| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Zhe Li, Jun Peng, Li Xiao, Yi-Shuai Zhang, Mei-Chun Liao, Xiao-Hui Li, Chang-Ping Hu, Han-Wu Deng, Yuan-Jian L. Reversal of isoprenaline-induced cardiac remodeling by rutaecarpine via stimulation of calcitonin gene-related peptide production. Canadian journal of physiology and pharmacology. vol 88. issue 10. 2011-02-25. PMID:20962894. |
after echocardiographic analysis was performed, blood samples were collected to quantify calcitonin gene-related peptide (cgrp), dorsal root ganglia were isolated for examining cgrp mrna expression, and the hearts were weighed and saved for evaluating the parameters related to apoptosis and hypertrophy. |
2011-02-25 |
2023-08-12 |
rat |
| Charlene S Simmonds, Christopher S Kovac. Role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development. Critical reviews in eukaryotic gene expression. vol 20. issue 3. 2011-02-24. PMID:21175413. |
it may also have effects on bone formation in the steps that occur after apoptosis of hypertrophic chondrocytes. |
2011-02-24 |
2023-08-12 |
Not clear |
| Mona Hedayat, Mohammad Jafar Mahmoudi, Noel R Rose, Nima Rezae. Proinflammatory cytokines in heart failure: double-edged swords. Heart failure reviews. vol 15. issue 6. 2011-02-08. PMID:20405319. |
cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. |
2011-02-08 |
2023-08-12 |
Not clear |
| Jianjian Shi, Yi-Wei Zhang, Yu Yang, Lumin Zhang, Lei We. ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice. Journal of molecular and cellular cardiology. vol 49. issue 5. 2011-01-18. PMID:20709073. |
we have recently reported that genetic deletion of rho-associated coiled-coil containing protein kinase 1 (rock1) inhibited several pathological events including cardiomyocyte apoptosis in compensated hypertrophic hearts. |
2011-01-18 |
2023-08-12 |
mouse |
| Jianjian Shi, Yi-Wei Zhang, Yu Yang, Lumin Zhang, Lei We. ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice. Journal of molecular and cellular cardiology. vol 49. issue 5. 2011-01-18. PMID:20709073. |
transgenic mice with cardiac-restricted overexpression of gαq develop compensated cardiac hypertrophy at young ages, but progress into lethal cardiomyopathy accompanied by increased apoptosis after pregnancy or at old ages. |
2011-01-18 |
2023-08-12 |
mouse |
| Jianjian Shi, Yi-Wei Zhang, Yu Yang, Lumin Zhang, Lei We. ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice. Journal of molecular and cellular cardiology. vol 49. issue 5. 2011-01-18. PMID:20709073. |
furthermore, transgenic overexpression of rock1 increased cardiomyocyte apoptosis and accelerated hypertrophic decompensation in gαq hearts in the absence of pregnancy stress. |
2011-01-18 |
2023-08-12 |
mouse |
| Nathan J Charles, Robert C Huebert, Sangjin Lee, Neeta Adhikari, Sean Polster, James E Rider, Elizabeth Braunlin, Ami Mariash, Maggie Robledo, David Schuweiler, Jennifer L Hal. Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function. Molecular and cellular biochemistry. vol 342. issue 1-2. 2011-01-04. PMID:20461448. |
the mitogen activated protein kinase (mapk) signaling pathway regulates multiple events leading to heart failure including ventricular remodeling, contractility, hypertrophy, apoptosis, and fibrosis. |
2011-01-04 |
2023-08-12 |
mouse |
| Lishu Zhang, Yan-Fang Guo, Yao-Zhong Liu, Yong-Jun Liu, Dong-Hai Xiong, Xiao-Gang Liu, Liang Wang, Tie-Lin Yang, Shu-Feng Lei, Yan Guo, Han Yan, Yu-Fang Pei, Feng Zhang, Christopher J Papasian, Robert R Recker, Hong-Wen Den. Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 25. issue 7. 2010-12-20. PMID:20200951. |
earlier studies indicated that during endochondral ossification, autophagy occurs prior to apoptosis of hypertrophic chondrocytes, and it also has been shown that some genes in the roa pathway (e.g., infg) may play important roles in osteoblastogenesis or osteoclastogenesis. |
2010-12-20 |
2023-08-12 |
human |
| Shujing Dai, Fangping Yuan, Jingyao Mu, Chengxin Li, Ning Chen, Shangzhi Guo, Justin Kingery, Sumanth D Prabhu, Roberto Bolli, Gregg Rokos. Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction. Journal of molecular and cellular cardiology. vol 49. issue 4. 2010-12-20. PMID:20655922. |
morphometric analysis showed hearts of amd3100-treated infarcted mice to have expanded scar, to be hypertrophic (confirmed by myocyte cross-section area) and dilated, with increased lv end systolic and end diastolic dimensions, and to have decreased scar collagen content; p-akt levels were attenuated and this was accompanied by increased apoptosis. |
2010-12-20 |
2023-08-12 |
mouse |
| Jin Guo, Hong-Zhu Li, Wei-Hua Zhang, Lu-Chuan Wang, Li-Na Wang, Li Zhang, Guang-Wei Li, Hong-Xia Li, Bao-Feng Yang, Lingyun Wu, Rui Wang, Chang-Qing X. Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion. Clinical and experimental pharmacology & physiology. vol 37. issue 3. 2010-12-14. PMID:20409080. |
it has also been suggested that casr has a crucial role in cardiac ischaemia-reperfusion injury, apoptosis and hypertrophy. |
2010-12-14 |
2023-08-12 |
rat |
| John P Konhilas, Dana M Boucek, Todd R Horn, Gary L Johnson, Leslie A Leinwan. The role of MEKK1 in hypertrophic cardiomyopathy. International heart journal. vol 51. issue 4. 2010-12-10. PMID:20716846. |
we conclude that the absence of mekk1 induces a more pronounced cardiac hypertrophy to hcm through altered expression of proteases implicated in cardiac remodeling and increased apoptosis. |
2010-12-10 |
2023-08-12 |
mouse |
| Flori R Sari, Kenichi Watanabe, Bambang Widyantoro, Rajarajan A Thandavarayan, Meilei Harima, Shaosong Zhang, Anthony J Muslin, Makoto Kodama, Yoshifusa Aizaw. Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798500. |
excessive endoplasmic reticulum stress (ers) triggers apoptosis in various conditions including diabetic cardiomyopathy and pressure overload-induced cardiac hypertrophy and heart failure. |
2010-12-08 |
2023-08-12 |
mouse |
| Jiang Xu, Oscar A Carretero, Tang-Dong Liao, Hongmei Peng, Edward G Shesely, Junxiao Xu, Thomas S Liu, James J Yang, Timothy L Reudelhuber, Xiao-Ping Yan. Local angiotensin II aggravates cardiac remodeling in hypertension. American journal of physiology. Heart and circulatory physiology. vol 299. issue 5. 2010-11-29. PMID:20833959. |
using this unique model, we tested the hypothesis that cardiac ang ii, acting on the angiotensin type 1 receptor (at(1)r), increases inflammation, oxidative stress, and apoptosis, accelerating cardiac hypertrophy and fibrosis. |
2010-11-29 |
2023-08-12 |
mouse |
| Yourka D Tchoukalova, Susanne B Votruba, Tamara Tchkonia, Nino Giorgadze, James L Kirkland, Michael D Jense. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 42. 2010-11-22. PMID:20921416. |
we found no depot-differences in preadipocyte replication or apoptosis that would explain lower-body adipocyte hyperplasia and abdominal s.c. adipocyte hypertrophy. |
2010-11-22 |
2023-08-12 |
Not clear |
| Monique C de Waard, Rien van Haperen, Thomas Soullié, Dennie Tempel, Rini de Crom, Dirk J Duncke. Beneficial effects of exercise training after myocardial infarction require full eNOS expression. Journal of molecular and cellular cardiology. vol 48. issue 6. 2010-11-16. PMID:20153335. |
mi resulted in marked lv remodeling, including cardiomyocyte hypertrophy and a reduction in capillary density, increased fibrosis and apoptosis, as well as lv systolic and diastolic dysfunction to the same extent in all genotypes. |
2010-11-16 |
2023-08-12 |
mouse |
| Sibylle Wenzel, Kirsten Henning, Andreas Habbig, Svenja Forst, Rolf Schreckenberg, Jacqueline Heger, Hagen Maxeiner, Klaus-Dieter Schlüte. TGF-beta1 improves cardiac performance via up-regulation of laminin receptor 37/67 in adult ventricular cardiomyocytes. Basic research in cardiology. vol 105. issue 5. 2010-11-16. PMID:20556404. |
tgf-beta1 plays an important role in cardiac fibrosis, apoptosis, induction of hypertrophy and contractile dysfunction. |
2010-11-16 |
2023-08-12 |
mouse |
| Junya Kuroda, Junichi Sadoshim. NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. vol 3. issue 4. 2010-11-16. PMID:20559780. |
increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. |
2010-11-16 |
2023-08-12 |
Not clear |
| Junya Kuroda, Junichi Sadoshim. NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. vol 3. issue 4. 2010-11-16. PMID:20559780. |
nox4 is localized primarily at mitochondria in cardiac myocytes, and upregulation of nox4 hypertrophic stimuli enhances o(2)(-) production, apoptosis, and mitochondrial dysfunction, thereby playing an important role in mediating cardiac dysfunction. |
2010-11-16 |
2023-08-12 |
Not clear |
| Junya Kuroda, Tetsuro Ago, Shouji Matsushima, Peiyong Zhai, Michael D Schneider, Junichi Sadoshim. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713697. |
in response to pressure overload (po), however, increases in nox4 expression and o(2)(-) production in mitochondria were abolished in c-nox4(-/-) mice, and c-nox4(-/-) mice exhibited significantly attenuated cardiac hypertrophy, interstitial fibrosis and apoptosis, and better cardiac function compared with wt mice. |
2010-11-15 |
2023-08-12 |
mouse |
| Dominic P Del Re, Takahisa Matsuda, Peiyong Zhai, Shumin Gao, Geoffrey J Clark, Louise Van Der Weyden, Junichi Sadoshim. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. The Journal of clinical investigation. vol 120. issue 10. 2010-11-10. PMID:20890045. |
it is the chief component of the mammalian hippo pathway and promotes apoptosis and inhibits compensatory cardiac hypertrophy, playing a critical role in mediating heart failure. |
2010-11-10 |
2023-08-12 |
mouse |