| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shant Der Sarkissian, Bun-Seng Tea, Rhian M Touyz, Denis deBlois, Taben M Hal. Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension : JASH. vol 7. issue 2. 2013-09-19. PMID:23414835. |
we previously reported that the at1 receptor antagonist valsartan and the angiotensin converting enzyme (ace) inhibitor enalapril decrease dna synthesis and stimulate apoptosis in interstitial fibroblasts and epicardial mesothelial cells during regression of ventricular hypertrophy in spontaneously hypertensive rats (shr). |
2013-09-19 |
2023-08-12 |
rat |
| Irene Pérez López, Luca Cariolato, Darko Maric, Ludovic Gillet, Hugues Abriel, Dario Divian. A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy. Molecular and cellular biology. vol 33. issue 15. 2013-09-16. PMID:23716597. |
our results indicate that disruption of the akap-lbc/p38 signaling complex inhibits compensatory cardiomyocyte hypertrophy in response to aortic banding-induced pressure overload and promotes early cardiac dysfunction associated with increased myocardial apoptosis, stress gene activation, and ventricular dilation. |
2013-09-16 |
2023-08-12 |
mouse |
| Dongxing Chen, Lindsay A Bashur, Bojian Liang, Martina Panattoni, Keiko Tamai, Ruggero Pardi, Guang Zho. The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo. Journal of cell science. vol 126. issue Pt 1. 2013-09-11. PMID:23203803. |
jab1 cko chondrocytes exhibited increased apoptosis, g2 phase cell cycle arrest, and increased expression of hypertrophic chondrocyte markers col10a1 and runx2. |
2013-09-11 |
2023-08-12 |
Not clear |
| Yuguang Zhao, Yi Tan, Shugang Xi, Yunqian Li, Cai Li, Jiuwei Cui, Xiaoqing Yan, Xiaokun Li, Guanjun Wang, Wei Li, Lu Ca. A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation. Diabetes. vol 62. issue 7. 2013-09-09. PMID:23423573. |
administration of sdf-1β to diabetic rats, induced by feeding a high-fat diet, followed by a small dose of streptozotocin, could significantly reduce cardiac apoptosis and increase ampk phosphorylation along with prevention of diabetes-induced cardiac oxidative damage, inflammation, hypertrophy, and remodeling. |
2013-09-09 |
2023-08-12 |
rat |
| A Mitra, T Basak, K Datta, S Naskar, S Sengupta, S Sarka. Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. Cell death & disease. vol 4. 2013-08-23. PMID:23559016. |
role of α-crystallin b as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. |
2013-08-23 |
2023-08-12 |
Not clear |
| A Mitra, T Basak, K Datta, S Naskar, S Sengupta, S Sarka. Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. Cell death & disease. vol 4. 2013-08-23. PMID:23559016. |
so, this study was designed to decipher the process of cardiomyocyte apoptosis during cardiac hypertrophy and mi in vivo. |
2013-08-23 |
2023-08-12 |
Not clear |
| A Mitra, T Basak, K Datta, S Naskar, S Sengupta, S Sarka. Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. Cell death & disease. vol 4. 2013-08-23. PMID:23559016. |
further downstream analysis revealed that mitochondrial pathway of apoptosis is instrumental in case of hypertrophy, whereas er stress-induced apoptosis is predominant during mi, which was confirmed by treatment with either sirna against vdac1 or er stress inhibitor tauroursodeoxycholic acid (tudca). |
2013-08-23 |
2023-08-12 |
Not clear |
| A Mitra, T Basak, K Datta, S Naskar, S Sengupta, S Sarka. Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. Cell death & disease. vol 4. 2013-08-23. PMID:23559016. |
the study demonstrated for the first time that two different organelles--mitochondria and er have predominant roles in mediating cardiomyocyte death signaling during hypertrophy and mi, respectively, and activation of cryab acts as a molecular switch in bypassing mitochondrial pathway of apoptosis during mi. |
2013-08-23 |
2023-08-12 |
Not clear |
| Min-Ji Cha, Jin-Kyung Jang, Onju Ham, Byeong-Wook Song, Se-Yeon Lee, Chang Yeon Lee, Jun-Hee Park, Jiyun Lee, Hyang-Hee Seo, Eunhyun Choi, Woo-min Jeon, Hye Jin Hwang, Hyun-Taek Shin, Eunmi Choi, Ki-Chul Hwan. MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ. Biochemical and biophysical research communications. vol 435. issue 4. 2013-08-20. PMID:23702479. |
calcium/calmodulin dependent protein kinase ii (camkii) is a critical regulator of ca(2+) signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. |
2013-08-20 |
2023-08-12 |
Not clear |
| O G Polovlkova, O A Makeeva, A A Lezhnev, I A Goncharova, E V Kulish, V M Shipulin, V P Puzyre. [Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans]. Molekuliarnaia biologiia. vol 47. issue 3. 2013-08-12. PMID:23888774. |
components of calcineurin pathway are involved in myocardium hypertrophy regulation, angiogenesis and apoptosis. |
2013-08-12 |
2023-08-12 |
Not clear |
| N V Zaĭtseva, M A Zemlianova, V N Zvezdin, O V Lebedinskaia, S V Melekhin, E V Saenko, R R Makhmudo. [Effect of nanodispersed manganese oxide (III, IV) on morphological properties of various tissues and body systems]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 2. 2013-08-06. PMID:23819324. |
the study of morphological features of tissue organs of experimental animals after a single intragastric administration of an aqueous suspension nanodis-dispersed manganese (iii, iv) at doses of 2000, 3500 and 5000 mg/kg showed complex of morphological changes in the form of circulatory disorders up to hemostasis and bleeding which lead to changes in the structure of organs, enhanced apoptosis, activation of macrophage system by proliferation and macrophage phagocytosis of degradation products of cells, hypertrophy of lymphoid tissue of immune system; development of histiocytic infiltrates in parenchymal organs and central nervous system. |
2013-08-06 |
2023-08-12 |
Not clear |
| Angelica M Amanso, Kathy K Griendlin. Differential roles of NADPH oxidases in vascular physiology and pathophysiology. Frontiers in bioscience (Scholar edition). vol 4. 2013-08-05. PMID:22202108. |
these enzymes have also been linked to processes leading to disease development, including migration, proliferation, hypertrophy, apoptosis and autophagy. |
2013-08-05 |
2023-08-12 |
Not clear |
| Yixuan Shi, Chao-Sheng Lo, Isabelle Chenier, Hasna Maachi, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Cha. Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice. American journal of physiology. Renal physiology. vol 304. issue 11. 2013-08-01. PMID:23552863. |
overexpression of cat attenuated renal oxidative stress; prevented hypertension; normalized rptc ace2 expression and urinary ang 1-7 levels (both were low in akita mice); ameliorated glomerular filtration rate, albuminuria, kidney hypertrophy, tubulointerstitial fibrosis, and tubular apoptosis; and suppressed profibrotic and proapoptotic gene expression in rptcs of akita cat-tg mice compared with akita mice. |
2013-08-01 |
2023-08-12 |
mouse |
| Yong Wang, Chun Li, Yuli Ouyang, Tianjiao Shi, Xiaomin Yang, Junda Yu, Qi Qiu, Jing Han, Yan Wu, Binghua Tang, Wei Wan. QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-17. PMID:23861715. |
moreover, nox4 was another key targets to inhibit the p53 and caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect. |
2013-07-17 |
2023-08-12 |
rat |
| Shunichi Shimizu, Masaaki Ishibashi, Sumito Kumagai, Teruaki Wajima, Toshihito Hiroi, Tatsuya Kurihara, Masakazu Ishii, Yuji Kiuch. Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. International journal of molecular medicine. vol 31. issue 3. 2013-07-10. PMID:23313998. |
sustained cardiac pressure overload induces mitochondrial dysfunction and apoptosis of cardiomyocytes leading to pathological cardiac hypertrophy and dysfunction. |
2013-07-10 |
2023-08-12 |
rat |
| Jia Dai, Di-Fei Shen, Zhou-Yan Bian, Heng Zhou, Hua-Wen Gan, Jing Zong, Wei Deng, Yuan Yuan, FangFang Li, Qing-Qing Wu, Lu Gao, Rui Zhang, Zhen-Guo Ma, Hong-Liang Li, Qi-Zhu Tan. IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis. PloS one. vol 8. issue 1. 2013-07-09. PMID:23349709. |
we observed that ikki-deficient mice showed significantly enhanced cardiac hypertrophy, cardiac dysfunction, apoptosis and fibrosis compared with wt mice. |
2013-07-09 |
2023-08-12 |
mouse |
| Nathan A Bracey, Paul L Beck, Daniel A Muruve, Simon A Hirota, Jiqing Guo, Habib Jabagi, James R Wright, Justin A Macdonald, James P Lees-Miller, Daniel Roach, Lisa M Semeniuk, Henry J Duf. The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β. Experimental physiology. vol 98. issue 2. 2013-07-08. PMID:22848083. |
cardiac-specific heterozygous overexpression of the calcineurin transgene (cntg) in mice results in cardiac hypertrophy, inflammation, apoptosis and ventricular dilatation. |
2013-07-08 |
2023-08-12 |
mouse |
| Yong Zeng, Junjie Li, Hong-Xia Wang, Shu-Bin Guo, Hui Yang, Xiang-Jun Zeng, Quan Fang, Chao-Shu Tang, Jie Du, Hui-Hua L. Transcriptional effects of E3 ligase atrogin-1/MAFbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes. PloS one. vol 8. issue 1. 2013-06-27. PMID:23335977. |
transcriptional effects of e3 ligase atrogin-1/mafbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes. |
2013-06-27 |
2023-08-12 |
rat |
| Man-Yi Ren, Shu-Jian Su. The role of TWEAK/Fn14 in cardiac remodeling. Molecular biology reports. vol 39. issue 11. 2013-06-26. PMID:22752727. |
the pathophysiological basis of heart failure is cardiac remodeling, a process that comprises structural and functional changes including cardiomyocyte proliferation, hypertrophy, necrosis, apoptosis, autophagy, interstitial fibrosis, contractile dysfunction and ventricular dilatation. |
2013-06-26 |
2023-08-12 |
Not clear |
| M M Azova, M L Blagonravov, V A Frolo. [The effect of ETA receptor blockade on cardiomyocyte apoptosis and myocardial hypertrophy development in genetically hypertensive rats]. Eksperimental'naia i klinicheskaia farmakologiia. vol 75. issue 12. 2013-06-24. PMID:23700663. |
[the effect of eta receptor blockade on cardiomyocyte apoptosis and myocardial hypertrophy development in genetically hypertensive rats]. |
2013-06-24 |
2023-08-12 |
rat |