| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Haimovitz-Friedman, C Cordon-Cardo, S Bayoumy, M Garzotto, M McLoughlin, R Gallily, C K Edwards, E H Schuchman, Z Fuks, R Kolesnic. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. The Journal of experimental medicine. vol 186. issue 11. 1997-12-30. PMID:9382882. |
tnf-binding protein, which protects against lps-induced death, blocked lps-induced ceramide generation and endothelial apoptosis, suggesting systemic tnf is required for both responses. |
1997-12-30 |
2023-08-12 |
mouse |
| A Haimovitz-Friedman, C Cordon-Cardo, S Bayoumy, M Garzotto, M McLoughlin, R Gallily, C K Edwards, E H Schuchman, Z Fuks, R Kolesnic. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. The Journal of experimental medicine. vol 186. issue 11. 1997-12-30. PMID:9382882. |
these investigations demonstrate that lps induces a disseminated form of endothelial apoptosis, mediated sequentially by tnf and ceramide generation, and suggest that this cascade is mandatory for evolution of the endotoxic syndrome. |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
tumour necrosis factor alpha (tnf alpha) suppresses apoptosis and induces dna synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
rat recombinant tnf alpha was found to stimulate dna synthesis and suppress apoptosis in isolated rat hepatocyte monolayers (p < or = 0.01). |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
suppression of mouse hepatocyte apoptosis by tnf alpha was not detected, possibly because of the low levels of apoptosis under control conditions. |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
however, when the levels of mouse hepatocyte apoptosis were augmented using tgf beta1, tnf alpha caused a significant suppression (p < or = 0.01). |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
the neutralization of tnf alpha using anti-tnf alpha antibodies abrogated significantly (p < or = 0.01) the suppression of apoptosis by the pp, nafenopin. |
1997-12-30 |
2023-08-12 |
mouse |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
interestingly ark signaling protects from apoptosis induced by serum deprivation, myc overexpression, or by tnf alpha but not from u.v. |
1997-12-29 |
2023-08-12 |
mouse |
| D Kobayashi, N Watanabe, N Yamauchi, N Tsuji, T Sato, H Sasaki, T Okamoto, Y Niits. Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells. Chemotherapy. vol 43. issue 6. 1997-12-29. PMID:9395855. |
in this report we show augmentation of tumor necrosis factor (tnf)-induced apoptosis by protein kinase c (pkc) inhibitors in human embryonic lung fibroblast (hel) cells. |
1997-12-29 |
2023-08-12 |
human |
| D Kobayashi, N Watanabe, N Yamauchi, N Tsuji, T Sato, H Sasaki, T Okamoto, Y Niits. Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells. Chemotherapy. vol 43. issue 6. 1997-12-29. PMID:9395855. |
we investigated whether sts or another potent pkc inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (h7), augmented tnf-induced apoptosis in normal human diploid cells and examined the effects of the pkc inhibitors on the expression of endogenous tnf (entnf) and manganous superoxide dismutase (mnsod) as possible cell resistance factors opposing tnf-induced apoptosis. |
1997-12-29 |
2023-08-12 |
human |
| R Schulte-Hermann, W Bursch, A Löw-Baselli, A Wagner, B Grasl-Kraup. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell biology and toxicology. vol 13. issue 4-5. 1997-12-24. PMID:9298254. |
in the liver, endogenous factors, such as transforming growth factor beta 1 (tgf-beta 1), activin a, cd95 ligand, and tumor necrosis factor (tnf) may be involved in induction of apoptosis. |
1997-12-24 |
2023-08-12 |
human |
| W Takasaki, Y Kajino, K Kajino, R Murali, M I Green. Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF alpha binding to its receptor. Nature biotechnology. vol 15. issue 12. 1997-12-18. PMID:9359109. |
biologically, the mimetics inhibited tnf alpha-mediated apoptosis. |
1997-12-18 |
2023-08-12 |
Not clear |
| P L Jones, D Ping, J M Bos. Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Molecular and cellular biology. vol 17. issue 12. 1997-12-16. PMID:9372929. |
manganese superoxide dismutase (mnsod), a tumor necrosis factor (tnf)-inducible reactive oxygen-scavenging enzyme, protects cells from tnf-mediated apoptosis. |
1997-12-16 |
2023-08-12 |
Not clear |
| H Walczak, M A Degli-Esposti, R S Johnson, P J Smolak, J Y Waugh, N Boiani, M S Timour, M J Gerhart, K A Schooley, C A Smith, R G Goodwin, C T Rauc. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. The EMBO journal. vol 16. issue 17. 1997-12-15. PMID:9311998. |
trail is a member of the tumor necrosis factor (tnf) family of cytokines and induces apoptosis in a wide variety of cells. |
1997-12-15 |
2023-08-12 |
human |
| G Denecker, P Vandenabeele, J Grooten, L C Penning, W Declercq, R Beyaert, W A Buurman, W Fier. Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine. vol 9. issue 9. 1997-12-15. PMID:9325011. |
the authors investigated the dependence on extracellular and intracellular free ca2+ in the induction of apoptosis and secretion of granulocyte-macrophage colony-stimulating factor (gm-csf) by tumour necrosis factor (tnf) in a rat/mouse t cell hybridoma pc60 r55/r75, using the ca2+ chelators egta and bapta/am, respectively. |
1997-12-15 |
2023-08-12 |
Not clear |
| G Denecker, P Vandenabeele, J Grooten, L C Penning, W Declercq, R Beyaert, W A Buurman, W Fier. Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine. vol 9. issue 9. 1997-12-15. PMID:9325011. |
this differential requirement for ca2+ illustrates the partial functional redundancy between tnf and il-1, showing the activation of cytokine gene expression through a ca(2+)-dependent activation of calcineurin, and a ca(2+)-independent activation of apoptosis, exerted solely by tnf. |
1997-12-15 |
2023-08-12 |
Not clear |
| K J Pulkk. Cytokines and cardiomyocyte death. Annals of medicine. vol 29. issue 4. 1997-12-11. PMID:9375993. |
both tnf and fas-ligand have been able to induce programmed cell death (apoptosis) of cardiomyocytes in various experimental studies. |
1997-12-11 |
2023-08-12 |
Not clear |
| K J Pulkk. Cytokines and cardiomyocyte death. Annals of medicine. vol 29. issue 4. 1997-12-11. PMID:9375993. |
tnf and some other cytokines are able to induce nitric oxide production, which depresses cardiac function and can induce apoptosis. |
1997-12-11 |
2023-08-12 |
Not clear |
| S Ansorge, F Bühling, T Kähne, U Lendeckel, D Reinhold, M Täger, S Wrenge. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in experimental medicine and biology. vol 421. 1997-11-25. PMID:9330689. |
inhibition of dna synthesis in t lymphocytes, b lymphocytes, nk cells and myelomonocytic cells as well as of the production of il-2, il-6 tnf alpha, il-1, il-10, il-12, il-13, ifn-gamma, gm-csf are not due to apoptosis of these cells. |
1997-11-25 |
2023-08-12 |
Not clear |
| C Binder, L Binder, M Kroemker, M Schulz, W Hiddeman. Influence of cycloheximide-mediated downregulation of glucose transport on TNF alpha-induced apoptosis. Experimental cell research. vol 236. issue 1. 1997-11-25. PMID:9344602. |
influence of cycloheximide-mediated downregulation of glucose transport on tnf alpha-induced apoptosis. |
1997-11-25 |
2023-08-12 |
Not clear |