| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reena Sharma, Vivek Yadav, Shikha Jha, Sayali Dighe, Sanyog Jai. Unveiling the potential of ursolic acid modified hyaluronate nanoparticles for combination drug therapy in triple negative breast cancer. Carbohydrate polymers. vol 338. 2024-05-19. PMID:38763723. |
in vitro, ha-ua/ptx nps exhibited higher cytotoxicity, apoptosis, and mitochondrial depolarization compared to ptx alone. |
2024-05-19 |
2024-05-27 |
Not clear |
| Dan Zhang, Zhiyuan Wang, Hongmei Deng, Simeng Yi, Tao Li, Xinjiang Kang, Jun Li, Chang Li, Tingting Wang, Bo Xiang, Guang L. Zinc Oxide Nanoparticles Damage the Prefrontal Lobe in Mouse: Behavioral Impacts and Key Mechanisms. Toxicology letters. 2024-05-17. PMID:38759938. |
analysis of the degs based on fold change reveals that zno nps primarily regulate cell survival, proliferation, and apoptosis in neural cells, damaging the prefrontal lobe. |
2024-05-17 |
2024-05-27 |
mouse |
| Heba A H Abd Elhameed, Mai S Attia, Amira A A Mohamed, Shaimaa M I Alexeree, Eman I El Behery, Mahmoud Alagawany, Mayada R Farag, Alessandro Di Cerbo, Mahmoud M Azzam, Suzan Attia Mawe. The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats. Biological trace element research. 2024-05-13. PMID:38739260. |
ag nps also upregulated the hepatic and renal genes involved in inflammation such as the interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), nuclear factor kappa b (nf-κβ), apoptosis such as the bcl2 associated x (bax), casp3, and other related to metabolism including asparagine synthetase (asns), suppressor of cytokine signaling 3 (socs3), myc proto-oncogene (myc), and c-c motif chemokine ligand 2 (ccl2). |
2024-05-13 |
2024-05-27 |
human |
| Shuqing Dong, Yuqi Huang, Hanrong Yan, Huarong Tan, Liying Fan, Minghao Chao, Yiping Ren, Ming Guan, Jiaxin Zhang, Zhao Liu, Fenglei Ga. Ternary heterostructure-driven photoinduced electron-hole separation enhanced oxidative stress for triple-negative breast cancer therapy. Journal of nanobiotechnology. vol 22. issue 1. 2024-05-12. PMID:38735931. |
zinc oxide nanoparticles (zno nps) stand as among the most significant metal oxide nanoparticles in trigger the formation of reactive oxygen species (ros) and induce apoptosis. |
2024-05-12 |
2024-05-27 |
Not clear |
| Yuhan Zheng, Qingyun Wei, Xuan Han, Xiangmin Tao, Tao Cao, Tianbao Chen, Peng Cao, Qichen Zha. Homologous polydopamine ameliorates haemolysis of melittin for enhancing its anticancer efficacy. Journal of materials chemistry. B. 2024-05-10. PMID:38726737. |
after cellular uptake, mpf nps induce cell apoptosis through the pi3k/akt-mediated p53 signaling pathway. |
2024-05-10 |
2024-05-27 |
mouse |
| Hanyue Zheng, Geyu Liang, Chunliu Guan, Lin Liu, Jiahui Dong, Jinshun Zhao, Meng Tang, Lu Kon. Mitochondrial Fission in Nickel Nanoparticle-Induced Reproductive Toxicity: An In Vitro GC-1 Cell Study. Nanomaterials (Basel, Switzerland). vol 14. issue 8. 2024-04-26. PMID:38668183. |
herein, we demonstrated that the exposure of ni nps to the mouse-derived spermatogonia cell line (gc-1 cells) triggered drp1-mediated mitochondrial division and the enhanced impairment of mitochondria, consequently promoting mitochondria-dependent cell apoptosis. |
2024-04-26 |
2024-04-28 |
Not clear |
| Fahimeh Badparvar, Ahmad Poursattar Marjani, Roya Salehi, Fatemeh Ramezan. Dual pH/redox-responsive hyperbranched polymeric nanocarriers with TME-trigger size shrinkage and charge reversible ability for amplified chemotherapy of breast cancer. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609391. |
dtx-loaded nps induced higher apoptosis (p value < 0.001) in mda-mb-231 cells (71.5 ± 2.8%) compared to free dtx (42.3 ± 3.1%). |
2024-04-12 |
2024-04-15 |
Not clear |
| Yu-Hsin Chen, I-Ju Liu, Tzu-Chen Lin, Min-Chen Tsai, Shang-Hsiu Hu, Tsai-Ching Hsu, Yi-Ting Wu, Bor-Show Tzang, Wen-Hsuan Chian. PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion. International journal of biological macromolecules. 2024-04-05. PMID:38580018. |
after being internalized by ct26 cells, the nps under near-infrared laser irradiation produced massive singlet oxygen with the aid of thermo-enhanced intracellular gsh depletion to elicit mitochondrial damage and lipid peroxide formation, thus leading to ferroptosis and apoptosis. |
2024-04-05 |
2024-04-10 |
Not clear |
| Xiaokang Zhu, Li Xie, Jinming Tian, Yang Jiang, Erqun Song, Yang Son. A Multi-Mode Rhein-Based Nano-Platform Synergizing Ferrotherapy/Chemotherapy-induced Immunotherapy for Enhanced Tumor Therapy. Acta biomaterialia. 2024-04-03. PMID:38570106. |
to address these limitations, we designed a multi-mode nano-platform (mp-fa@r-f nps), which exhibited a synergistic effect of ferroptosis, apoptosis and induced immune response for enhanced antitumor therapy. |
2024-04-03 |
2024-04-06 |
Not clear |
| E Wen, Yi Cao, Shiwen He, Yuezhou Zhang, Lanlan You, Tingqiu Wang, Zhigang Wang, Jun He, Yi Fen. The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis. Journal of nanobiotechnology. vol 22. issue 1. 2024-04-03. PMID:38570776. |
mechanismly, dtm@ka nps facilitated stat6-regulated mitochondrial precursor proteins transport via interacting with tom20 to further promote drp1-dependent fission and pink1/parkin-regulated mitophagy with enhanced lysosomal degradation for removing damaged mitochondria in pac and then reduce inflammation and apoptosis. |
2024-04-03 |
2024-04-06 |
Not clear |
| Junyan Chen, Kaidi Chen, Shuai Xue, Xiao Cheng, Yuwei Qi, Hangjie Wang, Wei Li, Guilin Cheng, Yang Xiong, Chaofeng Mu, Mancang G. Integration of caveolin-mediated cytosolic delivery and enzyme-responsive releasing of squalenoyl nanoparticles enhance the anti-cancer efficacy of chidamide in pancreatic cancer. International journal of pharmaceutics. 2024-04-01. PMID:38561133. |
following intraperitoneal administration to subcutaneous tumor-bearing nude mice, the a-c nps group demonstrated significant anti-pancreatic cancer efficacy, inducing cancer cell apoptosis and inhibiting proliferation in vivo. |
2024-04-01 |
2024-04-04 |
mouse |
| Yuanyuan He, Shidi Wu, Marion Rietveld, Maarten Vermeer, Luis J Cruz, Christina Eich, Abdoelwaheb El Ghalbzour. Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma. Biomaterials advances. vol 160. 2024-03-29. PMID:38552501. |
the results show that, in monolayer, dox@plga nps inhibited cancer cell growth and induced apoptosis in a dose- and time-dependent manner, with a weaker effect on cafs. |
2024-03-29 |
2024-04-01 |
human |
| Marzena Szwed, Agnieszka Marcza. Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment-The Current State of Knowledge. Cancers. vol 16. issue 6. 2024-03-28. PMID:38539491. |
therefore, nanoparticles (nps) are used in ht to apply heat only to tumor tissues to induce dna damage and the expression of heat shock proteins, which eventually result in apoptosis. |
2024-03-28 |
2024-03-30 |
Not clear |
| Yun Wang, Zhongrui Li, Haili Zhang, Peiye Wu, Yu Zhao, Renshi Li, Chao Han, Lei Wan. Berberine-based self-assembly agents with enhanced synergistic antitumor efficacy. Frontiers in pharmacology. vol 15. 2024-03-28. PMID:38545553. |
moreover, bbr-ga nps could lead to mitochondria-mediated cell apoptosis by regulating mitochondrial fission and dysfunction, while bbr-art nps induced ferroptosis in tumor cells. |
2024-03-28 |
2024-03-30 |
Not clear |
| Yuhang Chen, Chien-Shan Cheng, Peiwen Yang, Shu Dong, Lianyu Chen Che. Novel silicene-mesoporous silica nanoparticles conjugated Gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo. Nanotechnology. 2024-03-07. PMID:38452386. |
our research confirmed the functionality of smsn@g nps through immunoblotting and apoptotic assays, demonstrating its capacity to enhance the nuclear translocation of the nf-κb p65, further affect the protein levels of apoptosis-related genes, induce the apoptosis of tumor cells, and ultimately inhibit the growth of the tumor. |
2024-03-07 |
2024-03-10 |
Not clear |
| Tingting Yang, Hongfeng Gou, Ting Lin, Yunfan Yang, Xuelian Jin, Tian Dong, Yuanyuan Zhang, Xinchuan Che. Fisetin nanoparticles based on cells cycle and apoptosis intervention for the treatment of lymphoma and leukemia. International journal of pharmaceutics. 2024-03-07. PMID:38452832. |
the spherical and uniformly distributed fisetin nps effectively inhibited both tumor cells proliferation, arrested el4 cells g0/g1 phase and k562 cells g2/m phase, and induced apoptosis in vitro. |
2024-03-07 |
2024-03-10 |
Not clear |
| Tingting Yang, Hongfeng Gou, Ting Lin, Yunfan Yang, Xuelian Jin, Tian Dong, Yuanyuan Zhang, Xinchuan Che. Fisetin nanoparticles based on cells cycle and apoptosis intervention for the treatment of lymphoma and leukemia. International journal of pharmaceutics. 2024-03-07. PMID:38452832. |
in vivo, fisetin nps exhibited excellent tumor growth inhibition, effective inhibition of cell proliferation and angiogenesis, significant induction of apoptosis and ideal safety. |
2024-03-07 |
2024-03-10 |
Not clear |
| Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdou. Toxicity and Hepatoprotective Effects of ZnO Nanoparticles on Normal and High-Fat Diet-Fed Rat Livers: Mechanism of Action. Biological trace element research. 2024-03-05. PMID:38441796. |
antioxidant enzyme gene expression and activity were significantly augmented, while apoptosis, nlrp3 inflammasome, and inflammation pathways were significantly reduced by 5 mg/kg zno nps. |
2024-03-05 |
2024-03-07 |
rat |
| Wencan Wang, Chong Zhou, Zhangqiang Ma, Lianjie Zeng, Houpeng Wang, Xiu Cheng, Chenchen Zhang, Yue Xue, Yangyang Yuan, Jia Li, Liaoliao Hu, Jian Huang, Tao Luo, Liping Zhen. Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation. Ecotoxicology and environmental safety. vol 273. 2024-02-25. PMID:38402792. |
our findings provide insight into the toxic mechanisms associated with co-exposure to nps and tcs to kgn cells by inducing oxidative stress, activations of the nrf2-keap1-ho-1 pathway, autophagy, and apoptosis. |
2024-02-25 |
2024-02-28 |
human |
| Mingming Han, Tian Zhu, Zihan Zhou, Qin Si, Chenxi Zhu, Yiming Li, Qichen Jian. Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani. Fish & shellfish immunology. 2024-02-21. PMID:38382689. |
in terms of apoptosis, nps exposure led to reduced mrna expression of bcl2 and increased expression of caspase-3, caspase-8, and caspase-9, indicating an induction of apoptosis. |
2024-02-21 |
2024-02-24 |
Not clear |