| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominic P Del Re, Takahisa Matsuda, Peiyong Zhai, Shumin Gao, Geoffrey J Clark, Louise Van Der Weyden, Junichi Sadoshim. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. The Journal of clinical investigation. vol 120. issue 10. 2010-11-10. PMID:20890045. |
although the rassf1a/mst1 pathway promoted apoptosis in cardiomyocytes, thereby playing a detrimental role, the same pathway surprisingly inhibited fibroblast proliferation and cardiac hypertrophy through both cell-autonomous and autocrine/paracrine mechanisms, playing a protective role during pressure overload. |
2010-11-10 |
2023-08-12 |
mouse |
| Susanne U Miedlich, Eric D Zhu, Yves Sabbagh, Marie B Dema. The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice. Endocrinology. vol 151. issue 10. 2010-11-04. PMID:20685875. |
rachitic expansion of the hypertrophic chondrocyte layer of the growth plate, in the setting of hypophosphatemia, is due to impaired apoptosis of these cells. |
2010-11-04 |
2023-08-12 |
mouse |
| Susanne U Miedlich, Eric D Zhu, Yves Sabbagh, Marie B Dema. The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice. Endocrinology. vol 151. issue 10. 2010-11-04. PMID:20685875. |
because activation of the mitochondrial apoptotic pathway by phosphate is required for hypertrophic chondrocyte apoptosis in vivo, investigations were undertaken to address this paradox. |
2010-11-04 |
2023-08-12 |
mouse |
| Clifford R Elcombe, Barbara M Elcombe, John R Foster, David G Farrar, Reinhard Jung, Shu-Ching Chang, Gerald L Kennedy, John L Butenhof. Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. Archives of toxicology. vol 84. issue 10. 2010-11-03. PMID:20614104. |
responses to treatment with wy 14,643 were consistent with increased activation of pparα, specifically: increased cyp4a1 and peroxisomal β-oxidation; increased hepatocellular hypertrophy and cell proliferation; decreased apoptosis; and hypolipidaemia. |
2010-11-03 |
2023-08-12 |
mouse |
| Chong-Feng Bai, Jin-Cheng Liu, Rong Zhao, Wei Cao, Shui-Bin Liu, Xiao-Nan Zhang, Hong-Ju Guo, Qi Yang, Ding-Hua Yi, Ming-Gao Zha. Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats. Clinical and experimental pharmacology & physiology. vol 37. issue 7. 2010-11-02. PMID:20374255. |
the aim of the present study was to investigate the role of 5-ht(2b) receptors in the development of cardiomyocyte apoptosis and hypertrophy associated with noradrenaline (na) overload. |
2010-11-02 |
2023-08-12 |
rat |
| Mark F McCart. Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies. Medical hypotheses. vol 75. issue 2. 2010-10-20. PMID:20083360. |
oxidative stress is a mediator of the cardiomyocyte hypertrophy and apoptosis, the cardiac fibrosis, and the deficits in cardiac function which typify this syndrome, and may play a role in initiating and sustaining atrial fibrillation. |
2010-10-20 |
2023-08-12 |
Not clear |
| Pawel Dobrzyn, Agnieszka Dobrzyn, Makoto Miyazaki, James M Ntamb. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. Journal of lipid research. vol 51. issue 8. 2010-10-20. PMID:20363835. |
the heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (tg) content, increased stearoyl-coa desaturase (scd) activity, and increased myocyte apoptosis. |
2010-10-20 |
2023-08-12 |
mouse |
| Peifeng L. MicroRNAs in cardiac apoptosis. Journal of cardiovascular translational research. vol 3. issue 3. 2010-10-04. PMID:20560043. |
they play important roles in regulating cardiac physiological and pathological events such as hypertrophy, apoptosis, and heart failure. |
2010-10-04 |
2023-08-12 |
Not clear |
| L Zheng, J Xu, W Qiu, X Liu, C-M Zhao, D Chen, Y Che. Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 1. 2010-10-01. PMID:20228410. |
in conclusion recombinant human erythropoietin has cardioprotective effects in maladaptive cardiac hypertrophy by inhibiting nuclear factor-kappab activation, phosphorylation of p38-mapk pathway, and production of tumor necrosis factor-alpha, together leading to a reduced apoptosis. |
2010-10-01 |
2023-08-12 |
mouse |
| Kazuma Udo, Shigehisa Aoki, Kazuyoshi Uchihashi, Maki Kawasaki, Aki Matsunobu, Yuji Tokuda, Akifumi Ootani, Shuji Toda, Jiro Uozum. Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture. Kidney international. vol 78. issue 1. 2010-09-22. PMID:20336056. |
thus, our study shows that adipose tissue fragments promote the hypertrophy, polarization, and differentiation of mdck cells by attenuating their growth and apoptosis through opposing endocrine or paracrine effects of leptin and adiponectin. |
2010-09-22 |
2023-08-12 |
Not clear |
| Rusty L Montgomery, Eva van Rooi. MicroRNA regulation as a therapeutic strategy for cardiovascular disease. Current drug targets. vol 11. issue 8. 2010-09-22. PMID:20415653. |
as evident through gain- and loss-of-function studies in mice, it is apparent micrornas play specific and essential roles during cardiac hypertrophy, fibrosis, angiogenesis, apoptosis, and contractility. |
2010-09-22 |
2023-08-12 |
mouse |
| B D Boyan, J Hurst-Kennedy, T A Denison, Z Schwart. 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. The Journal of steroid biochemistry and molecular biology. vol 121. issue 1-2. 2010-09-20. PMID:20307662. |
24r,25-dihydroxyvitamin d3 [24r,25(oh)2d3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(oh)2d3 in hypertrophic cells. |
2010-09-20 |
2023-08-12 |
rat |
| Nathan A Wigner, Hilary F Luderer, Megan K Cox, Karen Sooy, Louis C Gerstenfeld, Marie B Dema. Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 25. issue 4. 2010-09-14. PMID:19839770. |
impaired phosphate-dependent apoptosis of hypertrophic chondrocytes is the molecular basis for rickets. |
2010-09-14 |
2023-08-12 |
mouse |
| Leighton R James, Catherine Le, James W Schole. Influence of glucosamine on glomerular mesangial cell turnover: implications for hyperglycemia and hexosamine pathway flux. American journal of physiology. Endocrinology and metabolism. vol 298. issue 2. 2010-09-01. PMID:19903862. |
cells exposed to high glucose may undergo hypertrophy, proliferation, and apoptosis, but the role of hexosamine flux in mediating these effects has not been fully elucidated. |
2010-09-01 |
2023-08-12 |
rat |
| Beata Zelazowska-Rutkowska, Jolanta Wysocka, Bozena Skotnick. Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. International journal of pediatric otorhinolaryngology. vol 74. issue 6. 2010-09-01. PMID:20338643. |
chosen factors of t and b cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. |
2010-09-01 |
2023-08-12 |
Not clear |
| Yu Hua Wang, Hassiba Ahmar, Helen R Irvin. Induction of apoptosis by plant natriuretic peptides in rat cardiomyoblasts. Peptides. vol 31. issue 6. 2010-08-17. PMID:20307601. |
atrial natriuretic peptide (anp) has an important role in maintaining the homeostasis of body fluids and blood pressure and also in preventing cardiac hypertrophy and initiating the process of apoptosis. |
2010-08-17 |
2023-08-12 |
rat |
| He Huang, Qi-Zhu Tang, Ai-Bing Wang, Manyin Chen, Ling Yan, Chen Liu, Hong Jiang, Qinglin Yang, Zhou-Yan Bian, Xue Bai, Li-Hua Zhu, Lang Wang, Hongliang L. Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling. Hypertension (Dallas, Tex. : 1979). vol 56. issue 2. 2010-08-10. PMID:20585109. |
constitutive overexpression of human a20 in the murine heart attenuated the hypertrophic response and markedly reduced inflammation, apoptosis, and fibrosis. |
2010-08-10 |
2023-08-12 |
mouse |
| He Huang, Qi-Zhu Tang, Ai-Bing Wang, Manyin Chen, Ling Yan, Chen Liu, Hong Jiang, Qinglin Yang, Zhou-Yan Bian, Xue Bai, Li-Hua Zhu, Lang Wang, Hongliang L. Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling. Hypertension (Dallas, Tex. : 1979). vol 56. issue 2. 2010-08-10. PMID:20585109. |
in conclusion, a20 improves cardiac functions and inhibits cardiac hypertrophy, inflammation, apoptosis, and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling. |
2010-08-10 |
2023-08-12 |
mouse |
| Nasser Chegin. Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Seminars in reproductive medicine. vol 28. issue 3. 2010-08-03. PMID:20414842. |
these autocrine/paracrine molecules with proinflammatory and profibrotic activities serve as major contributing factors in regulating cellular transformation, cell growth and apoptosis, angiogenesis, cellular hypertrophy, and excess tissue turnover, events central to leiomyoma growth. |
2010-08-03 |
2023-08-12 |
Not clear |
| Hiroyuki Tanak. [Bone and joint diseases in children. Rickets]. Clinical calcium. vol 20. issue 6. 2010-08-03. PMID:20513940. |
its basic pathophysiology has been revealed as a defect in apoptosis of hypertrophic chondrocytes induced by low phosphate concentration in the body fluid. |
2010-08-03 |
2023-08-12 |
Not clear |