| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Colquhoun, R I Schumache. gamma-Linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. Biochimica et biophysica acta. vol 1533. issue 3. 2001-12-13. PMID:11731331. |
gamma-linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in walker 256 rat carcinosarcoma cells. |
2001-12-13 |
2023-08-12 |
rat |
| S Takano, Y Aramaki, S Tsuchiy. Lipoxygenase may be involved in cationic liposome-induced macrophage apoptosis. Biochemical and biophysical research communications. vol 288. issue 1. 2001-12-07. PMID:11594761. |
furthermore, lipid peroxidation was observed following liposome treatment, but the apoptosis was not inhibited by the antioxidant alpha-tocopherol. |
2001-12-07 |
2023-08-12 |
Not clear |
| S Takano, Y Aramaki, S Tsuchiy. Lipoxygenase may be involved in cationic liposome-induced macrophage apoptosis. Biochemical and biophysical research communications. vol 288. issue 1. 2001-12-07. PMID:11594761. |
these findings suggested that lipoxygenase is responsible for ros generation, and ros but not lipid peroxidation acts as a key mediator in the progress of apoptosis induced by cationic liposomes. |
2001-12-07 |
2023-08-12 |
Not clear |
| C Ji, V Amarnath, J A Pietenpol, L J Marnet. 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. Chemical research in toxicology. vol 14. issue 8. 2001-11-01. PMID:11511183. |
we investigated the mechanism by which 4-hydroxynonenal (hne), a major aldehydic product of lipid peroxidation, induces apoptosis in tumor cells. |
2001-11-01 |
2023-08-12 |
human |
| C D Anuradha, S Kanno, S Hiran. Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells. Free radical biology & medicine. vol 31. issue 3. 2001-10-18. PMID:11461774. |
these results suggested that perhaps naf induced apoptosis by oxidative stress-induced lipid peroxidation, causing loss of deltapsi(m), and thereby releasing cytochrome c into the cytosol and further triggering the caspase cascade leading to apoptotic cell death in hl-60 cells. |
2001-10-18 |
2023-08-12 |
Not clear |
| A Agrawal, R K Kal. Radiation induced peroxidative damage: mechanism and significance. Indian journal of experimental biology. vol 39. issue 4. 2001-09-20. PMID:11491573. |
recent findings related to the close link between radiation-induced lipid peroxidation and apoptosis are likely to open new avenues for future research and to develop new approaches for radiomodification of biological effects. |
2001-09-20 |
2023-08-12 |
Not clear |
| B C Kim, B S Shon, Y W Ryoo, S P Kim, K S Le. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. Journal of dermatological science. vol 26. issue 3. 2001-08-09. PMID:11390204. |
this study suggests that melatonin pretreatment inhibits radiation-induced apoptosis, and melatonin exerts its radioprotective effect by inhibition of lipid peroxidation and without any involvement of the p53/p21 pathway. |
2001-08-09 |
2023-08-12 |
human |
| Y Yang, J Z Cheng, S S Singhal, M Saini, U Pandya, S Awasthi, Y C Awasth. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. The Journal of biological chemistry. vol 276. issue 22. 2001-07-26. PMID:11279091. |
hgsta2 transfection does not affect the function of antioxidant enzymes including gpx activity toward h(2)o(2) suggesting that the alpha class gsts play an important role in regulation of the intracellular concentrations of the lipid peroxidation products that may be involved in the signaling mechanisms of apoptosis. |
2001-07-26 |
2023-08-12 |
human |
| G Spitelle. Peroxidation of linoleic acid and its relation to aging and age dependent diseases. Mechanisms of ageing and development. vol 122. issue 7. 2001-07-12. PMID:11322990. |
it is speculated that the change from enzymic to nonenzymic lpo is connected with the switch from apoptosis to necrosis and that loohs produced in enzymic reactions are degraded specifically to signal compounds which induce physiological responses, while nonenzymic reactions seem to induce generation of reactive oxygen species, cell death and age related diseases. |
2001-07-12 |
2023-08-12 |
Not clear |
| E Waters, J H Wang, H P Redmond, Q D Wu, E Kay, D Bouchier-Haye. Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. American journal of physiology. Gastrointestinal and liver physiology. vol 280. issue 6. 2001-06-28. PMID:11352821. |
taurine administered before, simultaneously with, or 1 h after acetaminophen resulted in significant improvement in hepatic injury as represented by decrease of hepatocellular enzyme release and attenuation of hepatocyte apoptosis and necrosis, and this correlated with taurine-mediated attenuation of hepatic lipid peroxidation. |
2001-06-28 |
2023-08-12 |
rat |
| S J Stohs, D Bagchi, E Hassoun, M Bagch. Oxidative mechanisms in the toxicity of chromium and cadmium ions. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 20. issue 2. 2001-06-21. PMID:11394715. |
these reactive oxygen species result in increased lipid peroxidation, enhanced excretion of urinary lipid metabolites, modulation of intracellular oxidized states, dna damage, membrane damage, altered gene expression, and apoptosis. |
2001-06-21 |
2023-08-12 |
Not clear |
| W Zhang, Q He, L L Chan, F Zhou, M El Naghy, E B Thompson, N H Ansar. Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free radical biology & medicine. vol 30. issue 6. 2001-06-07. PMID:11295368. |
4-hydroxynonenal (hne), a reactive and cytotoxic end-product of lipid peroxidation, has been suggested to be a key mediator of oxidative stress-induced cell death and in various cell types has been shown to induce apoptosis. |
2001-06-07 |
2023-08-12 |
human |
| V Umansky, F Ratter, S Lampel, M Bucur, V Schirrmacher, A Ushmoro. Inhibition of nitric-oxide-mediated apoptosis in Jurkat leukemia cells despite cytochrome c release. Experimental cell research. vol 265. issue 2. 2001-06-07. PMID:11302692. |
moreover, an inhibitor of lipid peroxidation, trolox, suppressed apoptosis in jurkat cells induced by no donor glycerol trinitrate. |
2001-06-07 |
2023-08-12 |
human |
| T O Kishko, N P Dmitrenk. [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 72. issue 3. 2001-03-22. PMID:11200484. |
during the process of developing thymocytes apoptosis caused by papaverine the reaction of lipid peroxidation was intensified. |
2001-03-22 |
2023-08-12 |
Not clear |
| F Zhang, L Zhou, F Huang, Y Liang, G Zhan. U-74389G suppresses lipid peroxidation and apoptosis following focal cerebral ischemia and reperfusion in rats. Chinese medical journal. vol 111. issue 9. 2001-03-01. PMID:11155678. |
u-74389g suppresses lipid peroxidation and apoptosis following focal cerebral ischemia and reperfusion in rats. |
2001-03-01 |
2023-08-12 |
rat |
| Z Y Chen, N W Istfa. Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostaglandins, leukotrienes, and essential fatty acids. vol 63. issue 5. 2001-02-15. PMID:11090257. |
in contrast, the dha-induced apoptosis is partially reversed by a synthetic antioxidant, butylated hydroxytoluene, indicating that lipid peroxidation may be involved in apoptotic signaling pathway induced by dha. |
2001-02-15 |
2023-08-12 |
Not clear |
| A V Rao, C Shah. Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis. Free radical biology & medicine. vol 29. issue 10. 2001-02-02. PMID:11084290. |
if this increase in activity is inhibited with suitable inhibitors, the formation of products of lipid peroxidation is augmented, resulting in germ cell apoptosis. |
2001-02-02 |
2023-08-12 |
Not clear |
| A V Rao, C Shah. Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis. Free radical biology & medicine. vol 29. issue 10. 2001-02-02. PMID:11084290. |
also, when constitutive gst activity is inhibited, accumulation of products of lipid peroxidation occurs, resulting in increased cellular apoptosis. |
2001-02-02 |
2023-08-12 |
Not clear |
| J F Kalinich, R Ramakrishnan, D E McClain, N Ramakrishna. 4-Hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic T- and B-cell lines. Free radical research. vol 33. issue 4. 2001-02-01. PMID:11022844. |
4-hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic t- and b-cell lines. |
2001-02-01 |
2023-08-12 |
human |
| J F Kalinich, R Ramakrishnan, D E McClain, N Ramakrishna. 4-Hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic T- and B-cell lines. Free radical research. vol 33. issue 4. 2001-02-01. PMID:11022844. |
in our continuing studies on the role of membranes and lipid peroxidation in the induction of apoptosis, we investigated the effect of hne on cultured human malignant immune system cells. |
2001-02-01 |
2023-08-12 |
human |