| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emmanuel I Papadopoulos, George M Yousef, Andreas Scorila. Gemcitabine impacts differentially on bladder and kidney cancer cells: distinct modulations in the expression patterns of apoptosis-related microRNAs and BCL2 family genes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 5. 2015-07-31. PMID:25833690. |
cancer cells' viability as well as the ic50 doses of gemcitabine were estimated by the mtt assay, while the detection of cleaved parp via western blotting was used as an indicator of apoptosis. |
2015-07-31 |
2023-08-13 |
human |
| Yang Zhou, Liang Bo Zhu, Ai Fen Peng, Tao Fang Wang, Xin Hua Long, Song Gao, Rong Ping Zhou, Zhi Li Li. LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3‑kinase/Akt/fatty acid synthase signaling pathway in vitro. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25351625. |
mtt and fluorescence‑activated cell sorting assays were used to assess proliferation and apoptosis. |
2015-07-30 |
2023-08-13 |
Not clear |
| Pengcheng Li, Hesong Zeng, Jin Qin, Yuanlin Zou, Dan Peng, Houjuan Zuo, Zhengxiang Li. Effects of tetraspanin CD151 inhibition on A549 human lung adenocarcinoma cells. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25351816. |
the expression levels of cd151 were assayed by western blotting, proliferation was evaluated by mtt method and apoptosis was determined by flow cytometry. |
2015-07-30 |
2023-08-13 |
human |
| You Cheng Zhang, Liu Qing Guo, Xiao Chen, Gen Nian Wang, Ri Ni, Man Cai Wang, Feng Xian We. The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25370568. |
mtt assay and flow cytometry (fcm) were used to determine the rates of cell proliferation and apoptosis, respectively. |
2015-07-30 |
2023-08-13 |
human |
| Duqun Chen, Yifan Li, Zhengming Su, Zuhu Yu, Wenshui Yu, Yuchi Li, Yaoting Gui, Shangqi Yang, Yongqing La. Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25370896. |
the influence of mir‑125a‑5p on cell proliferation, migration and apoptosis was also determined, using an mtt assay, a wound scratch assay and flow cytometry, respectively. |
2015-07-30 |
2023-08-13 |
Not clear |
| Arif Khan, Ahmad N Aljarbou, Yousef H Aldebasi, Syed M Faisal, Masood A Kha. Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway. Cancer epidemiology. vol 38. issue 6. 2015-07-29. PMID:25448084. |
the effect of resveratrol on the growth of breast cancer cells was assessed as percent cell viability by cytotoxicity-based mtt assay and the induction of apoptosis was determined by cell-death detection elisa and flow cytometric analysis of annexin-v-pi binding. |
2015-07-29 |
2023-08-13 |
human |
| Kuan Lin Kuo, I Lin Ho, Chung Sheng Shi, June Tai Wu, Wei Chou Lin, Yu Chieh Tsai, Hong Chiang Chang, Chien Tso Chou, Chen Hsun Hsu, Ju Ton Hsieh, Shih Chen Chang, Yeong Shiau Pu, Kuo How Huan. MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: In vitro and in vivo studies. Cancer letters. vol 363. issue 2. 2015-07-29. PMID:25615422. |
the impact of mln4924 on uc cells was determined by measuring viability (mtt), proliferation (brdu incorporation), cell cycle progression (flow cytometry with propidium iodide staining) and apoptosis (flow cytometry with annexin v-fitc labeling). |
2015-07-29 |
2023-08-13 |
mouse |
| Xue-Jiao Lv, Li-Jing Zhao, Yu-Qiu Hao, Zhen-Zhong Su, Jun-Yao Li, Yan-Wei Du, Jie Zhan. Schisandrin B inhibits the proliferation of human lung adenocarcinoma A549 cells by inducing cycle arrest and apoptosis. International journal of clinical and experimental medicine. vol 8. issue 5. 2015-07-29. PMID:26221229. |
the aim of this study was to determine the effect of sch b on the proliferation, cell cycling, apoptosis and invasion of lung adenocarcinoma a549 cells by mtt, flow cytometry, wound healing and transwell invasion assays. |
2015-07-29 |
2023-08-13 |
human |
| Xiao Wang, Shaoxiang Wang, Yuting Liu, Dane Huang, Kai Zheng, Yi Zhang, Xiaoyan Wang, Qiuying Liu, Depo Yang, Yifei Wan. Comparative effects of SNX-7081 and SNX-2112 on cell cycle, apoptosis and Hsp90 client proteins in human cancer cells. Oncology reports. vol 33. issue 1. 2015-07-28. PMID:25334086. |
the cytotoxic effects were determined using an mtt assay and apoptosis was measured using flow cytometry. |
2015-07-28 |
2023-08-13 |
human |
| Maomao Wang, Xiaodong Deng, Qi Ying, Tingyan Jin, Ming Li, Chong Lian. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. Biochemical and biophysical research communications. vol 460. issue 2. 2015-07-28. PMID:25783051. |
the biological effects of mir-224 on the cell proliferation and apoptosis in meningioma cells were examined by mtt assay and apoptosis assay. |
2015-07-28 |
2023-08-13 |
Not clear |
| Cunjin Su, Aiming Shi, Guowen Cao, Tao Tao, Ruidong Chen, Zhanhong Hu, Zhu Shen, Hong Tao, Bin Cao, Duanmin Hu, Junjie Ba. Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation. Biochemical and biophysical research communications. vol 460. issue 4. 2015-07-27. PMID:25839662. |
we used mtt assay to detect cells proliferation, starch wound test to investigate cells migration, h2dcf-da to detect intracellular ros, sirna to interfere txnip and peroxisome proliferator-androgen receptor-alpha (ppar-α) expression, western blot to determine protein levels, flow cytometry to analyze apoptosis. |
2015-07-27 |
2023-08-13 |
human |
| Kanjoormana A Manu, Muthu K Shanmugam, Lalitha Ramachandran, Feng Li, Kodappully Sivaraman Siveen, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Frank Arfuso, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer. Cancer letters. vol 363. issue 1. 2015-07-20. PMID:25827070. |
the potential effect of ih on viability was analyzed by mtt assay, apoptosis by flow cytometric analysis, and nf-κb activation by dna binding as well as western blot assays. |
2015-07-20 |
2023-08-13 |
mouse |
| Jing Wang, Hong Wei, Baoxia Zhao, Mei Li, Weipeng Lv, Ling Lv, Bo Song, Shen L. The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro. Journal of molecular histology. vol 45. issue 6. 2015-07-15. PMID:25008024. |
in the three cell lines, subsequently cell growth curves and cell population doubling time were calculated by cell proliferation assay, the changes of cell viability were evaluated by trypan blue dye exclusion method and mtt assay, the cell cycle distribution and apoptosis were investigated by flow cytometry, the expressions of e-cadherin and vimentin used to indicate epithelial-mesenchymal transition (emt) were determined by western blot analysis, the protein expressions in egfr/kras/braf transduction pathway were detected by immunocytochemistry, and the mutations of egfr, kras and braf were detected by high resolution melting analysis and direct sequencing. |
2015-07-15 |
2023-08-13 |
human |
| Qinghua Jia, Xiaoqin Ha, Zhihua Yang, Ling Hui, Xiaopeng Yan. Hepatocyte growth factor protects human mesangial cells against apoptosis induced by lead damage. Biological trace element research. vol 162. issue 1-3. 2015-07-15. PMID:25154432. |
after lead-induced damage 48 h, the proliferation of hmcs was measured by mtt assay, and the apoptosis was assessed by flow cytometry. |
2015-07-15 |
2023-08-13 |
human |
| Benedetta Mannini, Estefania Mulvihill, Caterina Sgromo, Roberta Cascella, Reza Khodarahmi, Matteo Ramazzotti, Christopher M Dobson, Cristina Cecchi, Fabrizio Chit. Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. ACS chemical biology. vol 9. issue 10. 2015-07-14. PMID:25079908. |
the resulting oligomeric species have different degrees of cytotoxicity when added to the extracellular medium of the cells, as assessed by the extent of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) reduction, apoptosis, and influx of ca2+ into the cells. |
2015-07-14 |
2023-08-13 |
Not clear |
| Hassan Adwan, Ahmed Murtaja, Khamael Kadhim Al-Taee, Asim Pervaiz, Thomas Hielscher, Martin R Berge. Riproximin's activity depends on gene expression and sensitizes PDAC cells to TRAIL. Cancer biology & therapy. vol 15. issue 9. 2015-07-13. PMID:24918923. |
cytotoxicity in response to rpx was determined by mtt assay, apoptosis by flow cytometry and qrt-pcr for apoptosis related genes, and the modulation of the transcriptome was monitored by micro array analysis. |
2015-07-13 |
2023-08-13 |
human |
| Fubin Zhang, Xiaowei Song, Li Li, Jingfang Wang, Leyuan Lin, Cong Li, Hongtao Li, Yanju Lv, Yinghua Jin, Ying Liu, Yu Hu, Tao Xi. Polygala tenuifolia polysaccharide PTP induced apoptosis in ovarian cancer cells via a mitochondrial pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25501282. |
the results of mtt assay and apoptosis detection assay showed that ptp inhibited cellular proliferation of ovcar-3 cells and induced apoptotic cellular death via arresting cell circle at the g0/g1 phase. |
2015-07-09 |
2023-08-13 |
human |
| Jeong-Won Lee, Ji-Yoon Ryu, Gun Yoon, Hye-Kyung Jeon, Young-Jae Cho, Jung-Joo Choi, Sang Yong Song, In-Gu Do, Yoo-Young Lee, Tae-Joong Kim, Chel Hun Choi, Byoung-Gie Kim, Duk-Soo Ba. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer. International journal of cancer. vol 137. issue 1. 2015-07-06. PMID:25429856. |
cells were treated with sk inhibitor or fty720, and cell proliferation, apoptosis, angiogenesis and invasion were examined by mtt, facs, elisa and wound-healing assays, respectively. |
2015-07-06 |
2023-08-13 |
mouse |
| Zhongyong Jiang, Jie Xion. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Cell biochemistry and biophysics. vol 70. issue 2. 2015-07-02. PMID:24845152. |
we measured human hepatocarcinoma cell viability by mtt assay and annexin v-fitc/pi double staining, and evaluated the activity of caspase 3 and the expression of p53, bax, and bcl-2 proteins, involved in regulating cell apoptosis. |
2015-07-02 |
2023-08-13 |
human |
| Karuppiah Nagaraj, Gunasekaran Velmurugan, Subramanian Sakthinathan, Ponnambalam Venuvanalingam, Sankaralingam Arunachala. Influence of self-assembly on intercalative DNA binding interaction of double-chain surfactant Co(III) complexes containing imidazo[4,5-f][1,10]phenanthroline and dipyrido[3,2-d:2'-3'-f]quinoxaline ligands: experimental and theoretical study. Dalton transactions (Cambridge, England : 2003). vol 43. issue 48. 2015-07-02. PMID:25354359. |
the cytotoxic activity of these complexes on human liver carcinoma cancer cells were determined adopting mtt assay and specific staining techniques, which revealed that the viability of the cells thus treated was significantly decreased and the cells succumbed to apoptosis as seen in the changes in the nuclear morphology and cytoplasmic features. |
2015-07-02 |
2023-08-13 |
human |