| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Wang Pan, Jin-Song Huang, Shou-Rong Liu, Yi-Dan Shao, Jian-Jun Xi, Ruo-Yu He, Ting-Ting Shi, Rang-Xiao Zhuang, Jian-Feng Ba. Evaluation of the liver targeting and anti‑liver cancer activity of artesunate‑loaded and glycyrrhetinic acid‑coated nanoparticles. Experimental and therapeutic medicine. vol 26. issue 5. 2023-10-20. PMID:37854499. |
additionally, art/ga-peg-plga nps induced internal apoptosis pathways by upregulating the activity of cleaved caspase-3/7 and expression of cleaved poly (adp-ribose)-polymerase and phos-p38 mitogen-activated protein kinase in hepg2 cells. |
2023-10-20 |
2023-11-08 |
Not clear |
| Sanjib Das, Moumita Saha, Lokesh Chandra Mahata, Arya China, Niloy Chatterjee, Krishna Das Sah. Quercetin and 5-Fu Loaded Chitosan Nanoparticles Trigger Cell-Cycle Arrest and Induce Apoptosis in HCT116 Cells via Modulation of the p53/p21 Axis. ACS omega. vol 8. issue 40. 2023-10-16. PMID:37841142. |
cells were treated with cs-5-fu-qct nps and incubated for 12, 24, and 36 h, and apoptosis analysis (using annexin v/fitc), cell-cycle analysis, western blotting, and confocal microscopic analysis were performed. |
2023-10-16 |
2023-11-08 |
Not clear |
| Domenica Giannandrea, Marco Parolini, Valentina Citro, Beatrice De Felice, Alex Pezzotta, Nazanin Abazari, Natalia Platonova, Michela Sugni, Martina Chiu, Alessandro Villa, Elena Lesma, Raffaella Chiaramonte, Lavinia Casat. Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells. Journal of hazardous materials. vol 462. 2023-10-11. PMID:37820528. |
nps affect cell viability and induce ros production and apoptosis (by caspase 3/7 activation) in pre-osteoblasts, osteocytes, and pre-osteoclasts. |
2023-10-11 |
2023-10-15 |
human |
| Sarvenaz Kashefi, Samira Mohammadi-Yeganeh, Fatemeh Ghorbani-Bidkorpeh, Mahdi Shabani, Ameneh Koochaki, Mehrnoush Safarzadeh, Mostafa Haji Molla Hosein. Anti-cancer effects of a chitosan based nanoformulation expressing miR-340 on 4T1 breast cancer cells. Journal of pharmaceutical sciences. 2023-10-08. PMID:37806438. |
furthermore, nps demonstrated appropriate transfection efficiency and could induce apoptosis, so had toxicity in 4t1 bc cells. |
2023-10-08 |
2023-10-15 |
Not clear |
| Shushan Zhang, Yongquan Huang, Songying Pi, Hui Chen, Feile Ye, Chaoqun Wu, Liujun Li, Qing Ye, Yuhong Lin, Zhongzhen S. Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA. Journal of nanobiotechnology. vol 21. issue 1. 2023-10-03. PMID:37789342. |
we found that szp nps inhibited proliferation and stimulated apoptosis of residual tumor cells exposed to sublethal heat stress in an autophagy-dependent manner. |
2023-10-03 |
2023-10-07 |
Not clear |
| Heping Qiu, Jianwu Wang, Yi Zhi, Benhuang Yan, Yuandi Huang, Jinjin Li, Chongxing Shen, Linyong Dai, Qiang Fang, Chunmeng Shi, Weibing L. Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer. ACS applied materials & interfaces. 2023-09-28. PMID:37769147. |
encouragingly, intravesical instillation of hr-pdd nps improved drug retention in the bladder and promoted its accumulation in tumor tissue, resulting in better tumor proliferation inhibition and apoptosis in an orthotopic bladder cancer model in rats. |
2023-09-28 |
2023-10-07 |
rat |
| Lara Scheherazade Milane, Saket Dolare, Guangwen Ren, Mansoor Amij. Combination Organelle Mitochondrial Endoplasmic Reticulum Therapy (COMET) for multidrug resistant breast cancer. Journal of controlled release : official journal of the Controlled Release Society. 2023-09-17. PMID:37717658. |
the therapeutic rationale of comet is to reduce the apoptotic threshold in mdr cells with mind nps, followed by inducing the endoplasmic reticulum mediated unfolded protein response (upr) by stressing mdr cells with tunicamycin, and finally, directly inducing mitochondrial apoptosis with bam 7 which is a specific bcl-2 bax activator. |
2023-09-17 |
2023-10-07 |
Not clear |
| Wali Muhammad, Yiru Zhang, Jiaqi Zhu, Jieqi Xie, Shuqin Wang, Ruo Wang, Bing Feng, Jiahang Zhou, Wenyi Chen, Yanping Xu, Qigu Yao, Yingduo Yu, Hongcui Cao, Changyou Ga. Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury. Biomaterials advances. vol 154. 2023-09-15. PMID:37714042. |
the administration of azi+ibf@nps via the tail veins dramatically reduced the number of neutrophils, significantly reduced cell apoptosis and total protein concentration in vivo. |
2023-09-15 |
2023-10-07 |
Not clear |
| Xueqiang Sun, Fuxin Li, Lingyan Yuan, Zhitong Bing, Xun Li, Kehu Yan. pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis. Journal of biomedical materials research. Part B, Applied biomaterials. 2023-09-13. PMID:37702969. |
3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (mtt assay), hoechst 33342/pi staining, cell scratch assay, transwell and reverse transcription quantitative pcr (rt-qpcr) assays further demonstrated that res@zif-8/ta nps inhibited colon cancer cell migration and invasion, and promoted apoptosis of colon cancer cells, suggesting a therapeutic potential and demonstrating anti-cancer properties. |
2023-09-13 |
2023-10-07 |
Not clear |
| Suhair Sunoqrot, Samah Abusulieh, Osama H Abusar. Identifying Synergistic Combinations of Doxorubicin-Loaded Polyquercetin Nanoparticles and Natural Products: Implications for Breast Cancer Therapy. International journal of pharmaceutics. 2023-09-08. PMID:37683979. |
however, combinations containing cur exhibited greater pro-apoptotic effects compared to the single agents, with polymer-modified pqct nps presenting as a promising nanoplatform for enhancing dox's ability to promote cancer cell apoptosis. |
2023-09-08 |
2023-10-07 |
Not clear |
| Yuanxiang Yu, Sijin Chen, Yupeng Wang, Dongfang Zhou, Dehua W. Fighting Against Drug-resistant Tumor by The Induction of Excessive Mitophagy with Transferrin Nanomedicine. Macromolecular bioscience. 2023-09-07. PMID:37677756. |
additionally, htf@dox/qu nps can upregulate proapoptotic proteins to induce cellular apoptosis, thereby effectively reversing drug resistance. |
2023-09-07 |
2023-10-07 |
human |
| Jiraphong Suksiriworapong, Chittin Achayawat, Phutthikom Juangrattanakamjorn, Vincenzo Taresco, Valentina Cuzzucoli Crucitti, Krisada Sakchaisri, Somnuk Bunsup. Modification of Poly(Glycerol Adipate) with Tocopherol and Cholesterol Modulating Nanoparticle Self-Assemblies and Cellular Responses of Triple-Negative Breast Cancer Cells to SN-38 Delivery. Pharmaceutics. vol 15. issue 8. 2023-08-26. PMID:37631315. |
both types of nps did not affect apoptosis or the cell cycle of cancer cells. |
2023-08-26 |
2023-09-07 |
Not clear |
| Jiraphong Suksiriworapong, Chittin Achayawat, Phutthikom Juangrattanakamjorn, Vincenzo Taresco, Valentina Cuzzucoli Crucitti, Krisada Sakchaisri, Somnuk Bunsup. Modification of Poly(Glycerol Adipate) with Tocopherol and Cholesterol Modulating Nanoparticle Self-Assemblies and Cellular Responses of Triple-Negative Breast Cancer Cells to SN-38 Delivery. Pharmaceutics. vol 15. issue 8. 2023-08-26. PMID:37631315. |
compared with sn-38, the drug-loaded nps more profoundly induced sub-g1 in the cell cycle analysis and apoptosis of cancer cells in a similar pattern. |
2023-08-26 |
2023-09-07 |
Not clear |
| Xuemei Sun, Xuru Wang, Andy M Booth, Lin Zhu, Qi Sui, Bijuan Chen, Keming Qu, Bin Xi. New insights into the impact of polystyrene micro/nanoplastics on the nutritional quality of marine jacopever (Sebastes schlegelii). The Science of the total environment. 2023-08-26. PMID:37633373. |
nps triggered more cell apoptosis signals in ferroptosis and foxo signaling pathways than mps, destroying mitochondria structure. |
2023-08-26 |
2023-09-07 |
Not clear |
| Krishan Kumar, Shiv Govind Rawat, Manjit, Mohini Mishra, Priya, Ajay Kumar, Ruchi Chawl. Dual targeting pH responsive chitosan nanoparticles for enhanced active cellular internalization of gemcitabine in non-small cell lung cancer. International journal of biological macromolecules. 2023-07-31. PMID:37524283. |
in vitro cytotoxicity of nps quantified using cell based mtt, dapi and annexing-v/pi apoptosis assays showed superior antiproliferative activity of targeted nanoformulations (gmc-csn-sa-cxmab-nps ≫ gmc-csn-sa-nps, gmc-csn-cxmab-nps) over non-targeted nanoformulation (gmc-csn-nps) against a-549 cells. |
2023-07-31 |
2023-08-14 |
mouse |
| Eunsol Lee, Eun Seong Le. Development of pH-Responsive Hyaluronic Acid-Conjugated Cyclodextrin Nanoparticles for Chemo-/CO-Gas Dual Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514005. |
in vitro studies using mcf-7 tumor cells demonstrated that these nps were efficiently internalized by the cells expressing cd44 receptors and enhanced ptx/feco-mediated tumor cell apoptosis. |
2023-07-29 |
2023-08-14 |
Not clear |
| Pu Yao, Xiaowen Wang, Qianmei Wang, Qing Dai, Yu Peng, Qian Yuan, Nan Mou, Shan Lv, Bangbi Weng, Yu Wang, Fengjun Su. Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514014. |
in vitro cellular assays verified that dtx/rgd nps could be effectively internalized by 4t1 cells, obviously inducing apoptosis, blocking the cell cycle of 4t1 cells and consequently, killing tumor cells. |
2023-07-29 |
2023-08-14 |
mouse |
| Paola Trinidad Villalobos Gutiérrez, José Luis Muñoz Carrillo, Cuauhtémoc Sandoval Salazar, Juan Manuel Viveros Paredes, Oscar Gutiérrez Coronad. Functionalized Metal Nanoparticles in Cancer Therapy. Pharmaceutics. vol 15. issue 7. 2023-07-29. PMID:37514119. |
these nps can penetrate the cell and accumulate in the tumor tissue, resulting in a cytotoxic effect through the generation of ros, the induction of apoptosis, cell cycle arrest, dna fragmentation, and a photothermal effect. |
2023-07-29 |
2023-08-14 |
Not clear |
| Fatemeh Ghorbanzadeh, Davoud Jafari-Gharabaghlou, Mohammad Reza Dashti, Mehrdad Hashemi, Nosratollah Zargham. Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression. Medical oncology (Northwood, London, England). vol 40. issue 9. 2023-07-29. PMID:37515667. |
additionally, an apoptosis assay was conducted to assess the effect of free metf and metf-loaded nps on the programmed death of the caco2 cells, and the impact on the cell cycle was studied through a cell cycle test. |
2023-07-29 |
2023-08-14 |
human |
| Ramsés Santacruz-Márquez, Jodi A Flaws, Luz Del Carmen Sánchez-Peña, Isabel Hernández-Ocho. Exposure to Zinc Oxide Nanoparticles Increases Estradiol Levels and Induces an Antioxidant Response in Antral Ovarian Follicles In Vitro. Toxics. vol 11. issue 7. 2023-07-28. PMID:37505567. |
antral follicles from cd-1 mice were cultured with zno nps (5, 10, and 15 µg/ml) for 96 h. zno np exposure did not affect apoptosis and cell cycle regulators at any of the tested concentrations. |
2023-07-28 |
2023-08-14 |
mouse |