| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sajmina Khatun, Monika Pebam, Chandra Lekha Putta, Aravind Kumar Renga. Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells. Biomaterials science. 2023-02-13. PMID:36779378. |
enhanced uptake of ccs nps in zebrafish embryos and 4t1 cells, cancer cell toxicity of nearly 80-85%, sub-cellular mitochondrial localization, alterations of mitochondrial membrane potential, lysosomal localization, and reactive oxygen species generation that causes cancer cell apoptosis have been observed. |
2023-02-13 |
2023-08-14 |
zebrafish |
| Jingtong Zhao, Xupeng Mu, Xuejia Hou, Xiaowen Zhang, Ping Li, Jinlan Jian. Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA. Frontiers in oncology. vol 13. 2023-02-09. PMID:36756155. |
to make chemotherapy safer and more effective for osteosarcoma patients, biomimetic nanoparticles (nps) camouflaged by mesenchymal stem cell membranes (mscms) were synthesized to induce osteosarcoma cell apoptosis by co-delivering the anticancer drug doxorubicin hydrochloride(dox) and a small interfering rna (sirna). |
2023-02-09 |
2023-08-14 |
Not clear |
| Sitong Liu, Chen Zhang, Yuanyuan Zhou, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang, Zhong Ca. MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy. Biomaterials. vol 295. 2023-02-09. PMID:36758340. |
a series of in vitro studies showed that the sustained release of dex from damm nps suppressed synovial inflammation and simultaneously inhibited toll-like receptor 3 (tlr-3) production in chondrocytes, contributing to prevention of chondrocyte apoptosis through the inflammatory factor-dependent tlr-3/nf-κb signaling pathway via modulation of macrophage-chondrocyte crosstalk. |
2023-02-09 |
2023-08-14 |
mouse |
| Yi Yan, An Lu, Yun Dou, Zhen Zhang, Xiang-Yu Wang, Lin Zhai, Li-Ya Ai, Ming-Ze Du, Lin-Xia Jiang, Yuan-Jun Zhu, Yu-Jie Shi, Xiao-Yan Liu, Dong Jiang, Jian-Cheng Wan. Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-02-07. PMID:36748885. |
in vitro experiments demonstrate that these nps can significantly scavenge intracellular no similar to the levels as those in the normal group and downregulate the expression levels of ca9 mrna (≈90%), thereby repolarizing the m1 macrophages into the m2 phenotype and increasing the expression levels of pro-chondrogenic tgf-β1 mrna (≈1.3-fold), and inhibiting chondrocyte apoptosis. |
2023-02-07 |
2023-08-14 |
mouse |
| Jing Li, Yi-Fei Wang, Zi-Chun Shen, Qi Zou, Xiao-Fan Lin, Xiao-Yin Wan. Recent developments on natural polysaccharides as potential anti-gastric cancer substance: Structural feature and bioactivity. International journal of biological macromolecules. 2023-01-27. PMID:36706878. |
nps exhibited anti-gc activities in cell and animal experiments as well as clinical trials, and the mechanisms might be anti-proliferation, inducing apoptosis, anti-metastasis and anti-invasion, inducing autophagy, boosting immunity, anti-angiogenesis, reducing drug resistance, anti-angiogenesis, improving antioxidant level and changing metabolites. |
2023-01-27 |
2023-08-14 |
human |
| Shenglong Xia, Zimo Liu, Jieru Cai, Huiming Ren, Qi Li, Hongfang Zhang, Jing Yue, Quan Zhou, Tianhua Zhou, Liangjing Wang, Xiangrui Liu, Xuefei Zho. Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells. Journal of controlled release : official journal of the Controlled Release Society. 2023-01-24. PMID:36693527. |
non-coated nps loaded with atra) only showed the ability to induce apoptosis and decrease the α-sma expression in ahscs, respectively, tm-atra/nps induced both apoptosis and quiescence in ahscs, ultimately leading to improved fibrosis amelioration in both carbon tetrachloride-induced and methionine and choline deficient l-amino acid diet induced liver fibrosis mouse models. |
2023-01-24 |
2023-08-14 |
mouse |
| Chen Zhang, Wu Zhong, Ying Cao, Bohao Liu, Xiaojun Tao, Zhuan L. Sorafenib/2800Z Co-Loaded into Cholesterol and PEG Grafted Polylysine NPs for Liver Cancer Treatment. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678616. |
in addition, s2@pspc nps inhibited the proliferation and induced apoptosis of liver cancer cells in vitro. |
2023-01-21 |
2023-08-14 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research. 2023-01-20. PMID:36662347. |
this study investigated the effect of novel zinc oxide nanoparticles (zno nps) biosynthesized employing papaver somniferum leaf on oxidative stress, necrosis, and apoptosis in the leukemia cancer thp-1 cell. |
2023-01-20 |
2023-08-14 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research. 2023-01-20. PMID:36662347. |
thp-1 cells were subjected to an mtt, an edu proliferation, a lactate dehydrogenase release tests, a reactive oxygen species (ros) induction experiment, a dapi staining detection assay, and a flow cytometric analysis for annexin v to measure the effects of zno nps on cancer cell growth inhibition, apoptosis, and necrosis. |
2023-01-20 |
2023-08-14 |
Not clear |
| Afraa Ali Kadhim, Nahida R Abbas, Hussam H Kadhum, Salim Albukhaty, Majid S Jabir, Amel Muhson Naji, Sawsan S Hamzah, Mustafa K A Mohammed, Hassan Al-Karagol. Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line. Biological trace element research. 2023-01-20. PMID:36662347. |
it was observed that zno nps triggered necrosis (cell death) and apoptosis in the cell line. |
2023-01-20 |
2023-08-14 |
Not clear |
| Yuanyuan He, Raimundo Fernandes de Araújo Júnior, Rômulo S Cavalcante, Zhenfeng Yu, Timo Schomann, Zili Gu, Christina Eich, Luis J Cru. Effective breast cancer therapy based on palmitic acid-loaded PLGA nanoparticles. Biomaterials advances. vol 145. 2023-01-05. PMID:36603405. |
at the molecular level, plga-pa nps reduced the expression of genes associated with multi-drug resistance and inhibition of apoptosis, and induced apoptosis via a caspase-3-independent pathway in breast cancer cells. |
2023-01-05 |
2023-08-14 |
mouse |
| Quan Sun, Hongqin Ma, Jiaxiong Zhang, Baiyang You, Xiaohui Gong, Xiaolin Zhou, Jin Chen, Guogang Zhang, Jia Huang, Qiong Huang, Yurong Yang, Kelong Ai, Yongping Ba. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-12-25. PMID:36567266. |
the therapeutic mechanism of ssse nps is intensively investigated through a series of experiments and mainly involved five critical aspects of myocardial repair: protecting mitochondria, reducing cardiomyocyte apoptosis and ferroptosis, reducing inflammation and fibrosis, and promoting angiogenesis. |
2022-12-25 |
2023-08-14 |
Not clear |
| Meimei Wang, Yu Feng, Zhenxiao Cao, Na Yu, Juan Wang, Xiaowei Wang, Dixiang Kang, Mingqin Su, Jian Hu, Hua D. Multiple generation exposure to ZnO nanoparticles induces loss of genomic integrity in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 249. 2022-12-12. PMID:36508841. |
we observed that pristine zno nps elicit germ cell apoptosis to a greater extent than the 60-day aged zno nps. |
2022-12-12 |
2023-08-14 |
caenorhabditis_elegans |
| Han Wang, Yilan Wu, Xiaoyan Li. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 1. 2022-12-02. PMID:36459216. |
czt/pd-pt nps were synthesized and characterized, and their effects on pc-9 cell viability and apoptosis were determined. |
2022-12-02 |
2023-08-14 |
Not clear |
| Han Wang, Yilan Wu, Xiaoyan Li. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 1. 2022-12-02. PMID:36459216. |
tunel assay and western blot were respectively applied for the determination of cell apoptosis and apoptosis-related protein expression, while liver function-related index expression detection and liver histopathological detection were used to evaluate the hepatotoxicity of czt/pd-pt nps. |
2022-12-02 |
2023-08-14 |
Not clear |
| Han Wang, Yilan Wu, Xiaoyan Li. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer. Medical oncology (Northwood, London, England). vol 40. issue 1. 2022-12-02. PMID:36459216. |
in addition, czt/pd-pt nps significantly inhibited pc-9 cell viability and promoted cell apoptosis both in vitro and in vivo, exhibiting superior cytotoxicity. |
2022-12-02 |
2023-08-14 |
Not clear |
| Zhihang Yang, Yufan Du, Lei Lei, Xue Xia, Xiaorong Wang, Fan Tong, Yuan Li, Huile Ga. Co-delivery of ibrutinib and hydroxychloroquine by albumin nanoparticles for enhanced chemotherapy of glioma. International journal of pharmaceutics. 2022-11-27. PMID:36436742. |
cck-8 and apoptosis assays demonstrated that ibr&hcq hsa nps showed maximal cytotoxicity to c6 cells. |
2022-11-27 |
2023-08-14 |
mouse |
| Azam Bozorgi, Zahra Haghighi, Mohammad Rasool Khazaei, Maryam Bozorgi, Mozafar Khazae. The anti-cancer effect of chitosan/resveratrol polymeric nanocomplex against triple-negative breast cancer; an in vitro assessment. IET nanobiotechnology. 2022-11-24. PMID:36420812. |
herein, the authors synthesised chitosan nanoparticles (cs nps) as a resveratrol (rsv) carrier and evaluated their efficacy in stimulating apoptosis in mda-mb 231 cells. |
2022-11-24 |
2023-08-14 |
Not clear |
| Maqusood Ahamed, Rashid Lateef, Mohd Javed Akhtar, Pavan Rajanahall. Dietary Antioxidant Curcumin Mitigates CuO Nanoparticle-Induced Cytotoxicity through the Oxidative Stress Pathway in Human Placental Cells. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364205. |
the apoptosis data also exhibited that cuo nps modulate the expression of several genes (p53, bax, bcl-2, casp3, and casp9), the activity of enzymes (caspase-3 and -9), and mitochondrial membrane potential loss, which was successfully reverted by co-treatment with curcumin. |
2022-11-11 |
2023-08-14 |
human |
| Kuo-Wei Chen, Po-Hung Hsu, Hau-Lun Huang, Hao-Li Liu, Ya-Tin Lin, Che-Yu Hsu, Jui-Hsiang Lin, Yu-Hsin Li. Targeting nanoparticle-conjugated microbubbles combined with ultrasound-mediated microbubble destruction for enhanced tumor therapy. Pharmacological research. 2022-11-05. PMID:36334876. |
we demonstrated the transfer of targeted nps and their entry into gastric cancer cells through ligand-specific recognition, followed by enhanced cell growth inhibition owing to drug delivery-induced apoptosis. |
2022-11-05 |
2023-08-14 |
mouse |