| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Chen, A I Cederbau. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Molecular pharmacology. vol 53. issue 4. 1998-05-06. PMID:9547353. |
elevated lipid peroxidation plays an important role in the cyp2e1-dependent toxicity and apoptosis. |
1998-05-06 |
2023-08-12 |
Not clear |
| J C Copin, Y Li, L Reola, P H Cha. Trolox and 6,7-dinitroquinoxaline-2,3-dione prevent necrosis but not apoptosis in cultured neurons subjected to oxygen deprivation. Brain research. vol 784. issue 1-2. 1998-04-30. PMID:9518539. |
the results show that 6, 7-dinitroquinoxaline-2,3-dione (dnqx) and 6-hydroxy-2,5,7, 8-tetramethylchroman-2-carboxylic acid (trolox), which interfered with kainate receptor activation and lipid peroxidation respectively, prevented necrosis but allowed neurons to undergo apoptosis. |
1998-04-30 |
2023-08-12 |
Not clear |
| T T Turner, K S Tung, H Tomomasa, L W Wilso. Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biology of reproduction. vol 57. issue 6. 1998-02-11. PMID:9408230. |
testes were examined for evidence of 1) in situ apoptosis by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dutp)-biotin nick-end labeling (tunel) technique, 2) apoptosis by the dna "laddering" technique, 3) leukocyte margination and diapedesis in testicular vessels by immunocytochemical and histological techniques, and 4) testicular lipid peroxidation by the thiobarbituric acid reactive substances assay. |
1998-02-11 |
2023-08-12 |
rat |
| J N Keller, M S Kindy, F W Holtsberg, D K St Clair, H C Yen, A Germeyer, S M Steiner, A J Bruce-Keller, J B Hutchins, M P Mattso. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 2. 1998-02-03. PMID:9425011. |
mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. |
1998-02-03 |
2023-08-12 |
mouse |
| J N Keller, M S Kindy, F W Holtsberg, D K St Clair, H C Yen, A Germeyer, S M Steiner, A J Bruce-Keller, J B Hutchins, M P Mattso. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 2. 1998-02-03. PMID:9425011. |
the peroxynitrite scavenger uric acid and the antioxidants propyl gallate and glutathione prevented apoptosis induced by each apoptotic insult, suggesting central roles for peroxynitrite and membrane lipid peroxidation in oxidative stress-induced apoptosis. |
1998-02-03 |
2023-08-12 |
mouse |
| A J Bruce-Keller, J G Begley, W Fu, D A Butterfield, D E Bredesen, J B Hutchins, K Hensley, M P Mattso. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422344. |
collectively, our data suggest that bcl-2 is localized to mitochondrial and plasma membranes where it can act locally to suppress oxidative damage induced by a beta and h2o2, further highlighting the important role of lipid peroxidation in apoptosis. |
1998-02-02 |
2023-08-12 |
Not clear |
| J M Villalba, F Navarro, C Gómez-Díaz, A Arroyo, R I Bello, P Nava. Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane. Molecular aspects of medicine. vol 18 Suppl. 1997-11-14. PMID:9266501. |
addition of coq to intact cells prevents serum withdrawal-induced lipid peroxidation and apoptosis. |
1997-11-14 |
2023-08-12 |
Not clear |
| M P Barroso, C Gómez-Díaz, J M Villalba, M I Burón, G López-Lluch, P Nava. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. Journal of bioenergetics and biomembranes. vol 29. issue 3. 1997-11-14. PMID:9298711. |
hl-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. |
1997-11-14 |
2023-08-12 |
Not clear |
| M P Barroso, C Gómez-Díaz, J M Villalba, M I Burón, G López-Lluch, P Nava. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. Journal of bioenergetics and biomembranes. vol 29. issue 3. 1997-11-14. PMID:9298711. |
addition of ubiquinone to both cell cultures in the absence of serum improved cell survival with decreasing lipid peroxidation and apoptosis. |
1997-11-14 |
2023-08-12 |
Not clear |
| D P Hajjar, M E Haberlan. Lipoprotein trafficking in vascular cells. Molecular Trojan horses and cellular saboteurs. The Journal of biological chemistry. vol 272. issue 37. 1997-10-01. PMID:9287290. |
in addition to foam cell development, products of ldl peroxidation may activate endothelial cells, increase smooth muscle mitogenesis, or induce apoptosis because of the effects of oxysterols and products of lipid peroxidation (fig 1). |
1997-10-01 |
2023-08-12 |
Not clear |
| D G Tang, K V Hon. Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival. Journal of cellular physiology. vol 172. issue 2. 1997-09-11. PMID:9258337. |
apoptosis of w256 carcinosarcoma cells of the monocytoid origin induced by ndga involves lipid peroxidation and depletion of gsh: role of 12-lipoxygenase in regulating tumor cell survival. |
1997-09-11 |
2023-08-12 |
rat |
| D G Tang, K V Hon. Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival. Journal of cellular physiology. vol 172. issue 2. 1997-09-11. PMID:9258337. |
w256 cell apoptosis induced by ndga could also be effectively inhibited by gsh-elevating or thiol agents as well as by lipid peroxidation inhibitors and an inhibitor of mitochondria respiratory chain rotenone. |
1997-09-11 |
2023-08-12 |
rat |
| M P Barroso, C Gómez-Diaz, G Lopez-Lluch, M M Malagón, F L Crane, P Nava. Ascorbate and alpha-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2. Archives of biochemistry and biophysics. vol 343. issue 2. 1997-08-07. PMID:9224736. |
cells containing bcl-2 are partially protected against both lipid peroxidation and apoptosis and some cell lines, such as daudi, which lack this protein, are very sensitive to serum removal. |
1997-08-07 |
2023-08-12 |
Not clear |
| M P Barroso, C Gómez-Diaz, G Lopez-Lluch, M M Malagón, F L Crane, P Nava. Ascorbate and alpha-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2. Archives of biochemistry and biophysics. vol 343. issue 2. 1997-08-07. PMID:9224736. |
ascorbate (asc) and alpha-tocopherol (alphatoh) can prevent lipid peroxidation and apoptosis caused by serum withdrawal, when added to culture media, even in the absence of bcl-2. |
1997-08-07 |
2023-08-12 |
Not clear |
| I Kruman, A J Bruce-Keller, D Bredesen, G Waeg, M P Mattso. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185546. |
we now provide evidence that 4-hydroxynonenal (hne), an aldehydic product of membrane lipid peroxidation, is a key mediator of neuronal apoptosis induced by oxidative stress. |
1997-07-17 |
2023-08-12 |
rat |
| I Kruman, A J Bruce-Keller, D Bredesen, G Waeg, M P Mattso. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185546. |
oxidative insults (feso4 and amyloid beta-peptide) induced lipid peroxidation, cellular accumulation of hne, and apoptosis. |
1997-07-17 |
2023-08-12 |
rat |
| I Kruman, A J Bruce-Keller, D Bredesen, G Waeg, M P Mattso. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 13. 1997-07-17. PMID:9185546. |
antioxidants that suppress lipid peroxidation protected against apoptosis induced by oxidative insults, but not that induced by hne. |
1997-07-17 |
2023-08-12 |
rat |
| D Zhang, S Okada, Y Yu, P Zheng, R Yamaguchi, H Kasa. Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney. Cancer research. vol 57. issue 12. 1997-07-15. PMID:9192818. |
after 1 month of feeding, iron-induced tissue lipid peroxidation, apoptosis, and formation of 8-hydroxydeoxyguanosine, a known dna oxidative modification, were observed by cold schiff staining, in situ labeling method (staining by terminal deoxynucleotidyl transferase-mediated nick end labeling), and high-performance liquid chromatography with electrochemical detection system, respectively, in the groups of rats treated with ferric nitrilotriacetate (fe-nta; fe, 10 mg/kg body weight). |
1997-07-15 |
2023-08-12 |
rat |
| D Zhang, S Okada, Y Yu, P Zheng, R Yamaguchi, H Kasa. Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney. Cancer research. vol 57. issue 12. 1997-07-15. PMID:9192818. |
the results showed that vitamin e could inhibit tissue lipid peroxidation, apoptosis, 8-hydroxydeoxyguanosine formation, and the development of cancer [11 of 25 rats (44%) for vitamin e-sufficient versus 1 of 20 rats (5%) for vitamin e-supplemented rats, respectively]. |
1997-07-15 |
2023-08-12 |
rat |
| Q Chen, M Galleano, A I Cederbau. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. The Journal of biological chemistry. vol 272. issue 23. 1997-06-26. PMID:9169410. |
it is proposed that elevated production of reactive oxygen intermediates by cells expressing cyp2e1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. |
1997-06-26 |
2023-08-12 |
human |