| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M I Pörn-Ares, S C Chow, J P Slotte, S Orreniu. Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. Experimental cell research. vol 235. issue 1. 1997-09-30. PMID:9281351. |
exposure of u937 cells for 6 h to tnf or anti-fas mab induced apoptosis in 40-45% of the cells, as measured by fluorescent staining of nuclear chromatin. |
1997-09-30 |
2023-08-12 |
Not clear |
| M I Pörn-Ares, S C Chow, J P Slotte, S Orreniu. Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. Experimental cell research. vol 235. issue 1. 1997-09-30. PMID:9281351. |
pma was found to inhibit d609-induced apoptosis in u937 cells as well as cell death induced by tnf and anti-fas mab. |
1997-09-30 |
2023-08-12 |
Not clear |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
neutrophil superoxide release is required for spontaneous and fmlp-mediated but not for tnf alpha-mediated apoptosis. |
1997-09-24 |
2023-08-12 |
Not clear |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
pmn apoptosis was detected by dna fragmentation, and ultraviolet and light microscopy, and was quantified by flow cytometry; superoxide release was measured by superoxide dismutase-inhibitable reduction of ferricytochrome c. incubation of pmn with 20 ng/ml tumor necrosis factor (tnf)alpha induced superoxide release (8.8 +/- 7.5 nmol o2-/30 min, n = 7) in normal pmn and also resulted in apoptosis within 2 h, whereas a subactivating dose of 2 ng/ml tnf alpha, which did not trigger superoxide release (3.1 +/- 1.7 nmol o2-, n = 10), did facilitate apoptosis, although to a lesser degree. |
1997-09-24 |
2023-08-12 |
Not clear |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
pmn cultured under nonstimulating conditions underwent apoptotic cell death after 8 h. exogenous superoxide dismutase did not inhibit apoptosis induced by 20 ng/ml tnf alpha. |
1997-09-24 |
2023-08-12 |
Not clear |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
in conclusion, aging and fmlp-stimulated pmn undergo apoptosis by a superoxide release-dependent pathway, whereas tnf alpha-facilitated apoptosis appears to be unrelated to respiratory burst oxidase activity. |
1997-09-24 |
2023-08-12 |
Not clear |
| P C Singhal, P Sharma, K Reddy, V Sanwal, J Rawal, N Gibbons, N Frank. HIV-1 gp160 envelope protein modulates proliferation and apoptosis in mesangial cells. Nephron. vol 76. issue 3. 1997-09-22. PMID:9226228. |
tumor necrosis factor (tnf)-alpha enhanced (p < 0.001) mmc apoptosis, and anti-tnf-alpha antibodies inhibited gp160-induced mmc apoptosis. |
1997-09-22 |
2023-08-12 |
mouse |
| S C Wright, U Schellenberger, L Ji, H Wang, J W Larric. Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 11. issue 11. 1997-09-18. PMID:9285482. |
however, k562, which is relatively resistant to apoptosis induced by either tnf or uv light, did not activate cam-kii in response to these stimuli. |
1997-09-18 |
2023-08-12 |
Not clear |
| F Su, R J Schneide. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 16. 1997-09-08. PMID:9238048. |
hbx induced apoptosis by prolonged stimulation of n-myc and the stress-mediated mitogen-activated-protein kinase kinase 1 (mekk1) pathway but not by up-regulating tnf receptors. |
1997-09-08 |
2023-08-12 |
human |
| M W Marino, A Dunn, D Grail, M Inglese, Y Noguchi, E Richards, A Jungbluth, H Wada, M Moore, B Williamson, S Basu, L J Ol. Characterization of tumor necrosis factor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 15. 1997-08-27. PMID:9223320. |
tnf appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular and mediator responses at the local site and systemically, to editing (e.g., apoptosis) injured cells or effete immune cells and repairing inflammatory damage. |
1997-08-27 |
2023-08-12 |
mouse |
| J E Saavedra, T R Billiar, D L Williams, Y M Kim, S C Watkins, L K Keefe. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. Journal of medicinal chemistry. vol 40. issue 13. 1997-08-07. PMID:9207935. |
of five cell types examined, only cultured hepatocytes metabolized o2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (v-pyrro/no) to no, triggering cyclic guanosine 3',5'-monophosphate (cgmp) synthesis and protecting the hepatocytes from apoptotic cell death induced by treatment with tumor necrosis factor-alpha (tnf alpha) plus actinomycin d. in vivo, v-pyrro/no increased liver cgmp levels while minimally affecting systemic hemodynamics, protecting rats dosed with tnf alpha plus galactosamine from apoptosis and hepatotoxicity. |
1997-08-07 |
2023-08-12 |
rat |
| H Kojima, R Datt. Involvement of a CrmA-insensitive ICE/Ced-3-like protease in ceramide-induced apoptosis. Oncology research. vol 8. issue 12. 1997-07-21. PMID:9160353. |
ceramide has emerged as a novel lipid mediator of tumor necrosis factor (tnf)-induced apoptosis. |
1997-07-21 |
2023-08-12 |
Not clear |
| H Kojima, R Datt. Involvement of a CrmA-insensitive ICE/Ced-3-like protease in ceramide-induced apoptosis. Oncology research. vol 8. issue 12. 1997-07-21. PMID:9160353. |
these results indicate that ceramide-induced apoptosis involves the activation of a crma-insensitive protease that is distinct from that induced by tnf. |
1997-07-21 |
2023-08-12 |
Not clear |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
recently, it was demonstrated that tumor necrosis factor alpha (tnf alpha) appears to be involved in the formation of sc since neutralization of tnf alpha both in vitro and in vivo reduced uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
in summary, the data demonstrate that ptx can reduce the formation of sc both in vitro and in vivo and thus further support that tnf alpha is involved in uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| C J Gamard, G S Dbaibo, B Liu, L M Obeid, Y A Hannu. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. The Journal of biological chemistry. vol 272. issue 26. 1997-07-16. PMID:9195956. |
the p55 tumor necrosis factor (tnf) receptor shares with the related apo-1/fas antigen the ability to initiate apoptosis. |
1997-07-16 |
2023-08-12 |
Not clear |
| S H Khoo, L Pepper, N Snowden, A H Hajeer, P Vallely, E G Wilkins, B K Mandal, W E Ollie. Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression. AIDS (London, England). vol 11. issue 4. 1997-07-08. PMID:9084788. |
tumour necrosis factor (tnf)-alpha and lymphotoxin stimulate hiv replication and may induce apoptosis of hiv-infected and uninfected lymphocytes in vitro, thus accelerating disease progression and cd4 depletion. |
1997-07-08 |
2023-08-12 |
human |
| U Spengler, R Zachoval, H Gallati, M C Jung, R Hoffmann, G Riethmüller, G Pap. Serum levels and in situ expression of TNF-alpha and TNF-alpha binding proteins in inflammatory liver diseases. Cytokine. vol 8. issue 11. 1997-07-07. PMID:9047083. |
as cytotoxicity and apoptosis by tnf are mediated mainly via tnf-alpha r-b, our results are consistent with more severe tnf-alpha induced liver damage in alcoholic hepatitis as compared to viral hepatitis. |
1997-07-07 |
2023-08-12 |
Not clear |
| O Ebert, S Finke, A Salahi, M Herrmann, B Trojaneck, P Lefterova, E Wagner, R Kircheis, D Huhn, F Schriever, I G Schmidt-Wol. Lymphocyte apoptosis: induction by gene transfer techniques. Gene therapy. vol 4. issue 4. 1997-06-23. PMID:9176514. |
since apoptosis may be mediated via the tnf alpha and tnf alpha receptor pathway, we studied the amount of tnf secreted by transfected lymphocytes. |
1997-06-23 |
2023-08-12 |
Not clear |
| O Ebert, S Finke, A Salahi, M Herrmann, B Trojaneck, P Lefterova, E Wagner, R Kircheis, D Huhn, F Schriever, I G Schmidt-Wol. Lymphocyte apoptosis: induction by gene transfer techniques. Gene therapy. vol 4. issue 4. 1997-06-23. PMID:9176514. |
in conclusion, gene transfer techniques led to tnf secretion, apoptosis and necrosis of lymphocytes. |
1997-06-23 |
2023-08-12 |
Not clear |