| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Albert R Wielgus, Baozhong Zhao, Colin F Chignell, Dan-Ning Hu, Joan E Robert. Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells. Toxicology and applied pharmacology. vol 242. issue 1. 2009-12-30. PMID:19800903. |
exposure to an 8.5 j x cm(-2) dose of visible light in the presence of >5 microm fullerol induced tbars formation and early apoptosis, indicating phototoxic damage in the form of lipid peroxidation. |
2009-12-30 |
2023-08-12 |
human |
| Marco Siech, Zhengfei Zhou, Shaoxia Zhou, Bernd Bair, Andreas Alt, Stefan Hamm, Hans Gross, Jens Mayer, Hans G Beger, Xiaodong Tian, Marko Kornmann, Max G Bache. Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL). American journal of physiology. Gastrointestinal and liver physiology. vol 297. issue 6. 2009-12-17. PMID:19779015. |
we measured pac function (amylase, lipase), injury (lactic dehydrogenase), apoptosis (tunel, apo2.7, annexin v binding), oxidative stress, and lipid peroxidation (conjugated dienes, malondialdehyde, chemoluminescence); we also measured psc proliferation (bromodeoxyuridine incorporation), matrix synthesis (immunofluorescence of collagens and fibronectin, fibronectin immunoassay), and fatty acids in pac supernatants (gas chromatography). |
2009-12-17 |
2023-08-12 |
rat |
| Kai Kang, Mingyan Zhao, Hongchi Jiang, Gang Tan, Shangha Pan, Xueying Su. Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 15. issue 10. 2009-12-17. PMID:19790158. |
administration of nahs significantly attenuated the severity of liver injury and inhibited the production of lipid peroxidation, serum inflammatory factors [including nitric oxide, tumor necrosis factor alpha (tnf-alpha), interleukin 10, and intercellular cell adhesion molecule 1], cell apoptosis, and apoptosis-related proteins (including caspase-3, fas, fas ligand, and tnf-alpha), which were caused or elevated by hir, whereas pag aggravated them. |
2009-12-17 |
2023-08-12 |
rat |
| Noushin Amini-Shirazi, Asieh Hoseini, Akram Ranjbar, Azadeh Mohammadirad, Pooneh Khoshakhlagh, Nargues Yasa, Mohammad Abdollah. Inhibition of tumor necrosis factor and nitrosative/oxidative stresses by Ziziphora clinopoides (Kahlioti); a molecular mechanism of protection against dextran sodium sulfate-induced colitis in mice. Toxicology mechanisms and methods. vol 19. issue 2. 2009-12-04. PMID:19778264. |
the level of lipid peroxidation (lp), total antioxidant capacity (tac), total thiol molecules (ttm), antioxidant enzymes including superoxide dismutase (sod) and catalase (cat), and nitric oxide (no) as a marker of nitrosative stress, and tumor necrosis factor alpha (tnf-alpha) as a mediator of inflammation and apoptosis were measured in the colon homogenate. |
2009-12-04 |
2023-08-12 |
mouse |
| Eun Sun Cho, Young Jin Jang, Nam Joo Kang, Mun Kyung Hwang, Yong Taek Kim, Ki Won Lee, Hyong Joo Le. Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. Free radical biology & medicine. vol 46. issue 10. 2009-11-13. PMID:19248828. |
4-hydroxynonenal (hne), one of the aldehydic products of membrane lipid peroxidation, is reported to be elevated in the brains of ad patients and mediates the induction of neuronal apoptosis in the presence of oxidative stress. |
2009-11-13 |
2023-08-12 |
rat |
| Yu A Vladimirov, E V Proskurnina, E M Demin, N S Matveeva, O B Lubitskiy, A A Novikov, D Yu Izmailov, A N Osipov, V P Tikhonov, V E Kaga. Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis. Biochemistry. Biokhimiia. vol 74. issue 3. 2009-11-05. PMID:19364325. |
formation of free radicals in mitochondria plays a key role in the development of apoptosis, which includes formation of superoxide by the respiratory chain, formation of radicals by cytochrome c-cardiolipin complex in the presence of hydrogen peroxide or lipids, and chain lipid peroxidation resulting in cytochrome c release from mitochondria and initiation of the apoptotic cascade. |
2009-11-05 |
2023-08-12 |
Not clear |
| Masashi Hasegawa, Tohru Ogihara, Hiroshi Tamai, Mayo Hiro. Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: reduction of oxidative stress and maintenance of the glutathione redox state. Brain research. vol 1283. 2009-10-23. PMID:19524561. |
elevation of oxidative stress markers, including ortho-, meta-, and di-tyrosine (markers of protein oxidation) and 4-hydroxynonenal (lipid peroxidation) was significantly attenuated when the temperature was reduced by 5 degrees c. the half-cell reduction potential (ehc) of gssg/2gsh redox couple ranged from -220 to -180 mv in unstressed differentiated pc12 cells, and apoptosis was triggered when ehc exceeded -180 mv. |
2009-10-23 |
2023-08-12 |
Not clear |
| Shilian Hu, Shi Yin, Xiaodong Jiang, Dabing Huang, Gan She. Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. European journal of pharmacology. vol 616. issue 1-3. 2009-10-19. PMID:19576882. |
furthermore, melatonin decreased serum and tissue inflammatory cytokines levels, tissue lipid peroxidation, neutrophil infiltration and inhibited the apoptosis of hepatocytes. |
2009-10-19 |
2023-08-12 |
mouse |
| Ranjeet Verma, Bimla Nehr. Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease. Neurochemistry international. vol 55. issue 6. 2009-10-09. PMID:19375462. |
the important biochemical features of pd, being profound deficit in dopamine (da) content, reduced glutathione (gsh), and enhanced lipid peroxidation (lpo) in dopaminergic (da-ergic) neurons resulting in oxidative stress, mitochondrial dysfunction and apoptosis. |
2009-10-09 |
2023-08-12 |
rat |
| Zhanqing Li, Arash Nickkholgh, Xue Yi, Helge Bruns, Marie-Luise Gross, Katrin Hoffmann, Elvira Mohr, Markus Zorn, Markus W Büchler, Peter Schemme. Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. Journal of pineal research. vol 46. issue 4. 2009-09-17. PMID:19552759. |
biopsies were taken to evaluate tubular damage, the enzymatic activity of superoxide dismutase (sod) and lipid hydroperoxide (lpo), and the expression of nf-kbp65, inducible nitric oxide synthase (inos), caspase-3 as indices of oxidative stress, necrosis, and apoptosis, respectively. |
2009-09-17 |
2023-08-12 |
rat |
| Adem Aslan, Mustafa Cemek, Olcay Eser, Korhan Altunbaş, Mehmet Emin Buyukokuroglu, Murat Cosar, Orhan Baş, Yuksel Ela, Huseyin Fida. Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 18. issue 3. 2009-09-15. PMID:19130093. |
dex treatment slightly prevented lipid peroxidation and augmented endogenous antioxidative defense systems in csf or spinal cord tissue, but failed to prevent apoptosis or neurodeficit after traumatic sci. |
2009-09-15 |
2023-08-12 |
Not clear |
| Ozgur Kutuk, Elif Damla Arisan, Tugsan Tezil, Maria C Shoshan, Huveyda Basag. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis. vol 30. issue 9. 2009-09-15. PMID:19578044. |
cisplatin overcomes bcl-2-mediated resistance to apoptosis via preferential engagement of bak: critical role of noxa-mediated lipid peroxidation. |
2009-09-15 |
2023-08-12 |
Not clear |
| Ozgur Kutuk, Elif Damla Arisan, Tugsan Tezil, Maria C Shoshan, Huveyda Basag. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis. vol 30. issue 9. 2009-09-15. PMID:19578044. |
in conclusion, our findings suggest a novel mode of action for cisplatin to overcome bcl-2-mediated protection against apoptosis, which requires preferential activation of bak and p53-mediated upregulation of noxa protein levels and lipid peroxidation. |
2009-09-15 |
2023-08-12 |
Not clear |
| Larry Siu, Julie Foont, Jack R Wand. Hepatitis C virus and alcohol. Seminars in liver disease. vol 29. issue 2. 2009-09-08. PMID:19387918. |
some of the major postulated mechanisms responsible for disease progression include high rates of apoptosis, lipid peroxidation, and generation of free radicals and reactive oxygen species with reduced antioxidant capacity of the liver. |
2009-09-08 |
2023-08-12 |
Not clear |
| Stephen J Wood, Murat Yücel, Christos Pantelis, Michael Ber. Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress. Annals of the Academy of Medicine, Singapore. vol 38. issue 5. 2009-09-03. PMID:19521638. |
this is reflected by evidence of the manifold consequences of oxidative stress that include lipid peroxidation, protein carboxylation, dna damage and apoptosis - all potentially part of the process of neuroprogression in the disorder. |
2009-09-03 |
2023-08-12 |
Not clear |
| Jinu Kim, Young Mi Seok, Kyong-Jin Jung, Kwon Moo Par. Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. American journal of physiology. Renal physiology. vol 297. issue 2. 2009-08-27. PMID:19458120. |
i/r significantly increased interstitial extension, collagen deposition, apoptosis of tubular epithelial cells, nitrotyrosine expression, hydrogen peroxide production, and lipid peroxidation and decreased copper-zinc sod, manganese sod, and glucose 6-phosphate dehydrogenase activities in the kidneys 16 days after the procedure. |
2009-08-27 |
2023-08-12 |
mouse |
| Benedicto Oscar Colli, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti, Luiza da Silva Lopes, Luis Fernando Tirapell. Biochemical evaluation of focal non-reperfusion cerebral ischemia by middle cerebral artery occlusion in rats. Arquivos de neuro-psiquiatria. vol 66. issue 3B. 2009-08-19. PMID:18949271. |
despite significant changes in atp levels, the results indicated cell viability in the ischemic region as shown by the low rates of lipid peroxidation and apoptosis, findings probably related to the lack of reperfusion. |
2009-08-19 |
2023-08-12 |
human |
| Burton M Altura, Nilank C Shah, Xian-Cheng Jiang, Zhiqiang Li, José Luis Perez-Albela, Anthony C Sica, Bella T Altur. Short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues. American journal of physiology. Heart and circulatory physiology. vol 297. issue 1. 2009-08-12. PMID:19429813. |
short-term magnesium deficiency results in decreased levels of serum sphingomyelin, lipid peroxidation, and apoptosis in cardiovascular tissues. |
2009-08-12 |
2023-08-12 |
rat |
| Mubeen Ahmad Ansari, Hafiz Mohammad Abdul, Gururaj Joshi, Wycliffe O Opii, D Allan Butterfiel. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. The Journal of nutritional biochemistry. vol 20. issue 4. 2009-07-24. PMID:18602817. |
pretreatment of primary hippocampal cultures with quercetin significantly attenuated abeta(1-42)-induced cytotoxicity, protein oxidation, lipid peroxidation and apoptosis. |
2009-07-24 |
2023-08-12 |
Not clear |
| P Tessari, A Coracina, A Cosma, A Tieng. Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 19. issue 4. 2009-07-23. PMID:19359149. |
the latter likely involves oxidative stress, cytochrome p450 activation, lipid peroxidation, increased inflammatory cytokine production, activation of hepatic stellate cells and apoptosis. |
2009-07-23 |
2023-08-12 |
Not clear |