| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Han, Li-Bo Du, Anil Kumar, Hong-Ying Jia, Xing-Jie Liang, Qiu Tian, Guang-Jun Nie, Yang Li. Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis. Biomaterials. vol 33. issue 33. 2013-02-06. PMID:22922024. |
the effects of trolox-cs nps on raw264.7 cells damaged by tert-butylhydroperoxide (t-bhp) were determined by mtt assay for cell viability, mda assay for membrane lipid peroxidation, jc-1 probe and annexin v-fitc/pi double staining for mitochondria membrane potential (mmp) and raw264.7 apoptosis, respectively. |
2013-02-06 |
2023-08-12 |
Not clear |
| M A Rezvanfar, M A Rezvanfar, A Ahmadi, H A Shojaei Saadi, M Baeeri, M Abdollah. Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological evidences for beneficial effect of pioglitazone. Human & experimental toxicology. vol 31. issue 9. 2013-02-05. PMID:22076494. |
to determine the role of oxidative stress in pco, the level of cellular lipid peroxidation (lpo), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and peroxynitrite (onoo), and tumor necrosis factor alpha (tnf-α) as a marker of inflammation and apoptosis were measured in serum and the ovaries. |
2013-02-05 |
2023-08-12 |
rat |
| Neşe Tunçel, Orhan Tansel Korkmaz, Neslihan Tekin, Erol Şener, Fahrettin Akyüz, Mine Ina. Antioxidant and anti-apoptotic activity of vasoactive intestinal peptide (VIP) against 6-hydroxy dopamine toxicity in the rat corpus striatum. Journal of molecular neuroscience : MN. vol 46. issue 1. 2013-01-24. PMID:21850490. |
vip significantly protected neuronal tissue from oxidative stress and apoptosis by reducing lipid peroxidation and dna fragmentation. |
2013-01-24 |
2023-08-12 |
rat |
| Hirofumi Tsuru, Hirotomo Shibaguchi, Motomu Kuroki, Yuichi Yamashita, Masahide Kurok. Tumor growth inhibition by sonodynamic therapy using a novel sonosensitizer. Free radical biology & medicine. vol 53. issue 3. 2013-01-17. PMID:22588110. |
cell membrane lipid peroxidation increased significantly just after ultrasound irradiation with a sonosensitizer, but there was no increase in apoptosis. |
2013-01-17 |
2023-08-12 |
mouse |
| Elahe Taghiabadi, Mohsen Imenshahidi, Khalil Abnous, Fatemeh Mosafa, Mojtaba Sankian, Bahram Memar, Gholamreza Karim. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2013-01-16. PMID:23320028. |
in conclusion, sn may have protective effects against cardiotoxicity of acr by reducing lipid peroxidation, renewing the activities of antioxidant enzymes, and preventing apoptosis. |
2013-01-16 |
2023-08-12 |
mouse |
| Fumihiko Yoshino, Ayaka Yoshida, Eizo Okada, Yasue Okada, Yojiro Maehata, Chihiro Miyamoto, Sachi Kishimoto, Takero Otsuka, Tomoko Nishimura, Masaichi Chang-il Le. Dental resin curing blue light induced oxidative stress with reactive oxygen species production. Journal of photochemistry and photobiology. B, Biology. vol 114. 2012-11-30. PMID:22695226. |
these results indicated that (ros) such as hydrogen peroxide and hydroxyl radicals were generated in vsmcs by irradiation with blue light, and they induced cytotoxicity associated with oxidative stress, which increased lipid peroxidation and apoptosis. |
2012-11-30 |
2023-08-12 |
human |
| Kunga Mohan Ramkumar, Chinnasamy Manjula, Georgepeter Gnanakumar, Muzafar A Kanjwal, Thillai V Sekar, Ramasamy Paulmurugan, Palanisamy Rajagur. Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 81. issue 2. 2012-11-21. PMID:22446064. |
the mechanism of toxicity is mainly due to the induction of cellular oxidative stress, as revealed by elevated ros levels, reduced antioxidant levels, and increased lipid peroxidation leading to apoptosis. |
2012-11-21 |
2023-08-12 |
human |
| Tammy A Butterick, Joshua P Nixon, Charles J Billington, Catherine M Kot. Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model. Neuroscience letters. vol 524. issue 1. 2012-11-21. PMID:22796468. |
orexin a decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model. |
2012-11-21 |
2023-08-12 |
rat |
| Abdülhadi Cihangir Uğuz, Mustafa Nazıroğl. Effects of selenium on calcium signaling and apoptosis in rat dorsal root ganglion neurons induced by oxidative stress. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22476699. |
the aim of this study is to investigate the effects of selenium on lipid peroxidation, reduced glutathione (gsh), glutathione peroxidase (gsh-px), cytosolic ca(2+) release, cell viability (mtt) and apoptosis values in dorsal root ganglion (drg) sensory neurons of rats. |
2012-11-05 |
2023-08-12 |
rat |
| M A Rezvanfar, M A Rezvanfar, A Ahmadi, H A Shojaei-Saadi, M Baeeri, M Abdollah. Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary. Theriogenology. vol 78. issue 3. 2012-11-05. PMID:22541319. |
to determine the role of oxidative stress (os) in hyperandrogenism-induced pco, concentrations of cellular lipid peroxidation (lpo), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), peroxynitrite (onoo), and tumor necrosis factor (tnf)-α as a marker of inflammation and apoptosis were measured in serum and ovaries. |
2012-11-05 |
2023-08-12 |
rat |
| Nahoko Shinohara, Tsuyoshi Tsuduki, Junya Ito, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Iked. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochimica et biophysica acta. vol 1821. issue 7. 2012-11-02. PMID:22521763. |
examination of the mechanism of cell death showed that clnas induce apoptosis in dld-1 cells via lipid peroxidation. |
2012-11-02 |
2023-08-12 |
mouse |
| Nahoko Shinohara, Tsuyoshi Tsuduki, Junya Ito, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Iked. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochimica et biophysica acta. vol 1821. issue 7. 2012-11-02. PMID:22521763. |
collectively, these results suggest that the cytotoxic effect of clnas is dependent on intracellular incorporation and induction of apoptosis via lipid peroxidation. |
2012-11-02 |
2023-08-12 |
mouse |
| M Maneesh, H Jayalekshmi, Sanjiba Dutta, Amit Chakrabarti, D M Vasudeva. Role of oxidative stress in ethanol induced germ cell apoptosis - An experimental study in rats. Indian journal of clinical biochemistry : IJCB. vol 20. issue 2. 2012-10-30. PMID:23105535. |
chronic ethanol administration resulted in high oxidative stress in the testes either due to increased extent of lipid peroxidation or due to decreased antioxidant defenses, and thereby induces germ cell apoptosis leading to testicular atrophy. |
2012-10-30 |
2023-08-12 |
rat |
| Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Anina. Regulation of signal transduction by glutathione transferases. International journal of hepatology. vol 2012. 2012-10-25. PMID:23094162. |
for example, the lipid peroxidation product 4-hydroxynonenal (4-hne) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin j(2) (15d-pgj(2)) are metabolized by gsts and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis. |
2012-10-25 |
2023-08-12 |
Not clear |
| Zubaida Khatoon, R K Kal. Radiomodulation by Hoechst 33258 against radiation-induced damage in murine splenocytes. Indian journal of experimental biology. vol 50. issue 8. 2012-10-24. PMID:23016489. |
membrane lipid peroxidation, fluidity, specific activities of antioxidant enzymes, levels of nitric oxide, glutathione and apoptosis in presence and absence of different concentrations of hoechst 33258 has been assayed. |
2012-10-24 |
2023-08-12 |
mouse |
| Yuan-Peng Yen, Keh-Sung Tsai, Ya-Wen Chen, Chun-Fa Huang, Rong-Sen Yang, Shing-Hwa Li. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of toxicology. vol 86. issue 6. 2012-10-18. PMID:22622864. |
pretreatment with antioxidant n-acetylcysteine (nac, 0.5 mm) dramatically suppressed the increases in reactive oxygen species (ros), lipid peroxidation, er stress, caspase cascade activity, and apoptosis in as(2)o(3) (10 μm)-treated myoblasts. |
2012-10-18 |
2023-08-12 |
Not clear |
| Manuj Kr Bharali, Karabi Dutt. Testicular toxicity of para-phenylenediamine after subchronic topical application in rat. International journal of environmental health research. vol 22. issue 3. 2012-10-09. PMID:22149045. |
elevation of lipid peroxidation product in the testicular tissue indicated the potential oxidative stress that may be crucial in the induction of the apoptosis and further tissue injury in the ppd-treated rats. |
2012-10-09 |
2023-08-12 |
rat |
| Quan Fang Huang, Shi Jun Zhang, Li Zheng, Ming Liao, Min He, RenBin Huang, Lang Zhuo, Xing Li. Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 6. 2012-10-09. PMID:22446813. |
research on mechanism showed that ioa was able to markedly reduce lipid peroxidation, recruit the anti-oxidative defense system, and induce hsc apoptosis by down-regulating bcl-2 mrna, as well as inhibit the expression of α-smooth muscle actin and transforming growth factor β1 proteins. |
2012-10-09 |
2023-08-12 |
rat |
| Sibylle Grub, Urs A Boelsterli, Christian Trendelenburg, Wolfgang E Trommer, Armin Wol. Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicology mechanisms and methods. vol 13. issue 3. 2012-10-02. PMID:20021159. |
cyclosporine a (csa) produces oxidative stress and apoptosis in rat hepatocytes, but it is not known whether membrane lipid peroxidation plays a role in csa toxicity. |
2012-10-02 |
2023-08-12 |
rat |
| Sibylle Grub, Urs A Boelsterli, Christian Trendelenburg, Wolfgang E Trommer, Armin Wol. Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicology mechanisms and methods. vol 13. issue 3. 2012-10-02. PMID:20021159. |
addition of the ferric iron chelator desferrioxamine or the novel potent lipophilic iron chelator cgp72670 did not protect against csa-induced cell death, indicating that iron-catalyzed lipid peroxidation is unlikely to be involved in csa-mediated apoptosis. |
2012-10-02 |
2023-08-12 |
rat |