| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Ilona Izykowska, Marcin Nowak, Agnieszka Gomułkiewicz, Marzena Podhorska-Okołów, Adam Szelag, Piotr Dziegie. alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. Folia histochemica et cytobiologica. vol 48. issue 1. 2010-09-15. PMID:20529816. |
viability test (mtt assay), apoptosis evaluation (tunel reaction, detection of dna laddering and electron microscopy) were performed at 6 and 12 h of exposure to alpha-ama. |
2010-09-15 |
2023-08-12 |
dog |
| X X Xu, H R Jiang, H B Li, T N Zhang, Q Zhou, N Li. Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. Journal of dairy science. vol 93. issue 6. 2010-09-03. PMID:20494139. |
in the present study, we investigated the effect of the antitumor induced by exposing stomach cancer cell sgc-7901 to lactoferrin for 24 and 48 h. the cell viability was assessed by 3-(4,5)-dimethylthiahiazo(-z-yl)-3,5-di-phenytetrazoliumromide (mtt) assay and apoptosis was quantified by propidium iodide uptake and annexin v-fluorescein isothiocyanate fluorescent probe label through flow cytometry. |
2010-09-03 |
2023-08-12 |
human |
| Gregory Lee, Bixia G. Inhibition of in vitro tumor cell growth by RP215 monoclonal antibody and antibodies raised against its anti-idiotype antibodies. Cancer immunology, immunotherapy : CII. vol 59. issue 9. 2010-08-31. PMID:20473495. |
both rp215 and ab3 were shown to induce apoptosis of cultured cancer cells in vitro by tunel and mtt assays. |
2010-08-31 |
2023-08-12 |
mouse |
| Marcela S Tsuboy, Juliana C Marcarini, Rodrigo C Luiz, Iuri B Barros, Dalva T Ferreira, Lúcia R Ribeiro, Mário S Mantovan. In vitro evaluation of the genotoxic activity and apoptosis induction of the extracts of roots and leaves from the medicinal plant Coccoloba mollis (Polygonaceae). Journal of medicinal food. vol 13. issue 3. 2010-08-27. PMID:20438324. |
the results showed that the extract obtained from the roots of c. mollis is more cytotoxic than that obtained from the leaves and that the reduction in cell viability observed in the mtt assay was a result, at least in part, from the induction of apoptosis. |
2010-08-27 |
2023-08-12 |
Not clear |
| Hyung Bin Park, Young-Sool Hah, Jin-Won Yang, Jung-Been Nam, Se-Hyun Cho, Soon-Taek Jeon. Antiapoptotic effects of anthocyanins on rotator cuff tenofibroblasts. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 28. issue 9. 2010-08-20. PMID:20217837. |
anthocyanins demonstrated a dose-dependent ability to inhibit h(2)o(2)-induced apoptosis in cultured tenofibroblasts, as assessed by mtt assay and facs analysis. |
2010-08-20 |
2023-08-12 |
Not clear |
| Yuh-Lin Wu, Yu Ru Kou, Hui-Ling Ou, Han-Yun Chien, Kun-Han Chuang, Han-Hsun Liu, Tzong-Shyuan Lee, Cheng-Yen Tsai, Meng-Lun L. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. European journal of pharmacology. vol 635. issue 1-3. 2010-08-17. PMID:20307528. |
mtt, alamarblue, and annexin v apoptosis assays all suggested that this inhibition effect was not due to a cytotoxic effect mediated by glucosamine. |
2010-08-17 |
2023-08-12 |
human |
| Xiao-Mei Bao, Chun-Fang Wu, Guo-Ping L. Atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving Nox4 and p38MAPK. Atherosclerosis. vol 210. issue 1. 2010-08-16. PMID:20018284. |
apoptosis was evaluated by facs analysis and cell viability was determined by mtt assay. |
2010-08-16 |
2023-08-12 |
Not clear |
| Orestis Lyros, Annett Mueller, Florian Heidel, Carl C Schimanski, Ines Gockel, Peter R Galle, Hauke Lang, Markus Moehle. Analysis of anti-proliferative and chemosensitizing effects of sunitinib on human esophagogastric cancer cells: Synergistic interaction with vandetanib via inhibition of multi-receptor tyrosine kinase pathways. International journal of cancer. vol 127. issue 5. 2010-08-13. PMID:20039326. |
both egf and vegf were shown to stimulate tumor cell growth, and both sunitinib and vandetanib were found to be associated with significant dose-dependent inhibition of proliferation and an enhancement of apoptosis, as determined by mtt and propidium iodide/annexin v labeling assays, respectively. |
2010-08-13 |
2023-08-12 |
human |
| Zhiwei Wang, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Aamir Ahmad, Veronique Nogueira, Nissim Hay, Fazlul H Sarka. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. Journal of cellular biochemistry. vol 109. issue 4. 2010-08-12. PMID:20052673. |
using multiple cellular and molecular approaches such as mtt assay, apoptosis assay, gene transfection, real-time rt-pcr, western blotting, migration, invasion assay and elisa, we found that down-regulation of notch-1 or jagged-1 was mechanistically associated with inhibition of cell growth, migration, invasion and induction of apoptosis in prostate cancer cells, which was mediated via inactivation of akt, mtor, and nf-kappab signaling. |
2010-08-12 |
2023-08-12 |
Not clear |
| Xian-Qing Zhang, Xiao-Feng Huang, Shi-Jie Mu, Qun-Xing An, Ai-Jun Xia, Rui Chen, Dao-Cheng W. Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. Asian journal of andrology. vol 12. issue 3. 2010-08-05. PMID:20081872. |
cell growth and viability were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, and cell apoptosis was detected by flow cytometry, terminal deoxynucleotidyl transferase dutp nick end labelling (tunel) and electron microscopy. |
2010-08-05 |
2023-08-12 |
human |
| Meijia Gu, Hua Li, Chao Shen, Lin Wu, Wanhong Liu, Lixia Miao, Congyi Zhen. Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis. Cancer letters. vol 295. issue 2. 2010-07-30. PMID:20356671. |
likewise, overexpression of the brca1-e1aa-delta2-17 transcript resulted in cell death as measured by the mtt assay, and fluorescence activated cell sorting (facs) assays confirmed that this was caused by cellular apoptosis. |
2010-07-30 |
2023-08-12 |
human |
| Qin Hu, Ruile Pan, Liwei Wang, Bo Peng, Jingtian Tang, Xinmin Li. Platycodon grandiflorum induces apoptosis in SKOV3 human ovarian cancer cells through mitochondrial-dependent pathway. The American journal of Chinese medicine. vol 38. issue 2. 2010-07-29. PMID:20387232. |
3-(4,5- dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (mtt) assay was used to monitor cell numbers, annexin-v/propidium iodide (pi) staining, rt-pcr and western blot were used to examine cell apoptosis, caspases activation. |
2010-07-29 |
2023-08-12 |
human |
| Roberto E Favoni, Alessandra Pattarozzi, Michele Lo Casto, Federica Barbieri, Monica Gatti, Laura Paleari, Adriana Bajetto, Carola Porcile, Giovanni Gaudino, Luciano Mutti, Giorgio Corte, Tullio Flori. Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Current cancer drug targets. vol 10. issue 2. 2010-07-22. PMID:20088784. |
cell proliferation, dna synthesis and apoptosis were measured by mtt, thymidine incorporation and facs analysis; egfr, erk1/2 and akt expression and phosphorylation by western blot, whereas receptor sites were analyzed by binding studies. |
2010-07-22 |
2023-08-12 |
human |
| Yanmin Zhang, Youle Qu, Jie Zhang, Xiaojuan Wan. Ardipusilloside I purified from Ardisia pusilla competitively binds VEGFR and induces apoptosis in NCI-H460 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 7. 2010-07-21. PMID:20149613. |
the present study was to evaluate the effects of ardipusilloside i isolated from ardisia pusilla on the growth, vascular endothelial growth factor receptor (vegfr) expression and apoptosis of nci-h460 cell line by mtt, elisa and flow cytometer, respectively. |
2010-07-21 |
2023-08-12 |
Not clear |
| Hanna Lawnicka, Magdalena Kowalewicz-Kulbat, Paulina Sicinska, Zygmunt Kazimierczuk, Pawel Grieb, Henryk Stepie. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell and tissue research. vol 340. issue 2. 2010-07-21. PMID:20383646. |
cell growth as measured by the mtt and 5-bromo-2'-deoxyuridine incorporation assays is inhibited, and cell cycle analysis has revealed a slight induction of apoptosis. |
2010-07-21 |
2023-08-12 |
human |
| Ki-Soo Park, Jinsung Tae, Bongkum Choi, Young-Seok Kim, Cheol Moon, Sa-Hyun Kim, Han-Sin Lee, Jinhyun Kim, Junsung Kim, Jaeberm Park, Jung-Hee Lee, Jong Eun Lee, Jae-Won Joh, Sungjoo Ki. Characterization, in vitro cytotoxicity assessment, and in vivo visualization of multimodal, RITC-labeled, silica-coated magnetic nanoparticles for labeling human cord blood-derived mesenchymal stem cells. Nanomedicine : nanotechnology, biology, and medicine. vol 6. issue 2. 2010-06-30. PMID:19699324. |
mnps@sio2(ritc) showed photostability against ultraviolet light exposure and were nontoxic to human mscs, based on the mtt, apoptosis, and cell cycle arrest assays. |
2010-06-30 |
2023-08-12 |
mouse |
| Yunlan Li, Jinjie Liu, Qingshan L. Mechanisms by which the antitumor compound di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) induces apoptosis and the mitochondrial-mediated signaling pathway in human cancer SGC-7901 cells. Molecular carcinogenesis. vol 49. issue 6. 2010-06-29. PMID:20336762. |
inhibition of proliferation of four cancer cell lines compared with normal human hepatic l-o2 cells, cancer cell apoptosis, and expression of related mrna and protein were detected using the methyl thiazolyl tetrazolium (mtt), flow cytometry, reverse transcription polymerase chain reaction (rt-pcr), western blot, and dna ladder assays, and electron microscopy and immunocytochemistry. |
2010-06-29 |
2023-08-12 |
human |
| Xiaoguang Cao, Melissa Liu, Jingsheng Tuo, Defen Shen, Chi-Chao Cha. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20361964. |
in the in vitro experiment, cultured arpe-19 cells were exposed to 1 mm h(2)o(2) with or without 50 mum quercetin for 2 h. cellular viability, mitochondrial function, and apoptosis were assessed using crystal violet staining, mtt assay, and comet assay, respectively. |
2010-06-22 |
2023-08-12 |
mouse |
| Liang-Jie Fang, Xue-Ting Shao, Shuo Wang, Guo-Hua Lu, Tao Xu, Jian-Ying Zho. Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis. Planta medica. vol 76. issue 3. 2010-06-18. PMID:19774508. |
we incubated a549 cells with different concentrations of parthenolide in the absence or presence of a low-dose of oxaliplatin for 48 h. then, cell proliferation was determined by mtt assay, and flow cytometry was used to study apoptosis. |
2010-06-18 |
2023-08-12 |
human |
| Shiwei Jin, Fangxing Yang, Yang Hui, Ying Xu, Yuanan Lu, Jiankang Li. Cytotoxicity and apoptosis induction on RTG-2 cells of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and decabrominated diphenyl ether (BDE-209). Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 4. 2010-06-17. PMID:20159034. |
rtg-2 cells were incubated with different concentrations of bde-47 and bde-209 (1-100 microm) for 72 h, and a set of bioassays were conducted to measure: cell viability (evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) assay and neutral red (nr) uptake), lactate dehydrogenase (ldh) leakage, reactive oxygen species (ros) formation and cell apoptosis. |
2010-06-17 |
2023-08-12 |
Not clear |