| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weidong Qian, Xingjiang Xiong, Zhuyuan Fang, Haiting Lu, Zhensheng Wan. Protective effect of tetramethylpyrazine on myocardial ischemia-reperfusion injury. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-25. PMID:25152756. |
this paper reviewed the current research progress and evidence about the cardiovascular effects of tetramethylpyrazine, which included protecting mitochondria and improving energy metabolism, scavenging oxygen free radicals (ofrs) to inhibit lipid peroxidation, attenuating calcium (ca(2+)) overload and maintaining ca(2+) homeostasis in cells, inhibiting apoptosis and protecting myocardial cells, interfering with the inflammatory reaction and mitigating cell injury, interfering with cell signaling pathways, and improving function of endothelial cells and protecting myocardial cells. |
2014-08-25 |
2023-08-13 |
Not clear |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
using a human mesencephalic neuronal/glial culture model, which contains dopaminergic neurons, microglia, and astrocytes, we were able to show that the cb1/cb2 agonist win55,212-2 blunts gp120-induced neuronal damage as measured by dopamine transporter function, apoptosis and lipid peroxidation; these actions were mediated principally by the cb2 receptor. |
2014-08-05 |
2023-08-12 |
human |
| Eun-Ju Yang, Gyu Hwan Park, Kyung-Sik Son. Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells. Neurotoxicology. vol 39. 2014-07-23. PMID:24012889. |
liquiritigenin effectively reduced glutamate-induced early apoptosis through inhibition of ca(2+) influx, intracellular reactive oxygen species (ros) production, and lipid peroxidation. |
2014-07-23 |
2023-08-12 |
mouse |
| Qing Chen, Rong Zhang, Wei-min Li, Yu-jie Niu, Hui-cai Guo, Xue-hui Liu, Yu-chun Hou, Li-juan Zha. The protective effect of grape seed procyanidin extract against cadmium-induced renal oxidative damage in mice. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:23958968. |
however, the coadministration of gspe attenuated cd-induced lipid peroxidation, and antagonized renal apoptosis, probably associated with the expression of bax and bcl-2. |
2014-07-15 |
2023-08-12 |
mouse |
| Petek Piner, Nevin Üne. Oxidative stress and apoptosis was induced by bio-insecticide spinosad in the liver of Oreochromis niloticus. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24051243. |
this study was conducted to investigate acute toxic effects of spinosad on glutathione-related oxidative stress markers, lipid peroxidation, heat shock proteins, apoptosis in the liver of oreochromis niloticus selected as a model organism. |
2014-07-15 |
2023-08-12 |
Not clear |
| B F M Almeida, L G Narciso, L M Melo, P P Preve, A M Bosco, V M F Lima, P C Ciarlin. Leishmaniasis causes oxidative stress and alteration of oxidative metabolism and viability of neutrophils in dogs. Veterinary journal (London, England : 1997). vol 198. issue 3. 2014-07-09. PMID:24080475. |
neutrophils from uremic dogs with and without leishmaniasis had decreased viability and an increased apoptosis rate in addition to increased lipid peroxidation. |
2014-07-09 |
2023-08-12 |
Not clear |
| O G Shaker, N A H Sadi. Pathogenesis of preeclampsia: Implications of apoptotic markers and oxidative stress. Human & experimental toxicology. vol 32. issue 11. 2014-07-08. PMID:23515498. |
in conclusion, the elevations of mda, caspase-9 activity and the percentage of dna fragmentation in the placentas of women with pe implicate the involvement of lipid peroxidation and apoptosis in pe. |
2014-07-08 |
2023-08-12 |
Not clear |
| Deborah Chiabrando, Francesca Vinchi, Veronica Fiorito, Sonia Mercurio, Emanuela Tolosan. Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24782769. |
however, excess free-heme is highly toxic due to its ability to promote oxidative stress and lipid peroxidation, thus leading to membrane injury and, ultimately, apoptosis. |
2014-06-24 |
2023-08-13 |
Not clear |
| Verónica Rocío Vásquez-Garzón, José Roberto Macias-Pérez, Mónica Noemí Jiménez-García, Vanessa Villegas, Samia Fattel-Fazenta, Saúl Villa-Treviñ. The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis. Toxicologic pathology. vol 41. issue 6. 2014-05-08. PMID:23197198. |
this decrease occurred associated with an abolished den-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of poly (adp-ribose) polymerase (parp) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent. |
2014-05-08 |
2023-08-12 |
rat |
| Heidi L Lujan, Stephen E DiCarl. Mimicking the endogenous current of injury improves post-infarct cardiac remodeling. Medical hypotheses. vol 81. issue 4. 2014-04-07. PMID:23871584. |
secondary injury results from activation of inflammatory processes that can induce secondary damage by apoptosis, lipid peroxidation, oxidative stress, or free radical formation. |
2014-04-07 |
2023-08-12 |
Not clear |
| Akalesh Kumar Verma, Surya Bali Prasa. Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis. Anti-cancer agents in medicinal chemistry. vol 13. issue 7. 2014-02-13. PMID:23343079. |
cantharidin treatment induced apoptosis in dalton's lymphoma cells and also caused an oxidative stress due to generation of reactive oxygen species (ros) and an increase in lipid peroxidation. |
2014-02-13 |
2023-08-12 |
mouse |
| Shubhankar Suman, Olga C Rodriguez, Thomas A Winters, Albert J Fornace, Chris Albanese, Kamal Datt. Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production. Aging. vol 5. issue 8. 2014-01-31. PMID:23928451. |
radiation exposure was associated with increased chronic oxidative stress, oxidative dna damage, lipid peroxidation, and apoptosis. |
2014-01-31 |
2023-08-12 |
mouse |
| b' A Y\\xc3\\xbcce, G T\\xc3\\xbcrk, S \\xc3\\x87eriba\\xc5\\x9fi, M S\\xc3\\xb6nmez, M \\xc3\\x87ift\\xc3\\xa7i, M G\\xc3\\xbcven\\xc3\\xa. Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality. Andrologia. vol 45. issue 4. 2014-01-24. PMID:22862806.' |
body and reproductive organ weights, sperm characteristics, testicular lipid peroxidation and antioxidant enzyme activities, and testicular apoptosis via terminal deoxynucleotidyl transferase-mediated dutp nick end labelling (tunel) method were examined. |
2014-01-24 |
2023-08-12 |
rat |
| Kailun Zhang, Jing Zhao, Yunhai Yang, Zhiwei H. Cardioprotective effects of diazoxide on myocardial ischemia/reperfusion injury in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 6. 2014-01-23. PMID:17357490. |
it was concluded that diazoxide could protect the rats from myocardial ischemia/reperfusion injury, which might be contributed to the reduction of lipid peroxidation and cell apoptosis. |
2014-01-23 |
2023-08-12 |
rat |
| Abhay Puthli, Reeta Tiwari, Kaushala Prasad Mishr. Biochanin A enhances the radiotoxicity in colon tumor cells in vitro. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 32. issue 3. 2014-01-23. PMID:24266406. |
induced reactive oxygen species, mitochondrial membrane potential, lipid peroxidation, and caspase-3 activation were measured by fluorescence assays and the magnitude of induced apoptosis in cells was evaluated by flow cytometry. |
2014-01-23 |
2023-08-12 |
human |
| Ling-Yan Dong, Jie Jin, Gao Lu, Xiao-Li Kan. Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress. Marine drugs. vol 11. issue 3. 2014-01-06. PMID:23519150. |
here, astaxanthin was shown to reduce the apoptosis of rgcs and improve the levels of oxidative stress markers, including superoxide anion, malondialdehyde (mda, a marker of lipid peroxidation), 8-hydroxy-2-deoxyguanosine (8-ohdg, indicator of oxidative dna damage) and mnsod (manganese superoxide dismutase) activity in the retinal tissue of db/db mouse. |
2014-01-06 |
2023-08-12 |
mouse |
| Sathid Aimjongjun, Manote Sutheerawattananonda, Nanteetip Limpeancho. Silk lutein extract and its combination with vitamin E reduce UVB-mediated oxidative damage to retinal pigment epithelial cells. Journal of photochemistry and photobiology. B, Biology. vol 124. 2014-01-06. PMID:23651647. |
both luteins reduced cellular ros levels and lipid peroxidation mediated by uvb, and subsequently increased cell viability and reduced apoptosis. |
2014-01-06 |
2023-08-12 |
Not clear |
| Shiang-Suo Huang, Henrich Cheng, Ching-Min Tang, Mao-Wei Nien, Yuahn-Sieh Huang, I-Huei Lee, Jiu-Haw Yin, Terry B J Kuo, Cheryl C H Yang, Shen-Kou Tsai, Ding-I Yan. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental neurology. vol 247. 2013-11-26. PMID:23499832. |
furthermore, shh-n attenuated the extents of protein oxidation, lipid peroxidation, and apoptosis induced by focal ischemia/reperfusion. |
2013-11-26 |
2023-08-12 |
rat |
| Miriam Noa, Rosa Más, Maikel Valle, Sarahí Mendoza, Nilda Mendoz. Effect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 4. 2013-11-19. PMID:24250554. |
d-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the osteoclast apoptosis. |
2013-11-19 |
2023-08-12 |
rat |
| Jin-Long Li, Cheng-Yu Jiang, Shu Li, Shi-Wen X. Cadmium induced hepatotoxicity in chickens (Gallus domesticus) and ameliorative effect by selenium. Ecotoxicology and environmental safety. vol 96. 2013-11-18. PMID:23906702. |
histological and ultrastructural changes in the liver, the concentrations of cd and se, the lipid peroxidation (lpo) and nitric oxide (no) production, the activities of the antioxidants superoxide dismutase (sod) and glutathione peroxidase (gpx), nitric oxide synthase (nos) activities and apoptosis were determined. |
2013-11-18 |
2023-08-12 |
Not clear |