| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunseung Lee, Ju-Hee Lee, Kyung Hee Jung, Soon-Sun Hon. Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer. Oncology reports. vol 24. issue 4. 2011-01-06. PMID:20811676. |
the effect of deguelin on the proliferation and apoptosis in the gastric cancer cells were assessed by mtt and flow cytometry. |
2011-01-06 |
2023-08-12 |
Not clear |
| A Niedzwiecki, M W Roomi, T Kalinovsky, M Rat. Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer. Cancer metastasis reviews. vol 29. issue 3. 2010-12-21. PMID:20717705. |
in vitro studies demonstrated that nm was very effective in inhibition of cell proliferation (by mtt assay), mmp secretion (by gelatinase zymography), cell invasion (through matrigel), cell migration (by scratch test), induction of apoptosis (by live green caspase) and induction of pro-apoptotic genes in many diverse cancer cell lines. |
2010-12-21 |
2023-08-12 |
human |
| Y F Wu, X J Liang, Y Y Liu, W Gong, J X Liu, X P Wang, Z Q Zhuang, Y Guo, H Y She. +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. Neoplasma. vol 57. issue 6. 2010-12-16. PMID:20845987. |
it was shown in our results that the apoptosis rate and the proliferation inhibition rate increased significantly in survivin-positive cells mg-63 by using mtt and flow cytometry methods. |
2010-12-16 |
2023-08-12 |
human |
| Kaiwei Si, Juntian Liu, Langchong He, Xikuan Li, Wei Gou, Chuanhao Liu, Xiaoqi L. Caulophine protects cardiomyocytes from oxidative and ischemic injury. Journal of pharmacological sciences. vol 113. issue 4. 2010-12-14. PMID:20724803. |
viability of cardiomyocytes was assayed with the mtt method, and cell apoptosis was detected by flow cytometry. |
2010-12-14 |
2023-08-12 |
rat |
| Wei Wang, Elizabeth R Rayburn, Sadanandan E Velu, Deng Chen, Dwayaja H Nadkarni, Srinivasan Murugesan, Dongquan Chen, Ruiwen Zhan. A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action. Breast cancer research and treatment. vol 123. issue 2. 2010-12-08. PMID:19936915. |
we investigated the in vitro activity of ba-tpq on the survival, proliferation, and apoptosis of breast cancer cells using the mtt and brdurd assays, and annexin/annexin-pi staining and flow cytometry. |
2010-12-08 |
2023-08-12 |
mouse |
| Chun Zhang, Guohui Cui, Yan Chen, Ke Fa. Antitumor effect of interferon-alpha on U937 human acute leukemia cells in vitro and its molecular mechanism. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 5. 2010-12-07. PMID:18060623. |
in order to investigate the antitumor effect and molecular mechanism of interferon-alpha (ifn-alpha) on human acute myeloid leukemia cell line u937 cells in vitro, the proliferation of u937 cells was determined by mtt assay, the apoptosis rate was analyzed by flow cytometry (fcm), and the mrna expression of cell cycle regulatory protein cyclin e was detected by rt-pcr. |
2010-12-07 |
2023-08-12 |
human |
| Huijuan Wu, Danhui Weng, Hui Xin. Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 6. 2010-12-07. PMID:18231751. |
proliferation and chemosensitivity of cells to ddp were measured by mtt, and cell apoptosis was detected by flow cytometry after treatment with cisplatin. |
2010-12-07 |
2023-08-12 |
human |
| Lifeng An, Shumin Liu, Yang Dong, Bo Tang, Wanru Don. Protective effect of effective part of Acanthopanacis senticosus on damage of PC12 cells induced by MPP+. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 35. issue 15. 2010-12-03. PMID:20931860. |
cell viability and apoptosis of pc12 cells induced by mpp' were assayed by mtt and flow cytometry respectively in the presence or absence of the effective part of as. |
2010-12-03 |
2023-08-12 |
Not clear |
| Jinxin Wang, Junhai Ma, Qidong You, Li Zhao, Fan Wang, Chong Li, Qinglong Gu. Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents. European journal of medicinal chemistry. vol 45. issue 9. 2010-11-30. PMID:20605273. |
sequentially, thirteen new compounds were synthesized and their inhibitory activity on ht-29, bel-7402, bgc-823, and a549 cell lines were evaluated in vitro by mtt assay, and (38, 40)-epoxy-33-chlorogambogellic acid (4) was identified as a bgc-823 cell apoptosis inducer through mtt cell assay, observations of morphological changes, and annexin-v/pi double-staining assay. |
2010-11-30 |
2023-08-12 |
Not clear |
| Ki-Eun Bae, Han-Soo Chong, Dong-Sup Kim, Young-Woong Choi, Young-Sook Kim, Young-Kyoon Ki. Compounds from Viburnum sargentii Koehne and evaluation of their cytotoxic effects on human cancer cell lines. Molecules (Basel, Switzerland). vol 15. issue 7. 2010-11-29. PMID:20657380. |
our results showed that 9'-o-methylvibsanol (3) exhibited strong concentration-dependent anticancer effects according to the mtt assay and produced morphological changes consistent with apoptosis, as confirmed by ho3342 staining analysis revealed that more apoptotic cells were observed after 9'-omethylvibsanol (3) treatment. |
2010-11-29 |
2023-08-12 |
human |
| Wei Zhang, Yuan Shi, Yanzuo Chen, Shuangyin Yu, Junguo Hao, Jieqi Luo, Xianyi Sha, Xiaoling Fan. Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 75. issue 3. 2010-11-26. PMID:20451605. |
influence of pf-ptx on in vitro cytotoxicity was determined by mtt assay, while cellular apoptosis was detected by cell nuclei staining and annexin v-fitc apoptosis detection kit. |
2010-11-26 |
2023-08-12 |
human |
| Yumin Li, Xuejiao Zhu, Jingyi Gu, Haiyan Hu, Dawei Dong, Junlin Yao, Chunyan Lin, Jia Fe. Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis. Hematology (Amsterdam, Netherlands). vol 15. issue 4. 2010-11-16. PMID:20670480. |
amo-mir-21 alone effectively inhibited hl60 cell viability as measured by mtt assays and induced apoptosis as evaluated by flow cytometry, whereas amo-mir-21 in combination with ara-c enhanced hl60 cells to ara-c-sensitivity and promoted ara-c-induced apoptosis. |
2010-11-16 |
2023-08-12 |
Not clear |
| Lianmei Zhao, Baoen Shan, Yanyan Du, Mingxia Wang, Lihua Liu, Feng-Zhi Re. Periplocin from Cortex periplocae inhibits cell growth and down-regulates survivin and c-myc expression in colon cancer in vitro and in vivo via beta-catenin/TCF signaling. Oncology reports. vol 24. issue 2. 2010-11-10. PMID:20596624. |
our research results showed that cpp caused a dose- and time-dependent inhibition of cell growth as assessed by mtt assay and an induction in apoptosis as measured by flow cytometry and transmission electron microscopy. |
2010-11-10 |
2023-08-12 |
human |
| Debby Reuveni, Drora Halperin, Itamar Shalit, Esther Priel, Ina Fabia. Moxifloxacin enhances etoposide-induced cytotoxic, apoptotic and anti-topoisomerase II effects in a human colon carcinoma cell line. International journal of oncology. vol 37. issue 2. 2010-11-09. PMID:20596674. |
decatenation assay, band depletion and western blot analysis, cytotoxic assay (mtt), flow cytometric studies (cell cycle and survivin expression), apoptosis (dapi-sulforhodamine staining and caspase 3 activity) and il-8 and vegf secretion were determined. |
2010-11-09 |
2023-08-12 |
human |
| Hsien-Ming Wu, Andrew V Schally, Jung-Chien Cheng, Marta Zarandi, Jozsef Varga, Peter C K Leun. Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCδ-mediated activation of p53/p21. Cancer letters. vol 298. issue 1. 2010-10-28. PMID:20630651. |
by using mtt assay, immunoblotting for cleaved caspase-3 and tunel assays, we found that cell growth inhibition and apoptosis were induced in ghrh antagonist, jmr-132-treated cells by activating pkcδ and could be inhibited by treatment with pkc inhibitor, gf109203x. |
2010-10-28 |
2023-08-12 |
human |
| Hye Ri Yun, Hwa Seung Yoo, Dong Yeok Shin, Su Hyun Hong, Jong-Hwan Kim, Chong Kwan Cho, Yung Hyun Cho. Apoptosis induction of human lung carcinoma cells by Chan Su (Venenum Bufonis) through activation of caspases. Journal of acupuncture and meridian studies. vol 2. issue 3. 2010-10-27. PMID:20633494. |
treatment of a549 cells with skin of venenum bufonis resulted in the inhibition of cell growth and viability and the induction of apoptosis, which was shown by trypan blue counts, mtt assay, dapi staining and flow cytometry analysis. |
2010-10-27 |
2023-08-12 |
human |
| Zhijun Qu, Duande Lou, Yanfeng Pa. The role of IkappaBalpha in TNF-alpha-induced apoptosis in hepatic stellate cell line HSC-T6. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 4. 2010-10-26. PMID:17828497. |
the apoptosis and the rate of inhibition by tnf-alpha in both transfected and untransfected hsc-t6 cells were measured respectively by fac-scan side scatter analysis and mtt methods. |
2010-10-26 |
2023-08-12 |
Not clear |
| Vincent C H Wong, Andrew Morrison, Uri Tabori, Cynthia E Hawkin. Telomerase inhibition as a novel therapy for pediatric ependymoma. Brain pathology (Zurich, Switzerland). vol 20. issue 4. 2010-10-19. PMID:20184588. |
they were then subjected to telomerase inhibition (mst-312, 1 microm) and tested for effects on cell viability (mtt assay), proliferation (mib-1), apoptosis (cleaved caspase 3) and dna damage (gammah2ax). |
2010-10-19 |
2023-08-12 |
human |
| Jie Li, Ni Hou, Ahmad Faried, Soichi Tsutsumi, Hiroyuki Kuwan. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. European journal of cancer (Oxford, England : 1990). vol 46. issue 10. 2010-10-13. PMID:20231086. |
in the present study, apoptosis induced by 5-fu in 3 human colon cancer cell lines (hct116, dld-1, and dld-1/5-fu (a specific 5-fu-resistant sub-line)) was measured using mtt assay, dna fragmentation assay, hoechst 33342 staining, and caspase-3 immunoblotting. |
2010-10-13 |
2023-08-12 |
human |
| L Tian, X Chen, Y Sun, M Liu, D Zhu, J Re. Growth suppression of human laryngeal squamous cell carcinoma by adenoviral-mediated interleukin-12. The Journal of international medical research. vol 38. issue 3. 2010-09-28. PMID:20819436. |
the proliferation and apoptosis of hep-2 cells in vitro were detected by mtt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and flow cytometry. |
2010-09-28 |
2023-08-12 |
mouse |