| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Rezvanfar, M A Rezvanfar, A Ahmadi, H A Shojaei-Saadi, M Baeeri, M Abdollah. Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary. Theriogenology. vol 78. issue 3. 2012-11-05. PMID:22541319. |
to determine the role of oxidative stress (os) in hyperandrogenism-induced pco, concentrations of cellular lipid peroxidation (lpo), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), peroxynitrite (onoo), and tumor necrosis factor (tnf)-α as a marker of inflammation and apoptosis were measured in serum and ovaries. |
2012-11-05 |
2023-08-12 |
rat |
| Nahoko Shinohara, Tsuyoshi Tsuduki, Junya Ito, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Iked. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochimica et biophysica acta. vol 1821. issue 7. 2012-11-02. PMID:22521763. |
examination of the mechanism of cell death showed that clnas induce apoptosis in dld-1 cells via lipid peroxidation. |
2012-11-02 |
2023-08-12 |
mouse |
| Nahoko Shinohara, Tsuyoshi Tsuduki, Junya Ito, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Iked. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochimica et biophysica acta. vol 1821. issue 7. 2012-11-02. PMID:22521763. |
collectively, these results suggest that the cytotoxic effect of clnas is dependent on intracellular incorporation and induction of apoptosis via lipid peroxidation. |
2012-11-02 |
2023-08-12 |
mouse |
| M Maneesh, H Jayalekshmi, Sanjiba Dutta, Amit Chakrabarti, D M Vasudeva. Role of oxidative stress in ethanol induced germ cell apoptosis - An experimental study in rats. Indian journal of clinical biochemistry : IJCB. vol 20. issue 2. 2012-10-30. PMID:23105535. |
chronic ethanol administration resulted in high oxidative stress in the testes either due to increased extent of lipid peroxidation or due to decreased antioxidant defenses, and thereby induces germ cell apoptosis leading to testicular atrophy. |
2012-10-30 |
2023-08-12 |
rat |
| Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Anina. Regulation of signal transduction by glutathione transferases. International journal of hepatology. vol 2012. 2012-10-25. PMID:23094162. |
for example, the lipid peroxidation product 4-hydroxynonenal (4-hne) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin j(2) (15d-pgj(2)) are metabolized by gsts and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis. |
2012-10-25 |
2023-08-12 |
Not clear |
| Zubaida Khatoon, R K Kal. Radiomodulation by Hoechst 33258 against radiation-induced damage in murine splenocytes. Indian journal of experimental biology. vol 50. issue 8. 2012-10-24. PMID:23016489. |
membrane lipid peroxidation, fluidity, specific activities of antioxidant enzymes, levels of nitric oxide, glutathione and apoptosis in presence and absence of different concentrations of hoechst 33258 has been assayed. |
2012-10-24 |
2023-08-12 |
mouse |
| Yuan-Peng Yen, Keh-Sung Tsai, Ya-Wen Chen, Chun-Fa Huang, Rong-Sen Yang, Shing-Hwa Li. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of toxicology. vol 86. issue 6. 2012-10-18. PMID:22622864. |
pretreatment with antioxidant n-acetylcysteine (nac, 0.5 mm) dramatically suppressed the increases in reactive oxygen species (ros), lipid peroxidation, er stress, caspase cascade activity, and apoptosis in as(2)o(3) (10 μm)-treated myoblasts. |
2012-10-18 |
2023-08-12 |
Not clear |
| Manuj Kr Bharali, Karabi Dutt. Testicular toxicity of para-phenylenediamine after subchronic topical application in rat. International journal of environmental health research. vol 22. issue 3. 2012-10-09. PMID:22149045. |
elevation of lipid peroxidation product in the testicular tissue indicated the potential oxidative stress that may be crucial in the induction of the apoptosis and further tissue injury in the ppd-treated rats. |
2012-10-09 |
2023-08-12 |
rat |
| Quan Fang Huang, Shi Jun Zhang, Li Zheng, Ming Liao, Min He, RenBin Huang, Lang Zhuo, Xing Li. Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 6. 2012-10-09. PMID:22446813. |
research on mechanism showed that ioa was able to markedly reduce lipid peroxidation, recruit the anti-oxidative defense system, and induce hsc apoptosis by down-regulating bcl-2 mrna, as well as inhibit the expression of α-smooth muscle actin and transforming growth factor β1 proteins. |
2012-10-09 |
2023-08-12 |
rat |
| Sibylle Grub, Urs A Boelsterli, Christian Trendelenburg, Wolfgang E Trommer, Armin Wol. Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicology mechanisms and methods. vol 13. issue 3. 2012-10-02. PMID:20021159. |
cyclosporine a (csa) produces oxidative stress and apoptosis in rat hepatocytes, but it is not known whether membrane lipid peroxidation plays a role in csa toxicity. |
2012-10-02 |
2023-08-12 |
rat |
| Sibylle Grub, Urs A Boelsterli, Christian Trendelenburg, Wolfgang E Trommer, Armin Wol. Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicology mechanisms and methods. vol 13. issue 3. 2012-10-02. PMID:20021159. |
addition of the ferric iron chelator desferrioxamine or the novel potent lipophilic iron chelator cgp72670 did not protect against csa-induced cell death, indicating that iron-catalyzed lipid peroxidation is unlikely to be involved in csa-mediated apoptosis. |
2012-10-02 |
2023-08-12 |
rat |
| Sibylle Grub, Urs A Boelsterli, Christian Trendelenburg, Wolfgang E Trommer, Armin Wol. Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicology mechanisms and methods. vol 13. issue 3. 2012-10-02. PMID:20021159. |
in contrast, the classical chain-breaking lipid peroxidation inhibitor alpha-tocopherol was able to rescue cells from csa-induced cytotoxicity and apoptosis. |
2012-10-02 |
2023-08-12 |
rat |
| Xia Xie, Hai-Tao Wang, Chun-Li Li, Xu-Hong Gao, Jin-Lan Ding, Hai-Hua Zhao, Yong-Li L. Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury. Molecular medicine reports. vol 3. issue 4. 2012-10-02. PMID:21472290. |
to examine the potential protective effect of grb1 in aβ25-35-induced cytotoxicity, cells were pre-treated with grb1 for 24 h, and then aβ25-35 was added to the medium for an additional 24 h. exposure to aβ led to the accumulation of ros and lipid peroxidation, eventually causing a decrease in the bcl-2/bax ratio, caspase-3 activation, cell apoptosis and cell death. |
2012-10-02 |
2023-08-12 |
Not clear |
| Chan-Min Liu, Yuan-Lin Zheng, Jun Lu, Zi-Feng Zhang, Shao-Hua Fan, Dong-Mei Wu, Jie-Qiong M. Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environmental toxicology and pharmacology. vol 29. issue 2. 2012-10-02. PMID:21787598. |
in conclusion, these data suggest that quercetin protects the rat liver from lead-induced injury by attenuating lipid peroxidation, renewing the activities of antioxidant enzymes and inhibiting apoptosis. |
2012-10-02 |
2023-08-12 |
rat |
| Shuhua Yang, Ziwei Zhang, Jianbin He, Jinlong Li, Jiuli Zhang, Houjuan Xing, Shiwen X. Ovarian toxicity induced by dietary cadmium in hen. Biological trace element research. vol 148. issue 1. 2012-10-02. PMID:22367677. |
it indicated that cd exposure resulted in oxidative damage of hens' ovary tissue by altering antioxidant defense enzyme systems, lipid peroxidation, apoptosis and endocrine disturbance which may be possible underlying reproductive toxicity mechanisms induced by cd. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jin-Ying Zhao, Yan-Wei Li, Lin L. [The role of iron and hepcidin in hepatic fibrosis]. Sheng li ke xue jin zhan [Progress in physiology]. vol 41. issue 3. 2012-10-01. PMID:21416977. |
iron is proposed to play a role in promoting hepatic fibrosis by various mechanisms, including iron-catalyzed production of free radical and lipid peroxidation, alteration of essential biomolecules, triggering cell apoptosis and necrosis, and activation and transformation of the hepatic stellate cell into a myofibroblastic cell. |
2012-10-01 |
2023-08-12 |
Not clear |
| H Wu, D Wang, Z Shu, H Zhou, H Zuo, S Wang, Y Li, X Xu, N Li, R Pen. Cytokines produced by microwave-radiated Sertoli cells interfere with spermatogenesis in rat testis. Andrologia. vol 44 Suppl 1. 2012-09-27. PMID:22211786. |
these up-regulated cytokines can induce apoptosis and lipid peroxidation in the membrane of germ cells. |
2012-09-27 |
2023-08-12 |
rat |
| Robert Pazdro, John R Burges. Differential effects of α-tocopherol and N-acetyl-cysteine on advanced glycation end product-induced oxidative damage and neurite degeneration in SH-SY5Y cells. Biochimica et biophysica acta. vol 1822. issue 4. 2012-09-24. PMID:22261284. |
however, vitamin e has been studied in cell culture systems with primary focus on apoptosis and lipid peroxidation, while its influences on age-induced protein and dna oxidation, intracellular antioxidant status and cell morphology remain largely unknown. |
2012-09-24 |
2023-08-12 |
Not clear |
| WeiNa Xu, WenBin Liu, KangLe Lu, YangYang Jiang, GuiFeng L. Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo. Fish physiology and biochemistry. vol 38. issue 3. 2012-09-17. PMID:21986809. |
the current study revealed that trichlorfon influenced fish plasma antioxidative status, caused lipid peroxidation (lpo) then resulted in hepatocytes apoptosis. |
2012-09-17 |
2023-08-12 |
cat |
| Jin-Xia Zhai, Xing-Hua Wang, Zhao-Xiang Zhang, Li-Wei Zou, Shu-Shu Din. [Studying the lipid peroxidation index, morphology and apoptosis in testis of male BALB/c mice exposed to polybrominated diphenyl ether (BDE-209)]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 29. issue 4. 2012-09-10. PMID:21941785. |
[studying the lipid peroxidation index, morphology and apoptosis in testis of male balb/c mice exposed to polybrominated diphenyl ether (bde-209)]. |
2012-09-10 |
2023-08-12 |
mouse |