| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Azova, M L Blagonravov, V A Frolo. [The effect of ETA receptor blockade on cardiomyocyte apoptosis and myocardial hypertrophy development in genetically hypertensive rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 75. issue 12. 2013-06-24. PMID:23700663. |
cardiomyocyte apoptosis and hypertrophy have been studied in the left and right ventricular myocardium of spontaneously hypertensive rats without treatment and after 10-day administration of the eta-receptor antagonist bq-123. |
2013-06-24 |
2023-08-12 |
rat |
| M M Azova, M L Blagonravov, V A Frolo. [The effect of ETA receptor blockade on cardiomyocyte apoptosis and myocardial hypertrophy development in genetically hypertensive rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 75. issue 12. 2013-06-24. PMID:23700663. |
it is established that bq-123 prevents the activation of cardiomyocyte apoptosis and significantly decreases the extent of hypertrophy development in the left ventricular myocardium, but does not influence the same mechanisms in the right ventricular myocardium. |
2013-06-24 |
2023-08-12 |
rat |
| Liang Chen, Zhenxiang Wang, Shirong Li, Guangjian Zhao, Maosheng Tian, Zhicheng Su. SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. PloS one. vol 7. issue 12. 2013-06-11. PMID:23226515. |
sfrp2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. |
2013-06-11 |
2023-08-12 |
Not clear |
| Liang Chen, Zhenxiang Wang, Shirong Li, Guangjian Zhao, Maosheng Tian, Zhicheng Su. SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. PloS one. vol 7. issue 12. 2013-06-11. PMID:23226515. |
our previous studies have suggested that secreted frizzled-related protein 2 (sfrp2) is involved in hs formation and that the suppression of sfrp2 promotes apoptosis of hypertrophic scar fibroblasts (hsfbs). |
2013-06-11 |
2023-08-12 |
Not clear |
| Liang Chen, Zhenxiang Wang, Shirong Li, Guangjian Zhao, Maosheng Tian, Zhicheng Su. SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. PloS one. vol 7. issue 12. 2013-06-11. PMID:23226515. |
in conclusion, sfrp2 appears to interact with slug to affect the apoptosis of hypertrophic scar fibroblasts. |
2013-06-11 |
2023-08-12 |
Not clear |
| R H Ritchie, J E Love, K Huynh, B C Bernardo, D C Henstridge, H Kiriazis, Y K Tham, G Sapra, C Qin, N Cemerlang, E J H Boey, K Jandeleit-Dahm, X-J Du, J R McMulle. Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes. Diabetologia. vol 55. issue 12. 2013-05-31. PMID:23001375. |
diabetic cardiomyopathy is characterised by diastolic dysfunction, oxidative stress, fibrosis, apoptosis and pathological cardiomyocyte hypertrophy. |
2013-05-31 |
2023-08-12 |
mouse |
| Xavier Lieben Louis, Ryan Murphy, Sijo Joseph Thandapilly, Liping Yu, Thomas Netticada. Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide. BMC complementary and alternative medicine. vol 12. 2013-05-21. PMID:22931510. |
garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide. |
2013-05-21 |
2023-08-12 |
Not clear |
| Linn Moore, Dong Fan, Ratnadeep Basu, Vijay Kandalam, Zamaneh Kassir. Tissue inhibitor of metalloproteinases (TIMPs) in heart failure. Heart failure reviews. vol 17. issue 4-5. 2013-05-07. PMID:21717224. |
hence, disruption of the ecm will result in structural instability as well as activation of a number of signaling pathways that could lead to fibrosis, hypertrophy, and apoptosis. |
2013-05-07 |
2023-08-12 |
Not clear |
| Mohammad T Elnakish, Mohamed D H Hassona, Mazin A Alhaj, Leni Moldovan, Paul M L Janssen, Mahmood Khan, Hamdy H Hassanai. Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis. PloS one. vol 7. issue 8. 2013-04-25. PMID:22936985. |
moreover, rac-mediated o(2)·(-) generation, cardiomyocyte apoptosis, and myocardial fibrosis seem to play a pivotal role in the transition from cardiac hypertrophy to cardiac dilation and failure. |
2013-04-25 |
2023-08-12 |
mouse |
| Dominic P Del Re, Yanfei Yang, Noritsugu Nakano, Jaeyeaon Cho, Peiyong Zhai, Takanobu Yamamoto, Nailing Zhang, Norikazu Yabuta, Hiroshi Nojima, Duojia Pan, Junichi Sadoshim. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. The Journal of biological chemistry. vol 288. issue 6. 2013-04-19. PMID:23275380. |
after chronic mi (28 days), yap(+/f)cre mice had significantly increased myocyte apoptosis and fibrosis, with attenuated compensatory cardiomyocyte hypertrophy, and further impaired function versus yap(+/f) control mice. |
2013-04-19 |
2023-08-12 |
mouse |
| Dominic P Del Re, Yanfei Yang, Noritsugu Nakano, Jaeyeaon Cho, Peiyong Zhai, Takanobu Yamamoto, Nailing Zhang, Norikazu Yabuta, Hiroshi Nojima, Duojia Pan, Junichi Sadoshim. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. The Journal of biological chemistry. vol 288. issue 6. 2013-04-19. PMID:23275380. |
studies in isolated cardiomyocytes demonstrated that yap1 expression is sufficient to promote increased cell size and hypertrophic gene expression and protected cardiomyocytes against h(2)o(2)-induced cell death, whereas yap1 depletion attenuated phenylephrine-induced hypertrophy and augmented apoptosis. |
2013-04-19 |
2023-08-12 |
mouse |
| Eduardo Martinez-Abundis, Venkatesh Rajapurohitam, James V Haist, Xiaohong T Gan, Morris Karmazy. The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. PloS one. vol 7. issue 7. 2013-04-09. PMID:22848545. |
these effects were associated with increased apoptosis as evidenced by increased tunel staining and caspase 3 activity, both of which were prevented by the transition pore inhibitor sanglifehrin a. leptin enhanced stat3 activation whereas a stat 3 inhibitor peptide prevented leptin-induced mitochondrial transition pore opening as well as the hypertrophic and pro-apoptotic effects of the peptide. |
2013-04-09 |
2023-08-12 |
rat |
| Inês Falcão-Pires, Adelino F Leite-Moreir. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart failure reviews. vol 17. issue 3. 2013-04-05. PMID:21626163. |
left ventricular hypertrophy, metabolic abnormalities, extracellular matrix changes, small vessel disease, cardiac autonomic neuropathy, insulin resistance, oxidative stress, and apoptosis are the most important contributors to diabetic cardiomyopathy onset and progression. |
2013-04-05 |
2023-08-12 |
human |
| Bo Sun, Rong Huo, Yue Sheng, Yue Li, Xin Xie, Chang Chen, Hui-Bin Liu, Na Li, Cheng-Bo Li, Wen-Ting Guo, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 61. issue 2. 2013-03-20. PMID:23248151. |
bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. |
2013-03-20 |
2023-08-12 |
mouse |
| Bo Sun, Rong Huo, Yue Sheng, Yue Li, Xin Xie, Chang Chen, Hui-Bin Liu, Na Li, Cheng-Bo Li, Wen-Ting Guo, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 61. issue 2. 2013-03-20. PMID:23248151. |
in this study, we investigated the role of bmp4 in cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. |
2013-03-20 |
2023-08-12 |
mouse |
| Bo Sun, Rong Huo, Yue Sheng, Yue Li, Xin Xie, Chang Chen, Hui-Bin Liu, Na Li, Cheng-Bo Li, Wen-Ting Guo, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 61. issue 2. 2013-03-20. PMID:23248151. |
in turn, bmp4 induced cardiomyocyte hypertrophy, apoptosis, and cardiac fibrosis, and these pathological consequences were inhibited by the treatment with bmp4 inhibitors noggin and dmh1. |
2013-03-20 |
2023-08-12 |
mouse |
| Bo Sun, Rong Huo, Yue Sheng, Yue Li, Xin Xie, Chang Chen, Hui-Bin Liu, Na Li, Cheng-Bo Li, Wen-Ting Guo, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 61. issue 2. 2013-03-20. PMID:23248151. |
the underlying mechanism that bmp4-induced cardiomyocyte hypertrophy and apoptosis was through increasing nadph oxidase 4 expression and reactive oxygen species-dependent pathways. |
2013-03-20 |
2023-08-12 |
mouse |
| Bo Sun, Rong Huo, Yue Sheng, Yue Li, Xin Xie, Chang Chen, Hui-Bin Liu, Na Li, Cheng-Bo Li, Wen-Ting Guo, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 61. issue 2. 2013-03-20. PMID:23248151. |
lentivirus-mediated overexpression of bmp4 recapitulated hypertrophy and apoptosis in cultured cardiomyocytes. |
2013-03-20 |
2023-08-12 |
mouse |
| Mei Zhao, Wei-Jin Zan. [The bidirectional roles of macroautophagy in the regulation of heart disease]. Sheng li ke xue jin zhan [Progress in physiology]. vol 42. issue 2. 2013-03-14. PMID:21770252. |
this paper reviews the research progress of macroautophagy in the regulation of heart disease, including macroautophagy formation, the relationship between macroautophagy and apoptosis, macroautophagy under the conditions of myocardial ischemia-reperfusion, hypertrophy and heart failure, in order to find a new method for the treatment. |
2013-03-14 |
2023-08-12 |
Not clear |
| Giuseppe Distefano, Pietro Sciacc. Molecular pathogenesis of myocardial remodeling and new potential therapeutic targets in chronic heart failure. Italian journal of pediatrics. vol 38. 2013-03-12. PMID:22971785. |
typical features of myocardial remodeling are represented by cardiomyocytes hypertrophy and apoptosis, extracellular matrix alterations, mesenchymal fibrotic and phlogistic processes and by cardiac gene expression modifications with fetal genetic program reactivation. |
2013-03-12 |
2023-08-12 |
Not clear |