| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianxu Zhang, Di Wu, Zhen Xing, Shaojun Liang, Haobo Han, Hui Shi, Yan Zhang, Yan Yang, Quanshun L. N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells. Colloids and surfaces. B, Biointerfaces. vol 129. 2016-02-16. PMID:25829127. |
due to the exogenous p53 expression, the inhibition of cell proliferation was observed through mtt analysis, attributing to the activation of apoptosis and cell cycle arrest. |
2016-02-16 |
2023-08-13 |
Not clear |
| Rui Xiong, Wenbo Zhou, David Siegel, Russell R A Kitson, Curt R Freed, Christopher J Moody, David Ros. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Molecular pharmacology. vol 88. issue 6. 2016-02-12. PMID:26405178. |
in this study, our data demonstrated that 19-phenyl-ga, a lead 19bqa in the ga series, was redox stable and exhibited little toxicity relative to its parent quinone ga in human dopaminergic sh-sy5y cells as examined by oxygen consumption, trypan blue, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (mtt), and apoptosis assays. |
2016-02-12 |
2023-08-13 |
human |
| Ji-lin Ye, You-jiang Yu, Ai-lian Wu, Dong-yan Wang, Yong-chun Liu, Yan-qing Li. [Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 10. 2016-02-11. PMID:26837170. |
inhibition of the cell proliferation was measured with mtt assay and cell apoptosis was detected with formation of dna ladders in agarose gel electrophoresis, and activation of caspase activity. |
2016-02-11 |
2023-08-13 |
human |
| Zumin Xu, Yufang Zuo, Jin Wang, Zhonghua Yu, Fang Peng, Yuanyuan Chen, Yong Dong, Xiao Hu, Qichao Zhou, Honglian Ma, Yong Bao, Ming Che. Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells. Oncology reports. vol 33. issue 6. 2016-02-09. PMID:25891540. |
the cells were tested for apoptosis with flow cytometry, for viability with mtt, for mobility and adhesion capacity. |
2016-02-09 |
2023-08-13 |
human |
| Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling L. MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis. Oncology reports. vol 33. issue 6. 2016-02-09. PMID:25963391. |
the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) and hoechst staining assays showed that mir-18a had no effect on the proliferation and apoptosis of cervical cancer cells after transfection. |
2016-02-09 |
2023-08-13 |
human |
| Constanze Buhrmann, Parviz Shayan, Patricia Kraehe, Bastian Popper, Ajay Goel, Mehdi Shakibae. Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochemical pharmacology. vol 98. issue 1. 2016-02-09. PMID:26310874. |
the effect of resveratrol in parental crc cell lines (hct116, sw480) and their corresponding isogenic 5-fu-chemoresistant derived clones (hct116r, sw480r) was examined by mtt assays, intercellular junction formation and apoptosis by electron- and immunoelectron microscopy, nuclear factor-kappab (nf-κb) and nf-κb regulated gene products by western blot analysis in a 3d-alginate microenvironment. |
2016-02-09 |
2023-08-13 |
Not clear |
| Weiying Gu, Lili Xiang, Tingxiu Jiang, Guanghua Luo, Jiang Wei, Jiannong Cen, Zixing Chen, Guoqiang Qiu, Mei Zeng, Xiaoying Zhan. Changes of Apolipoprotein M Gene Expression During the Cell Differentiation and Apoptosis Induced by Simvastatin in Combination with All-Trans Retinoic Acid in Human Promyelocytic Leukemia Cell Line NB4. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion. vol 32. issue 1. 2016-02-09. PMID:26855507. |
mtt method was used to assay the growth inhibition rate and flow cytometry to detect cd11b expression level and the early stage apoptosis ratio. |
2016-02-09 |
2023-08-13 |
human |
| Shuang Wang, Shisheng Li, Qinglai Tang, Shu Yang, Shuhui Wang, Jiajia Liu, Mi Yang, Xinming Yan. Overexpression of Tiam1 promotes the progression of laryngeal squamous cell carcinoma. Oncology reports. vol 33. issue 4. 2016-02-04. PMID:25672412. |
to investigate the effects of tiam1 on the progression of lscc, tiam1/c1199 plasmid was transfected into lscc, and proliferation, apoptosis, migration and invasion of transfected cells were examined using mtt, flow cytometry, wound-healing and transwell assay, respectively. |
2016-02-04 |
2023-08-13 |
human |
| Gui-Bo Sun, Meng Qin, Yun Luo, Rui-Le Pan, Xiang-Bao Meng, Min Wang, Yan-Hui Zou, Xiao-Bo Su. [Protect effects and the underlying mechanisms of myricitrin against vascular endothelial cells apoptosis induced by oxidative stress]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 4. 2016-02-02. PMID:23833954. |
the h2o2-induced apoptosis of vascular endothelial cells was detected using mtt reduction, tunel assay, jc-1 and ros staining. |
2016-02-02 |
2023-08-12 |
Not clear |
| Jian-Wu Tang, Jing Li. [Apoptosis of MDA-MB-231 cells induced by berberine alpha-hydroxy beta-decanoylethyl sulfonate]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 1. 2016-02-02. PMID:24783518. |
to investigate the cell proliferation inhibition and apoptosis induced by berberine a-hydroxy f-decanoylethyl sulfonate (hb) on mda-mb-231 cells in vitro, and the inhibitory effect of hb on the expression of poly adenosine diphosphate rna polymerase (parp), mtt assay was used to detect the viability of mda-mb-231 cells and cell cycle was examined by flow cytometry. |
2016-02-02 |
2023-08-13 |
Not clear |
| Qian Wu, Ning Wang, Yan Wang, Guang-Yun Wang, Xin-Xin Pia. [Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 2. 2016-02-02. PMID:25975022. |
to investigate the neuroprotective of ligustilide (lig) against glutamate-induced apoptosis of pc12 cells, cell viability were examined by mtt assay. |
2016-02-02 |
2023-08-13 |
Not clear |
| Yang Chen, Cheng Chen, Yiyun Xiao, Xiuzhen Zhang, Yuxiang Che. Liposomes Encapsulating 10-Hydroxycamptothecin-Cyclodextrin Complexes and Their In Vitro Anti-Tumor Activities. Journal of nanoscience and nanotechnology. vol 15. issue 5. 2016-02-01. PMID:26505006. |
the hepatoma (hepg-2), lung cancer (a549), and gastric cancer (sgc-7901) cell lines were used as models for preliminary evaluation of anti-cancer effect from the hydroxycamptothecin inclusion liposomes, done by mtt colorimetry, cytometer experiments, and apoptosis staining. |
2016-02-01 |
2023-08-13 |
Not clear |
| Xiao-dan Zhang, Yan-nan Yang, Shu-jing Wang, Da-ling Zhu, Li-wei Wang, Jie-jing Sheng, Sha-sha Son. [Effect of puerarin on PI3K/AKT pathway-mediated apoptosis of PASMCs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 15. 2016-02-01. PMID:26677708. |
with the serum starvation group (sd group) as the control group, the mtt colorimetry method, annexin v-fitc apoptosis detection kit and western blot were used to detect pue's effect on apoptosis of rat pasmcs. |
2016-02-01 |
2023-08-13 |
rat |
| Jing Su, Wenjuan Yu, Miaozi Gong, Jiangfeng You, Jianying Liu, Jie Zhen. Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway. Journal of cellular biochemistry. vol 116. issue 7. 2016-01-29. PMID:25735224. |
mtt assays showed that overexpression of tmsg1/lass2 inhibited cell proliferation; and morphological observations and flow cytometric assays with annexin v/propidium iodide showed tmsg1/lass2 overexpression increased apoptosis in these cells. |
2016-01-29 |
2023-08-13 |
human |
| Jiandong Yuan, Junzhe Lang, Cailong Liu, Kai Zhou, Lei Chen, Yangbo Li. The expression and function of miRNA-451 in osteosarcoma. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-01-26. PMID:25471786. |
mtt, flow cytometric, and scratch migration assay were used to test the proliferation, apoptosis, and migration of mir-451 transfection osteosarcoma cells, and a mouse model was used to investigate tumorigenesis. |
2016-01-26 |
2023-08-13 |
mouse |
| Daoyang Zhou, Yingfeng Wan, Dajiang Xie, Yirong Wang, Junhua Wei, Qingfeng Yan, Peng Lu, Lianjie Mo, Jixi Xie, Shuxu Yang, Xuchen Q. DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells. Experimental & molecular medicine. vol 47. 2016-01-26. PMID:26337869. |
cell viability and apoptosis were assessed using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide (mtt) and tdt-mediated dutp-biotin nick end labeling assays, respectively. |
2016-01-26 |
2023-08-13 |
Not clear |
| Fang Hua, Jian-Fei Xue, Xiao-Xi Lü, Zhuo-Wei H. [DEDD decreases Smad3 activity, promotes tumor cell apoptosis and inhibits proliferation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 5. 2016-01-25. PMID:23888690. |
the effects of the full length dedd and its two truncated mutants on cell apoptosis and proliferation had also been explored by flow cytometry and mtt assay. |
2016-01-25 |
2023-08-12 |
Not clear |
| Qiu-Ju Xu, Li-Li Hou, Guo-Qiang Hu, Song-Qiang Xi. [Molecular mechanism of ophiopogonin B induced cellular autophagy of human cervical cancer HeLa cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 6. 2016-01-25. PMID:23984518. |
mtt assay, flow cytometric analysis, acridine orange staining, lyso-tracker red staining and hela-gfp-lc3 transfect cells assay were used to detect the proliferation activity, apoptosis and autophagy of hela cells. |
2016-01-25 |
2023-08-12 |
human |
| Wei-Chou Lin, Kuan-Lin Kuo, Chung-Sheng Shi, June-Tai Wu, Ju-Ton Hsieh, Hong-Chiang Chang, Shih-Ming Liao, Chien-Tso Chou, Chih-Kang Chiang, Wei-Shuo Chiu, Tzu-Yuan Chiu, Yeong-Shiau Pu, I-Lin Ho, Zuo-He Wang, Shih-Chen Chang, Shing-Hwa Liu, Yung-Ming Jeng, Kuo-How Huan. MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study. American journal of cancer research. vol 5. issue 11. 2016-01-25. PMID:26807316. |
the cytotoxic effects of mln4924 and/or cisplatin were measured by cell viability (mtt), proliferation (brdu incorporation), apoptosis (flow cytometry with annexin v-fitc labeling), and the expression of cell apoptosis-related proteins (western blotting). |
2016-01-25 |
2023-08-13 |
mouse |
| Roberta Marino, Dana C Baiu, Saswati Bhattacharya, Benjamin Titz, Ellen Hebron, Bryan D Menapace, Sorabh Singhal, Jens C Eickhoff, Fotis Asimakopoulos, Jamey P Weichert, Mario Ott. Tumor-selective anti-cancer effects of the synthetic alkyl phosphocholine analog CLR1404 in neuroblastoma. American journal of cancer research. vol 5. issue 11. 2016-01-25. PMID:26807322. |
using flow cytometry, mtt assay, western blotting and caspase 3/7 assay, we confirm that in vitro treatment with clr1404 leads to robust apoptosis and cell death in multiple nb cell lines and is associated with akt inhibition, while sparing normal cells. |
2016-01-25 |
2023-08-13 |
mouse |