| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Rocco Caminiti, Rosaria Meli, Placido Bramanti, Salvatore Cuzzocre. Effect of thalidomide on signal transduction pathways and secondary damage in experimental spinal cord trauma. Shock (Augusta, Ga.). vol 30. issue 3. 2008-12-09. PMID:18197140. |
thalidomide treatment significantly reduced the degree of: 1) spinal cord inflammation and tissue injury (histological score); 2) neutrophil infiltration (myeloperoxidase evaluation); 3) inos, nitrotyrosine, lipid peroxidation, and cytokine expression (tnf-alpha and il-1beta); 4) apoptosis (terminal deoxynucleotidyltransferase-mediated utp end labeling staining, and bax and bcl-2 expression); and 5) nuclear factor-kappab activation. |
2008-12-09 |
2023-08-12 |
mouse |
| Werner Schmid, Alice Assinger, Alexander Lee, Edith Bielek, Elisabeth Koller, Ivo Vol. Platelet-stimulating effects of oxidized LDL are not attributable to toxic properties of the lipoproteins. Thrombosis research. vol 122. issue 5. 2008-12-04. PMID:18387657. |
in the present work, we show that copper-oxidized ldl mediate severe toxic effects towards a macrophage cell line (decrease in both the number of adherent cells and the amount of incorporated tritiated thymidine, induction of apoptosis and subsequent loss of membrane integrity)--effects that are presumably attributable to products emerging from lipid peroxidation. |
2008-12-04 |
2023-08-12 |
human |
| F Hispard, A de Vaufleury, H Martin, S Devaux, R P Cosson, R Scheifler, L Richert, A Berthelot, P-M Bado. Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues. Ecotoxicology and environmental safety. vol 70. issue 3. 2008-10-31. PMID:17532469. |
however, lipid peroxidation as well as catalase and caspase 3 (a marker of apoptosis) activities were not modified. |
2008-10-31 |
2023-08-12 |
rat |
| Gouda K Hela. Systemic administration of Zn2+ during the reperfusion phase of transient cerebral ischaemia protects rat hippocampus against iron-catalysed postischaemic injury. Clinical and experimental pharmacology & physiology. vol 35. issue 7. 2008-10-20. PMID:18215188. |
injected zncl(2), which can induce expression of brain mt, increase the anti-oxidant capacity and diminish iron-catalysed lipid peroxidation and apoptosis. |
2008-10-20 |
2023-08-12 |
rat |
| Xianghua Xiao, Juntian Liu, Jingwen Hu, Xiuping Zhu, Hua Yang, Chaoyun Wang, Yuanhui Zhan. Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18602385. |
calcium and lipid peroxidation play important roles in oxidative stress-induced cellular injury and apoptosis, which ultimately cause cell death. |
2008-10-15 |
2023-08-12 |
Not clear |
| Sung-Chun Tang, Justin D Lathia, Pradeep K Selvaraj, Dong-Gyu Jo, Mohamed R Mughal, Aiwu Cheng, Dominic A Siler, William R Markesbery, Thiruma V Arumugam, Mark P Mattso. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Experimental neurology. vol 213. issue 1. 2008-09-15. PMID:18586243. |
toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. |
2008-09-15 |
2023-08-12 |
mouse |
| Silvio De Flora, Francesco D'Agostini, Roumen Balansky, Anna Camoirano, Cristina Cartiglia, Mariagrazia Longobardi, Giorgia Travaini, Vernon E Steele, Carlo Pesce, Alberto Izzott. High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light. Mutation research. vol 659. issue 1-2. 2008-09-12. PMID:18155953. |
our further experiments showed that exposure of mice to environmental cigarette smoke, during the first 5 weeks of life, resulted in a variety of significant alterations of intermediate biomarkers, including cytogenetic damage in bone marrow and peripheral blood, formation of lipid peroxidation products, increase of bulky dna adduct levels, induction of oxidative dna damage, and overexpression of ogg1 gene in lung, stimulation of apoptosis, hyperproliferation and loss of fhit protein in pulmonary alveolar macrophages and/or bronchial epithelial cells, and early histopathological alterations in the respiratory tract. |
2008-09-12 |
2023-08-12 |
mouse |
| Analía Lorena Tomat, Felipe Inserra, Luciana Veiras, María Constanza Vallone, Ana María Balaszczuk, María Angeles Costa, Cristina Arran. Moderate zinc restriction during fetal and postnatal growth of rats: effects on adult arterial blood pressure and kidney. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 2. 2008-09-09. PMID:18525016. |
activation of renal apoptosis, reduction in catalase activity, glutathione peroxidase activity, and glutathione levels and increase in lipid peroxidation end products could explain these morphometric changes. |
2008-09-09 |
2023-08-12 |
rat |
| Analía Lorena Tomat, Felipe Inserra, Luciana Veiras, María Constanza Vallone, Ana María Balaszczuk, María Angeles Costa, Cristina Arran. Moderate zinc restriction during fetal and postnatal growth of rats: effects on adult arterial blood pressure and kidney. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 2. 2008-09-09. PMID:18525016. |
these animals showed signs of renal fibrosis, proteinuria, increased renal apoptosis, and higher lipid peroxidation end products. |
2008-09-09 |
2023-08-12 |
rat |
| Gilbert R Kinsey, Jason L Blum, Marisa D Covington, Brian S Cummings, Jane McHowat, Rick G Schnellman. Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. Journal of lipid research. vol 49. issue 7. 2008-09-05. PMID:18398221. |
decreased ipla2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. |
2008-09-05 |
2023-08-12 |
Not clear |
| Subhash Chander Gangar, Ashwani Kou. Histochemical, ultrastructural, and biochemical evidences for Azadirachta indica-induced apoptosis in benzo(a)pyrene-induced murine forestomach tumors. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 27. issue 3. 2008-09-02. PMID:18652569. |
however, levels of lpo were found to increase in the tumorous tissue of mice that received aaile along with b(a)p when compared to mice receiving only b(a)p. taken together, observations of the present study suggest that a. indica induces apoptosis in b(a)p-induced murine forestomach tumors. |
2008-09-02 |
2023-08-12 |
mouse |
| Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida, Etsuo Nik. Effect of oxygen concentration on free radical-induced cytotoxicity. Bioscience, biotechnology, and biochemistry. vol 72. issue 6. 2008-08-25. PMID:18540111. |
it was found that alkyl radicals markedly aggravated jurkat cell apoptosis under low oxygen pressure and this was ascribed to a hypoxic condition caused by the consumption of oxygen by alkyl radicals giving peroxyl radicals and subsequent lipid peroxidation by a chain mechanism. |
2008-08-25 |
2023-08-12 |
Not clear |
| W Pickering, E Gray, A H Goodall, T W Barrowcliff. Effects of apoptosis and lipid peroxidation on T-lymphoblastoid phospholipid-dependent procoagulant activity. Journal of thrombosis and haemostasis : JTH. vol 6. issue 7. 2008-08-13. PMID:18601681. |
effects of apoptosis and lipid peroxidation on t-lymphoblastoid phospholipid-dependent procoagulant activity. |
2008-08-13 |
2023-08-12 |
Not clear |
| Giuseppe M Campo, Angela Avenoso, Salvatore Campo, Angela D'Ascola, Paola Traina, Dario Samà, Alberto Calatron. NF-kB and caspases are involved in the hyaluronan and chondroitin-4-sulphate-exerted antioxidant effect in fibroblast cultures exposed to oxidative stress. Journal of applied toxicology : JAT. vol 28. issue 4. 2008-07-15. PMID:17879260. |
a possible explanation for these results, since lipid peroxidation intermediates may induce nf-kb and caspase activation, is that ha and c4s indirectly blocked nf-kb dna binding and apoptosis by inhibiting reactive oxygen species (ros) production. |
2008-07-15 |
2023-08-12 |
human |
| K Negishi, E Noiri, R Maeda, D Portilla, T Sugaya, T Fujit. Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury. Kidney international. vol 73. issue 12. 2008-07-07. PMID:18368030. |
cisplatin-induced renal necrosis and apoptosis were significantly reduced in bezafibrate pretreated transgenic mice and this correlated with decreased accumulation of lipid and lipid peroxidation products. |
2008-07-07 |
2023-08-12 |
mouse |
| Ilaria Cosci, Elena Moretti, Giulia Collode. Lipid peroxidation in human spermatozoa from men with genitourinary infections. Systems biology in reproductive medicine. vol 54. issue 2. 2008-07-03. PMID:18446648. |
the incidence of lpo was compared with sperm pathologies (apoptosis, immaturity, necrosis) evaluated by transmission electron microscopy (tem) and motility. |
2008-07-03 |
2023-08-12 |
human |
| Ilaria Cosci, Elena Moretti, Giulia Collode. Lipid peroxidation in human spermatozoa from men with genitourinary infections. Systems biology in reproductive medicine. vol 54. issue 2. 2008-07-03. PMID:18446648. |
group 3 included 6 infected patients with progressive motility < or =22%, low levels of lpo with a higher percentage of apoptosis and necrosis. |
2008-07-03 |
2023-08-12 |
human |
| Giuseppe M Campo, Angela Avenoso, Salvatore Campo, Angela D'Ascola, Paola Traina, Dario Samà, Alberto Calatron. The antioxidant effect exerted by TGF-1beta-stimulated hyaluronan production reduced NF-kB activation and apoptosis in human fibroblasts exposed to FeSo4 plus ascorbate. Molecular and cellular biochemistry. vol 311. issue 1-2. 2008-06-18. PMID:18224424. |
since it was previously reported that antioxidants can work as inhibitors of nf-kb and apoptosis induction we can hypothesize that endogenous ha, by inhibiting lipid peroxidation, may block a step whereby free radical activity converges in the signal transduction pathway leading to nf-kb and caspase activation. |
2008-06-18 |
2023-08-12 |
human |
| Fu Yu, Ziren Wang, Bao Ju, Yongqiang Wang, Jing Wang, Decheng Ba. Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 59. issue 6. 2008-06-17. PMID:18222074. |
cell apoptosis, lipid peroxidation and dna damage were increased, and activities of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase were decreased in retina of chlorpyrifos-administrated mice (63mg/kg, single treatment, via oral gavage). |
2008-06-17 |
2023-08-12 |
mouse |
| Ghaffar Shokouhi, R Shane Tubbs, Mohammadali M Shoja, Leila Roshangar, Mehran Mesgari, Amir Ghorbanihaghjo, Naser Ahmadi, Farzam Sheikhzadeh, Jafar S Ra. The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. Life sciences. vol 82. issue 15-16. 2008-06-17. PMID:18336840. |
the effects of aerobic exercise training on the age-related lipid peroxidation, schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. |
2008-06-17 |
2023-08-12 |
rat |