| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T E Thorne, C Voelkel-Johnson, W M Casey, L W Parks, S M Laste. The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor. Journal of virology. vol 70. issue 12. 1997-01-23. PMID:8970973. |
most cell types are resistant to apoptosis induced by tumor necrosis factor (tnf) unless the cells are treated with a sensitizing agent. |
1997-01-23 |
2023-08-12 |
Not clear |
| G Natoli, A Costanzo, A Ianni, D J Templeton, J R Woodgett, C Balsano, M Levrer. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science (New York, N.Y.). vol 275. issue 5297. 1997-01-23. PMID:8985011. |
interaction of the p55 tumor necrosis factor receptor 1 (tnf-r1)-associated signal transducer tradd with fadd signals apoptosis, whereas the tnf receptor-associated factor 2 protein (traf2) is required for activation of the nuclear transcription factor nuclear factor kappa b. tnf-induced activation of the stress-activated protein kinase (sapk) was shown to occur through a noncytotoxic traf2-dependent pathway. |
1997-01-23 |
2023-08-12 |
Not clear |
| H Kikuchi, R Iizuka, S Sugiyama, G Gon, H Mori, M Arai, K Mizumoto, S Imajoh-Ohm. Monocytic differentiation modulates apoptotic response to cytotoxic anti-Fas antibody and tumor necrosis factor alpha in human monoblast U937 cells. Journal of leukocyte biology. vol 60. issue 6. 1997-01-22. PMID:8975882. |
vd-or ra-treated u937 cells acquired resistance against fas- or tnf receptor (tnfr)-mediated apoptosis, whereas apoptotic cell death was accelerated in ifn-gamma-treated cells. |
1997-01-22 |
2023-08-12 |
human |
| H B Shu, M Takeuchi, D V Goedde. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 24. 1997-01-16. PMID:8943045. |
in contrast, tnf receptor 2 (tnf-r2) interacts with the tnf receptor associated factors 2/1 (traf2/traf1) heterocomplex, which mediates the recruitment of two cellular inhibitor of apoptosis proteins (c-iap1 and c-iap2) to tnf-r2. |
1997-01-16 |
2023-08-12 |
Not clear |
| D M Vanags, M I Pörn-Ares, S Coppola, D H Burgess, S Orreniu. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. The Journal of biological chemistry. vol 271. issue 49. 1997-01-09. PMID:8940103. |
a detailed kinetic analysis of three extranuclear end points of apoptosis, phosphatidylserine exposure, alpha-fodrin degradation, and plasma membrane blebbing, was performed and compared with nuclear fragmentation and the activation of the interleukin-1beta-converting enzyme (ice)-like proteases in jurkat t lymphocytes stimulated by anti-fas monoclonal antibody (anti-fas mab) and in monocytic u937 cells stimulated by tumor necrosis factor (tnf) and cycloheximide. |
1997-01-09 |
2023-08-12 |
Not clear |
| J P Herlihy, M W Vermeulen, C A Hale. Human alveolar macrophages prevent apoptosis in polymorphonuclear leukocytes. The American journal of physiology. vol 271. issue 5 Pt 1. 1997-01-09. PMID:8944710. |
in eight of nine patients, am-cm contained tumor necrosis factor (tnf), which modestly delayed am apoptosis so that the percentage of pmn apoptotic at 24 h was 77 +/- 6% in am-cm compared with 91 +/- 2% in um (p < 0.05). |
1997-01-09 |
2023-08-12 |
human |
| S H Hsu, T R Tsai, C N Lin, M H Yen, K W Ku. Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR I which may lead to cell apoptosis. Biochemical and biophysical research communications. vol 229. issue 1. 1997-01-09. PMID:8954074. |
since tnf receptor i has been involved in apoptosis, the overexpression of tnf receptor i may be related with the mechanism of cytotoxicity of solamargine. |
1997-01-09 |
2023-08-12 |
human |
| P D Katsikis, M E García-Ojeda, E S Wunderlich, C A Smith, H Yagita, K Okumura, N Kayagaki, M Alderson, L A Herzenberg, L A Herzenber. Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals. International immunology. vol 8. issue 8. 1997-01-08. PMID:8918700. |
in this study we examine the role of fas, ctla-4, tumor necrosis factor (tnf) receptors (tnfr) and cd30, receptors known to be involved in t cell activation-induced cell death (aicd), in the spontaneous and activation (anti-cd3)-induced apoptosis of peripheral blood t cells from asymptomatic hiv-infected individuals. |
1997-01-08 |
2023-08-12 |
Not clear |
| A Karsan, E Yee, J M Harla. Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. The Journal of biological chemistry. vol 271. issue 44. 1996-12-26. PMID:8910286. |
while tnf directly causes apoptosis of tumor cells and virally infected cells, normal cells are generally resistant. |
1996-12-26 |
2023-08-12 |
human |
| A Kaipia, S Y Chun, K Eisenhauer, A J Hsue. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895358. |
tumor necrosis factor-alpha (tnf alpha) is a cytokine capable of inducing apoptosis in diverse cell types, and the apoptotic effect of tnf alpha is, partially, coupled to the sphingomyelin signaling pathway with ceramide as a second messenger. |
1996-12-17 |
2023-08-12 |
rat |
| A Kaipia, S Y Chun, K Eisenhauer, A J Hsue. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895358. |
because tnf alpha has been localized in the rat ovary, and tnf alpha treatment increases granulosa cell ceramide production, we studied the effect of treatment with tnf alpha and ceramide on follicle apoptosis. |
1996-12-17 |
2023-08-12 |
rat |
| A Kaipia, S Y Chun, K Eisenhauer, A J Hsue. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895358. |
to study the mechanism of tnf alpha and ceramide action, the effect of sodium aurathiomalate (atm), an inhibitor of interleukin-1 beta-converting enzyme/ced-3-related cystine proteases known to be essential in the execution of mammalian cell apoptosis, was studied. |
1996-12-17 |
2023-08-12 |
rat |
| A Kaipia, S Y Chun, K Eisenhauer, A J Hsue. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895358. |
treatment with atm (1 mm) prevented the apoptosis-inducing effect of both tnf alpha and ceramide, suggesting a role for cysteine proteases in mediating follicle apoptosis. |
1996-12-17 |
2023-08-12 |
rat |
| A Kaipia, S Y Chun, K Eisenhauer, A J Hsue. Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895358. |
in summary, treatment with tnf alpha or its second messenger, ceramide, stimulates apoptosis of early antral follicles in culture, suggesting a potential role for tnf alpha as an intraovarian regulator of follicle atresia by acting through the ceramide signaling pathway. |
1996-12-17 |
2023-08-12 |
rat |
| Z G Liu, H Hsu, D V Goeddel, M Kari. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. vol 87. issue 3. 1996-12-16. PMID:8898208. |
dissection of tnf receptor 1 effector functions: jnk activation is not linked to apoptosis while nf-kappab activation prevents cell death. |
1996-12-16 |
2023-08-12 |
Not clear |
| Z G Liu, H Hsu, D V Goeddel, M Kari. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. vol 87. issue 3. 1996-12-16. PMID:8898208. |
through its type 1 receptor (tnfr1), the cytokine tnf elicits an unusually wide range of biological responses, including inflammation, tumor necrosis, cell proliferation, differentiation, and apoptosis. |
1996-12-16 |
2023-08-12 |
Not clear |
| Y Kato, A Morikawa, T Sugiyama, N Koide, G Z Jiang, K Takahashi, T Yokoch. Role of tumor necrosis factor-alpha and glucocorticoid on lipopolysaccharide (LPS)-induced apoptosis of thymocytes. FEMS immunology and medical microbiology. vol 12. issue 3-4. 1996-12-11. PMID:8745003. |
the injection of anti-tumor necrosis factor (tnf)-alpha antibody or ru38486, a glucocorticoid receptor antagonist, into mice definitely inhibited lps-induced apoptosis of thymocytes. |
1996-12-11 |
2023-08-12 |
mouse |
| A E Dear, Y Shen, M Rüegg, R L Medcal. Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression. European journal of biochemistry. vol 241. issue 1. 1996-12-05. PMID:8898893. |
plasminogen-activator inhibitor type 2 (pai-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(tnf)-mediated apoptosis. |
1996-12-05 |
2023-08-12 |
cat |
| S Gon, T Gatanaga, F Send. Involvement of two types of TNF receptor in TNF-alpha induced neutrophil apoptosis. Microbiology and immunology. vol 40. issue 6. 1996-12-04. PMID:8839434. |
involvement of two types of tnf receptor in tnf-alpha induced neutrophil apoptosis. |
1996-12-04 |
2023-08-12 |
human |
| B S Polla, A Cossarizz. Stress proteins in inflammation. EXS. vol 77. 1996-12-03. PMID:8856986. |
we propose that mitochondria are a key organelle in determining the outcome of inflammation, because they are both the cellular "switchboard" for apoptosis and a selective target for the protective effects of hsp against the cytotoxic effects of tnf alpha and ros. |
1996-12-03 |
2023-08-12 |
Not clear |