| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Madesh, Raghul Murugan, Avra Sau, S Jubie, Akey Krishna Swaroop, Rajakrishnan Rajagopal, Kathiravan Muthu Kumaradoss, Jesu Arockiara. Nano-Encapsulated Coumarin Derivative, CS-QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model. Journal of biochemical and molecular toxicology. vol 39. issue 4. 2025-03-27. PMID:40143626. |
cs-qm2 significantly increases intracellular ros, resulting in higher lpo and induces apoptosis in neoplasm tissues. |
2025-03-27 |
2025-03-30 |
cat |
| Gong-Ming Yuan, Feng-Ya Su, Pei-Yun Li, Yong-Ming Guo, Jian Zhang, Yuan Xu, Zhong-Xi Lü, Ji-Yu Zhao, Yi-Nan Gon. Cerebral protective effect of acupuncture based on its regulative effect on programmed cell death. Zhen ci yan jiu = Acupuncture research. vol 50. issue 2. 2025-03-09. PMID:40059056. |
in the present paper, we sum up the protective effect of acupuncture therapy from 1) cell apoptosis (for example, improving post-surgery cognition impairment, traumatic brain injury and ischemic stroke by relieving mitochondrial damage, activating mitochondrial autophagy, increasing blood-brain barrier permeability, and thus reducing cell apoptosis ), 2) cell autophagy (for example, improving post-surgery cognition impairment, traumatic brain injury and ischemic stroke by relieving mitochondrial damage, activating mitochondrial autophagy, and increasing blood-brain barrier permeability, and thus reducing cell apoptosis), 3) pyroptosis (for example, inhibiting abnormally-activated inflammasomes, and caspase and gasdermin d activity to remit pyroptosis in the treatment of stroke, depression, parkinson's disease, and alzheimer's disease animal models), 4) ferroptosis (for instance, regulating iron ion metabolism, relieving lipid peroxidation damage, and thus playing a brain protection role in the treatment of ischemic and hemorrhagic stroke animal models), 5) necroptosis (inhibiting necrotic apoptosis mediated by receptor-interacting protein kinase 1 in intracerebral hemorrhage rats), and so on. |
2025-03-09 |
2025-03-12 |
rat |
| Seda Yakut, Merve Karabulut, Recep Hakkı Koca, Elif Erbaş, Seçkin Özkanlar, Berrin Tarakçı Gençer, Adem Kara, K J Senthil Kuma. Protective Effects of Bromelain in Testicular Torsion-Detorsion: Reducing Inflammation, Oxidative Stress, and Apoptosis While Enhancing Sperm Quality. Biomolecules. vol 15. issue 2. 2025-02-26. PMID:40001595. |
using western blotting, testicular tissue was examined for histopathological alterations, antioxidant enzymes (gsh, sod), lipid peroxidation (mda), apoptosis, and survival-related proteins (tlr4, caspase-3, bcl-2, nrf-2, ho-1, pi3k, mtor, akt-1). |
2025-02-26 |
2025-02-28 |
Not clear |
| Elham Einafshar, Pegah Bahrami, Fatemeh Pashaei, Paniz Naseri, Altin Ay Gharanjik, Atefe Mirteimoori, Nastaran Daraeebaf, Yegane Marami, Amirhossein Sahebkar, Hossein Hossein. The potential of curcumin in mitigating acetaminophen-induced liver damage. Naunyn-Schmiedeberg's archives of pharmacology. 2025-02-26. PMID:40009170. |
through its ability to scavenge free radicals, prevent lipid peroxidation, restore glutathione (gsh) levels, and inhibit apoptosis, curcumin has been found to significantly reduce oxidative stress and protect liver tissue from apap toxicity in various studies. |
2025-02-26 |
2025-02-28 |
Not clear |
| Yuanyuan Li, Tingting Zhang, Qiaoxing Mou, Sirui Liu, Wanxing Wu, Simei Wang, Xiaoyu Yan, Jie Liang, Mengfan Yan, Weiying Liu, Xiaoqi Pa. Overexpression of Methionine Sulfoxide Reductase A Alleviates Acrylamide-Induced Neurotoxicity by Mitigating Lipid Peroxidation and Mitochondria-Dependent Apoptosis In Vivo and In Vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2025-02-22. PMID:39986565. |
overexpression of methionine sulfoxide reductase a alleviates acrylamide-induced neurotoxicity by mitigating lipid peroxidation and mitochondria-dependent apoptosis in vivo and in vitro. |
2025-02-22 |
2025-02-25 |
rat |
| Mohammadrasool Ghasemi, Hamid Nazarian, Zahra Shams Mofarahe, Pourya Raee, Ali Moradi, Zohreh Khavari, Marefat Ghaffari Novi. The Effect of Edaravone Supplementation Prior to Cryopreservation on Sperm Parameters, DNA Integrity, Apoptosis, Lipid Peroxidation, and Mitochondrial Membrane Potential in Infertile Men with Asthenoteratozoospermia. Reproductive sciences (Thousand Oaks, Calif.). 2025-02-21. PMID:39982650. |
the effect of edaravone supplementation prior to cryopreservation on sperm parameters, dna integrity, apoptosis, lipid peroxidation, and mitochondrial membrane potential in infertile men with asthenoteratozoospermia. |
2025-02-21 |
2025-02-23 |
human |
| Mohammadrasool Ghasemi, Hamid Nazarian, Zahra Shams Mofarahe, Pourya Raee, Ali Moradi, Zohreh Khavari, Marefat Ghaffari Novi. The Effect of Edaravone Supplementation Prior to Cryopreservation on Sperm Parameters, DNA Integrity, Apoptosis, Lipid Peroxidation, and Mitochondrial Membrane Potential in Infertile Men with Asthenoteratozoospermia. Reproductive sciences (Thousand Oaks, Calif.). 2025-02-21. PMID:39982650. |
the groups were assessed for motility, morphology, viability, apoptosis, lipid peroxidation, mitochondrial membrane potential (mmp), dna fragmentation index (dfi), glutathione (gsh), atp, and ros production. the freeze + edaravone group significantly improved total sperm motility (p < 0.0001), progressive and non-progressive sperm motility (p < 0.01), viability (p < 0.0001), morphology (p < 0.001), dfi (p < 0.0001) and live sperm cells (p < 0.0001) post-thawing compared to freeze group. |
2025-02-21 |
2025-02-23 |
human |
| Parisa Alipour-Jenaghard, Hossein Daghigh-Kia, Reza Masoudi, Ali Hatef. MitoQ Preserves Epigenetic Modifications and Quality Parameters of Rooster Sperm During Cryopreservation Process. Reproduction in domestic animals = Zuchthygiene. vol 60. issue 2. 2025-02-18. PMID:39963986. |
this study aims to investigate the effect of the cryopreservation process in the presence of mitoq as a mitochondrial-targeted antioxidant on epigenetic changes and other quality parameters (motility, morphology, mitochondrial activity, acrosome integrity, lipid peroxidation, dna fragmentation, apoptosis status, and ros concentration) of rooster sperm. |
2025-02-18 |
2025-02-23 |
chicken |
| Walaa E Abd El Hady, Mohamed A Shahin, Alaa A Omar, Mahmoud A E Hassan, Sameh A Abdelnour, Amany A Elkashef, Wael A Khali. Development of Ziziphus spina-christi (Sidr) leaf extract-loaded hyaluronic acid and their potential in mitigating oxidative stress during semen cryopreservation. International journal of biological macromolecules. 2025-02-16. PMID:39956224. |
ex-vivo trials demonstrated that zscle-hs (50-100 μg) supplementation in freezing extenders significantly enhanced cryopreserved ram sperm quality by improving sperm function, kinematics, and antioxidant capacity, while mitigating apoptosis, lipid peroxidation, and acrosome damage, and preserving sperm ultrastructure. |
2025-02-16 |
2025-02-23 |
Not clear |
| Qiyu Yang, Chunyan Wang, Jingwei Cao, Zhanbin Tang, Shurong Dua. AKR1C1 protects against intracerebral hemorrhage by suppressing neuronal cell death via the P53/SLC7A11/GPX4 axis. Brain research bulletin. 2025-02-12. PMID:39938753. |
moreover, akr1c1 upregulation repressed cell apoptosis and ferroptosis induced by ich through downregulating the expression of pro-apoptotic factors, inhibiting iron accumulation and lipid peroxidation, along with increasing the expression of solute carrier family 7 member 11 (slc7a11) and glutathione peroxidase 4 (gpx4). |
2025-02-12 |
2025-02-15 |
rat |
| Xirui Yang, Songwei Li, Hao Guo, Siqi Wang, Huilan Sun, Jixue Wang, Xingxing Yua. Metabolic dysregulation in glaucoma. Clinical & experimental optometry. 2025-02-12. PMID:39938920. |
alterations in lipid metabolism, including changes in fatty acid profiles and lipid peroxidation, contribute to cellular injury and apoptosis of retinal ganglion cells. |
2025-02-12 |
2025-02-15 |
Not clear |
| Yulun Wu, Ziying Zhang, Minhui Ren, Yao Chen, Jingying Zhang, Jiarui Li, Feng Gao, Yongli Bao, Yanxin Huang, Xiaoguang Yang, Zhenbo Son. Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions. Cells. vol 14. issue 3. 2025-02-12. PMID:39937004. |
furthermore, it enhanced apoptosis and ferroptosis, as demonstrated by alterations in apoptotic protein expression and elevated levels of lipid reactive oxygen species (ros), malondialdehyde (mda), lipid peroxidation (lpo), and fe |
2025-02-12 |
2025-02-14 |
Not clear |
| S Madesh, Senthilkumar Palaniappan, Anand Aravind, Avra Sau, Mikhlid H Almutairi, Bader O Almutairi, Ilavenil Soundharrajan, S Karthick Raja Namasivayam, Kathiravan Muthu Kumaradoss, Jesu Arockiara. Mitigation of gentamycin induced acute kidney injury due to benzothiazole derivatives N1 and N5: Antioxidant and renoprotective mechanisms in-vivo zebrafish. Toxicology letters. 2025-02-08. PMID:39921194. |
treatment with n1 and n5 significantly reduced ros levels, apoptosis, and lipid peroxidation and restored antioxidant enzyme activities. |
2025-02-08 |
2025-02-11 |
zebrafish |
| Yankui Liu, Anjie Chen, Yufan Wu, Jiang Ni, Rong Wang, Yong Mao, Ning Sun, Yuanyuan M. Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer. Cell death & disease. vol 16. issue 1. 2025-02-05. PMID:39910035. |
the mtch2-silenced xenografts exhibited increased apoptosis, elevated lipid peroxidation, and decreased atp levels. |
2025-02-05 |
2025-02-08 |
mouse |
| Saeed Alshahrani, Mohammad Ashafaq, Abdulmajeed M Jali, Yosif Almoshari, Mohammad Intakhab Alam, Hamad Al Shahi, Ayed A Alshamrani, Sohail Hussai. Nephrotoxic effect of cypermethrin ameliorated by nanocurcumin through antioxidative mechanism. Naunyn-Schmiedeberg's archives of pharmacology. 2025-01-29. PMID:39878820. |
after the termination of the study, lpo, 4-hne, gsh, antioxidant catalase, and sod were evaluated as markers of inflammation and apoptosis along with elisa, qrt-pcr, and histopathology were used to assess morphological changes. |
2025-01-29 |
2025-01-31 |
rat |
| Saeed Alshahrani, Mohammad Ashafaq, Abdulmajeed M Jali, Yosif Almoshari, Mohammad Intakhab Alam, Hamad Al Shahi, Ayed A Alshamrani, Sohail Hussai. Nephrotoxic effect of cypermethrin ameliorated by nanocurcumin through antioxidative mechanism. Naunyn-Schmiedeberg's archives of pharmacology. 2025-01-29. PMID:39878820. |
although lpo, inflammation, and apoptosis are reduced, antioxidant status is improved by nc. |
2025-01-29 |
2025-01-31 |
rat |
| Abbas Farshad, Emilia Diel, Axel Wehren. Evaluating the Protective Effects of MitoQ and Antifreeze Protein III on Cryopreserved Canine Sperm. Animals : an open access journal from MDPI. vol 15. issue 2. 2025-01-25. PMID:39858270. |
post-thaw, samples were evaluated for motility, viability, membrane and acrosome integrity, lipid peroxidation, apoptosis indicators, mitochondrial function, and reactive oxygen species (ros-h |
2025-01-25 |
2025-01-28 |
Not clear |
| Mohamad Hosein Safari, Payman Rahimzadeh, Elmira Alaei, Mina Alimohammadi, Negin Esfandiari, Salman Daneshi, Neda Malgard, Najma Farahani, Afshin Taheriazam, Mehrdad Hashem. Targeting Ferroptosis in Gastrointestinal Tumors: Interplay of Iron-Dependent Cell Death and Autophagy. Molecular and cellular probes. 2025-01-21. PMID:39837469. |
ferroptosis is a regulated cell death mechanism distinct from apoptosis, autophagy, and necroptosis, marked by iron accumulation and lipid peroxidation. |
2025-01-21 |
2025-01-24 |
Not clear |
| N Asadzadeh, R Masoudi, R Nateghi, N D Davachi, H J Barfourooshi, P M Bartlewsk. The effects of mitoquinol mesylate on post-thaw characteristics and fertilizing ability of rooster semen cryopreserved in the Beltsville medium. Theriogenology. vol 235. 2025-01-16. PMID:39818001. |
following the thawing of cryopreserved semen doses, we evaluated the following sperm parameters: motility and morphology, membrane integrity and mitochondrial function, acrosome integrity, apoptosis status, lipid peroxidation, dna fragmentation, reactive oxygen species (ros) accumulation, epigenetic patterns (dna methylation and histone modifications), and fertilizing ability. |
2025-01-16 |
2025-01-19 |
chicken |
| N Asadzadeh, R Masoudi, R Nateghi, N D Davachi, H J Barfourooshi, P M Bartlewsk. The effects of mitoquinol mesylate on post-thaw characteristics and fertilizing ability of rooster semen cryopreserved in the Beltsville medium. Theriogenology. vol 235. 2025-01-16. PMID:39818001. |
moreover, the addition of 10 and 100 nm of mitoquinol mesylate significantly reduced lipid peroxidation, apoptosis rate, dna fragmentation and ros concentrations compared with all other dilutions and was associated with a higher (p ≤ 0.05) fertilization rate compared with a non-supplemented control group, albeit it was still significantly lower compared with that obtained using fresh semen. |
2025-01-16 |
2025-01-19 |
chicken |