| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katharina Korpis, Frauke Weber, Stefanie Brune, Bernhard Wünsch, Patrick J Bednarsk. Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24331758. |
these results provide evidence that, by initiating lpo and changes in mitochondrial membrane potential, both compounds induce apoptosis and autophagy in rpmi 8226 cells. |
2014-11-06 |
2023-08-12 |
human |
| James P Fabisiak, Grigory G Borisenko, Valerian E Kaga. Quantitative method of measuring phosphatidylserine externalization during apoptosis using electron paramagnetic resonance (EPR) spectroscopy and annexin-conjugated iron. Methods in molecular biology (Clifton, N.J.). vol 1105. 2014-11-06. PMID:24623256. |
the application of this technique, alone and in concert with the ps oxidation method presented in the previous chapter, will greatly aid in studying the mechanistic connection between lipid peroxidation and translocation events during apoptosis. |
2014-11-06 |
2023-08-12 |
Not clear |
| Arash Nickkholgh, Zhanqing Li, Xue Yi, Elvira Mohr, Rui Liang, Saulius Mikalauskas, Marie-Luise Gross, Markus Zorn, Steffen Benzing, Heinz Schneider, Markus W Büchler, Peter Schemme. Effects of a preconditioning oral nutritional supplement on pig livers after warm ischemia. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery. vol 2012. 2014-10-31. PMID:22791934. |
administration of pons before and after tissue damage protects the liver from warm iri via mechanisms including decreasing oxidative stress, lipid peroxidation, apoptosis, and necrosis. |
2014-10-31 |
2023-08-12 |
Not clear |
| Hongmei Liu, Xiaoming Li, Fei Qin, Kaixun Huan. Selenium suppresses oxidative-stress-enhanced vascular smooth muscle cell calcification by inhibiting the activation of the PI3K/AKT and ERK signaling pathways and endoplasmic reticulum stress. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 19. issue 3. 2014-10-31. PMID:24390545. |
the following processes may explain the inhibitory effects of selenite: (1) selenite significantly suppressed oxidative stress, as evidenced by the decrease of the oxidative status of the cell and lipid peroxidation levels, as well as by the increase of the total protein thiol content and the activity of the antioxidant selenoenzyme glutathione peroxidase; (2) selenite significantly attenuated oxidative-stress-induced activation of the phosphatidylinositol 3-kinase/akt and extracellular-signal-regulated kinase signaling pathways, resulting in decreased osteoblastic differentiation of vsmcs; (3) selenite significantly inhibited oxidative-stress-activated endoplasmic reticulum stress, thereby leading to decreased apoptosis. |
2014-10-31 |
2023-08-12 |
Not clear |
| Deepa K Ingawale, Satish K Mandlik, Suresh R Nai. Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion. Environmental toxicology and pharmacology. vol 37. issue 1. 2014-10-28. PMID:24322620. |
serum biomarkers enzymes, liver function, oxidative stress associated events like free radicals formation, lipid peroxidation, enzyme antioxidants and participation of cytokines (tumour necrosis factor-α, transforming growth factor-β, tumour necrosis factor-related apoptosis inducing ligand), and other biomolecules (fas and c-jun n-terminal kinase) are also discussed. |
2014-10-28 |
2023-08-12 |
Not clear |
| Xing Zhou, Chao-Fen Su, Zheng Zhang, Chen-Yu Wang, Jin-Qi Luo, Xiao-Wen Zhou, Liang Cai, Li Yan, Wei Zhang, Huan-Min Lu. Neuroprotective effects of methyl 3,4-dihydroxybenzoate against H₂O₂-induced apoptosis in RGC-5 cells. Journal of pharmacological sciences. vol 125. issue 1. 2014-10-24. PMID:24849190. |
the rate of apoptosis, level of lipid peroxidation, and mitochondrial membrane potential (mmp) were detected by flow cytometry. |
2014-10-24 |
2023-08-13 |
Not clear |
| Chao Zeng, Jinyi Wang, Na Li, Mingzhi Shen, Dongjuan Wang, Qiujun Yu, Haichang Wan. AKAP150 mobilizes cPKC-dependent cardiac glucotoxicity. American journal of physiology. Endocrinology and metabolism. vol 307. issue 4. 2014-10-23. PMID:25005497. |
akap150 inhibition also abrogated high-glucose-induced cardiomyocyte apoptosis (tunel staining and annexin v/propidium iodide flow cytometry) and oxidative stress (ros production, nadph oxidase activity, and lipid peroxidation). |
2014-10-23 |
2023-08-13 |
rat |
| Yuan Peng, Qian Chen, Tao Yang, Yanyan Tao, Xiong Lu, Chenghai Li. Cultured mycelium Cordyceps sinensis protects liver sinusoidal endothelial cells in acute liver injured mice. Molecular biology reports. vol 41. issue 3. 2014-10-17. PMID:24442316. |
compared to that in the normal control, more severe liver inflammation and hepatocyte apoptosis, worse hepatic lipid peroxidation demonstrated by the increased asafr, ·oh and mda, but decreased sod and gst, increased mmp-2/9 activities and vcam-1, icam-1 and vwf expressions, which revealed obvious lsec injury and scaffold structure broken, were shown in the model control. |
2014-10-17 |
2023-08-12 |
mouse |
| Paramasivan Poornima, Ching Feng Weng, Viswanadha Vijaya Padm. Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest. BioFactors (Oxford, England). vol 40. issue 1. 2014-10-14. PMID:23983146. |
neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of mapks, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation. |
2014-10-14 |
2023-08-12 |
human |
| Mustafa Nazıroğlu, Mehmet Sahin, Bilal Ciğ, Mehmet Aykur, Ijlal Erturan, Yunus Uga. Hypericum perforatum modulates apoptosis and calcium mobilization through voltage-gated and TRPM2 calcium channels in neutrophil of patients with Behcet's disease. The Journal of membrane biology. vol 247. issue 3. 2014-10-09. PMID:24452864. |
caspase-3, caspase-9, apoptosis, lipid peroxidation, and [ca²⁺](i) values were high in the patient groups, although cell viability, glutathione (gsh), and glutathione peroxidase (gsh-px) values were low in patient group. |
2014-10-09 |
2023-08-12 |
human |
| Manoj Kumar, Prabhaker Dwivedi, Anil Kumar Sharma, Muthu Sankar, Rajendra Damu Patil, Nittin Dev Sing. Apoptosis and lipid peroxidation in ochratoxin A- and citrinin-induced nephrotoxicity in rabbits. Toxicology and industrial health. vol 30. issue 1. 2014-09-29. PMID:22773436. |
apoptosis and lipid peroxidation in ochratoxin a- and citrinin-induced nephrotoxicity in rabbits. |
2014-09-29 |
2023-08-12 |
rabbit |
| Manoj Kumar, Prabhaker Dwivedi, Anil Kumar Sharma, Muthu Sankar, Rajendra Damu Patil, Nittin Dev Sing. Apoptosis and lipid peroxidation in ochratoxin A- and citrinin-induced nephrotoxicity in rabbits. Toxicology and industrial health. vol 30. issue 1. 2014-09-29. PMID:22773436. |
in the present study, both ota and cit were evaluated for their potential to induce oxidative damage by determining lipid peroxidation (lpo) through malondialdehyde (mda) assay and apoptosis by flow cytometry, gel electrophoresis and renal ultrastructural morphology in rabbits fed with diets containing ota (0.75 mg/kg feed), cit (15 mg/kg feed) and ota + cit (0.75 and 15 mg/kg feed, respectively) up to 60 days. |
2014-09-29 |
2023-08-12 |
rabbit |
| Manoj Kumar, Prabhaker Dwivedi, Anil Kumar Sharma, Muthu Sankar, Rajendra Damu Patil, Nittin Dev Sing. Apoptosis and lipid peroxidation in ochratoxin A- and citrinin-induced nephrotoxicity in rabbits. Toxicology and industrial health. vol 30. issue 1. 2014-09-29. PMID:22773436. |
the results suggested that low concentrations of ota and cit either alone or in combination induced apoptosis in a time-dependent manner and lpo in the rabbit kidney, which appeared to play a major role in the pathogenesis of nephrotoxicity. |
2014-09-29 |
2023-08-12 |
rabbit |
| W Y Wani, A Sunkaria, D R Sharma, R J L Kandimalla, A Kaushal, E Gerace, A Chiarugi, K D Gil. Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation. Neuroscience. vol 258. 2014-09-29. PMID:24231740. |
reactive oxygen species (ros) generation followed by protein carbonylation, lipid peroxidation, decreased antioxidant defenses (decreased mn-superoxide dismutase (mnsod) activity and decreased glutathione levels) and subsequent caspase activation mediated the apoptosis. |
2014-09-29 |
2023-08-12 |
rat |
| D Jia, L-J Heng, R-H Yang, G-D Ga. Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways. Neuroscience. vol 258. 2014-09-29. PMID:24252320. |
the present study investigated the effects of fish oil supplementation on the lipid peroxidation, inflammation and neuron apoptosis in the hippocampus of streptozotocin (stz)-induced diabetes rats. |
2014-09-29 |
2023-08-12 |
rat |
| N V Medvedev, N K Gorshunov. [Significance age-related predictors of chronic heart failure in determining the risk of death in elderly patients with hypertension]. Advances in gerontology = Uspekhi gerontologii. vol 27. issue 1. 2014-09-22. PMID:25051770. |
in order to establish the prognostic value of age-related pathogenesis and the development of heart failure related to lipid peroxidation, endogenous subclinical inflammation, apoptosis, sarcopenia, interstitial myocardial fibrosis in the risk of mortality and survival rates, for the first time the results of echocardiography, enzyme immunoassay, bioimpedansmetry with the scale of the seattle model of heart failure performed in 84 elderly patients with arterial hypertension stage ii (middle age 68,3 +/- 1,8 years) were compared. |
2014-09-22 |
2023-08-13 |
Not clear |
| Yongde Xu, Hongen Lei, Ruili Guan, Zhezhu Gao, Huixi Li, Lin Wang, Weidong Song, Bing Gao, Zhongcheng Xi. Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model. Biochemical and biophysical research communications. vol 450. issue 1. 2014-09-21. PMID:24875356. |
in the present study, sperm characteristics, serum testosterone, steroidogenic enzymes (star and 3β-hsd), and the vimentin apical extension of sertoli cells decreased significantly in the stz group compared with those in the normal controls (p<0.05), while johnsen's score, testicular lipid peroxidation, spermatogenic cell apoptosis, and the expressions of nf-κb and wnt4 significantly increased (p<0.05). |
2014-09-21 |
2023-08-13 |
rat |
| Yan Li, Xue Shi, Jingwen Zhang, Xiang Zhang, Robert C G Marti. Hepatic protection and anticancer activity of curcuma: a potential chemopreventive strategy against hepatocellular carcinoma. International journal of oncology. vol 44. issue 2. 2014-09-11. PMID:24270742. |
the hepatic tissue was evaluated for histology, cd4+ cell, interferon-γ, apoptosis, lipid peroxidation, 8-hydroxy-deoxyguanosine and mnsod. |
2014-09-11 |
2023-08-12 |
mouse |
| Songsheng Shi, Weizhong Yang, Xiankun Tu, Chunmei Chen, Chunhua Wan. Ischemic preconditioning reduces ischemic brain injury by suppressing nuclear factor kappa B expression and neuronal apoptosis. Neural regeneration research. vol 8. issue 7. 2014-09-10. PMID:25206708. |
these results suggested that ischemic preconditioning plays a protective effect against ischemic brain injury by suppressing the inflammatory response, reducing lipid peroxidation, and neuronal apoptosis via inhibition of nuclear factor-κb and cleaved caspase-3 expression. |
2014-09-10 |
2023-08-13 |
rat |
| Hassan I H El-Sayyad, Soad A Khalifa, Asma S Al-Gebaly, Ahmed A El-Mans. Aging related changes of retina and optic nerve of Uromastyx aegyptia and Falco tinnunculus. ACS chemical neuroscience. vol 5. issue 1. 2014-09-09. PMID:24215233. |
concomitantly, there was a marked increase of oxidative stress involved reduction of neurotransmitters and antioxidant enzymes and an increase of lipid peroxidation, caspase-3 and -7, subg0/g1 apoptosis, and p53. |
2014-09-09 |
2023-08-12 |
Not clear |