| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Klefstrom, E Arighi, T Littlewood, M Jäättelä, E Saksela, G I Evan, K Alital. Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. The EMBO journal. vol 16. issue 24. 1998-02-19. PMID:9405367. |
the c-terminal domain of p53, which is a transacting dominant inhibitor of wild-type p53, failed to inhibit apoptosis by c-myc and tnf, suggesting that the cell death was not dependent on the transcription-activating function of p53. |
1998-02-19 |
2023-08-12 |
mouse |
| C Hermann, A M Zeiher, S Dimmele. Shear stress inhibits H2O2-induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase. Arteriosclerosis, thrombosis, and vascular biology. vol 17. issue 12. 1998-02-03. PMID:9437209. |
similar results were obtained when apoptosis was stimulated by tumor necrosis factor alpha (tnf alpha). |
1998-02-03 |
2023-08-12 |
human |
| T Tsuj. [Cell-biological changes on the disordered tissues]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. vol 51. issue 5. 1998-02-02. PMID:9436362. |
it seems that appearance of necrosis and apoptosis is caused by action of tnf alpha derived from neutrophils, since generation of tnf alpha was confirmed electron microscopically. |
1998-02-02 |
2023-08-12 |
rat |
| J Dong, M Naito, T Mashima, W H Jang, T Tsuru. Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-alpha-induced apoptosis. Journal of cellular physiology. vol 174. issue 2. 1998-01-30. PMID:9428804. |
tumor necrosis factor-alpha (tnf-alpha) is a cytokine that induces apoptosis in various cell systems by binding to the tnf receptor (tnfr). |
1998-01-30 |
2023-08-12 |
human |
| T Taniguchi, M Takata, A Ikeda, E Momotani, K Sekikaw. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Laboratory investigation; a journal of technical methods and pathology. vol 77. issue 6. 1998-01-27. PMID:9426403. |
tnf alpha-deficient mice are resistant to lethal doses of endotoxin and d-galactosamine without hepatocyte apoptosis, yet demonstrate thymus apoptosis. |
1998-01-27 |
2023-08-12 |
mouse |
| T Taniguchi, M Takata, A Ikeda, E Momotani, K Sekikaw. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Laboratory investigation; a journal of technical methods and pathology. vol 77. issue 6. 1998-01-27. PMID:9426403. |
our results indicated an important role for tnf alpha in germinal center formation and in the sepsis-induced hepatocyte apoptosis that precedes liver failure. |
1998-01-27 |
2023-08-12 |
mouse |
| M Toborek, E M Blanc, S Kaiser, M P Mattson, B Henni. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. Journal of lipid research. vol 38. issue 10. 1998-01-21. PMID:9374137. |
to test this hypothesis, oxidative stress, intracellular calcium levels, endothelial barrier function, cell viability, and apoptosis were measured in vascular endothelial cells treated with 90 microm linoleic acid (18:2, n-6) and/or 20 ng/ml tnf (100 u/ml). |
1998-01-21 |
2023-08-12 |
Not clear |
| M Toborek, E M Blanc, S Kaiser, M P Mattson, B Henni. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. Journal of lipid research. vol 38. issue 10. 1998-01-21. PMID:9374137. |
although initial treatment with tnf or 18:2 significantly increased oxidative stress and intracellular calcium levels, only exposure to tnf induced apoptosis in cultured endothelial cells. |
1998-01-21 |
2023-08-12 |
Not clear |
| M Toborek, E M Blanc, S Kaiser, M P Mattson, B Henni. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. Journal of lipid research. vol 38. issue 10. 1998-01-21. PMID:9374137. |
furthermore, the combined exposure to 18:2 + tnf potentiated tnf-induced apoptosis. |
1998-01-21 |
2023-08-12 |
Not clear |
| P Ranjan, A Sodhi, A Srivastav. Cisplatin and interferon-gamma treated murine macrophages induce apoptosis in tumor cell lines. Anti-cancer drugs. vol 8. issue 8. 1998-01-16. PMID:9396625. |
in l929 cells, the effector molecule was found to be tumor necrosis factor (tnf)-alpha as apoptosis was blocked by the addition of anti-tnf-alpha antibodies to the co-culture but the addition of l-nmma or snp had no effect. |
1998-01-16 |
2023-08-12 |
Not clear |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
mitochondrial ultracondensation, but not swelling, is involved in tnf alpha-induced apoptosis in human t-lymphoblastic leukaemic cells. |
1998-01-05 |
2023-08-12 |
human |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
conformational alterations of mitochondria induced by tumour necrosis factor-alpha (tnf alpha), and the association with tnf alpha-induced apoptosis, were, therefore, studied in the human acute t-lymphoblastic leukaemia (t-all) cell line, ccrf-cem and its vinblastine-resistant cem/vlb100 cell line by transmission electron microscopy (tem). |
1998-01-05 |
2023-08-12 |
human |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
ultracondensed (uc phase) mitochondria were observed in cells undergoing both tnf alpha-induced and spontaneous apoptosis and were seen when tnf alpha-induced apoptosis was inhibited by 3-methyladenine (3ma). |
1998-01-05 |
2023-08-12 |
human |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
we conclude that tnf alpha-induced mitochondrial swelling and apoptosis are separate events. |
1998-01-05 |
2023-08-12 |
human |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
mitochondrial ultracondensation is associated with the processes signalling apoptosis and is not a result of tnf alpha-induced apoptotic shrinkage. |
1998-01-05 |
2023-08-12 |
human |
| A Haimovitz-Friedman, C Cordon-Cardo, S Bayoumy, M Garzotto, M McLoughlin, R Gallily, C K Edwards, E H Schuchman, Z Fuks, R Kolesnic. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. The Journal of experimental medicine. vol 186. issue 11. 1997-12-30. PMID:9382882. |
tnf-binding protein, which protects against lps-induced death, blocked lps-induced ceramide generation and endothelial apoptosis, suggesting systemic tnf is required for both responses. |
1997-12-30 |
2023-08-12 |
mouse |
| A Haimovitz-Friedman, C Cordon-Cardo, S Bayoumy, M Garzotto, M McLoughlin, R Gallily, C K Edwards, E H Schuchman, Z Fuks, R Kolesnic. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. The Journal of experimental medicine. vol 186. issue 11. 1997-12-30. PMID:9382882. |
these investigations demonstrate that lps induces a disseminated form of endothelial apoptosis, mediated sequentially by tnf and ceramide generation, and suggest that this cascade is mandatory for evolution of the endotoxic syndrome. |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
tumour necrosis factor alpha (tnf alpha) suppresses apoptosis and induces dna synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
rat recombinant tnf alpha was found to stimulate dna synthesis and suppress apoptosis in isolated rat hepatocyte monolayers (p < or = 0.01). |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
suppression of mouse hepatocyte apoptosis by tnf alpha was not detected, possibly because of the low levels of apoptosis under control conditions. |
1997-12-30 |
2023-08-12 |
mouse |