19 |
2023-08-12 |
mouse |
| Peter Moritz Becher, Diana Lindner, Kapka Miteva, Konstantinos Savvatis, Christin Zietsch, Bastian Schmack, Sophie Van Linthout, Dirk Westermann, Heinz-Peter Schultheiss, Carsten Tschöp. Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade. Hypertension (Dallas, Tex. : 1979). vol 59. issue 5. 2012-06-14. PMID:22493071. |
this was associated with less cardiac hypertrophy, fibrosis, inflammation, and cardiac apoptosis (p<0.05). |
2012-06-14 |
2023-08-12 |
mouse |
| Pamela J Plant, Michelle L North, Andrew Ward, Michael Ward, Nivedita Khanna, Judy Correa, Jeremy A Scott, Jane Bat. Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma. American journal of respiratory cell and molecular biology. vol 46. issue 4. 2012-06-11. PMID:22108300. |
we correlated functional changes in airways newtonian resistance (rn), peripheral tissue damping (g), and elastance (h) with the relative contributions of proliferation, hypertrophy, and apoptosis to increased asm mass. |
2012-06-11 |
2023-08-12 |
mouse |
| Pamela J Plant, Michelle L North, Andrew Ward, Michael Ward, Nivedita Khanna, Judy Correa, Jeremy A Scott, Jane Bat. Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma. American journal of respiratory cell and molecular biology. vol 46. issue 4. 2012-06-11. PMID:22108300. |
we report that asm proliferation and diminished apoptosis occur during the acute phase, followed by the development of smooth muscle hypertrophy and an increased muscle mass with chronic challenge, that correlate strongly with increased airway newtonian resistance. |
2012-06-11 |
2023-08-12 |
mouse |
| Seung-Won Choi, Da-Un Jeong, Jeong-Ah Kim, Boyoung Lee, Kyu Sang Joeng, Fanxin Long, Dae-Won Ki. Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation. The Biochemical journal. vol 443. issue 3. 2012-06-08. PMID:22507129. |
consistent with these expression patterns, nkx3.2 has been shown to enhance chondrocyte differentiation and cell survival, while inhibiting chondrocyte hypertrophy and apoptosis. |
2012-06-08 |
2023-08-12 |
mouse |
| Shabina Rehman, Mohammad Husain, Anju Yadav, Balakuntalam S Kasinath, Ashwani Malhotra, Pravin C Singha. HIV-1 promotes renal tubular epithelial cell protein synthesis: role of mTOR pathway. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253885. |
tubular cell hiv-infection has been reported to manifest in the form of cellular hypertrophy and apoptosis. |
2012-05-29 |
2023-08-12 |
mouse |