| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Higuchi, S Matsukaw. Glutathione depletion induces giant DNA and high-molecular-weight DNA fragmentation associated with apoptosis through lipid peroxidation and protein kinase C activation in C6 glioma cells. Archives of biochemistry and biophysics. vol 363. issue 1. 1999-04-22. PMID:10049497. |
lipid peroxidation and protein kinase c (pk-c) activation were observed during the apoptosis of c6 cells, and these events were inhibited by antioxidants and iron chelators without affecting bso-induced gsh depletion. |
1999-04-22 |
2023-08-12 |
rat |
| Y Higuchi, S Matsukaw. Glutathione depletion induces giant DNA and high-molecular-weight DNA fragmentation associated with apoptosis through lipid peroxidation and protein kinase C activation in C6 glioma cells. Archives of biochemistry and biophysics. vol 363. issue 1. 1999-04-22. PMID:10049497. |
these results suggest that during apoptosis induced by gsh-depletion caused by bso, reactive oxygen species endogenously produced cause lipid peroxidation and that the lipid peroxidation induced pk-c activation, processes which are thought to be involved in the giant dna, high-molecular-weight dna, and the internucleosomal dna fragmentations. |
1999-04-22 |
2023-08-12 |
rat |
| A Ushmorov, F Ratter, V Lehmann, W Dröge, V Schirrmacher, V Umansk. Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. Blood. vol 93. issue 7. 1999-04-19. PMID:10090945. |
an inhibitor of lipid peroxidation, trolox, significantly suppressed no-mediated apoptosis in apo-s jurkat cells, whereas bongkrekic acid (ba), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. |
1999-04-19 |
2023-08-12 |
human |
| O Inanami, K Takahashi, M Kuwabar. Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells. International journal of radiation biology. vol 75. issue 2. 1999-03-23. PMID:10072176. |
the relationship between post-irradiation treatment with trolox, an antioxidant that inhibits lipid peroxidation, and x-ray-induced apoptosis, with regard to signal transduction pathways, was examined in molt-4, a human leukaemia cell line. |
1999-03-23 |
2023-08-12 |
human |
| J G Ren, R L Zheng, Y M Shi, B Gong, J F L. Apoptosis, redifferentiation and arresting proliferation simultaneously triggered by oxidative stress in human hepatoma cells. Cell biology international. vol 22. issue 1. 1999-02-02. PMID:9828081. |
the possible mechanism of the differentiation and apoptosis induced by oxidative stress may be related to the lipid peroxidation of cell membrane. |
1999-02-02 |
2023-08-12 |
human |
| J P Fabisiak, Y Y Tyurina, V A Tyurin, J S Lazo, V E Kaga. Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine. Biochemistry. vol 37. issue 39. 1998-10-28. PMID:9753467. |
to assess the role of lipid peroxidation in apoptosis, we used 2,2'-azobis(2,4-dimethylisovaleronitrile) (amvn) to generate peroxyl radicals within cellular membranes of hl-60 cells. |
1998-10-28 |
2023-08-12 |
Not clear |
| J P Fabisiak, Y Y Tyurina, V A Tyurin, J S Lazo, V E Kaga. Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine. Biochemistry. vol 37. issue 39. 1998-10-28. PMID:9753467. |
amvn-induced lipid peroxidation was followed by apoptosis as determined by nuclear condensation, dna fragmentation, and annexin v binding to externalized phosphatidylserine (ps). |
1998-10-28 |
2023-08-12 |
Not clear |
| Q Chen, M Galleano, A I Cederbau. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 22. issue 4. 1998-10-08. PMID:9660301. |
it is proposed that elevated production of reactive oxygen intermediates by cells expressing cyp2e1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. |
1998-10-08 |
2023-08-12 |
human |
| L Tenneti, D M D'Emilia, C M Troy, S A Lipto. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. Journal of neurochemistry. vol 71. issue 3. 1998-09-21. PMID:9721720. |
taken together, our results suggest that ca2+ influx and mitochondrial depolarization occur upstream from caspase activation, whereas ros formation and lipid peroxidation may be downstream events in the cascade leading to cortical neuronal apoptosis. |
1998-09-21 |
2023-08-12 |
Not clear |
| C L Limoli, A Hartmann, L Shephard, C R Yang, D A Boothman, J Bartholomew, W F Morga. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer research. vol 58. issue 16. 1998-09-17. PMID:9721883. |
induction of apoptosis by agents such as actinomycin d, etoposide, and staurosporine and induction of necrosis by sodium azide were accompanied by an increase in the level of intracellular peroxy radicals and lipid peroxidation products, two independent end points that are typically associated with oxidative stress. |
1998-09-17 |
2023-08-12 |
Not clear |
| R A Hawkins, K Sangster, M J Arend. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. The Journal of pathology. vol 185. issue 1. 1998-09-15. PMID:9713361. |
the extent of pufa-induced lipid peroxidation, measured as malondialdehyde (mda), also correlated with the proportion of apoptosis induced in mia-pa-ca-2 cells (r = 0.69, p = 0.025) or hl-60 cells (r = 0.64, p = 0.043), as well as with the number of fatty acid double bonds (r = 0.82, p = 0.0015). |
1998-09-15 |
2023-08-12 |
Not clear |
| C Velez-Pardo, M J Del Rio, G Ebinger, G Vauqueli. Monoamine and iron-related toxicity: from "serotonin-binding proteins" to lipid peroxidation and apoptosis in PC12 cells. General pharmacology. vol 31. issue 1. 1998-08-05. PMID:9595272. |
monoamine and iron-related toxicity: from "serotonin-binding proteins" to lipid peroxidation and apoptosis in pc12 cells. |
1998-08-05 |
2023-08-12 |
Not clear |
| C Velez-Pardo, M J Del Rio, G Ebinger, G Vauqueli. Monoamine and iron-related toxicity: from "serotonin-binding proteins" to lipid peroxidation and apoptosis in PC12 cells. General pharmacology. vol 31. issue 1. 1998-08-05. PMID:9595272. |
dopamine in combination with iron induces lipid peroxidation and apoptosis in pc12 cells by a stress oxidative-ca2+ independent mechanism. |
1998-08-05 |
2023-08-12 |
Not clear |
| A A Nanj. Apoptosis and alcoholic liver disease. Seminars in liver disease. vol 18. issue 2. 1998-08-03. PMID:9606815. |
exposure of hep g2 cells expressing cytochrome p450 2e1 to arachidonic acid leads to increased lipid peroxidation and apoptosis. |
1998-08-03 |
2023-08-12 |
Not clear |
| J Frank, D K Kelleher, A Pompella, O Thews, H K Biesalski, P Vaupe. Enhancement of oxidative cell injury and antitumor effects of localized 44 degrees C hyperthermia upon combination with respiratory hyperoxia and xanthine oxidase. Cancer research. vol 58. issue 13. 1998-07-23. PMID:9661874. |
tumors were investigated for: (a) thiobarbituric acid-reactive substance formation and protein-bound 4-hydroxynonenal, as indicators of lipid peroxidation; (b) reactive oxygen-mediated protein modifications; (c) apoptosis; and (d) tumor volume growth. |
1998-07-23 |
2023-08-12 |
rat |
| J Frank, D K Kelleher, A Pompella, O Thews, H K Biesalski, P Vaupe. Enhancement of oxidative cell injury and antitumor effects of localized 44 degrees C hyperthermia upon combination with respiratory hyperoxia and xanthine oxidase. Cancer research. vol 58. issue 13. 1998-07-23. PMID:9661874. |
these findings indicate that the antitumor effect of ht is at least partially mediated through the selective induction of lipid peroxidation and oxidative injury in tumor cells, leading to apoptosis. |
1998-07-23 |
2023-08-12 |
rat |
| I Giardino, A K Fard, D L Hatchell, M Brownle. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes. vol 47. issue 7. 1998-07-10. PMID:9648836. |
aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. |
1998-07-10 |
2023-08-12 |
rat |
| I Giardino, A K Fard, D L Hatchell, M Brownle. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes. vol 47. issue 7. 1998-07-10. PMID:9648836. |
in this study, the effects of preincubation with ag on oxidant-induced apoptosis, oxidant-induced intracellular reactive oxygen species (ros) production, and lipid peroxidation were determined in rat retinal müller cells and compared with the effects of ngf, a protein that protects neuronal cells from oxidative stress. |
1998-07-10 |
2023-08-12 |
rat |
| I Giardino, A K Fard, D L Hatchell, M Brownle. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes. vol 47. issue 7. 1998-07-10. PMID:9648836. |
these data demonstrate that ag can act as an antioxidant in vivo, quenching hydroxyl radicals and lipid peroxidation in cells and tissues and preventing oxidant-induced apoptosis. |
1998-07-10 |
2023-08-12 |
rat |
| Q Chen, A I Cederbau. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Molecular pharmacology. vol 53. issue 4. 1998-05-06. PMID:9547353. |
the antioxidants vitamin e, vitamin c, or trolox prevented the lipid peroxidation as well as the cytotoxicity and apoptosis, as did transfection with plasmid containing antisense cyp2e1 or overexpression of bcl-2. |
1998-05-06 |
2023-08-12 |
Not clear |